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Total 37508 results found since Jan 2013.

In search for globally disordered apo-parvalbumins: Case of parvalbumin β-1 from coho salmon.
Abstract Parvalbumin (PA) is a classical EF-hand calcium-binding protein of muscle, neuronal, and other tissues, and a major fish allergen. Although certain apo-PAs lack tertiary structure, functional implications of that feature and its structural prerequisites remain unclear. In a search for unstable PAs, we probed conformational stability of parvalbumin β-1 from coho salmon (csPA), a cold water fish species, using circular dichroism, scanning calorimetry, hydrophobic probe fluorescence, limited proteolysis, chemical crosslinking and dynamic light scattering techniques. Apo-csPA is shown to be mainly monomeric ...
Source: Cell Calcium - October 17, 2017 Category: Cytology Authors: Vologzhannikova AA, Khorn PA, Kazakov AS, Ismailov RG, Sokolov AS, Uversky VN, Permyakov EA, Permyakov SE Tags: Cell Calcium Source Type: research

Molecules, Vol. 23, Pages 953: Search for Partner Proteins of A. thaliana Immunophilins Involved in the Control of Plant Immunity
A. Bruskin The involvement of plant immunophilins in multiple essential processes such as development, various ways of adapting to biotic and abiotic stresses, and photosynthesis has already been established. Previously, research has demonstrated the involvement of three immunophilin genes (AtCYP19-1/ROC3, AtFKBP65/ROF2, and AtCYP57) in the control of plant response to invasion by various pathogens. Current research attempts to identify host target proteins for each of the selected immunophilins. As a result, candidate interactors have been determined and confirmed using a yeast 2-hybrid (Y2H) system for protein&a...
Source: Molecules - April 19, 2018 Category: Chemistry Authors: Inna A. Abdeeva Gennady V. Pogorelko Liliya G. Maloshenok Maria V. Mokrykova Oksana V. Fursova Sergey A. Bruskin Tags: Article Source Type: research

In search of antiepileptogenic treatments for post-traumatic epilepsy.
Abstract Post-traumatic epilepsy (PTE) occurs in 20% of individuals with acquired epilepsy, and can impact significantly the quality of life due to the seizures and other functional or cognitive and behavioral outcomes of the traumatic brain injury (TBI) and PTE. There is no available antiepileptogenic or disease modifying treatment for PTE. Animal models of TBI and PTE have been developed, offering useful insights on the value of inflammatory, neurodegenerative pathways, hemorrhages and iron accumulation, calcium channels and other target pathways that could be used for treatment development. Most of the existing...
Source: Neurobiology of Disease - June 21, 2018 Category: Neurology Authors: Saletti PG, Ali I, Casillas-Espinosa PM, Semple BD, Lisgaras C, Moshé SL, Galanopoulou AS Tags: Neurobiol Dis Source Type: research

Search for the Source of the Retinal Relaxing Factor.
CONCLUSIONS: the RRF is not released from vascular cells and probably neither from glial cells. The retinal cell type which does release the RRF remains unclear. Veratridine does not stimulate the RRF release in mice and the RRF release in chickens is calcium-dependent as well as calcium-independent. PMID: 29966443 [PubMed - as supplied by publisher]
Source: Current Eye Research - July 2, 2018 Category: Opthalmology Authors: Vanden Daele L, Boydens C, Devoldere J, Remaut K, Van de Voorde J Tags: Curr Eye Res Source Type: research

Proteomic study on neurite responses to oxidative stress: search for differentially expressed proteins in isolated neurites of N1E-115 cells.
Authors: Fukui K, Okihiro S, Ohfuchi Y, Hashimoto M, Kato Y, Yoshida N, Mochizuki K, Tsumoto H, Miura Y Abstract Reactive oxygen species attack several living organs and induce cell death. Previously, we found axonal/dendrite degeneration before the induction of cell death in hydrogen peroxide-treated neuroblastoma: N1E-115 cells and primary neurons. This phenomenon may be connected with membrane oxidation, microtubule destabilization and disruption of intracellular calcium homeostasis. However, its detailed mechanisms are not fully understood. Here, we identified proteins after treatment with hydrogen peroxide usi...
Source: Journal of Clinical Biochemistry and Nutrition - February 3, 2019 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Lead Poisoning and Intelligence: A Search for Cause and Effect in the Scottish Mental Surveys.
Authors: Krebs C Abstract In 1932 and again in 1947, the Scottish Council for Research in Education conducted the Scottish Mental Surveys. Testing two cohorts, one in 1932 and another in 1947, researchers set out to measure-using the same validated test each time-the intelligence of every Scottish child 11 years of age. The stated impetus for the Surveys was a fear that average Scottish intelligence was declining. But when investigators compared the results of the 1947 Survey with those from 1932 their predictions were completely upended. Instead of average intelligence declining, it had risen, substantially. The...
Source: Journal of Environmental and Public Health - November 30, 2019 Category: Environmental Health Tags: J Environ Public Health Source Type: research

Increasing dietary sodium chloride promotes urine dilution and decreases struvite and calcium oxalate relative supersaturation in healthy dogs and cats
The objective of this study was to compare the short ‐term effect of four diets differing only in NaCl content (base diet with 0.3% sodium and diets with added NaCl to achieve 0.7, 1.0 and 1.3% sodium as fed) on urinary ion concentrations and relative supersaturation (RSS) of struvite and calcium oxalate in dogs and cats. In both species, there was a significant increase in water intake and urine volume as dietary NaCl increased. Urine sodium concentration increased with increasing dietary NaCl. The highest sodium diet increased urinary calcium excretion in dogs only, while decreasing urinary calcium concentration. Calci...
Source: Journal of Animal Physiology and Animal Nutrition - March 11, 2020 Category: Zoology Authors: Yann Queau, Esther S. Bijsmans, Alexandre Feugier, Vincent C. Biourge Tags: ORIGINAL ARTICLE Source Type: research

Seasonal Variation and Global Public Interest in the Internet Searches for Osteoporosis
CONCLUSIONS: Google search query volumes related to osteoporosis follow strong seasonal patterns with late winter peaks and summer troughs. Further studies aimed at elucidating the possible mechanisms behind seasonality in osteoporosis are needed. Moreover, Internet data including the top rising topics may alert physicians to strengthen the propaganda of osteoporosis timely, so as to further promote the development of public health interventions.PMID:34189139 | PMC:PMC8195644 | DOI:10.1155/2021/6663559
Source: Biomed Res - June 30, 2021 Category: Research Authors: Chao Wang Xiong Shu Jianfeng Tao Yanzhuo Zhang Yue Yuan Chengai Wu Source Type: research

Calcium and vitamin D for increasing bone mineral density in premenopausal women
CONCLUSIONS: Our results do not support the isolated or combined use of calcium and vitamin D supplementation in healthy premenopausal women as a public health intervention to improve BMD in the total hip or lumbar spine, and therefore it is unlikely to have a benefit for the prevention of fractures (vertebral and non-vertebral). The evidence found suggests that there is no need for future studies in the general population of premenopausal women; however, studies focused on populations with a predisposition to diseases related to bone metabolism, or with low bone mass or osteoporosis diagnosed BMD would be useful.PMID:3670...
Source: Cochrane Database of Systematic Reviews - January 27, 2023 Category: General Medicine Authors: Luc ía Méndez-Sánchez Patricia Clark Tania M Winzenberg Peter Tugwell Paulina Correa-Burrows Rebecca Costello Source Type: research

Freshwater mussels in an impacted watershed: Influences of pollution from point and non-point sources
Chemosphere. 2022 Aug 6:135966. doi: 10.1016/j.chemosphere.2022.135966. Online ahead of print.ABSTRACTThe Grand River watershed in a densely populated region of Ontario supports one of the richest assemblages of freshwater mussels in Canada. However, water quality in this watershed is influenced by urban development, agriculture, and industry. Mussel populations and water chemistry in the lower Grand River and the Boston Creek tributary were evaluated to determine whether point sources of pollution such as discharges of domestic wastewater and industrial effluent, and non-point sources of pollution are affecting mussel dis...
Source: Chemosphere - August 9, 2022 Category: Chemistry Authors: Erin E Hayward Patricia L Gillis C James Bennett Ryan S Prosser Joseph Salerno Tanner Liang Shelby Robertson Chris D Metcalfe Source Type: research