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Nutrition: Calcium
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Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair
This study for the first time demonstrates that vascular smooth muscle cell-specific deletion of SIRT6 facilitates vascular calcification via suppression of DNA damage repair. Therefore, modulation of SIRT6 and DNA damage repair may represent a therapeutic strategy for vascular calcification.PMID:36367517 | DOI:10.1016/j.yjmcc.2022.10.009
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Siyi Wang Li Li Qingchun Liang Yuanzhi Ye Zirong Lan Qianqian Dong An Chen Mingwei Fu Yining Li Xiaoyu Liu Jing-Song Ou Lihe Lu Jianyun Yan Source Type: research
Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2022 Dec 25;54(12):1-11. doi: 10.3724/abbs.2022179.ABSTRACTThe large-conductance calcium-activated potassium (BK) channel is a critical regulator and potential therapeutic target of vascular tone and architecture, and abnormal expression or dysfunction of this channel is linked to many vascular diseases. Vascular remodelling is the early pathological basis of severe vascular diseases. Delaying the progression of vascular remodelling can reduce cardiovascular events, but the pathogenesis remains unclear. To clarify the role of BK channels in vascular remodelling, we use rats with BK chan...
Source: Acta Biochimica et Biophysica Sinica - December 14, 2022 Category: Biochemistry Authors: Jing Bi Yanru Duan Meili Wang Chunyu He Xiaoyue Li Xi Zhang Yan Tao Yunhui Du Huirong Liu Source Type: research
Epidermal Growth Factor Receptor Inhibition Prevents Vascular Calcifying Extracellular Vesicle Biogenesis
Am J Physiol Heart Circ Physiol. 2023 Feb 24. doi: 10.1152/ajpheart.00280.2022. Online ahead of print.ABSTRACTChronic kidney disease (CKD) increases the risk of cardiovascular disease, including vascular calcification, leading to higher mortality. Release of calcifying extracellular vesicles (EVs) by vascular smooth muscle cells (VSMCs) promotes ectopic mineralization of vessel walls. Caveolin-1 (CAV1), a structural protein in the plasma membrane, plays a major role in calcifying EV biogenesis in VSMCs. Epidermal growth factor receptor (EGFR) co-localizes with and influences the intracellular trafficking of CAV1. The goal ...
Source: Atherosclerosis - February 24, 2023 Category: Cardiology Authors: Amirala Bakhshian Nik Hooi Hooi Ng Sophie K Ashbrook Patrick Sun Francesco Iacoviello Paul R Shearing Sergio Bertazzo Deniel Mero Bohdan B Khomtchouk Joshua D Hutcheson Source Type: research
