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Nutrition: Calcium
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Total 39934 results found since Jan 2013.
High-mobility group box-1 promotes vascular calcification in diabetic mice via endoplasmic reticulum stress
J Cell Mol Med. 2021 Mar 16. doi: 10.1111/jcmm.16075. Online ahead of print.ABSTRACTSeveral studies reported the role of endoplasmic reticulum stress (ERS) in vascular calcification. High-mobility group box-1 (HMGB-1) plays a substantial role in diabetes and its complications. However, relatively little information is available regarding the association between HMGB-1 and calcification, and the underlying mechanism has still remained elusive. Therefore, in the present study, we attempted to indicate whether HMGB-1 could promote vascular calcification via ERS in diabetes. After induction of diabetes by Streptozotocin (STZ),...
Source: J Cell Mol Med - March 16, 2021 Category: Molecular Biology Authors: Zheng Chen Ran Li Li-Gang Pei Zhong-Hai Wei Jun Xie Han Wu Biao Xu Source Type: research
Restoration of critical defects in the rabbit mandible using osteoblasts and vascular endothelial cells co-cultured with vascular stent-loaded nano-composite scaffolds
In this study, we prepared poly-caprolactone/nano-hydroxyapatite/beta-calcium phosphate (PCL/nHA/β-TCP) composite scaffolds loaded with poly-(lactic-co-glycolic acid)/nano-hydroxyapatite/collagen/heparin sodium (PLGA/nHA/Col/HS) nanofiber small vascular stent by electrospinning and hot press forming-particle leaching methods. Supramolecular electrostatic self-assembly technology was used to modify the surfaces of small vascular stents to aid in hydrophilicity and anticoagulation. The surfaces of composite scaffolds were modified with an Arg-Gly-Asp (RGD) short peptide by physical adsorption to supply cell adhesion sites. ...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 23, 2021 Category: Materials Science Authors: Hong Zhen Xu Jian Sheng Su Source Type: research
Differential Contribution of Renal Cytochrome P450 Enzymes to Kidney Endothelial Dysfunction and Vascular Oxidative Stress in Obesity
Biochem Pharmacol. 2021 Nov 22:114850. doi: 10.1016/j.bcp.2021.114850. Online ahead of print.ABSTRACTArachidonic acid (AA)-derived cytochrome P450 (CYP) derivatives, epoxyeicosatrienoic acids (EETs) and 20-hidroxyeicosatetranoic acid (20-HETE), play a key role in kidney tubular and vascular functions and blood pressure. Altered metabolism of CYP epoxygenases and CYP hydroxylases has differentially been involved in the pathogenesis of metabolic disease-associated vascular complications, although the mechanisms responsible for the vascular injury are unclear. The present study aimed to assess whether obesity-induced changes ...
Source: Biochemical Pharmacology - November 25, 2021 Category: Drugs & Pharmacology Authors: Mercedes Mu ñoz Elvira L ópez-Oliva Est éfano Pinilla Claudia Rodr íguez Mar ía Pilar Martínez Cristina Contreras Alfonso G ómez Sara Benedito Javier S áenz-Medina Luis Rivera Dolores Prieto Source Type: research
Vascular Calcification: Key Roles of Phosphate and Pyrophosphate
Int J Mol Sci. 2021 Dec 17;22(24):13536. doi: 10.3390/ijms222413536.ABSTRACTCardiovascular complications due to accelerated arterial stiffening and atherosclerosis are the leading cause of morbimortality in Western society. Both pathologies are frequently associated with vascular calcification. Pathologic calcification of cardiovascular structures, or vascular calcification, is associated with several diseases (for example, genetic diseases, diabetes, and chronic kidney disease) and is a common consequence of aging. Calcium phosphate deposition, mainly in the form of hydroxyapatite, is the hallmark of vascular calcificatio...
Source: Atherosclerosis - December 24, 2021 Category: Cardiology Authors: Ricardo Villa-Bellosta Source Type: research
Dopamine 1 receptors inhibit apoptosis via activating CSE/H < sub > 2 < /sub > S pathway in high glucose-induced vascular endothelial cells
This article is protected by copyright. All rights reserved.PMID:35293655 | DOI:10.1002/cbin.11794
Source: Cell Biology International - March 16, 2022 Category: Cytology Authors: Hongzhu Li Ren Wu Yuxin Xi Hongxia Li Guiquan Chang Fengqi Sun Can Wei Lijie Jiao Xin Wen Gensheng Zhang Altaany Zaid Jinghui Hao Source Type: research
MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF- β1 signaling
Commun Biol. 2022 Apr 19;5(1):364. doi: 10.1038/s42003-022-03313-z.ABSTRACTVascular calcification occurs in arterial aging, atherosclerosis, diabetes mellitus, and chronic kidney disease. Transforming growth factor-β1 (TGF-β1) is a key modulator driving the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs), leading to vascular calcification. We hypothesize that milk fat globule-epidermal growth factor 8 (MFG-E8), a glycoprotein expressed in VSMCs, promotes the osteogenic transdifferentiation of VSMCs through the activation of TGF-β1-mediated signaling. We observe that the genetic deletion of MFG-E8...
Source: Atherosclerosis - April 20, 2022 Category: Cardiology Authors: Hou-Yu Chiang Pao-Hsien Chu Shao-Chi Chen Ting-Hein Lee Source Type: research
Vascular calcification: Molecular mechanisms and therapeutic interventions
MedComm (2020). 2023 Jan 3;4(1):e200. doi: 10.1002/mco2.200. eCollection 2023 Feb.ABSTRACTVascular calcification (VC) is recognized as a pathological vascular disorder associated with various diseases, such as atherosclerosis, hypertension, aortic valve stenosis, coronary artery disease, diabetes mellitus, as well as chronic kidney disease. Therefore, it is a life-threatening state for human health. There were several studies targeting mechanisms of VC that revealed the importance of vascular smooth muscle cells transdifferentiating, phosphorous and calcium milieu, as well as matrix vesicles on the progress of VC. However,...
Source: Atherosclerosis - January 9, 2023 Category: Cardiology Authors: Wei Pan Wei Jie Hui Huang Source Type: research
TRPV4 channels promote vascular permeability in retinal vascular disease
This study aimed to determine the role of transient receptor potential vanilloid 4 (TRPV4), a calcium (Ca2+)-permeable cation channel, in the pathophysiology of retinal vascular disease. The retinal vein occlusion (RVO) murine model was created by irradiating retinal veins using lasers. TRPV4 expression and localization were evaluated in RVO mice retinas. In addition, we examined the effects of TRPV4 antagonists (RQ-00317310, HC-067047, GSK2193874, and GSK2798745) on retinal edema, blood flow, and ischemic areas in RVO mice. Furthermore, changes in the retinal expression of tumor necrosis factor (TNF)-α and aquaporin4 (AQ...
Source: Cell Research - February 11, 2023 Category: Cytology Authors: Anri Nishinaka Miruto Tanaka Kentaro Ohara Eiji Sugaru Yuji Shishido Akemi Sugiura Yukiko Moriguchi Amane Toui Shinsuke Nakamura Kaoru Shimada Shuzo Watanabe Hideaki Hara Masamitsu Shimazawa Source Type: research
