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Nutrition: Calcium
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Total 39934 results found since Jan 2013.
TRPV4 channels promote vascular permeability in retinal vascular disease
This study aimed to determine the role of transient receptor potential vanilloid 4 (TRPV4), a calcium (Ca2+)-permeable cation channel, in the pathophysiology of retinal vascular disease. The retinal vein occlusion (RVO) murine model was created by irradiating retinal veins using lasers. TRPV4 expression and localization were evaluated in RVO mice retinas. In addition, we examined the effects of TRPV4 antagonists (RQ-00317310, HC-067047, GSK2193874, and GSK2798745) on retinal edema, blood flow, and ischemic areas in RVO mice. Furthermore, changes in the retinal expression of tumor necrosis factor (TNF)-α and aquaporin4 (AQ...
Source: Experimental Eye Research - February 11, 2023 Category: Opthalmology Authors: Anri Nishinaka Miruto Tanaka Kentaro Ohara Eiji Sugaru Yuji Shishido Akemi Sugiura Yukiko Moriguchi Amane Toui Shinsuke Nakamura Kaoru Shimada Shuzo Watanabe Hideaki Hara Masamitsu Shimazawa Source Type: research
Subclinical Vascular Composites Predict Clinical Cardiovascular Disease, Stroke, and Dementia: The Multi-Ethnic Study of Atherosclerosis (MESA)
CONCLUSIONS: Subclinical vascular composites of arteriosclerosis and atherosclerosis may be useful biomarkers to inform the vascular pathways contributing to events of CVD, CHD, stroke, and dementia.PMID:37205504 | PMC:PMC10187443 | DOI:10.1101/2023.05.01.23289364
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Timothy M Hughes Jordan Tanley Haiying Chen Christopher L Schaich Joseph Yeboah Mark A Espeland Joao A C Lima Bharath Ambale-Venkatesh Erin D Michos Jingzhong Ding Kathleen Hayden Ramon Casanova Suzanne Craft Stephen R Rapp Jos é A Luchsinger Annette L F Source Type: research
Extracellular vesicles in atherosclerosis and vascular calcification: the versatile non-coding RNAs from endothelial cells and vascular smooth muscle cells
Front Med (Lausanne). 2023 Jul 4;10:1193660. doi: 10.3389/fmed.2023.1193660. eCollection 2023.ABSTRACTAtherosclerosis (AS) is characterized by the accumulation of lipids, fibrous elements, and calcification in the innermost layers of arteries. Vascular calcification (VC), the deposition of calcium and phosphate within the arterial wall, is an important characteristic of AS natural history. However, medial arterial calcification (MAC) differs from intimal calcification and cannot simply be explained as the consequence of AS. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are directly involved in AS and VC ...
Source: Atherosclerosis - July 20, 2023 Category: Cardiology Authors: Fengyi Yu Yingjie Duan Chongmei Liu Hong Huang Xiangcheng Xiao Zhangxiu He Source Type: research
SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome
CONCLUSIONS: Our study for the first time demonstrates that CANA exerts a protective effect on vascular calcification at least partially via suppressing NLRP3 signaling pathway. Therefore, supplementation of CANA as well as inhibition of NLRP3 inflammasome presents a potential therapy for vascular calcification.PMID:37523743 | DOI:10.1093/cvr/cvad119
Source: Cell Research - July 31, 2023 Category: Cytology Authors: An Chen Zirong Lan Li Li Luting Xie Xiaoyu Liu Xiulin Yang Siyi Wang Qingchun Liang Qianqian Dong Liyun Feng Yining Li Yuanzhi Ye Mingwei Fu Lihe Lu Jianyun Yan Source Type: research
Effects of intravenous sodium thiosulfate on vascular calcification in dialysis patients with end-stage renal disease: a systematic review and meta-analysis
CONCLUSIONS: Intravenous STS may slow down the progression of vascular calcification and ameliorate arterial stiffness in dialysis patients. Reliably defining the efficacy and safety of intravenous STS in attenuating the progression of vascular calcification requires a high-quality trial with a large sample size.PMID:37526956 | DOI:10.5830/CVJA-2023-020
Source: Cardiovascular Journal of Africa - August 1, 2023 Category: Cardiology Authors: Yu-Huan Song AiBing Ning Na Guo Ying Yang Fei Tang Na Zhao Jun Hu Hong Wu Ting Peng Yue-Fei Xiao Guang-Yan Cai Source Type: research
Overexpression of HOTAIR attenuates Pi-induced vascular calcification by inhibiting Wnt/ β-catenin through regulating miR-126/Klotho/SIRT1 axis
This study aimed to identify the explicit molecular mechanism underlying HOTAIR regulated vascular calcification. In the phosphate (Pi)-induced calcification model of human aortic smooth muscle cells (HASMCs), we investigated whether HOTAIR was involved in the regulation of miR-126. The luciferase reporter was used to examine the effect of HOTAIR on miR-126 and miR-126 on Klotho 3'-UTR. Furthermore, we overexpressed Klotho to verify the regulation of Klotho on SIRT1, as well as their roles in mediating Pi-induced calcification in HASMCs via the Wnt/β-catenin signaling pathway. Finally, the results were verified in an in v...
Source: Molecular and Cellular Biochemistry - May 20, 2021 Category: Biochemistry Authors: Yan Chen Chong Huang Shu-Ying Zhu Hong-Chang Zou Cheng-Yun Xu Yan-Xia Chen Source Type: research
Neuromedin B modulates phosphate-induced vascular calcification
In this study, we found that the expression of neuromedin B (NMB) and NMB receptor is upregulated in phosphate-induced calcification of vascular smooth muscle cells (VSMCs). Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/β-catenin signaling and VSMC apoptosis. PD168368 also attenuated the arterial calcification in cultured aortic rings and in a rat model of chronic kidney disease. The results of this study suggest that NMB-NMB receptor axis may have potential therapeutic value in the diagnosis and treatment of vasc...
Source: BMB Reports - October 22, 2021 Category: Biochemistry Authors: Hyun-Joo Park Mi-Kyoung Kim Yeon Yeon Hyung Joon Kim Soo-Kyung Bae Moon-Kyoung Bae Source Type: research
