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Neuromedin B modulates phosphate-induced vascular calcification
In this study, we found that the expression of neuromedin B (NMB) and NMB receptor is upregulated in phosphate-induced calcification of vascular smooth muscle cells (VSMCs). Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/β-catenin signaling and VSMC apoptosis. PD168368 also attenuated the arterial calcification in cultured aortic rings and in a rat model of chronic kidney disease. The results of this study suggest that NMB-NMB receptor axis may have potential therapeutic value in the diagnosis and treatment of vasc...
Source: BMB Reports - October 22, 2021 Category: Biochemistry Authors: Hyun-Joo Park Mi-Kyoung Kim Yeon Yeon Hyung Joon Kim Soo-Kyung Bae Moon-Kyoung Bae Source Type: research

CTRP3 is a coronary artery calcification biomarker and protects against vascular calcification by inhibiting β-catenin nuclear translocation to prevent vascular smooth muscle cell osteogenic differentiation
CONCLUSIONS: CTRP3 may serve as a valuable screening biomarker and a novel therapeutic target in CAC, particularly in diabetes patients.PMID:34774387 | DOI:10.1016/j.jjcc.2021.10.018
Source: Journal of Cardiology - November 14, 2021 Category: Cardiology Authors: Demin Liu Xiaowei Cui Rui Lu Haijuan Hu Guoqiang Gu Source Type: research

2-Benzyllawsone protects against polymicrobial sepsis and vascular hyporeactivity in swiss albino mice
CONCLUSIONS: LT-9 showed potent biological activity against sepsis and was found to be well tolerated in the toxicity study in Swiss albino mice and showed promise for the benzyllawsone class of molecules against sepsis for the development of novel pharmacophore.PMID:35032484 | DOI:10.1016/j.ejphar.2022.174757
Source: European Journal of Pharmacology - January 15, 2022 Category: Drugs & Pharmacology Authors: Pankaj Yadav Hina Iqbal Kapil Kumar Parmanand Kumar Divya Mishra Arjun Singh Anirban Pal Pradipto Mukhopadhyay Beena Vamadevan Dhirendra Singh Arvind Singh Negi Debabrata Chanda Source Type: research

Pathways involved in the human vascular Tetrabromobisphenol A response: calcium and potassium channels and nitric oxide donors
Toxicology. 2022 Mar 20:153158. doi: 10.1016/j.tox.2022.153158. Online ahead of print.ABSTRACTTetrabromobisphenol A (TBBPA) is a flame retardant that can contaminate the environment and human being, acting as an endocrine disruptor. Several studies propose a correlation between TBBPA exposure and adverse health outcomes, however, at vascular level TBBPA effects are still poorly understood. Thus, considering that the vascular tonus is regulated by vasoactive substances (serotonin and histamine) which are involved in some pathological processes, this work aimed to analyse the direct effects and the 24hours exposure of TBBPA ...
Source: Toxicology - March 24, 2022 Category: Toxicology Authors: Joana Feiteiro Sandra M Rocha Melissa Mariana Cl áudio J Maia Elisa Cairr ão Source Type: research

Pathways involved in the human vascular Tetrabromobisphenol A response: Calcium and potassium channels and nitric oxide donors
Toxicology. 2022 Mar 20;470:153158. doi: 10.1016/j.tox.2022.153158. Online ahead of print.ABSTRACTTetrabromobisphenol A (TBBPA) is a flame retardant that can contaminate the environment and human being, acting as an endocrine disruptor. Several studies propose a correlation between TBBPA exposure and adverse health outcomes, however, at vascular level TBBPA effects are still poorly understood. Thus, considering that the vascular tonus is regulated by vasoactive substances (serotonin and histamine) which are involved in some pathological processes, this work aimed to analyse the direct effects and the 24 h exposure of TBBPA...
Source: Toxicology - March 24, 2022 Category: Toxicology Authors: Joana Feiteiro Sandra M Rocha Melissa Mariana Cl áudio J Maia Elisa Cairr ão Source Type: research

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