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Nutrition: Calcium
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Total 39934 results found since Jan 2013.
Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells
CONCLUSIONS: Our findings support an important role of erythrocyte ARG1 for NO bioavailability and L-arginine metabolism in VSMCs, which controls atherosclerotic lesion composition and calcification.PMID:36252109 | DOI:10.1161/ATVBAHA.122.318338
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Rajinikanth Gogiraju Luisa Renner Magdalena L Bochenek Konstantinos Zifkos Michael Molitor Sven Danckwardt Philip Wenzel Thomas M ünzel Stavros Konstantinides Katrin Sch äfer Source Type: research
Hypertensive vascular and cardiac remodeling protection by allicin in spontaneous hypertension rats via CaMK Ⅱ/NF-κB pathway
This study also provided new mechanistic insights into the anti-hypertensive vascular and cardiac remodeling effects of allicin, highlighting its therapeutic potential.PMID:36271577 | DOI:10.1016/j.biopha.2022.113802
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Weiyu Liu Shaojun Xu Shuangqin Liang Changling Duan Zhilan Xu Le Zhao Feifei Wen Qiuyan Li Yikui Li Jinyan Zhang Source Type: research
Vascular Smooth Muscle Cells Become Prone to Altered Behavior with Age
The altered signaling environment in aged tissue produces changes in cell behavior, some of which is adaptive and helpful, and some of which is maladaptive and harmful. In some cases the same process can be one or the other depending on context. Cellular senescence, for example, is helpful in the contexts of cancer suppression and regeneration from injury, but only up until the point at which senescent cells are no longer removed as rapidly as they are created, at which point their continued, unrelenting pro-growth, pro-inflammatory signaling contributes to many of the forms of tissue dysfunction observed in aging.
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Source: Fight Aging! - December 2, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A multi-target protective effect of Danggui-Shaoyao-San on the vascular endothelium of atherosclerotic mice
CONCLUSIONS: Collectively, DGSY can alleviate vascular endothelium damage and delay the occurrence of AS, and the underlying mechanism may be related to the multi-target protective of DGSY.PMID:36803348 | DOI:10.1186/s12906-023-03883-3
Source: Atherosclerosis - February 21, 2023 Category: Cardiology Authors: Yuemeng Sun Yushan Gao Lu Zhou Yixing Lu Yulin Zong Haoyu Zhu Yang Tang Fengjie Zheng Yan Sun Yuhang Li Source Type: research
Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn ( < em > Crataegus anamesa < /em > Sarg.) extracts in cardiovascular diseases
This study aimed to review the vascular protective effects and molecular mechanisms of hawthorn and its extracts on cardiovascular diseases (CVDs). Hawthorn has a wide range of biological functions. Evidence suggests that the active components of HE reduce oxidative stress and inflammation, regulate lipid levels to prevent lipid accumulation, and inhibit free cholesterol accumulation in macrophages and foam cell formation. Additionally, hawthorn extract (HE) can protect vascular endothelial function, regulate endothelial dysfunction, and promote vascular endothelial relaxation. It has also been reported that the effective ...
Source: Atherosclerosis - June 20, 2023 Category: Cardiology Authors: Mengkai Lu Lei Zhang Jinyuan Pan Huishan Shi Muxin Zhang Chao Li Source Type: research
NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension.
Conclusions -These results reveal a dysregulation of the glutamate-NMDAR axis in the pulmonary arteries of PAH patients, and identify vascular NMDARs as targets for anti-remodeling treatments in PAH.
PMID: 29444988 [PubMed - as supplied by publisher]
Source: Circulation - February 14, 2018 Category: Cardiology Authors: Dumas SJ, Bru-Mercier G, Courboulin A, Quatredeniers M, Rücker-Martin C, Antigny F, Nakhleh MK, Ranchoux B, Gouadon E, Vinhas MC, Vocelle M, Raymond N, Dorfmüller P, Fadel E, Perros F, Humbert M, Cohen-Kaminsky S Tags: Circulation Source Type: research
Vascular smooth muscle contraction in hypertension
AbstractHypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to increased vascular contraction and arterial remodelling. These processes are regulated by complex-interacting systems such as the renin-angiotensin-aldosterone system, sympathetic nervous system, immune activation, and oxidative stress, which influence vascular smooth musc...
Source: Cardiovascular Research - January 31, 2018 Category: Cardiology Source Type: research
Evidence for Pyrophosphate to be the Primary Inhibitor of Vascular Calcification
This open access commentary notes the evidence to suggest that therapies based on raised levels of pyrophosphate in blood vessel walls to reduce age-related calcification. The mineralization of blood vessel walls through deposition of calcium, calcification, is one of the mechanisms that contributes to vascular stiffness with age. It impairs the ability of blood vessels to contract and relax as they should. This is a serious issue, as it breaks the feedback mechanisms that control blood pressure, leading to hypertension, vascular disease, and heart failure as heart muscle grows and weakens.
From my point of view, th...
Source: Fight Aging! - December 11, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Systematic Review and Meta-Analysis of Interventions to Slow Progression of Abdominal Aortic Aneurysm in Mouse Models.
CONCLUSIONS: There is low-quality evidence that a range of drugs are effective in limiting AAA progression when administered early after AAA induction in mouse models. Some of these drugs, such as antiplatelet and renin-angiotensin system inhibitors, have been reported to be ineffective in clinical trials.
PMID: 33567871 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Phie J, Thanigaimani S, Golledge J Tags: Arterioscler Thromb Vasc Biol Source Type: research
Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage
In this study we have examined the reactivity of HOCl and HOSCN with human coronary artery smooth muscle cells (HCASMC), given the key role of this cell type in maintaining vascular function. HOCl reacts rapidly with the cells, resulting in extensive cell death by both necrosis and apoptosis, and increased levels of intracellular calcium. In contrast, HOSCN reacts more slowly, with cell death occurring only after prolonged incubation, and in the absence of the accumulation of intracellular calcium. Exposure of HCASMC to HOCl also influences mitochondrial respiration, decreases glycolysis, lactate release, the production of...
Source: Free Radical Biology and Medicine - February 25, 2021 Category: Biology Authors: Konstantina Flouda John Mercer Michael J Davies Clare L Hawkins Source Type: research
κ-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling
Aging (Albany NY). 2021 May 20;13. doi: 10.18632/aging.203050. Online ahead of print.ABSTRACTIn the present study, the effects and mechanism of action of U50,488H (a selective κ-opioid receptor agonist) on calcification of rat vascular smooth muscle cells (VSMCs) induced by β-glycerophosphate (β-GP) were investigated. VSMCs were isolated and cultured in traditional FBS-based media. A calcification model was established in VSMCs under hyperphosphatemia and intracellular calcium contents. Alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and lactate were detected in cell culture supernatants before and after treatm...
Source: Aging - May 21, 2021 Category: Biomedical Science Authors: Jin Niu Chen Wu Min Zhang Zhen Yang Zhenhua Liu Feng Fu Jun Li Na Feng Xiaoming Gu Shumiao Zhang Yali Liu Rong Fan Juan Li Jianming Pei Source Type: research
Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling
In this study we investigated the role of large-conductance calcium-activated potassium (BK) channels in 3 experimental VC models. VC was induced in vascular smooth muscle cells (VSMCs) by β-glycerophosphate (β-GP), or in rats by subtotal nephrectomy, or in mice by high-dosage vitamin D3. We showed that the expression of BK channels in the artery of CKD rats with VC and in β-GP-treated VSMCs was significantly decreased, which was functionally confirmed by patch-clamp recording. In β-GP-treated VSMCs, BK channel opener NS1619 (20 μM) significantly alleviated VC by decreasing calcium content and alkaline phosphatase act...
Source: Acta Pharmacologica Sinica - June 24, 2021 Category: Drugs & Pharmacology Authors: Feng-Ling Ning Jie Tao Dan-Dan Li Lu-Lu Tian Meng-Ling Wang Svetlana Reilly Cheng Liu Hui Cai Hong Xin Xue-Mei Zhang Source Type: research
