Filtered By:
Nutrition: Calcium
This page shows you your search results in order of relevance. This is page number 20.
Order by Relevance | Date
Total 39934 results found since Jan 2013.
Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling
In this study we investigated the role of large-conductance calcium-activated potassium (BK) channels in 3 experimental VC models. VC was induced in vascular smooth muscle cells (VSMCs) by β-glycerophosphate (β-GP), or in rats by subtotal nephrectomy, or in mice by high-dosage vitamin D3. We showed that the expression of BK channels in the artery of CKD rats with VC and in β-GP-treated VSMCs was significantly decreased, which was functionally confirmed by patch-clamp recording. In β-GP-treated VSMCs, BK channel opener NS1619 (20 μM) significantly alleviated VC by decreasing calcium content and alkaline phosphatase act...
Source: Acta Pharmacologica Sinica - June 24, 2021 Category: Drugs & Pharmacology Authors: Feng-Ling Ning Jie Tao Dan-Dan Li Lu-Lu Tian Meng-Ling Wang Svetlana Reilly Cheng Liu Hui Cai Hong Xin Xue-Mei Zhang Source Type: research
Considering Mechanistic Links Between Vascular Calcification and Osteoporosis
With advancing age, regulatory pathways involved in bone remodeling are activated inappropriately in smooth muscle cells of blood vessel walls and cardiac tissue. The result is calcification of tissue, making it inflexible, and disrupting the normal elasticity. That leads to hypertension and other, worse cardiovascular issues. Inflammatory signaling and the presence of senescent cells appear to be involved in causing this process, but firmly proven chains of cause and effect are yet to be established, as is the case for all too much of the panoply of dysfunctions that arise in the progression of degenerative aging.
...
Source: Fight Aging! - November 23, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice
CONCLUSIONS: The heterogeneity of ECs is established as early as the embryonic stage. The deficiency of miR-126 disrupts the differentiation and diversification of embryonic ECs, suggesting that miR-126 plays an essential role in the maintenance of ECs heterogeneity.PMID:35021856 | DOI:10.1161/ATVBAHA.121.317093
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 13, 2022 Category: Cardiology Authors: Fang-Hao Guo Ya-Na Guan Jun-Jun Guo Lu-Jun Zhang Jing-Jing Qiu Yong Ji Alex F Chen Qing Jing Source Type: research
Circular RNA circSmoc1-2 regulates vascular calcification by acting as a miR-874-3p sponge in vascular smooth muscle cells
In conclusion, we revealed that the circSmoc1-2/miR-874-3p/Adam19 axis regulates VC, suggesting that circSmoc1-2 may be a novel therapeutic target in the treatment of VC.PMID:35036071 | PMC:PMC8752879 | DOI:10.1016/j.omtn.2021.12.031
Source: Atherosclerosis - January 17, 2022 Category: Cardiology Authors: Juhee Ryu Nakwon Choe Duk-Hwa Kwon Sera Shin Yeong-Hwan Lim Gwangho Yoon Ji Hye Kim Hyung Seok Kim In-Kyu Lee Youngkeun Ahn Woo Jin Park Hyun Kook Young-Kook Kim Source Type: research
Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice
CONCLUSIONS: The heterogeneity of ECs is established as early as the embryonic stage. The deficiency of miR-126 disrupts the differentiation and diversification of embryonic ECs, suggesting that miR-126 plays an essential role in the maintenance of ECs heterogeneity.PMID:35021856 | DOI:10.1161/ATVBAHA.121.317093
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 13, 2022 Category: Cardiology Authors: Fang-Hao Guo Ya-Na Guan Jun-Jun Guo Lu-Jun Zhang Jing-Jing Qiu Yong Ji Alex F Chen Qing Jing Source Type: research
CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via the miR-106a-5p/MFN2 Axis
J Cardiovasc Transl Res. 2022 Apr 25. doi: 10.1007/s12265-022-10247-8. Online ahead of print.ABSTRACTAtherosclerosis is the most common arterial disease and is closely related to vascular calcification. CircHIPK3 has been implicated in atherosclerosis development, but the possible downstream regulatory mechanisms remain unclear. The levels of circHIPK3, miR-106a and MFN2 in tissues and blood samples of patients with atherosclerosis were detected by RT-qPCR. The levels of circHIPK3, miR-106a and MFN2 were detected by RT-qPCR and the expression levels of MFN2, osteogenic and cartilage differentiation marker proteins were det...
Source: Atherosclerosis - April 25, 2022 Category: Cardiology Authors: Wen-Bo Zhang You-Fei Qi Zhan-Xiang Xiao Hao Chen Sa-Hua Liu Zhen-Zhen Li Zhao-Fan Zeng Hong-Fei Wu Source Type: research
Bax inhibitor 1 inhibits vascular calcification in mice by activating optic atrophy 1 expression
CONCLUSION: BI-1 inhibits VC possibly by promoting the expression of OPA1, reducing calcium deposition and inhibiting osteogenic differentiation and apoptosis of the vascular smooth muscle cells.PMID:35426795 | PMC:PMC9010980 | DOI:10.12122/j.issn.1673-4254.2022.03.03
Source: Journal of Southern Medical University - April 15, 2022 Category: Universities & Medical Training Authors: W Chen H DU G Qian Y Zhou Y Chen Q Ma X Wu Y Sha Source Type: research
