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Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway
In conclusion, our results suggest that fisetin is a promising natural agent for the treatment of renal injury caused by diabetes and atherosclerosis. We reveal that fisetin is an inhibitor of CD36 for reducing the progression of kidney fibrosis, and fisetin-regulated CD36 may be a therapeutic target for the treatment of renal fibrosis.PMID:37225845 | DOI:10.1038/s41401-023-01106-6
Source: Acta Pharmacologica Sinica - May 24, 2023 Category: Drugs & Pharmacology Authors: Ting-Feng Zou Zhi-Gang Liu Pei-Chang Cao Shi-Hong Zheng Wen-Tong Guo Tian-Xiang Wang Yuan-Li Chen Ya-Jun Duan Qing-Shan Li Chen-Zhong Liao Zhou-Ling Xie Ji-Hong Han Xiao-Xiao Yang Source Type: research

Proanthocyanidins: A novel approach to Henoch ‑Schonlein purpura through balancing immunity and arresting oxidative stress via TLR4/MyD88/NF‑κB signaling pathway (Review)
Exp Ther Med. 2023 May 9;25(6):300. doi: 10.3892/etm.2023.11999. eCollection 2023 Jun.ABSTRACTHenoch-Schonlein purpura (HSP), a recurrent and immunoglobulin (Ig)A-mediated vasculitis, presents not only as skin lesions but also as systemic involvement that can be life-threatening. Although the etiology of HSP remains unknown, immune imbalance and oxidative stress (OS) are primary contributors to its pathogenesis, alongside the abnormal activation of Toll-like receptor (TLR)/myeloid differentiation primary response gene 88 (MyD88)/nuclear factor-κB (NF-κB) pathway. TLRs, especially TLR4, stimulate downstream signaling mole...
Source: Experimental and Therapeutic Medicine - May 25, 2023 Category: General Medicine Authors: Yuxin Xie Qiyan Deng Menglu Guo Xiaolong Li Deihai Xian Jianqiao Zhong Source Type: research

Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate in adult rats
This study investigated whether Hsd could attenuate impairments of hippocampal neural stem cells related to apoptosis induced by MTX. Spraque-Dawley rats (n = 24) were divided into 4 groups: (1) Vehicle group received propylene glycol (21 days) and 0.9% normal saline (day 8 and 15), (2) Hsd group received 100 mg/kg (21 days), (3) MTX group received 75 mg/kg (days 8 and 15) and (4) MTX+Hsd group received MTX, 75 mg/kg (day 8 and 15) and Hsd 100 mg/kg (21 days). Our results showed that MTX decreased hippocampal neural stem cells including SRY (sex determining region Y)-box 2 (SOX2) and nestin. MTX diminished vascular related...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 19, 2023 Category: Drugs & Pharmacology Authors: Salinee Naewla Ram Prajit Nataya Sritawan Kornrawee Suwannakot Apiwat Sirichoat Anusara Aranarochana Peter Wigmore Jariya Umka Welbat Source Type: research

How to Read News About Breakthrough Medical Technologies?
In the era of “fake news”, click-bait articles and a tremendous amount of spam, it is important to be vigilant. We have to spot what’s real and what’s fake medical news. It is easy to over-hype a technology or get false hope, but we must battle this. I summarized the best methods that help filter gold out of the information garbage. Don’t let online scam artists (or anyone else for that matter) fool you! I received an e-mail recently. It looked just as my phone bill, every detail of it seemed to be real. The sender was noreply@telekom.hu, which also seemed believable since the phone company’s name is also ...
Source: The Medical Futurist - July 27, 2017 Category: Information Technology Authors: nora Tags: Social media in Healthcare fake news gc4 hype medical news online online scam technology Source Type: blogs

Traditional Medicinal Uses and Pharmacological Properties of Rhus chinensis Mill.: A Systematic Review
Conclusion Utilization of R. chinensis appears promising and describes its possible uses for human health with activities like anticaries, antibacterial, antimicrobial, antidiarrhoeal, antiviral, antioxidant, anticholesterol and antidiabetic. Further exploratory studies are required to scientifically validate the existing traditional practices in relation to its health benefits.
Source: European Journal of Integrative Medicine - June 28, 2018 Category: Complementary Medicine Source Type: research

Traditional medicinal uses and pharmacological properties of Rhus chinensis Mill.: A systematic review
ConclusionUtilization of R. chinensis appears promising and describes its possible uses for human health with activities like anticaries, antibacterial, antimicrobial, antidiarrhoeal, antiviral, antioxidant, anticholesterol and antidiabetic. Further exploratory studies are required to scientifically validate the existing traditional practices in relation to its health benefits.
Source: European Journal of Integrative Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research

10 Top Questions You Had For Dr. Google In 2018
(CNN) — People were curious about the keto diet, ALS and endometriosis in 2018. Those are just a few of the health-related topics that had Internet surfers in the United States turning to Dr. Google with questions this year, according to a top 10 list from the search engine giant. The data, based on search terms, was collected from January to mid-December. Last year, some of the top health-related questions searched on Google included what causes hiccups, how to stop snoring, how long flu lasts and what is lupus. Some of the top health-related questions on Google in 2016 were related to Zika, traumatic brain injuries...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 21, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Offbeat Google Local TV Source Type: news

Effects of nutrients and exercises to attenuate oxidative stress and prevent cardiovascular disease.
CONCLUSION: The recognition of appropriate nutrients and exercise with antioxidant properties may be an important supportive approach to impair early vascular aging and to prevent cardiovascular disease. PMID: 30652637 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - January 16, 2019 Category: Drugs & Pharmacology Authors: Neves MF, Cunha MR, Paula T Tags: Curr Pharm Des Source Type: research

Top 10 Health Questions America Asked Dr. Google In 2019
(CNN) — Google users in the United States had a lot of questions about blood pressure, the keto diet and hiccups in 2019. Those topics were among the 10 most-searched health-related questions on the search engine this year, according to new data from Google. The list was based on search terms collected between January and early December. Last year, the top health-related questions Googled by people in the US included what is amyotrophic lateral sclerosis, or ALS, what is endometriosis and how long does weed stay in your urine. In 2017, what is lupus, how long does the flu last and what causes hiccups were some of the...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 12, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Google Source Type: news

Molecules, Vol. 25, Pages 103: Distribution of Flavan-3-ol Species in Ripe Strawberry Fruit Revealed by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging
Hatta Flavan-3-ols, which comprise proanthocyanidins and their monomers, are major flavonoids in strawberries, and they have a wide range of biological activities and health benefits. However, their spatial distribution in strawberry fruit remains poorly understood. Therefore, we performed matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI), to visualize flavan-3-ols in ripe strawberry fruit. Peaks matching the m/z values of flavan-3-ols [M &minus; H]&minus; ions were detected in the negative ion mode using 1,5-diaminonaphthalene as matrix. Catechin and/or epicatechin, ...
Source: Molecules - December 25, 2019 Category: Chemistry Authors: Enomoto Takahashi Takeda Hatta Tags: Article Source Type: research

Molecules, Vol. 25, Pages 2859: Pomegranate Peel as Suitable Source of High-Added Value Bioactives: Tailored Functionalized Meat Products
orenzo In the last few years, the consumer&rsquo;s concern with the relationship between health and diet has led to the search of foods with functional properties beyond the nutritional. In this framework, the consumption of pomegranate has increased due to their sensorial attributes and remarkable amounts of bioactive compounds, which generate, at the same time, huge amounts of by-products. A search in the Scopus database for the last 10 years has revealed the rising interest in pomegranate peel (PP), the main residue from this fruit. The meat industry is a food sector that has had to search for new alternativ...
Source: Molecules - June 20, 2020 Category: Chemistry Authors: Patricia Gull ón Gonzalo Astray Beatriz Gull ón Igor Tomasevic Jos é M. Lorenzo Tags: Review Source Type: research

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