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Nutrition: Iron
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Ferroportin-mediated iron export from vascular endothelial cells in retina and brain.
Abstract
Retinal iron accumulation has been implicated in the pathogenesis of age-related macular degeneration (AMD) and other neurodegenerative diseases. The retina and the brain are protected from the systemic circulation by the blood retinal barrier (BRB) and blood brain barrier (BBB), respectively. Iron levels within the retina and brain need to be tightly regulated to prevent oxidative injury. The method of iron entry through the retina and brain vascular endothelial cells (r&bVECs), an essential component of the BRB and BBB, is not fully understood. However, localization of the cellular iron exporter, fe...
Source: Experimental Eye Research - July 15, 2019 Category: Opthalmology Authors: Baumann BH, Shu W, Song Y, Simpson EM, Lakhal-Littleton S, Dunaief JL Tags: Exp Eye Res Source Type: research
High-phosphate induced vascular calcification is reduced by iron citrate through inhibition of extracellular matrix osteo-chondrogenic shift in VSMCs
High serum phosphate (Pi) levels strongly associate with cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients with vascular calcification playing a major role in the pathogenesis of related cardiovascular disease. High-Pi challenged vascular smooth muscle cells (VSMCs) undergo simil-osteoblastic transformation and actively deposit calcium-phosphate crystals. Iron-based Pi-binders are used to treat hyperphosphatemia in CKD patients.
Source: International Journal of Cardiology - October 7, 2019 Category: Cardiology Authors: Paola Ciceri, Monica Falleni, Delfina Tosi, Carla Martinelli, Gaetano Bulfamante, Geoofrey A. Block, Piergiorgio Messa, Mario Cozzolino Source Type: research
Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver
Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying protein hemoglobin, RBCs contain the vast majority of the body’s iron, which is known to be a limiting nutrient in marine ecosystems. Since lower RBC levels also lead to reduced iron requirements, we hypothesize that low iron availability was an additional evolutionary driver of Antarctic fish speciation. Antarctic Icefish of the family Channichthyidae are known to have an extreme alteration of ir...
Source: Frontiers in Physiology - November 11, 2019 Category: Physiology Source Type: research
Long-term follow-up in patients with gastric antral vascular ectasia (GAVE) after treatment with endoscopic band ligation (EBL)
Conclusion This is the first study to evaluate long-term response and recurrence in patients with GAVE after treatment with EBL and predictors of clinical response after initial endoscopic therapy have been identified. While we were able to demonstrate excellent remission achievement rates in our GAVE patients who had undergone EBL, close clinical follow-up is clearly required as almost 50 % will have recurrence at around 18 months. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | open access Full text
Source: Endoscopy International Open - November 24, 2019 Category: Gastroenterology Authors: Eccles, John Falk, Vanessa Montano-Loza, Aldo J. Zepeda-G ómez, Sergio Tags: Original article Source Type: research
Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAH Ⅱ/eNOS/NO pathway.
In this study, HUVECs was treated with 50 μM iron dextran and 20 μM Que for 48 h. We found that Que attenuated the damages induced by iron, as evidenced by decreased ROS generation, increased DDAHⅡexpression and activity, reduced ADMA level, increased NO content and p-eNOS/eNOS ratio, and eventually caused a decrease in apoptosis. After addition of pAD/DDAHⅡ-shRNA, the effects of Que mentioned above were reversed. Meanwhile, iron overload induced mitochondrial oxidative stress, reduced mitochondrial membrane potential and increased mitochondrial permeability transition pores (mPTP) opening, which were also part...
Source: European Journal of Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Chen X, Li H, Wang Z, Zhou Q, Chen S, Yang B, Yin D, He H, He M Tags: Eur J Pharmacol Source Type: research
Cigarette Smoke Extract Induces Ferroptosis in Vascular Smooth Muscle Cells.
Abstract
Cigarette smoking is a major risk factor for aortic aneurysm and dissection; however, no causative link between smoking and these aortic disorders has been proven. In the present study, we investigated the mechanism by which cigarette smoke affects vascular wall cells and found that cigarette smoke extract (CSE) induced a novel form of regulated cell death termed ferroptosis in VSMCs. CSE markedly induced cell death in A7r5 cells and primary rat VSMCs, but not in endothelial cells, which was completely inhibited by specific ferroptosis inhibitors (Ferrostatin-1 [Fer-1] and Liproxstatin-1) and an iron chel...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 23, 2020 Category: Physiology Authors: Sampilvanjil A, Karasawa T, Yamada N, Komada T, Higashi T, Baatarjav C, Watanabe S, Kamata R, Ohno N, Takahashi M Tags: Am J Physiol Heart Circ Physiol Source Type: research
Nobiletin Regulates ROS/ADMA/DDAHII/eNOS/NO Pathway and Alleviates Vascular Endothelium Injury by Iron Overload.
In this study, we have identified the protective effects of Nob, and its underlying molecular mechanism in human umbilical vein endothelial cells (HUVECs) suffered from iron overload via ROS/ADMA/DDAHII/eNOS/NO pathway. We found that compared with 50 μM iron dextran treatment, co-treatment with 20 μM Nob increased cell viability and decreased lactate dehydrogenase activity. Besides, Nob could upregulate DDAHII expression and activity, promote eNOS phosphorylation to produce more NO, reduce ADMA content, and therefore increase superoxide dismutase, catalase, and glutathione peroxidase activities, and decrease malondiald...
Source: Biological Trace Element Research - January 29, 2020 Category: Biology Authors: Wang Z, Yang B, Chen X, Zhou Q, Li H, Chen S, Yin D, He H, He M Tags: Biol Trace Elem Res Source Type: research
The cost-effectiveness of radiofrequency ablation for treating patients with gastric antral vascular ectasia refractory to first line endoscopic therapy.
CONCLUSIONS: RFA treatment is likely to be cost-effective for patients with ongoing symptoms following failure of first line therapy with APC and could lead to substantive reductions in health care resource.
PMID: 32212980 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - March 29, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research
Pulmonary Vascular Disease as a Systemic and Multisystem Disease
This article covers the chronic heart failure syndrome, including the systemic consequences of right ventricle-pulmonary artery uncoupling and neurohormonal activation, skeletal and respiratory muscle effects, systemic endothelial dysfunction and coronary artery disease, systemic inflammation and infection, endocrine and metabolic changes, the liver and gut axis, sleep, neurologic complications, and skin and iron metabolic changes.
Source: Clinics in Chest Medicine - January 8, 2021 Category: Respiratory Medicine Authors: Katherine Kearney, Eugene Kotlyar, Edmund M.T. Lau Source Type: research
Guide to use of ferumoxytol for hepatic vascular assessment as part of dual contrast MRI
AbstractMagnetic resonance imaging (MRI) assessment of hepatic vasculature can be challenging in the setting of liver disease and liver lesions. The widely used hepatobiliary contrast agent gadoxetate is an extracellular contrast agent that provides excellent soft tissue characterization but has limitations as a vascular contrast agent. Ferumoxytol is an iron oxide nanoparticle with superparamagnetic properties that can be used as blood pool contrast agent to provide dedicated vascular assessment. We provide a detailed protocol for evaluation of pediatric liver vasculature using ferumoxytol, after imaging of the parenchyma...
Source: Pediatric Radiology - August 21, 2023 Category: Radiology Source Type: research
Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia
Sustained hypoxia over several hours induces a progressive rise in pulmonary artery systolic pressure (PASP). Administration of intravenous iron immediately prior to the hypoxia exposure abrogates this effect, suggesting that manipulation of iron stores may modify hypoxia-induced pulmonary hypertension. Iron (ferric carboxymaltose) administered intravenously has a plasma half-life of 7-12 h. Thus any therapeutic use of intravenous iron would require its effect on PASP to persist long after the iron-sugar complex has been cleared from the blood. To examine this, we studied PASP during sustained (6 h) hypoxia on 4 separate d...
Source: Journal of Applied Physiology - August 15, 2016 Category: Physiology Authors: Bart, N. K., Curtis, M. K., Cheng, H.-Y., Hungerford, S. L., McLaren, R., Petousi, N., Dorrington, K. L., Robbins, P. A. Tags: ARTICLES Source Type: research
Recurrent bleeding of oral vascular malformation in a patient with hereditary hemorrhagic telangiectasia
Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease characterized by mucocutaneous telangiectatic lesions, arteriovenous malformations and recurrent spontaneous epistaxis. A 61-year-old white male patient sought dental service because of a recurrent gingival bleeding. He had previously been diagnosed with HHT. His medical history included pulmonary hypertension, brain abscess, arterial hypertension, iron deficiency anemia, recurrent episodes of epistaxis and oral bleeding. Physical examination revealed numerous telangiectatic lesions on the face, tongue, buccal mucosa, palate, gums and a vascular malformati...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - July 28, 2017 Category: ENT & OMF Authors: THA ÍS DOS SANTOS FONTES PEREIRA, LEANDRO MORAIS RODRIGUES, RICARDO SANTIAGO GOMEZ Tags: CPP - Clinical Poster Presentation Source Type: research
Comparative Biology and the Search for Longevity-Associated Genes
One of the primary goals of the aging research community is to determine exactly how aging progresses from moment to moment at the detailed level of genes and cellular biochemistry. This is a sizable task, not particularly driven by any application in medicine, and will be only incrementally more advanced by the time that rejuvenation therapies based on the SENS model of damage repair are a going concern. The big advantage of the damage repair approach is that it bypasses the need to understand exactly how aging progresses: since the root cause damage is known, it is possible to make progress immediately and quantify the r...
Source: Fight Aging! - March 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Sa1905 ENDOSCOPIC MANAGEMENT OF REFRACTORY GASTRIC ANTRAL VASCULAR ECTASIA (GAVE) WITH CRYOBALLOON THERAPY: MULTICENTER EXPERIENCE WITH 6 MONTH FOLLOW-UP.
Gastric antral vascular ectasia (GAVE), also known as “watermelon stomach”, is the cause of upper gastrointestinal (GI) bleeding in approximately 4% of cases. Patients with GAVE commonly present with iron deficiency anemia and require multiple blood transfusions. Endoscopic management has primarily been thermoablative with argon plasma coagulation, however, two thirds of patients remain transfusion dependent. Cryoablation is an emerging alternative to thermoablation, and has been used in esophageal diseases such as Barrett’s esophagus (BE) in which nitrous oxide gas is constrained within a low pressure balloon.
Source: Gastrointestinal Endoscopy - May 30, 2018 Category: Gastroenterology Authors: Anish Patel, Arvind J. Trindade, Harshit S. Khara, S Vikas Kumar, Nadia Ansari, Tai-Ping Lee, David L. Diehl, Amrita Sethi Tags: Saturday abstract Source Type: research
118 endoscopic radiofrequency ablation is an effective therapy in patients with symptomatic anaemia secondary to gastric antral vascular ectasia
Gastric antral vascular ectasia (GAVE) is a rare cause of gastrointestinal bleeding (GIB). Patients often require regular blood transfusions and long-term oral or intravenous iron supplementation to manage symptomatic anaemia impacting on quality of life. Endoscopic therapy (ET) for GAVE includes argon plasma coagulation (APC), laser therapy and endoscopic band ligation. In some patients, these measures are not successful with significant effects on their health and quality of life. Radio-frequency ablation (RFA) may provide a solution in these patients.
Source: Gastrointestinal Endoscopy - May 30, 2018 Category: Gastroenterology Authors: Cormac Magee, Gideon Lipman, Durayd Alzoubaidi, Martin A. Everson, Rami Sweis, Matthew Banks, David G. Graham, Laurence Lovat, Charles Murray, Rehan Haidry Tags: Oral abstract Source Type: research
