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Total 106717 results found since Jan 2013.

Folate deficiency promotes differentiation of vascular smooth muscle cells without affecting the methylation status of regulated genes.
Abstract Elevated serum homocysteine, an intermediate of cellular one-carbon metabolism, is an independent risk factor for cardiovascular disease (CVD). Folate deficiency increases serum homocysteine and may contribute to CVD progression. Vascular smooth muscle cells regulate vascular contractility, but also contribute to repair processes in response to vascular injury. Nutritional deficiencies, like folate deficiency, are thought to impact on this phenotypic plasticity, possibly by epigenetic mechanisms.                 We have investigated the effect of folate deficiency on vascular smooth muscle ...
Source: The Biochemical Journal - September 16, 2019 Category: Biochemistry Authors: Kolb AF, Petrie L, Mayer CD, Pirie L, Duthie SJ Tags: Biochem J Source Type: research

The Seed Coat Extract of Black Soybean Decreases Nicotine-Induced Vascular Fiber Degradation by Suppressing Matrix Metalloproteinase 2 Expression.
This study focuses on proanthocyanidins, well known for their potent antioxidant activity. We speculated that proanthocyanidins can suppress nicotine-induced weakening of vascular walls. To estimate the effect of black soybean seed coat extract (BSSCE), rich in proanthocyanidins, on nicotine-induced weakening of the aortic wall, mice were divided into four groups: the control diet and distilled water group (named C), BSSCE solution diet and distilled water group (named B), control diet and 0.5 mg/mL nicotine solution group (named CN), and BSSCE solution diet and 0.5 mg/mL nicotine solution group (named BN). Nicotine-induce...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effects of repetitive diet-induced fluctuations in plasma phosphorus on vascular calcification and inflammation in rats with early-stage chronic kidney disease.
Authors: Tani M, Tanaka S, Takamiya K, Sakaue M, Ito M Abstract Cardiovascular disease is a major cause of death among hemodialysis patients. Hyperphosphatemia induces cardiovascular disease through vascular endothelial dysfunction and calcification. Repetition of a short-term excessive-phosphorus (P) diet causes transient elevations in plasma P and subsequent vascular endothelial dysfunction in normal rats. The purpose of this study was to investigate the effects of the P fluctuation on vascular calcification and inflammation in rats after unilateral nephrectomy as an early-stage chronic kidney disease (CKD) model...
Source: Journal of Clinical Biochemistry and Nutrition - April 2, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Vascular access as a survival factor for the haemodialysis population: a retrospective study.
CONCLUSIONS: A functional arteriovenous fistula is a significant predictor of survival in the population dependent on haemodialysis, independently of sociodemographic parameters and serious comorbidities. Therefore, if various types of vascular accesses are applicable for the patient, AVF should be prioritized over CVC. PMID: 32519532 [PubMed - as supplied by publisher]
Source: International Angiology - June 12, 2020 Category: Cardiology Tags: Int Angiol Source Type: research

Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures
Weightlessness and physical inactivity have deleterious cardiovascular effects. The space environment and its ground-based models offer conditions to study the cardiovascular effects of physical inactivity in the absence of other vascular risk factors, particularly at the macro- and microcirculatory levels. However, the mechanisms involved in vascular dysfunction and remodeling are not sufficiently studied in the context of weightlessness and its analogs including models of physical inactivity. Here, we summarize vascular and microvascular changes induced by space flight and observed in models of microgravity and physical ...
Source: Frontiers in Physiology - August 19, 2020 Category: Physiology Source Type: research

Effects of dietary fiber on vascular calcification by repetitive diet-induced fluctuations in plasma phosphorus in early-stage chronic kidney disease rats.
This study investigated the effects of dietary fiber on vascular calcification by repeated P fluctuations in early-stage CKD rats. Unilateral nephrectomy rats were used as an early-stage CKD model. For 36 days, a P fluctuation (LH) group was fed low-P (0.02% P) and high-P (1.2% P) diets alternating every 2 days, and a P fluctuation with dietary fiber intake (LH + F) group was fed low-P and high-P diets containing dietary fiber alternating every 2 days. The effect on vascular calcification was measured calcium content. Effects on uremic toxin were measured levels of indoxyl sulfate (IS) and investigated gut microbiota. Th...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Digestive n ‐6 Lipid Oxidation, a Key Trigger of Vascular Dysfunction and Atherosclerosis in the Western Diet: Protective Effects of Apple Polyphenols
Conclusionn ‐6 lipid oxidation during digestion may be a key factor of vascular impairments. Nevertheless, an antioxidant strategy can limit 4‐HNE formation during digestion and thus durably protect vascular function.
Source: Molecular Nutrition and Food Research - February 3, 2021 Category: Food Science Authors: Ga ëtan Bolea, Clothilde Philouze, Mathilde Dubois, Sydney Risdon, Anaïs Humberclaude, Christian Ginies, Anne‐Laure Charles, Bernard Geny, Cyril Reboul, Claire Arnaud, Claire Dufour, Grégory Meyer Tags: Research Article Source Type: research

Glu298Asp (rs1799983) Polymorphism Influences Postprandial Vascular Reactivity and the Insulin Response to Meals of Varying Fat Composition in Postmenopausal Women: Findings from the Randomized, Controlled Dietary Intervention and VAScular function (DIVAS)-2 Study
ConclusionsOur findings suggest the Glu298Asp polymorphism may represent a potential determinant of the inter-individual variability in postprandial responsiveness of %FMD and insulin to acute meal fat composition in postmenopausal women. Further studies are required to confirm these observations.This trial was registered atclinicaltrials.gov as NCT02144454.
Source: Journal of Nutrition - March 9, 2021 Category: Nutrition Source Type: research

The acute and postprandial effects of sugar moiety on vascular and metabolic health outcomes in adolescents
This study explored the cardiometabolic responses to sugar moieties acutely, and following a subsequent mixed meal tolerance test (MMTT). Twenty-one healthy adolescents (N  = 10 female, 14.3 ± 0.4 years) completed 3 experimental and 1 control condition, in a counterbalanced order. These consisted of different drinks to compare the effect of 300 mL of water (control), or 300 mL of water mixed with 60 g of glucose, fructose or sucrose, on vascular function (flow-m ediated dilation (FMD), microvascular reactivity (total hyperaemic response; TRH), and cerebrovascular reactivity (CVR)), and blood samples for uric acid, gl...
Source: Applied Physiology, Nutrition, and Metabolism - February 17, 2021 Category: Physiology Authors: Jodie L. Koep Alan R. Barker Rhys Banks Rohit R. Banger Alice Lester Kate M. Sansum Max E. Weston Bert Bond Source Type: research

Magnesium intake and vascular structure and function: the Hoorn Study
ConclusionWe did not find associations between dietary magnesium intake and multiple markers of vascular structure and function, in either cross-sectional or longitudinal analyses.
Source: European Journal of Nutrition - September 7, 2021 Category: Nutrition Source Type: research

< em > Gardenia jasminoides < /em > J. Ellis extract GJ-4 attenuates hyperlipidemic vascular dementia in rats via regulating PPAR- γ-mediated microglial polarization
CONCLUSION: Our results implied that GJ-4 might be a promising drug to improve VD through the regulation of microglial M1/M2 polarization and the subsequent inhibition of neuro-inflammation.PMID:35950104 | PMC:PMC9338452 | DOI:10.29219/fnr.v66.8101
Source: Food and Nutrition Research - August 11, 2022 Category: Nutrition Authors: Hui Liu Caixia Zang Junmei Shang Zihong Zhang Lu Wang Hanyu Yang Chanjuan Sheng Fangyu Yuan Cheng Ju Fangyuan Li Yang Yu Xinsheng Yao Xiuqi Bao Dan Zhang Source Type: research