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Environmental dose of 16 priority-controlled PAHs mixture induce damages of vascular endothelial cells involved in oxidative stress and inflammation
Toxicol In Vitro. 2021 Dec 10;79:105296. doi: 10.1016/j.tiv.2021.105296. Online ahead of print.ABSTRACTEpidemiological studies have shown that cardiovascular diseases caused by PM2.5 pollution account for the second death rate in China. Polycyclic aromatic hydrocarbons (PAHs) are one important group of persistent organic pollutants absorbed on PM2.5. Though individual PAH is related to vascular disease, the relationship between environmental PAHs exposure and vascular damages is still unclear. To explore the effect of PAHs on blood vessel, human umbilical vein endothelial cells (HUVECs) are treated with 16 priority-control...
Source: Toxicology in Vitro - December 13, 2021 Category: Toxicology Authors: Jiaying He Qihua Pang Chengmeng Huang Jiaqi Xie Jindian Hu Lei Wang Congcong Wang Lingxue Meng Ruifang Fan Source Type: research
An organic selenium and VEGF-conjugated bioinspired coating promotes vascular healing
Biomaterials. 2022 Jul 2;287:121654. doi: 10.1016/j.biomaterials.2022.121654. Online ahead of print.ABSTRACTThe introduction of drug-eluting stents (DESs) have yield a significant reduction in the incidence of re-stenosis, however, challenges remain including incomplete healing of the endothelium, inflammatory response and thrombogenesis at the site of vascular wall injury. Here, we developed a novel stent with polyphenol-polyamine surface combining the biological functions of nitric oxide gas and VEGF, selectively promoting the proliferation and migration of endothelial cells while suppressing smooth muscle cells. Compare...
Source: Biomaterials - July 17, 2022 Category: Materials Science Authors: Bo Zhang Yumei Qin Li Yang Huining Wan Lu Yuan Yunbing Wang Source Type: research
Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
Eur J Med Res. 2022 Nov 4;27(1):232. doi: 10.1186/s40001-022-00833-6.ABSTRACTAngiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorder...
Source: Cell Research - November 5, 2022 Category: Cytology Authors: Ahmad Hoseinzadeh Hamed Ghoddusi Johari Mohammad Hossein Anbardar Lobat Tayebi Ehsan Vafa Milad Abbasi Ahmad Vaez Ali Golchin Ali Mohammad Amani Ali Jangjou Source Type: research
Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging
Optical imaging in the second near infrared window (NIR-II) provides a prospective strategy to early diagnosis and curative effect assessment of vascular anomalies. This review summarizes optimizations of the NIR-II probes regarding fluorescence imaging, photoacoustic imaging, and optical coherence tomography to enable mapping of complicated vascular networks in deep tissues and molecular variations associated with vascular diseases. AbstractOptical imaging in the second near infrared region (NIR-II, 1000 –1700 nm) provides higher resolution and deeper penetration depth for accurate and real-time vascular anatomy, blo...
Source: Small - October 13, 2021 Category: Nanotechnology Authors: Zi'an Wang,
Xuan Wang,
Jian ‐Bo Wan,
Fujian Xu,
Nana Zhao,
Meiwan Chen Tags: Review Source Type: research
Sclerostin, vascular risk factors, and brain atrophy in excessive drinkers
ConclusionPrevalence of vascular calcification in alcoholics is very high. Vascular calcium deposits are related to brain atrophy. Serum sclerostin is strongly related to brain shrinkage and also shows a significant relationship with vascular calcifications, only displaced by advanced age.
Source: Frontiers in Human Neuroscience - February 21, 2023 Category: Neuroscience Source Type: research
Long-Term Exposure to Fine Particulate Constituents and Vascular Damage in a Population with Metabolic Abnormality in China
CONCLUSION: Chronic exposure to PM2.5 and PM2.5 constituents was related to vascular damage in the abnormal metabolic population in China. The heterogeneous contribution of different PM2.5 constituents to vessel bed damage is worthy of attention when developing targeted strategies.PMID:37032101 | DOI:10.5551/jat.64062
Source: Journal of Atherosclerosis and Thrombosis - April 9, 2023 Category: Cardiology Authors: Lijin Lin Huxiang Huang Fang Lei Tao Sun Ze Chen Kun Qin Manyao Li Yingying Hu Xuewei Huang Xingyuan Zhang Peng Zhang Xiao-Jing Zhang Zhi-Gang She Jingjing Cai Shujuan Yang Peng Jia Hongliang Li Source Type: research
Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta.
Abstract
Nitroglycerin (Gtn) is a treatment for cardiovascular patients due to its vasodilatory actions, but induces tolerance when given chronically. A proposed mechanism is the superoxide (O2(-))-oxidative stress hypothesis, which suggests that Gtn increases O2(-) production. Nitric oxide (NO) exists in three different redox states; the protonated, reduced state, nitroxyl anion (HNO) is an emerging candidate in vascular regulation. HNO is resistant to scavenging and of particular interest in conditions where high levels of reactive oxygen species (ROS) exist. We hypothesize that treatment with Gtn will exacerbat...
Source: European Journal of Pharmacology - August 19, 2017 Category: Drugs & Pharmacology Authors: Wynne BM, Labazi H, Carneiro ZN, Tostes RC, Webb RC Tags: Eur J Pharmacol Source Type: research
Bis(1,4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridiolato)zinc(II) exhibits strong cytotoxicity and a high intracellular accumulation in cultured vascular endothelial cells.
This study showed that the tetracoordinate structure of the Zn-06 molecule, which contains two sulfur and two oxygen atoms attached to the zinc atom, facilitated its accumulation within vascular endothelial cells whereas the whole structure of the zinc complex was involved in its cytotoxicity in the cells. The present data suggest that a part of the structure, especially the binding site of the metal atom, was responsible for accumulation of zinc complexes, and the entire structure is responsible for their cytotoxicity in vascular endothelial cells.
PMID: 30726811 [PubMed - in process]
Source: Journal of Toxicological Sciences - February 8, 2019 Category: Toxicology Tags: J Toxicol Sci Source Type: research
Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension
Conclusion
Our study demonstrates that targeting of Pin1 with small molecule inhibitor, Juglone, might be an attractive future therapeutic strategy for PAH and right heart disease secondary to PAH.
Source: European Respiratory Journal - August 25, 2022 Category: Respiratory Medicine Authors: Rai, N., Sydykov, A., Kojonazarov, B., Wilhelm, J., Manaud, G., Veeroju, S., Ruppert, C., Perros, F., Ghofrani, H. A., Weissmann, N., Seeger, W., Schermuly, R. T., Novoyatleva, T. Tags: Lung biology and experimental studies, Pulmonary vascular disease Original Articles: Pulmonary hypertension and basic science Source Type: research
Vascular Stiffness Has Two Components, Which Complicates Compensatory Therapeutic Approaches
In conclusion, this study highlights the importance of investigating whether vasodilatory drugs, used as antihypertensive medication, have an adverse effect on large arteries by increasing their stiffness, which has inherent potential cardiovascular risks.
Link: https://doi.org/10.1038/s41440-022-01012-0
Source: Fight Aging! - September 27, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Dietary intake of inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus.
In this study, we examined an acute effect of these high phosphorus meals intake on vascular-endothelium function. This was a randomized, double-blind, cross-over test study design targeting healthy young men. We conducted a food intake test using two test meals, one high in organic phosphorus from organic food sources, and one high in inorganic phosphorus from food additives. Endothelium-dependent vasodilation, phosphorus and calcium in the urine and blood, and phosphorus-related hormones were measured preprandial to 120 min postprandial. The results showed higher serum and urine phosphorus values after the high inorgani...
Source: Journal of Clinical Biochemistry and Nutrition - April 5, 2018 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research
Publisher Correction: Controlling an organic synthesis robot with machine learning to search for new reactivity
Publisher Correction: Controlling an organic synthesis robot with machine learning to search for new reactivity, Published online: 24 July 2018; doi:10.1038/s41586-018-0412-8Publisher Correction: Controlling an organic synthesis robot with machine learning to search for new reactivity
Source: Nature AOP - July 24, 2018 Category: Research Authors: Jaros ław M. Granda Liva Donina Vincenza Dragone De-Liang Long Leroy Cronin Source Type: research
