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Prokinetics for functional dyspepsia.
CONCLUSIONS: Due to low, or very low, quality of evidence, we are unable to say whether prokinetics are effective for the treatment of functional dyspepsia . We are uncertain which of the individual prokinetic drugs is the most effective as well as whether prokinetics can improve quality of life. Apart from cisapride, prokinetics are well-tolerated. Good quality RCTs are needed to verify the efficacy of prokinetics. PMID: 30335201 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 18, 2018 Category: General Medicine Authors: Pittayanon R, Yuan Y, Bollegala NP, Khanna R, Leontiadis GI, Moayyedi P Tags: Cochrane Database Syst Rev Source Type: research

The pathological spectrum behind migraine aura status: a case series
ConclusionsIn front of a patient with a MAS, an organic lesion of the brain must be suspected, until a complete negative vascular and neuroradiological diagnostic workup has been performed. A spectrum of underlying pathologies (vascular or demyelinating diseases, epileptic or degenerative conditions) may cause a MAS-like clinical onset. The variability of aura symptoms may result in a real diagnostic challenge.
Source: Neurological Sciences - December 6, 2018 Category: Neurology Source Type: research

The effects of menthol on exercise performance and thermal sensation: a meta-analysis
ConclusionsExercise performance can be improved by application of non-thermally cooling menthol, which also reduces perceptual measures of thermal sensation. Internal application appears to be the best strategy to improve performance.
Source: Journal of Science and Medicine in Sport - December 7, 2018 Category: Sports Medicine Source Type: research

Fecal volatile organic compounds for early detection of colorectal cancer: where are we now?
ConclusionBased on the included studies, fecal VOC analyses seem promising for future screening of CRC and AA, with potentially improved test performances allowing for earlier detection of AA and CRC and consequently earlier initiation of treatment, possibly reducing morbidity and mortality rates next to lower rates of (unnecessary) colonoscopies.
Source: Journal of Cancer Research and Clinical Oncology - December 15, 2018 Category: Cancer & Oncology Source Type: research

From the multi-target approach to MMP2/CK2 to the identification of potent and selective MMP13 inhibitors
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB02990C, PaperPastor Miryam, JOSE MARIA ZAPICO RODRIGUEZ, Claire Coderch, Maciej Mas łyk, Rostyslav R Panchuk, Beatriz de Pascual-Teresa, Ana Ramos In this article we describe our efforts in the search of MMP2/CK2 dual targeting inhibitors. We have followed a rational drug design approach based on our experience in the selective... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - December 18, 2018 Category: Molecular Biology Authors: Pastor Miryam Source Type: research

Unexpectedly High Cross-plane Thermoelectric Performance of Layered Carbon Nitrides
J. Mater. Chem. A, 2018, Accepted Manuscript DOI: 10.1039/C8TA10500F, PaperZhidong Ding, Meng An, Shenqiu Mo, Xiaoxiang Yu, Zelin Jin, Yuxuan Liao, Keivan Esfarjani, Jing-Tao L ü, Junichiro Shiomi, Nuo Yang Organic thermoelectric (TE) materials create a brand new perspective to search for high-efficiency TE materials, due to their small thermal conductivity. The overlap of pz orbitals, commonly existing in organic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - December 19, 2018 Category: Chemistry Authors: Zhidong Ding Source Type: research

Treatment with new organic nitrites in pulmonary hypertension of acute experimental pulmonary embolism
In conclusion, PDNO is a NO donor and an efficient vasodilator in the pulmonary circulation. Treatment with this or similar organic nitrites intravenously may be a future option to avoid right heart failure in life‐threatening acute pulmonary em bolism.
Source: Pharmacology Research and Perspectives - January 22, 2019 Category: Drugs & Pharmacology Authors: Kristofer F. Nilsson, Lars E. Gustafsson Tags: ORIGINAL ARTICLE Source Type: research

Distributed Chemistry
ConclusionLab automation is a good match for any problem that can be reduced to a parallelizable search through some well-understood space. For years, the majority of such efforts have centered on analytical chemistry and biochemistry. Although a network of ChemPU units optimizing azo dye colors is a far cry from a graduate student optimizing a palladium-coupling reaction, it's not that far off. The availability of platforms like ChemPU, built from cheap, off-the-shelf components, infinitely hackable, and under the control of potentially very sophisticated software, could help transform those areas of experimental chemistr...
Source: Depth-First - February 12, 2019 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

The Role of Revascularization of the Profunda Femoris Artery in Vasculogenic Impotence
ConclusionIn patients with Leriche ’s syndrome, revascularization of the profunda femoris artery (profundoplasty) ameliorates vasculogenic impotence through the improvement of the pelvic blood flow via the collateral circulation.
Source: Hellenic Journal of Surgery - October 31, 2018 Category: Surgery Source Type: research

Highly regioselective and sustainable solar click reaction: A new Post-synthetic modified triazole organic polymer as recyclable photocatalyst for regioselective azide-alkyne cycloaddition reaction
Green Chem., 2019, Accepted Manuscript DOI: 10.1039/C9GC00894B, PaperDolly Yadav, Nem Singh, Tae Wu Kim, no-Joong Park, Jae Young Kim, JIN-OOK BAEG The synthesis of pharmaceutically active 1,2,3-triazoles is been continuously scrutinized in search of a unique and effective catalysts to make the process efficient, green and sustainable. Here we are presenting... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - April 5, 2019 Category: Chemistry Authors: Dolly Yadav Source Type: research

High-throughput computational screening of metal –organic frameworks with topological diversity for hexane isomer separations
Phys. Chem. Chem. Phys., 2019, Advance Article DOI: 10.1039/C8CP07527A, PaperLiang Peng, Qiao Zhu, Pinglian Wu, Xuanjun Wu, Weiquan Cai A large-scale computational screening of 13 512 MOFs with topological diversity was carried out to search the optimal candidates for the simultaneous separation of two dimethyl butanes from the quinary equimolar mixture of hexane isomers. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 8, 2019 Category: Chemistry Authors: Liang Peng Source Type: research

Microbiota of the Gut-Lymph Node Axis: Depletion of Mucosa-Associated Segmented Filamentous Bacteria and Enrichment of Methanobrevibacter by Colistin Sulfate and Linco-Spectin in Pigs
This study aimed to characterize shifts in microbial community structure across the intestinal mucosa-enteric lymph node axis in order to understand the effects of two commonly used antibiotics (Linco-Spectin and Colistin sulfate; oral application). We hypothesized that these antibiotics influence GI microbiota diversity and community structure and that, as a result, the ICLN-ileum axis is altered through permeability changes and changed translocation patterns. Medicated-feed antibiotics are still heavily used, not only in the E.U. but worldwide in case of infections. In addition to the taxonomic community profiling survey...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives
Conclusions Based on the structure of sanguinarine, fourteen phenanthridine derivatives 8a-m were synthesized and evaluated for their cytotoxic activity against five different human cancer cell lines. Among the evaluated compounds, 8a exhibited a broad spectrum of anti-proliferative activities against all the tested cancer cell lines. Further mechanistic assay revealed that compound 8a could inhibit the activity of both DNA Top I and Top II, as well as preventing cell transition from S to G2 phase dose-dependently. Apoptosis studies against MCF-7 cells indicated that downregulation of Bcl-2 and upregulation of Bax express...
Source: Frontiers in Oncology - April 15, 2019 Category: Cancer & Oncology Source Type: research

Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model
Conclusion: The genome-wide screen in the yeast deletion library allowed us to identify a large number of host genes required for AaCdtB cytotoxicity. Further investigation could lead to more insights into the mechanisms of CdtB intoxication. Introduction Bacterial pathogens often possess several virulence factors to facilitate colonization and survival in hosts. Cytolethal distending toxin (CDT) is a genotoxin produced by many Gram-negative pathogens, such as Escherichia coli, Aggregatibacter actinomycetemcomitans, Haemophilus ducreyi, Shigella dysenteriae, Helicobacter hepaticus, and Campylobacter species (Gargi ...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research