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Total 3861 results found since Jan 2013.

All about pain pharmacology: what pain physicians should know.
Authors: Kim KH, Seo HJ, Abdi S, Huh B Abstract From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of the emotional pain component includes antianxiety drugs, antidepressants, and antipsychotics. The anti-anxiety drugs have anti-anxious, sedative, and somnolent effects. The antipsychotics are effective in patients with positive symptoms of psychosis. On the other hand, the sensory pain component can be divided into nociceptive and neuropathic pain. Non-steroidal ...
Source: Korean Journal of Pain - April 4, 2020 Category: Anesthesiology Tags: Korean J Pain Source Type: research

Phenytoin Cream for the Treatment of Sciatic Pain: Clinical Effects and Theoretical Considerations: Case Report.
Authors: Russell AL, Kopsky DJ, Hesselink JMK Abstract Chronic sciatic pain is difficult to treat. Patients often suffer from considerable pain and are severely hampered in their everyday activities. Most pharmacologic analgesic treatments have disappointing effects, and often are limited due to adverse events. New treatments are therefore needed. Surprisingly we found fast pain reduction after applying topical phenytoin cream at the painful dermatome in a 55-year-old patient suffering from sciatic pain due to pathology of a disc. This patient was treatment resistant for 13 years. Prescribing topical analgesic cr...
Source: Journal of Pain and Palliative Care Pharmacotherapy - March 3, 2020 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats.
Abstract Histone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic effects in animal models of persistent pain. The HDAC family comprises 18 genes; however, the different effects of distinct classes of HDACIs on pain relief remain unclear. The aim of this study was to determine the efficacy of these HDACIs on attenuating thermal hyperalgesia in persistent inflammatory pain. Persistent inflammatory pain was induced by injecting Complete Freund's Adjuvant (CFA) into the left hind paw of rats. Then, HDACIs targeting class I (entinostat (MS-275)) ...
Source: Pain Research and Management - March 1, 2019 Category: Anesthesiology Authors: Mao Y, Zhou J, Liu X, Gu E, Zhang Z, Tao W Tags: Pain Res Manag Source Type: research

Membrane Stabilizer Medications in the Treatment of Chronic Neuropathic Pain: a Comprehensive Review.
Abstract PURPOSE OF REVIEW: Neuropathic pain is often debilitating, severely limiting the daily lives of patients who are affected. Typically, neuropathic pain is difficult to manage and, as a result, leads to progression into a chronic condition that is, in many instances, refractory to medical management. RECENT FINDINGS: Gabapentinoids, belonging to the calcium channel blocking class of drugs, have shown good efficacy in the management of chronic pain and are thus commonly utilized as first-line therapy. Various sodium channel blocking drugs, belonging to the categories of anticonvulsants and local anesthe...
Source: Pain Physician - April 30, 2019 Category: Anesthesiology Authors: Viswanath O, Urits I, Jones MR, Peck JM, Kochanski J, Hasegawa M, Anyama B, Kaye AD Tags: Curr Pain Headache Rep Source Type: research

Reorganization of Masseter and Temporalis Muscle Single Motor Unit Activity During Experimental Masseter Muscle Pain.
CONCLUSION: The present findings suggest that most biting-task-related jaw muscle SMUs remain active during experimental muscle noxious stimulation. There was some evidence in both the anterior temporalis and masseter muscles for motor unit recruitment and de-recruitment consistent with a motor unit reorganization during experimental pain. PMID: 31465032 [PubMed - as supplied by publisher]
Source: Journal of Orofacial Pain - August 31, 2019 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review
This article reviews the acute neural transmission of pain, pruritus, and nausea symptoms, which can begin in the periphery and/or viscera. The subsequent multiple pathways in the central nervous system that become involved in the processing of these symptoms are also discussed. The authors describe human brain imaging studies that have revealed consistent cortical and subcortical networks  activated by these symptoms, including sensory, limbic, and associative regions. In particular, the authors discuss information revealed by the studies regarding the primary somatosensory cortex, secondary somatosensory cortex, anterio...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Neurologic Systems and Symptoms Neurology Pain Review central processing nausea pruritus Source Type: research

Gene Therapy Targets Chronic Pain
Scientists at New York University have developed a gene therapy for chronic pain. The technology works by targeting the NaV1.7 sodium ion channel present on neurons, which is an important component of the pain response. The researchers encoded a vers...
Source: Medgadget - August 25, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine Pain Management chronic pain nyu Source Type: blogs

Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery: a randomized, double-blind controlled trial
This study focuses on the effectiveness of LP5 on allodynia, hyperalgesia, and thermal stimuli in postsurgery knee localized neuropathic pain. A randomized double-blind, 2 parallel groups, controlled trial (NCT02763592) took place in 36 patients (age, 69.4 ± 7.3 years) at the Clinical Pharmacology Center, University Hospital Clermont-Ferrand, France. Patients randomly received LP5 or placebo plaster during 3 months. Neuropathic pain intensity and several parameters (dynamic mechanical allodynia, mechanical [von Frey], heat and cold detection and pain thresholds [Pathway Medoc], and size of the allodynic area were recorded...
Source: Pain - April 25, 2019 Category: Anesthesiology Tags: Research Paper Source Type: research

Pre-incisional Preventive Precise Multimodal Analgesia May Enhance the Rehabilitation Process of Acute Postoperative Pain Following Total Laparoscopic Hysterectomy: A Randomized Controlled Trial
CONCLUSION: Pre-incisional PPMA may enhance the rehabilitation process of acute postoperative pain after TLH.PMID:37192230
Source: Pain Physician - May 16, 2023 Category: Anesthesiology Authors: Mengyao Qi Wei Xiao Shijun Wang Liane Zhou Anxia Wan Shuai Feng Dongxu Yao Chunxiu Wang Shuyi Yang Tianlong Wang Source Type: research

The effect of lacosamide in peripheral neuropathic pain: A randomized, double ‐blind, placebo‐controlled, phenotype‐stratified trial
ConclusionWe could not confirm that lacosamide was more efficacious in patients with the irritable nociceptor type, but the study was prematurely closed, so we cannot exclude a small difference.SignificanceTreatment of neuropathic pain is often a trial and error process. Little is known about which patient benefit from which kind of medication. The sodium channel blocker lacosamide shows variable effect on neuropathic pain. Pain sensory phenotype, as defined by quantitative sensory testing, did not predict response to treatment with lacosamide.
Source: European Journal of Pain - August 11, 2023 Category: Anesthesiology Authors: Malin Erika Carmland, Melissa Dall Kreutzfeldt, Jakob Vormstrup Holbech, Peter Kolind Brask ‐Thomsen, Thomas Krøigård, Peter Nørregaard Hansen, Hatice Tankisi, Troels Staehelin Jensen, Flemming Winther Bach, Søren Hein Sindrup, Nanna Brix Tags: ORIGINAL ARTICLE Source Type: research

A Buthus martensii Karsch scorpion sting targets Nav1.7 in mice and mimics a phenotype of human chronic pain
This study not only reveals a new mechanism underlying BV-evoked pain but also enriches our knowledge of key structural elements of scorpion toxins that are pivotal for toxin–Nav1.7 interactions, which facilitates the design of novel Nav1.7 selective modulators.
Source: Pain - January 24, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

The Role of Exparel Plus Meloxicam for Postoperative Pain Management
AbstractPurpose of ReviewAcute postoperative pain reduction is a major target against the opioid crisis. While opioids have traditionally been the mainstay for postoperative analgesia, current practice has focused on a multimodal approach to pain control, including ultrasound-guided blocks with longer acting local anesthetic agents.Recent FindingsNon-steroidal anti-inflammatory drugs (NSAIDs), such as meloxicam, are an important class of medications utilized to manage pain in the perioperative period. An additional treatment used in perioperative or postoperative pain relief is Exparel, a bupivacaine (sodium channel blocke...
Source: Current Pain and Headache Reports - January 29, 2020 Category: Neurology Source Type: research

Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain
We describe a small molecule Nav1.7 inhibitor, ST-2530, that is an analog of the naturally occurring sodium channel blocker saxitoxin. When evaluated against human Nav1.7 by patch-clamp electrophysiology using a protocol that favors the resting state, the Kd of ST-2530 was 25 ± 7 nM. ST-2530 exhibited greater than 500-fold selectivity over human voltage-gated sodium channel isoforms Nav1.1–Nav1.6 and Nav1.8. Although ST-2530 had lower affinity against mouse Nav1.7 (Kd = 250 ± 40 nM), potency was sufficient to assess analgesic efficacy in mouse pain models. A 3-mg/kg dose administered subcutaneously was broadly analgesi...
Source: Pain - March 25, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research

A Randomized Controlled Trial to Manage Postoperative Ocular Pain after Pterygium Excision with Conjunctival Autograft Transplantation with a Single Application of 2% Sodium Hyaluronate
CONCLUSION: A single topical application of 2% SH in pterygium excision was effective in relieving pain in the early postoperative period without any adverse effects. This innovation may provide alternative pain control in pterygium surgery.PMID:35795593 | PMC:PMC9252703 | DOI:10.1155/2022/5144516
Source: Pain Research and Management - July 7, 2022 Category: Anesthesiology Authors: Winai Chaidaroon Sirawit Isipradit Phit Upaphong Chutikarn Dejkriengkraikul Source Type: research