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Total 24019 results found since Jan 2013.

Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
CONCLUSIONS: Besides the development of an epiretinal membrane in one patient, the intravitreal application of allogeneic BM-MSCs appeared to be intraocularly well tolerated. Consequently, not only NA-AION but also BM-MSCs deserve more clinical investigational resources and a larger randomized multicenter trial that would provide stronger evidence both about safety and the potential therapeutic efficacy of intravitreally injected allogeneic BM-MSCs in acute NA-AION.TRIAL REGISTRATION: Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NEUROSTEM). NCT03173638...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jose C Pastor Salvador Pastor-Idoate Marina L ópez-Paniagua Marta Para Francisco Blazquez Esther Murgui Ver ónica García Rosa M Coco-Mart ín Source Type: research

Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor-alpha signalling
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17963. Online ahead of print.ABSTRACTRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age-related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen-glucose deprivation (OGD)-induced IR-injured RPE ce...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Tzong-Bor Sun Kuo-Feng Huang Ko-Chi Niu Cheng-Hsien Lin Wen-Pin Liu Chao-Hung Yeh Shu-Chun Kuo Ching-Ping Chang Source Type: research

Retinopathy is associated with impaired cognition in patients undergoing peritoneal dialysis
Conclusions: Retinopathy, a condition common in patients undergoing PD, was associated with global cognitive impairment. These findings highlight retinopathy, can serve as a valuable primary screening tool for assessing the risk of cognitive decline.PMID:37732397 | DOI:10.1080/0886022X.2023.2258989
Source: Renal Failure - September 21, 2023 Category: Urology & Nephrology Authors: Jinlan Liao Qijie Wei Yingying He Yumei Liao Zibo Xiong Qing Wang Dayong Ding Xiaoyan Huang Zuying Xiong Yonggui Wu Source Type: research

Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor-alpha signalling
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17963. Online ahead of print.ABSTRACTRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age-related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen-glucose deprivation (OGD)-induced IR-injured RPE ce...
Source: J Cell Mol Med - September 21, 2023 Category: Molecular Biology Authors: Tzong-Bor Sun Kuo-Feng Huang Ko-Chi Niu Cheng-Hsien Lin Wen-Pin Liu Chao-Hung Yeh Shu-Chun Kuo Ching-Ping Chang Source Type: research

Novel ophthalmic findings and deep phenotyping in Williams-Beuren syndrome
Conclusion WBS is a complex multisystem genetic disorder with diverse ophthalmic findings that differ from those seen in isolated elastin mediated SVAS. These results suggest other genes within the WBS critical region, aside from ELN, may be involved in observed ocular phenotypes and perhaps broader ocular development. Furthermore, retinal arteriolar tortuosity may provide future insight into systemic vascular findings in WBS.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Huryn, L. A., Flaherty, T., Nolen, R., Prasov, L., Zein, W. M., Cukras, C. A., Osgood, S., Raja, N., Levin, M. D., Vitale, S., Brooks, B. P., Hufnagel, R. B., Kozel, B. A. Tags: Open access Original articles - Clinical science Source Type: research

Central retinal vein and artery occlusion associated with sildenafil: a case report and review of the literature
ConclusionSildenafil may be associated with severe retinal vascular accidents in otherwise healthy young individuals.
Source: Journal of Medical Case Reports - September 20, 2023 Category: General Medicine Source Type: research

Treatment strategy for BVO-ME based on long-term outcomes correlating retinal structure by OCT image and visual acuity
Intravitreal anti-vascular endothelial growth factor (VEGF) is a mainstream treatment for reducing ME secondary to BRVO (BVO-ME). Regrettably, most reports of intravitreal anti-VEGF for BVO-ME have disclosed o...
Source: BMC Ophthalmology - September 20, 2023 Category: Opthalmology Authors: Yuki Hattori, Ryo Fujiwara, Hidetsugu Mori, Motoki Kimura, Haruhiko Yamada and Kanji Takahashi Tags: Research Source Type: research

Cilioretinal artery occlusion secondary to central retinal vein occlusion
Can J Ophthalmol. 2023 Sep 16:S0008-4182(23)00271-5. doi: 10.1016/j.jcjo.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37726095 | DOI:10.1016/j.jcjo.2023.08.010
Source: Canadian Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Heather M McDonald Armin Handzic Edward Margolin Source Type: research

A novel primary porcine retinal pigment epithelium cell model with preserved properties
CONCLUSIONS: This work describes, for the first time, a pRPE cell model that exhibits preserved RPE properties for several passages on cell culture plastic plates. Though RPE characteristics were maintained for at least 6 passages, the reduced CRALBP and RPE-65 with passaging emphasize that lower passage cells are advantageous to utilise, and that morphology, barrier function and ZO-1 localisation cannot be solely employed as a quality measure of RPE identity. Pigs are phylogenetically similar to humans, including similar physiology, anatomy and immune system. Therefore, porcine RPE cells constitute a relevant model system...
Source: Current Eye Research - September 19, 2023 Category: Opthalmology Authors: Dinna Zhou Anne Petersen Julia Adel öf Malin Hernebring Madeleine Zetterberg Source Type: research

Optical coherence tomography angiography in birdshot chorioretinopathy
CONCLUSION: Our study demonstrates the potential contribution of OCTA as a new non-invasive imaging technology that monitors disease activity in BSCR patients.PMID:37723901 | DOI:10.1177/11206721231203265
Source: European Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Francesco Pichi Andrea Lembo Paolo Nucci Piergiorgio Neri Source Type: research

Cilioretinal artery occlusion secondary to central retinal vein occlusion
Can J Ophthalmol. 2023 Sep 16:S0008-4182(23)00271-5. doi: 10.1016/j.jcjo.2023.08.010. Online ahead of print.NO ABSTRACTPMID:37726095 | DOI:10.1016/j.jcjo.2023.08.010
Source: Canadian Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Heather M McDonald Armin Handzic Edward Margolin Source Type: research

Optical coherence tomography angiography in birdshot chorioretinopathy
CONCLUSION: Our study demonstrates the potential contribution of OCTA as a new non-invasive imaging technology that monitors disease activity in BSCR patients.PMID:37723901 | DOI:10.1177/11206721231203265
Source: European Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Francesco Pichi Andrea Lembo Paolo Nucci Piergiorgio Neri Source Type: research

A novel primary porcine retinal pigment epithelium cell model with preserved properties
CONCLUSIONS: This work describes, for the first time, a pRPE cell model that exhibits preserved RPE properties for several passages on cell culture plastic plates. Though RPE characteristics were maintained for at least 6 passages, the reduced CRALBP and RPE-65 with passaging emphasize that lower passage cells are advantageous to utilise, and that morphology, barrier function and ZO-1 localisation cannot be solely employed as a quality measure of RPE identity. Pigs are phylogenetically similar to humans, including similar physiology, anatomy and immune system. Therefore, porcine RPE cells constitute a relevant model system...
Source: Current Eye Research - September 19, 2023 Category: Opthalmology Authors: Dinna Zhou Anne Petersen Julia Adel öf Malin Hernebring Madeleine Zetterberg Source Type: research