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Nutrition: Zinc

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Total 18496 results found since Jan 2013.

Integrated Network Pharmacology and Proteomic Analyses of Targets and Mechanisms of Jianpi Tianjing Decoction in Treating Vascular Dementia
CONCLUSIONS: JTD may suppress VD development via multiple components, targets, and pathways. It may thus serve as a complementary treatment option for patients with VD.PMID:36714532 | PMC:PMC9876684 | DOI:10.1155/2023/9021546
Source: Evidence-based Complementary and Alternative Medicine - January 30, 2023 Category: Complementary Medicine Authors: Jidan Liu Juanfen Gong Jinchao Xu Mengyuan Fang Meng Su Weiguang Li Yiyi Wu Yang Hui Yingchun He Source Type: research

The MEK-ERK-Egr-1 axis and its regulation in cardiovascular disease
This article reviews recent progress on the MEK-ERK-Egr-1 cascade, notably regulation in conjunction with factors and agents such as TET2, TRIB2, MIAT, SphK1, cAMP, teneligliptin, cholinergic drugs, red wine and flavonoids, wogonin, febuxostat, docosahexaenoic acid and AT1R blockade. Such insights should provide new opportunity for therapeutic intervention in CVD.PMID:37734428 | DOI:10.1016/j.vph.2023.107232
Source: Vascular Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Authors: Levon M Khachigian Source Type: research

Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Virtual screening and in vitro assays of novel hits as promising DPP-4 inhibitors
This study involves a virtual screening using the crystallographic structure of DPP-4 and a compound subset from the ZINC database. To filter this compound subset, we used some physicochemical properties, positioning at the three DPP-4 binding sites, molecular interactions, and ADME-Tox properties. The conformations of ligands obtained from AutoDock Vina were analyzed using a consensus with other algorithms (AutoDock and GOLD). The compounds selected from virtual screening were submitted to biological assays using the "DPPIV-Glo™ protease assay". Cytotoxicity tests were also performed. One promising compound (ZINC1572309...
Source: Biochimie - December 24, 2021 Category: Biochemistry Authors: Simone Queiroz Pantale ão Eric Allison Philot Heberth de Paula Mirela In ês de Sairre Angelica Nakagawa Lima Loren Monielly Pires Raquel Alves Dos Santos Ana Ligia Scott Kathia Maria Honorio Source Type: research

The Popularity of the Dietary Supplements and Functional Foods in The Coronavirus Pandemic Among The Google Users in the USA, UK, Germany, Italy and France
CONCLUSION: Google Trends can be a beneficial tool for following public interest in identifying outbreak-related misinformation, and scientific studies and statements from authorities and the media play a potential role in driving internet searches.PMID:33601014 | PMC:PMC7883724 | DOI:10.1016/j.ctim.2021.102682
Source: Complementary Therapies in Medicine - February 18, 2021 Category: Complementary Medicine Authors: Elif G ünalan İrem Kaya Cebioğlu Özge Çonak Source Type: research

Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates
CONCLUSIONS: Enteral supplementation of zinc in preterm infants compared to no supplementation or placebo may moderately decrease mortality and probably improve short-term weight gain and linear growth, but may have little or no effect on common morbidities of prematurity. There are no data to assess the effect of zinc supplementation on long-term neurodevelopment.PMID:33710626 | DOI:10.1002/14651858.CD012797.pub2
Source: Cochrane Database of Systematic Reviews - March 12, 2021 Category: General Medicine Authors: Eveline Staub Katrina Evers Lisa M Askie Source Type: research

No Sting Barrier Film to Protect Skin in Adult Patients: Findings From a Scoping Review With Implications for Evidence ‐Based Practice
ABSTRACT BackgroundIn the industrialized world, approximately 1–1.5% of the population has received treatments for skin lesions. In the 1990s, a polymeric barrier film called the No Sting Barrier Film (NSBF) was developed as an alternative to petrolatum‐based ointments and zinc oxide formulas. To date, few studies have explored the effectiveness of NSBF in protecting skin integrity. AimsTo map the methods, fields and outcomes used to produce evidence on NSBF effectiveness. MethodsA scoping review was performed in 2015. A search strategy for identifying relevant studies was designed and performed. Systematic reviews, me...
Source: Worldviews on Evidence-Based Nursing - July 31, 2017 Category: Nursing Authors: Chiara Micheli, Alvisa Palese, Federica Canzan, Elisa Ambrosi Tags: Original Article Source Type: research

Focus on increased serum angiotensin-converting enzyme level: From granulomatous diseases to genetic mutations.
Abstract Angiotensin I-converting enzyme (ACE) is a well-known zinc-metallopeptidase that converts angiotensin I to the potent vasoconstrictor angiotensin II and degrades bradykinin, a powerful vasodilator, and as such plays a key role in the regulation of vascular tone and cardiac function. Increased circulating ACE (cACE) activity has been reported in multiple diseases, including but not limited to granulomatous disorders. Since 2001, genetic mutations leading to cACE elevation have also been described. This review takes advantage of the identification of a novel ACE mutation (25-IVS25 + 1G > A) in tw...
Source: Clinical Biochemistry - June 18, 2018 Category: Biochemistry Authors: Lopez-Sublet M, di Lanzacco LC, Jan Danser AH, Lambert M, Elourimi G, Persu A Tags: Clin Biochem Source Type: research

Macrophage Polarization in Physiological and Pathological Pregnancy
Conclusions Altogether, this review summarized the current knowledge of the polarization of macrophages and their regulatory mechanisms at different stages of pregnancy, as well as the roles of these cells in pathological processes. Although current evidence provides a compelling argument that macrophages are important in pregnancy, our understanding of the roles and mechanisms of macrophages in pregnancy is still rudimentary. Since macrophages exhibit functional plasticity, they may be ideal targets for therapeutic manipulation during pathological pregnancy. Additional studies are needed to better define the functions an...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury
Conclusion Ventilator induced lung injury is characterized by compromised vascular endothelial barrier protection and the production of edemagenic agents in response to mechanical stretch that may lead to overdistention depending upon tidal volume and ventilation frequency (Dos Santos and S.sky, 2000; Lionetti et al., 2005; Birukova et al., 2006). This mechanical-force initiated cellular injury results in cytoskeletal rearrangement. FAs play a central role in mechanotransduction and cytoskeletal rearrangement (De et al., 2010; Ladoux and Nicolas, 2012; Iskratsch et al., 2014; De, 2018). Here, we present the known picture ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Fight Aging! Newsletter, April 5th 2021
In this study, the research team designed a way to identify small molecules that improve the function of ABCA1 in the body while avoiding unwanted effects to the liver. The researchers honed in on a specific small molecule, CL2-57, due to its ability to stimulate ABCA1 activity with positive effects on liver and plasma triglycerides. The use of this compound showed improved glucose tolerance and insulin sensitivity, as well as reduced weight gain, among other beneficial effects. Age-Related Upregulation of Autophagy as a Possible Contribution to Bat Longevity https://www.fightaging.org/archives/2021/04/age-rela...
Source: Fight Aging! - April 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Prophylactic drug management for febrile seizures in children
CONCLUSIONS: We found reduced recurrence rates for intermittent diazepam and continuous phenobarbital, with adverse effects in up to 30% of children. The apparent benefit for clobazam treatment in one trial needs to be replicated. Levetiracetam also shows benefit with a good safety profile; however, further study is required. Given the benign nature of recurrent febrile seizures, and the high prevalence of adverse effects of these drugs, parents and families should be supported with adequate contact details of medical services and information on recurrence, first aid management, and, most importantly, the benign nature of ...
Source: Cochrane Database of Systematic Reviews - June 16, 2021 Category: General Medicine Authors: Martin Offringa Richard Newton Sarah J Nevitt Katerina Vraka Source Type: research