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Nutrition: Zinc

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Total 18496 results found since Jan 2013.

Crosstalk of copper and zinc in the pathogenesis of vascular dementia
J Clin Biochem Nutr. 2022 Jul;71(1):7-15. doi: 10.3164/jcbn.22-40. Epub 2022 Jul 1.ABSTRACTCopper and zinc are essential for normal brain functions. Both are localized in presynaptic vesicles and are secreted into synaptic clefts during neuronal excitation. Despite their significance, excesses of copper and zinc are neurotoxic. In particular, excess zinc after transient global ischemia plays a central role in the ischemia-induced neurodegeneration and pathogenesis of vascular type senile dementia. We previously found that sub-lethal concentrations of copper remarkably exacerbated zinc-induced neurotoxicity, and we investig...
Source: Clinical Biochemistry - July 29, 2022 Category: Biochemistry Authors: Masahiro Kawahara Ken-Ichiro Tanaka Midori Kato-Negishi Source Type: research

Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells.
Authors: Fujie T, Segawa Y, Uehara A, Nakamura T, Kimura T, Yoshida E, Yamamoto C, Uchiyama M, Naka H, Kaji T Abstract Vascular endothelial cells are in direct contact with blood. Inorganic zinc is thought to be incapable of inducing metallothionein, which protects cells from heavy metal toxicity and oxidative stress, in vascular endothelial cells. Here, we aimed to further characterize the induction of metallothionein in vascular endothelial cells. Our results confirmed that inorganic zinc could not induce metallothionein in vascular endothelial cells. Moreover, ZnSO4 could not activate both the metal response ele...
Source: Journal of Toxicological Sciences - March 12, 2016 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Potential roles of Kruppel ‐like factors in mediating adverse vascular effects of nanomaterials: A review
AbstractThe development of nanotechnology leads to the exposure of human beings to nanomaterials (NMs), and there is a health concern about the adverse vascular effects of NMs. Current data from epidemiology, controlled human exposure, and animal studies suggested that exposure to NMs could induce cardiopulmonary effects. In support of in vivo findings, in vitro studies showed that direct contact of vascular cells with NMs could induce endothelial cell (EC) activation and promote macrophage foam cell formation, although only limited studies showed that NMs could damage vascular smooth muscle cells and promote their phenoty...
Source: Journal of Applied Toxicology - April 10, 2021 Category: Toxicology Authors: Yi Cao Tags: REVIEW ARTICLE Source Type: research

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells
In this study, we report that ZnONPs can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner. In addition, both the lipid reactive oxygen species (ROS) scavenger ferrostatin-1 and the iron chelator deferiprone attenuated ZnONPs-induced cell death. Intriguingly, we found that ZnONPs-induced ferroptosis is macroautophagy/autophagy-dependent, because the inhibition of autophagy with a pharmacological inhibitor or by ATG5 gene knockout profoundly mitigated ZnONPs-induced ferroptosis. We further d...
Source: Autophagy - April 12, 2021 Category: Cytology Authors: Xia Qin Jun Zhang Bin Wang Ge Xu Xi Yang Zhen Zou Chao Yu Source Type: research

Potential roles of Kruppel ‐like factors in mediating adverse vascular effects of nanomaterials: A review
AbstractThe development of nanotechnology leads to the exposure of human beings to nanomaterials (NMs), and there is a health concern about the adverse vascular effects of NMs. Current data from epidemiology, controlled human exposure, and animal studies suggested that exposure to NMs could induce cardiopulmonary effects. In support of in vivo findings, in vitro studies showed that direct contact of vascular cells with NMs could induce endothelial cell (EC) activation and promote macrophage foam cell formation, although only limited studies showed that NMs could damage vascular smooth muscle cells and promote their phenoty...
Source: Journal of Applied Toxicology - April 10, 2021 Category: Toxicology Authors: Yi Cao Tags: REVIEW ARTICLE Source Type: research

Expression of CD70 Modulates NO and Redox Status in Endothelial Cells
CONCLUSIONS: Taken together, these data establish CD70 as a novel regulatory protein in endothelial NO and reactive oxygen species homeostasis, with implications for human vascular disease.PMID:35924558 | DOI:10.1161/ATVBAHA.122.317866
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 4, 2022 Category: Cardiology Authors: Arvind K Pandey Markus Waldeck-Weiermair Quinn S Wells Wusheng Xiao Shambhu Yadav Emrah Eroglu Thomas Michel Joseph Loscalzo Source Type: research