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Total 25327 results found since Jan 2013.

Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence.
Authors: Chang D, Liu J, Bilinski K, Xu L, Steiner GZ, Seto SW, Bensoussan A Abstract Dementia is a leading cause of mental and physical disability. Vascular dementia (VaD) is the second most common cause of dementia after Alzheimer's disease (AD) constituting 10-15% of the dementia population. Currently there are no approved pharmaceutical options for VaD and the conventional anti-AD therapies provide only modest, short-term relief of symptoms associated with VaD. Herbal medicines have been used for the management of dementia-like symptoms for centuries and may provide viable therapies for VaD due to their multico...
Source: Evidence-based Complementary and Alternative Medicine - January 26, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Pharmacotherapy for Vascular Cognitive Impairment
AbstractVascular cognitive impairment (VCI) is the second most common type of dementia after Alzheimer ’s disease (AD). Stroke and cardiovascular risk factors have been linked to both AD and VCI and potentially can affect cognitive function in mid and later life. Various pharmacological agents, including donepezil, galantamine, and memantine, approved for the treatment of AD have shown modest cogni tive benefits in patients with vascular dementia (VaD). However, their functional and global benefits have been inconsistent. Donepezil has shown some cognitive benefit in patients with VaD only, and galantamine has shown some...
Source: CNS Drugs - August 7, 2017 Category: Neurology Source Type: research

Beneficial effects of hydroalcoholic extract and flavonoids from Zuccagnia punctata in a rabbit model of vascular dysfunction induced by high cholesterol diet
In conclusion, the present study demonstrated that a ZpE and its major flavonoids had beneficial effects in arteries with vascular dysfunction induced by hypercholesterolemia. The refore its use as herbal medicine to prevent cardiovascular risks factors may be promising.
Source: Medicinal Chemistry Research - October 1, 2017 Category: Chemistry Source Type: research

Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis < b > < i > in Vitro < /i > < /b > and < b > < i > in Vivo < /i > < /b >
Conclusion: DCQD can reduce capillary endothelial damage in acute pancreatitis-associated intestinal injury and the mechanism may be associated with the regulation of endothelial barrier function-associated proteins AQP-1, MMP9, and JAM-C.Cell Physiol Biochem 2017;44:2395 –2406
Source: Cellular Physiology and Biochemistry - December 20, 2017 Category: Cytology Source Type: research

Effect of Yin-Xing-Tong-Zhi Tablets on Improving Vascular Cognitive Impairment No Dementia.
Conclusion: YXTZTs may delay the development of cognitive impairment in VCIND patients by modulating expression of VCIND-associated proinflammatory factors. PMID: 29853963 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Alpha-Isocubebene modulates vascular tone by inhibiting myosin light chain phosphorylation in murine thoracic aorta
Aim: α-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined. To determine the role played by ICB on the regulation of vasc ular tone, we investigated the inhibitory effects of ICB on vascular contractile responses by adrenergic α-receptor agonists. In addition, we investigated the role on myosin light chain (MLC) phosphorylation and cytosolic calcium concentration in vascular smooth muscle cells (VSMC).
Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: E.J. Kim, B.H. Ye, S.E. Baek, Y.W. Choi, S.Y. Park, C.D. Kim Source Type: research

Dihydromyricetin from ampelopsis grossedentata protects against vascular neointimal formation via induction of TR3.
Abstract Vine tea has been used as a medicinal herb in traditional Chinese medicine for hundreds of years. As the most abundant ingredient in vine tea, Dihydromyricetin (DHM) has been reported to exert anti-inflammatory, antioxidant, and anti-cardiovascular disease. However, the role of DHM in injury-induced neointimal formation remains poorly characterized. We determined the effects of DHM on ligation-induced carotid artery neointimal formation. We found that ligation-induced carotid artery neointimal formation could be significantly attenuated by DHM treatment. We provide evidence that DHM increases orphan nucle...
Source: European Journal of Pharmacology - September 5, 2018 Category: Drugs & Pharmacology Authors: Huang B, Li Y, Yao Y, Shu W, Chen M Tags: Eur J Pharmacol Source Type: research

Huayu Tongmai Granules protects against vascular endothelial dysfunction via up-regulating miR-185 and down-regulating RAGE.
Conclusion Huayu Tongmai Granules appear to have a therapeutic effect on diabetic angiopathy that is most likely mediated by miR-185/RAGE axis. PMID: 30201694 [PubMed - as supplied by publisher]
Source: Bioscience Reports - September 10, 2018 Category: Biomedical Science Authors: Liu X, Wang D, Yang X, Lei L Tags: Biosci Rep Source Type: research

Molecules, Vol. 24, Pages 343: Hwangryunhaedok-Tang Exerts Neuropreventive Effect on Memory Impairment by Reducing Cholinergic System Dysfunction and Inflammatory Response in a Vascular Dementia Rat Model
Jin Jeong Hwangryunhaedok-tang (HRT) is a traditional oriental herbal formula used in Asian countries for treating inflammatory diseases and controlling fever. Our present study aimed to determine whether HRT has therapeutic effects for patients with vascular dementia (VaD) using a bilateral common carotid artery occlusion (BCCAO) rat model and assessing spatial memory impairment and activation of neuroinflammation. BCCAO was performed in male Sprague Dawley rats to induce VaD, and oral HRT was administered daily for 30 d. Our data showed that HRT ameliorated BCCAO-induced memory and cognitive impairment in behavioral ...
Source: Molecules - January 18, 2019 Category: Chemistry Authors: Eunjin Sohn Yu Jin Kim Hye-Sun Lim Bu-Yeo Kim Soo-Jin Jeong Tags: Article Source Type: research

Study on the multi-targets mechanism of triphala on cardio-cerebral vascular diseases based on network pharmacology.
CONCLUSIONS: This study revealed the complex components and pharmacological mechanism of Triphala, and obtained some potential therapeutic targets of CCVDs, which could provide theoretical basis for the research and development of new drugs for treating CCVDs. PMID: 31112872 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 17, 2019 Category: Drugs & Pharmacology Authors: Wang W, Liu T, Yang L, Ma Y, Dou F, Shi L, Wen A, Ding Y Tags: Biomed Pharmacother Source Type: research

Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability
AbstractAcute respiratory distress syndrome (ARDS) is a severe acute disease that threatens human health, and few drugs that can effectively treat this disease are available. Fraxin, one of the main active ingredients of Cortex Fraxini, a Chinese herbal medicine, has presented various pharmacological and biological activities. However, the effects of fraxin on ARDS have yet to be reported. In the present study, the protective effect of fraxin in lipopolysaccharide (LPS)-induced ARDS in a mouse model was analyzed. Results from the hematoxylin and eosin staining showed that fraxin might alleviate pathological changes in the ...
Source: Inflammation - July 3, 2019 Category: Allergy & Immunology Source Type: research

Inhibitory effects of herbal decoction Ojeoksan on proliferation and migration in vascular smooth muscle cells.
Authors: Han BH, Yoon JJ, Kim HY, Ahn YM, Jin SN, Wen JF, Lee HS, Lee YJ, Kang DG Abstract The proliferation of vascular smooth muscle cells plays a crucial role in pathogenesis of cardiovascular disease. The principal objective of this study was to determine the effects of Ojeoksan (OJS) on human aortic smooth muscle cell (HASMC) proliferation induced by tumor necrosis factor α (TNF-aα). Thymidine incorporation after TNF-α treatment was increased and this effect was inhibited significantly by OJS treatment. HASMC proliferation and migration by kinetic live cell imaging were also reduced by treatment with OJS. T...
Source: Journal of Physiology and Pharmacology - August 24, 2019 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Piper sarmentosum Leaves Aqueous Extract Attenuates Vascular Endothelial Dysfunction in Spontaneously Hypertensive Rats.
Authors: Hashim Fauzy F, Mohd Zainudin M, Ismawi HR, Elshami TFT Abstract Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb's antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positiv...
Source: Evidence-based Complementary and Alternative Medicine - September 6, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The effects of anticancer medicinal herbs on vascular endothelial growth factor based on pharmacological aspects: a review study.
Abstract As a complicated process of forming new blood vessels from the present vasculature endothelium, angiogenesis plays a critical role in the progression of cancer, through developing new blood vessels in tumor cells. Angiogenesis is regulated by proteins known as inhibitor or activator molecules, affected by different medicinal herbs and small molecules. In the present review, the molecular mechanisms of tumor angiogenesis are outlined, focusing on the pharmacological aspects and molecular mechanisms of natural compounds used in chemotherapy and their effects on angiogenesis, focusing on vascular endothelial...
Source: Nutrition and Cancer - October 24, 2019 Category: Cancer & Oncology Authors: Fakhri S, Abbaszadeh F, Jorjani M, Pourgholami MH Tags: Nutr Cancer Source Type: research

Tanshinone ⅡA inhibits homocysteine-induced proliferation of vascular smooth muscle cells via miR-145/CD40 signaling.
Abstract Tanshinone IIA (Tan IIA), isolated from the traditional Chinese herb Danshen, exhibits broad cardiovascular protective effects. However, the effect of Tan IIA on Homocysteine (Hcy)-induced proliferation of vascular smooth muscle cells (VSMCs) remains unknown. We herein determined whether Tan IIA exerted anti-proliferative effect in Hcy-treating VSMCs, and further investigated the underlying mechanism (miR-145/CD40 signaling). The results showed that Tan IIA significantly inhibited VSMCs proliferation induced by Hcy in a dose-dependent manner, and reversed the VSMCs injury as indicated by decreased KLF4 an...
Source: Biochemical and Biophysical Research communications - November 18, 2019 Category: Biochemistry Authors: Li Y, Chen F, Guo R, Jia S, Li W, Zhang B Tags: Biochem Biophys Res Commun Source Type: research