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Vascular Protective Effects of < em > Malus toringoides < /em > (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs
In this study, we examined the vascular protection provided by a 70% ethanol extract of M. toringoides (EMT) in human umbilical vein endothelial cells (HUVECs) grown in high-glucose medium and in a high-fat diet/streptozotocin-induced rat diabetes model. EMT significantly suppressed the expression of cell adhesion molecules in both HUVECs and diabetic rats. EMT also inhibited activation of the CX3CL1/CX3CR1 axis and the nuclear factor kappa B (NF-κB) signaling pathway in vivo and in vitro. The results provide a significant information on the vasoprotective properties of M. toringoides that may contribute to the developmen...
Source: Evidence-based Complementary and Alternative Medicine - October 31, 2022 Category: Complementary Medicine Authors: Xiangyu Wang Tong Wang Liying Gao Tsering Dikye Linsha Dong Ruiying Yuan Ning Meng Jing Yang Eun-Rhan Woo Dong-Sung Lee Yuefei Wang Bin Li Shan Huang Source Type: research
Preliminary Study of the Distinctive Mechanism of Shenqi Compound in Treating Rats with Type 2 Diabetes Mellitus by Comparing with Metformin
CONCLUSION: Comparing SQC with metformin to treat T2DM rats revealed several potential gene targets. These genes provide clues for elucidating the therapeutic mechanisms of SQC.PMID:36752289 | DOI:10.2174/1570161121666230208130349
Source: Current Vascular Pharmacology - February 8, 2023 Category: Drugs & Pharmacology Authors: Xiaoxu Fu Xiujuan Zhou Ya Liu Yuanhong Lei Hongyan Xie Yulin Leng Hong Gao Chunguang Xie Source Type: research
Modular characteristics and mechanism of action of herbs for vascular calcification treatment in Chinese medicine: a data mining and network pharmacology-based identification
CONCLUSIONS: Our work, accomplished by network pharmacology and data mining, increases our understanding of TCM in VC therapy and may offer insightful information for future drug discovery investigations.PMID:36930472 | DOI:10.26355/eurrev_202303_31539
Source: European Review for Medical and Pharmacological Sciences - March 17, 2023 Category: Drugs & Pharmacology Authors: C Yang X Peng H-Y Liu X-Q Li G-C Rao Z-Y Xie Q-F Yang L Du C-G Xie Source Type: research
Molecular Interaction Networks and Cardiovascular Disease Risk: The Role of Food Bioactive Small Molecules
Arterioscler Thromb Vasc Biol. 2023 Apr 27. doi: 10.1161/ATVBAHA.122.318332. Online ahead of print.ABSTRACTDiet is a well-known modifiable risk factor for cardiovascular diseases, which are the leading cause of death worldwide. However, our current understanding of the human diet is still limited in terms of fully capturing the role of dietary compounds in the intraspecies and interspecies biochemical networks that determine our health. This is due, in part, to a lack of detailed information on the presence of small molecules in food (molecular weight, ≤1000 daltons), their amounts, and their interactions with known prot...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 2, 2023 Category: Cardiology Authors: Farzaneh Nasirian Giulia Menichetti Source Type: research
Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
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Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review
AbstractBackgroundAdenomyosis commonly occurs with abnormal uterine bleeding (AUB) and is associated with subfertility and a higher miscarriage rate. Recent evidence showed abnormal vascularization in the endometrium in patients with adenomyosis, suggesting a role of angiogenesis in the pathophysiology of AUB and subfertility in adenomyosis and providing a possible treatment target.Objective and rationaleWe hypothesized that the level of abnormal vascularization and expression of angiogenic markers is increased in the ectopic and eutopic endometrium of adenomyosis patients in comparison with the endometrium of control pati...
Source: Human Reproduction Update - September 2, 2019 Category: OBGYN Source Type: research
Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review
ConclusionBerberine could impede the development of dementia via multiple mechanisms: preventing brain damages and enhancing cognition directly in the brain, and indirectly through alleviating risk factors such as metabolic dysfunction, and cardiovascular, kidney and liver diseases. This study provided evidence to support the value of berberine in the prevention of dementia associated with MetS.
Source: Journal of Integrative Medicine - January 17, 2020 Category: Complementary Medicine Source Type: research
