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Polysaccharide from Fuzi protects against Ox ‑LDL‑induced calcification of human vascular smooth muscle cells by increasing autophagic activity.
In conclusion, the present study demonstrated for the first time to the best of the authors' knowledge that FPS can protect against Ox‑LDL‑induced vascular calcification in human VSMCs, and that this likely occurs via the activation of autophagy. This supports the hypothesis that autophagy may be an endogenous protective mechanism counteracting vascular calcification, and that FPS may be used as a potential therapeutic for vascular calcification.
PMID: 29393437 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - February 4, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF- α Stimulation.
Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF-α Stimulation.
Evid Based Complement Alternat Med. 2018;2018:1024974
Authors: Choi ES, Yoon JJ, Han BH, Jeong DH, Kim HY, Ahn YM, Eun SY, Lee YJ, Kang DG, Lee HS
Abstract
Samul-Tang (SMT), consisting of four medicinal herbs, is a well-known herbal prescription treating hematological disorders related symptoms. Our previous study demonstrated that SMT attenuated inflammation of vascular endothelial cells. In condition of retained vascular dysfunction, vascular inflammation is initiated and results in activation of...
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats.
Abstract
Scutellaria baicalensis Georgi is an extensively used medicinal herb for the treatment of hypertension in traditional Chinese medicine. Baicalin is the most abundant flavone compound present in Scutellaria baicalensis Georgi and endothelium-dependent vascular activities of baicalin have been suggested. However, the pharmacological implications and mechanisms of baicalin under hypertensive conditions remain to be investigated. The current study examined the blood pressure-lowering effect of baicalin in a spontaneously hypertensive rat (SHR) model. Moreover, vascular activities and mechanisms of baicalin we...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 24, 2018 Category: Drugs & Pharmacology Authors: Ding L, Jia C, Zhang Y, Wang W, Zhu W, Chen Y, Zhang T Tags: Biomed Pharmacother Source Type: research
Aqueous extract of Salvia miltiorrhiza Bunge-Radix Puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats.
Abstract
Vascular diabetic complications are the leading cause of mortality and morbidity for diabetes. The present study was designed to investigate the protective effect of herb pair Salvia miltiorrhiza Bunge-Radix Puerariae (DG) on diabetic vascular injury induced by streptozotocin. The protective effect of DG was determined by oral administration of DG (50 and 200 mg/kg) in rats and on high glucose (HG)-induced endothelial injury. DG showed no effect on body weight, fasting blood glucose (FBG) but decreased the serum levels of insulin, nitric oxide (NO), hydrogen peroxide (H2O2), malondialdehyde (MDA), solub...
Source: Food and Chemical Toxicology - April 21, 2019 Category: Food Science Authors: Zhao W, Yuan Y, Zhao H, Han Y, Chen X Tags: Food Chem Toxicol Source Type: research
Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis
Conclusions: Our studies not only found the novel bioactive components from Salvia miltiorrhiza but also clarified the molecular mechanism underlying Sal-miR-1 and 3 inhibition of VSMC migration and monocyte adhesion to VSMCs. These results add important knowledge to the pharmacological actions and bioactive components of Salvia miltiorrhiza. Sal-miR-1 and 3-regulated OTUD7B/KLF4/NMHC IIA axis may represent a therapeutic target for vascular remodeling.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Gao-shan Yang, Bin Zheng, Yan Qin, Jing Zhou, Zhan Yang, Xin-hua Zhang, Hong-ye Zhao, Hao-jie Yang, Jin-kun Wen Tags: Research Paper Source Type: research
Icariside II Attenuates Vascular Remodeling Via Wnt7b/CCND1 Axis
In conclusion, our findings demonstrate that ICS-II possesses significant antiproliferative qualities that counteracts aberrant vascular neointimal hyperplasia. This phenomenon most likely occurs due to the suppression of the Wnt7b/CCND1 axis.
Source: Journal of Cardiovascular Pharmacology - July 1, 2022 Category: Cardiology Tags: Original Article Source Type: research
< em > Sidaxue < /em > , a traditional Guizhou Miao herbal medicine formula, reduces necroptosis and synovial vascular proliferation in rats with collagen-induced arthritis by inhibiting the RIPK1/RIPK3/MLKL pathway
CONCLUSION: SX can improve synovial angiogenesis in CIA rats possibly by inhibiting the activation of RIP1/RIP3/MLKL signaling pathway and down-regulating the expression of the vascular growth factors VEGF, Ang-1, MMP9, and Stat-3.PMID:36651244 | PMC:PMC9878417 | DOI:10.12122/j.issn.1673-4254.2022.12.04
Source: Journal of Southern Medical University - January 18, 2023 Category: Universities & Medical Training Authors: Y Wang X Dai C Chen P Cheng S Chen X Li X Bi Y Cheng C Wu N Wu Source Type: research
Analysis of Potential Mechanism of Herbal Formula Taohong Siwu Decoction against Vascular Dementia Based on Network Pharmacology and Molecular Docking
In this study, a network pharmacology approach together with molecular docking validation was used to explore the probable mechanism of action of TSD against VaD. A total of 44 active components, 202 potential targets of components, and 3,613 VaD-related targets including 161 intersecting were obtained. The potential chemical components including kaempferol, baicalein, beta-carotene, luteolin, quercetin, and beta-sitosterol involved in the inflammatory response, oxidative stress, and apoptosis might have potential therapeutic effects on the treatment of VaD. The potential core targets including AKT1, CASP3, IL1β, JUN, and...
Source: Cell Research - February 2, 2023 Category: Cytology Authors: Ruixin He Fengjiao He Zhenliang Hu Yifang He Xinting Zeng Yao Liu Liang Tang Ju Xiang Jianming Li Binsheng He Qin Xiang Source Type: research
< em > Sidaxue < /em > , a traditional Guizhou Miao herbal medicine formula, reduces necroptosis and synovial vascular proliferation in rats with collagen-induced arthritis by inhibiting the RIPK1/RIPK3/MLKL pathway
CONCLUSION: SX can improve synovial angiogenesis in CIA rats possibly by inhibiting the activation of RIP1/RIP3/MLKL signaling pathway and down-regulating the expression of the vascular growth factors VEGF, Ang-1, MMP9, and Stat-3.PMID:36651244 | PMC:PMC9878417 | DOI:10.12122/j.issn.1673-4254.2022.12.04
Source: Journal of Southern Medical University - January 18, 2023 Category: Universities & Medical Training Authors: Y Wang X Dai C Chen P Cheng S Chen X Li X Bi Y Cheng C Wu N Wu Source Type: research
Analysis of Potential Mechanism of Herbal Formula Taohong Siwu Decoction against Vascular Dementia Based on Network Pharmacology and Molecular Docking
In this study, a network pharmacology approach together with molecular docking validation was used to explore the probable mechanism of action of TSD against VaD. A total of 44 active components, 202 potential targets of components, and 3,613 VaD-related targets including 161 intersecting were obtained. The potential chemical components including kaempferol, baicalein, beta-carotene, luteolin, quercetin, and beta-sitosterol involved in the inflammatory response, oxidative stress, and apoptosis might have potential therapeutic effects on the treatment of VaD. The potential core targets including AKT1, CASP3, IL1β, JUN, and...
Source: Biomed Res - February 2, 2023 Category: Research Authors: Ruixin He Fengjiao He Zhenliang Hu Yifang He Xinting Zeng Yao Liu Liang Tang Ju Xiang Jianming Li Binsheng He Qin Xiang Source Type: research
< em > Sidaxue < /em > , a traditional Guizhou Miao herbal medicine formula, reduces necroptosis and synovial vascular proliferation in rats with collagen-induced arthritis by inhibiting the RIPK1/RIPK3/MLKL pathway
CONCLUSION: SX can improve synovial angiogenesis in CIA rats possibly by inhibiting the activation of RIP1/RIP3/MLKL signaling pathway and down-regulating the expression of the vascular growth factors VEGF, Ang-1, MMP9, and Stat-3.PMID:36651244 | PMC:PMC9878417 | DOI:10.12122/j.issn.1673-4254.2022.12.04
Source: Journal of Southern Medical University - January 18, 2023 Category: Universities & Medical Training Authors: Y Wang X Dai C Chen P Cheng S Chen X Li X Bi Y Cheng C Wu N Wu Source Type: research
