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Nutrition: Vitamins

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Total 43792 results found since Jan 2013.

Vitamin K Deficiency: An Emerging Player in the Pathogenesis of Vascular Calcification and an Iatrogenic Consequence of Therapies in Advanced Renal Disease.
Abstract Vascular calcification is a known complication of chronic kidney disease (CKD). The prevalence of vascular calcification in patients with non-dialysis-dependent CKD stages 3-5 has been shown to be as high as 79%. [1] Vascular calcification has been associated with increased risk for mortality, hospital admissions, and cardiovascular disease. [1] [2] [3] [4] Alterations in mineral and bone metabolism play a pivotal role in the pathogenesis of vascular calcification in CKD. As CKD progresses, levels of fibroblast growth factor-23 (FGF-23), parathyroid hormone (PTH) and serum phosphorus increase and 1,25-(OH...
Source: Am J Physiol Renal P... - August 23, 2020 Category: Urology & Nephrology Authors: Levy D, Grewal R, Le TH Tags: Am J Physiol Renal Physiol Source Type: research

Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial
Discussion: Evidence of successful regression or retardation of vascular calcification will support the conduct of larger and longer-term trials aimed at reducing cardiovascular disease mortality and major adverse cardiovascular events in this high-risk population using a safe and inexpensive strategy Trial registration: ClinicalTrials.gov NCT02870829. Registered on 17 August 2016 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02870829 National University Hospital's Institutional Review Board (2015/01000)
Source: Medicine - September 4, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

MiR155 modulates vascular calcification by regulating Akt-FOXO3a signalling and apoptosis in vascular smooth muscle cells.
In conclusion, miR155 deficiency attenuates vascular calcification by increasing Akt phosphorylation and FOXO3a degradation, and thus reducing VSMC apoptosis induced by calcification medium. PMID: 33210462 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - November 18, 2020 Category: Molecular Biology Authors: Li Y, Sun W, Saaoud F, Wang Y, Wang Q, Hodge J, Hui Y, Yin S, Lessner SM, Kong X, Fan D Tags: J Cell Mol Med Source Type: research

Steroid hormones and first trimester vascular remodeling
Vitam Horm. 2021;116:363-387. doi: 10.1016/bs.vh.2021.02.003. Epub 2021 Mar 10.ABSTRACTSuccessful implantation and placentation require neoangiogenesis and the remodeling of the uterine spiral arteries. Progesterone and estradiol control various of the placental functions, but their role in vascular remodeling remains controversial. Therefore, this chapter aims to summarize the current knowledge regarding the role of steroid hormones in the uteroplacental vascular remodeling during the first trimester of gestation.PMID:33752825 | DOI:10.1016/bs.vh.2021.02.003
Source: Vitamins and Hormones - March 23, 2021 Category: Endocrinology Authors: V A Ca ñumil E Bogetti F L de la Cruz Borthiry M L Ribeiro J S Beltrame Source Type: research