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Total 91451 results found since Jan 2013.
Clinical trials in Charcot-Marie-Tooth disorders: a retrospective and preclinical assessment
ConclusionCurrent CMT trials are exploring procedural and molecular therapeutic options with substantial participation of the pharmaceutical industry worldwide. Emerging drug therapies directed at molecular pathogenesis are being advanced in human clinical trials; however, the majority remain within animal investigations.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
Natalizumab Treatment Induces Proinflammatory CD4 T Cells Preferentially in the Integrin {beta}7+ Compartment
Discussion
Our study shows that circulating integrin β7+ memory CD4 T cells of patients with relapsing-remitting MS under natalizumab are enriched in proinflammatory cells supporting the hypothesis that integrin β7+ memory CD4 T cells could play a pathogenic role in the disease rebound observed at natalizumab discontinuation.
Source: Neurology Neuroimmunology and Neuroinflammation - September 22, 2023 Category: Neurology Authors: Nguyen Ky, M., Duran, A., Hasantari, I., Bru, A., Deloire, M., Brochet, B., Ruet, A., Schmitt, N. Tags: All Immunology, Multiple sclerosis Research Article Source Type: research
Sleep in marathon and ultra-marathon runners: A brief narrative review
Conclusions: In summary, the longer the distance of a running race, the greater the importance of an optimal sleep for race performance as well as the impact of a race on sleep.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
Diffusion tensor free water MRI predicts progression of FLAIR white matter hyperintensities after ischemic stroke
DiscussionBaseline increased interstitial fluid, estimated as FW on DTI, predicted the progression of NAWM to WMH over the following year. These results implicate the presence of FW in the pathogenesis of cerebral small vessel disease progression.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
Peripheral electrical stimulation on neuroplasticity and motor function in stroke patients: a systematic review and meta-analysis
Conclusions Electrostimulation is able to promote neuroplasticity and increase motor function, generating positive effects in the treatment of individuals with post-stroke sequelae.PMID:37732768 | DOI:10.1080/01616412.2023.2257419
Source: Neurological Research - September 21, 2023 Category: Neurology Authors: Aline Cristina Beijora Ana Paula Back Andersom Ricardo Fr éz M árcia Rosângela Buzanello Azevedo Gladson Ricardo Flor Bertolini Source Type: research
The effects of cycling on walking outcomes in adults with stroke: a systematic review
CONCLUSION: Considerable heterogeneity was observed across cycling protocols with respect to intensity, frequency, exercise duration and protocol duration. However, none of the studies reported declines in walking outcomes and improvements were measured in the absence of task-specific gait training. Cycling interventions employing moderate- to high-intensity aerobic training and 24 sessions or more may be optimal in improving gait velocity and walking capacity.PMID:37732513 | DOI:10.1080/10749357.2023.2259167
Source: Topics in Stroke Rehabilitation - September 21, 2023 Category: Neurology Authors: Madeeha Khan Logan M Maag Mary Pat Harnegie Susan M Linder Source Type: research
Posterior semicircular canal cupulolithiasis during acute pontomedullary demyelination
We describe a woman with MS who developed a sixth nerve palsy and gaze-evoked nystagmus, caused by demyelination near or within areas classically involved in central positional vertigo. However, she also had positional vertigo from coincident BPPV (and not central positional vertigo). This was initially a treatment resistant-posterior semicircular canal cupulolithiasis but it later progressed to a posterior semicircular canal canalolithiasis, with symptoms promptly resolving after a repositioning manoeuvre.PMID:37734945 | DOI:10.1136/pn-2023-003884
Source: Practical Neurology - September 21, 2023 Category: Neurology Authors: Sara Matos Ana In ês Martins Andr é Jorge Maria do Carmo Mac ário Daniela Pereira Michael Strupp Jo ão Lemos Source Type: research
Bilateral thalamic infarction: role of CT perfusion imaging
Pract Neurol. 2023 Sep 21:pn-2023-003769. doi: 10.1136/pn-2023-003769. Online ahead of print.NO ABSTRACTPMID:37734944 | DOI:10.1136/pn-2023-003769
Source: Practical Neurology - September 21, 2023 Category: Neurology Authors: Vibuthi Sisodia Stefan D Roosendaal Bart E K S Swinnen Anke Wouters Source Type: research
Excitability of somatosensory cortex is increased in ALS: A SEP recovery function study
CONCLUSIONS: Our findings demonstrated increased somatosensory cortical excitability in ALS, which was associated with clinical parameters such as reduced pulmonary function and motor strength.SIGNIFICANCE: Somatosensory cortical excitability is impaired in ALS. Whether this is associated with increased motor cortical excitability requires further studies.PMID:37734132 | DOI:10.1016/j.clinph.2023.08.013
Source: Clinical Neurophysiology - September 21, 2023 Category: Neurology Authors: B ülent Cengiz Özlem Kurtkaya Koçak Tu ğba Erdoğan Ece Yan ık G ökhan Pek Yusuf Savrun H Evren Boran H Reha Kuruo ğlu Source Type: research
Assisted reproductive technology outcomes and management considerations for people with epilepsy
Curr Opin Endocrinol Diabetes Obes. 2023 Sep 22. doi: 10.1097/MED.0000000000000838. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Epilepsy is a common neurologic condition amongst people with reproductive capacity, and assisted reproductive technology (ART) is being increasingly utilized. A recent population-based study described favorable outcomes of ART in this population, but other work shows how fluctuating sex hormones may influence medication concentrations and seizures.RECENT FINDINGS: This review discusses hormonal influences on epilepsy and catamenial epilepsy, considerations regarding fertility in women with e...
Source: Epilepsy Curr - September 21, 2023 Category: Neurology Authors: Regan J Lemley Paula Emanuela Voinescu Source Type: research
Motivation-related influences on fNIRS signals during walking exercise: a permutation entropy approach
This study provides early evidence to suggest that while different motivational environments during walking activity influence the magnitude of fNIRS signals, they may not influence the regularity of cortical signals. However, the magnitude of PE difference between motivational conditions was related to self-determined motivation in the aPFC, and this is an area warranting further investigation.PMID:37733031 | DOI:10.1007/s00221-023-06707-5
Source: Brain Research - September 21, 2023 Category: Neurology Authors: Sarah M Schwab Dalton Cooper Nicole S Carver Sarah Doren Pierce Boyne Source Type: research
The effects of cycling on walking outcomes in adults with stroke: a systematic review
CONCLUSION: Considerable heterogeneity was observed across cycling protocols with respect to intensity, frequency, exercise duration and protocol duration. However, none of the studies reported declines in walking outcomes and improvements were measured in the absence of task-specific gait training. Cycling interventions employing moderate- to high-intensity aerobic training and 24 sessions or more may be optimal in improving gait velocity and walking capacity.PMID:37732513 | DOI:10.1080/10749357.2023.2259167
Source: Topics in Stroke Rehabilitation - September 21, 2023 Category: Neurology Authors: Madeeha Khan Logan M Maag Mary Pat Harnegie Susan M Linder Source Type: research
The effect of type 2 diabetes and diabetic peripheral neuropathy on predictive grip force control
This study investigated the impact of type 2 diabetes and diabetic peripheral neuropathy on grip force control during object manipulation. The study included three age-matched groups: type 2 diabetes alone (n = 11), type 2 diabetes with neuropathy (n = 13), and healthy controls (n = 12). Grip force control variables derived from lifting and holding an experimental cup were the ratio between grip force and load forces during lifting (GFR), latency 1 and latency 2, which represented the time between the object's grip and its lift-off from the table, and the period between object's lift-off and the grip force peak, respective...
Source: Brain Research - September 21, 2023 Category: Neurology Authors: Marcio Dos Santos Abdalghani Yahya Patricia Kluding Mamatha Pasnoor Jo Wick Wen Liu Source Type: research
Analyzing characteristics of collateral flow to parasylvian cortical arteries by three-dimensional digital subtraction angiography –magnetic resonance angiography fusion imaging in adult moyamoya disease
ConclusionIn MMD hemispheres, the hemodynamic sources of the PSCAs above the SF are more varied than those below the SF and present a typical conversion trend from ICAs to non-ICAs with advancing Suzuki stages. Analyzing the hemodynamic sources of the PSCAs can help in understanding the conversion pattern of compensatory vascular systems, predicting episodes in MMD, and preoperatively evaluating suitable recipient vessel selection for bypass surgery to avoid postoperative CHP.
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research
A mini-review on functional magnetic resonance imaging on brain structure of vascular cognitive impairment
Vascular cognitive impairment (VCI) is the initial stage of vascular dementia (VaD). Early diagnosis and treatment of VCI are crucial to prevent the progression of VaD. In order to gain a better understanding of VCI, this study aimed to investigate the use of advanced imaging techniques such as structural magnetic resonance imaging (sMRI) and resting-state functional magnetic resonance imaging (rs-fMRI). These techniques allow researchers to observe the structural and functional changes in the brain that are associated with VCI. Functional magnetic resonance imaging (fMRI) and sMRI techniques have been widely used in studi...
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research
