This page shows you your search results in order of relevance. This is page number 8.

Order by Relevance | Date

Total 4438870 results found since Jan 2013.

Phenotypic spectrum of a patient with Gorlin’s syndrome and role of dermoscopy in the early detection of basal cell carcinomas
We describe the case of a patient with clinical and imaging features of Gorlin syndrome, and highlight the role of dermoscopy in the early detection of basal cell carcinomas. In addition, we discuss the dermoscopic features of palmar pits.
Source: Anais Brasileiros de Dermatologia - June 27, 2015 Category: Dermatology Source Type: research

Gorlin-Goltz Syndrome: Case report and literature review.
This article includes a case report and an extensive review of the GGS with regard to its history, incidence, etiology, features, investigations, diagnostic criteria, keratocystic odontogenic tumor and treatment modalities. PMID: 26604511 [PubMed - as supplied by publisher]
Source: Journal of Oral and Maxillofacial Pathology - November 30, 2015 Category: ENT & OMF Tags: J Oral Maxillofac Pathol Source Type: research

Confocal and dermoscopic features of basal cell carcinoma in Gorlin-Goltz syndrome: A case report.
Abstract Gorlin-Goltz (GS) syndrome is an autosomal dominant disease linked to a mutation in the PTCH gene. Major criteria include the onset of multiple basal cell carcinoma (BCC), keratocystic odontogenic tumours in the jaws and bifid ribs. Dermoscopy and reflectance confocal microscopy represent imaging tools that are able to increase the diagnostic accuracy of skin cancer in a totally noninvasive manner, without performing punch biopsies. Here we present a case of a young woman in whom the combined approach of dermoscopy and RCM led to the identification of multiple small inconspicuous lesions as BCC and thus t...
Source: The Australasian Journal of Dermatology - January 14, 2016 Category: Dermatology Authors: Casari A, Argenziano G, Moscarella E, Lallas A, Longo C Tags: Australas J Dermatol Source Type: research

Congenital Mirror Movements in Gorlin Syndrome: A Case Report With DTI and Functional MRI Features
Congenital mirror movements are rare conditions that define the inability to perform unimanual movements. Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a genetic disorder with multiple nevi predisposing to basal cell carcinoma, odontogenic keratocysts, and skeletal malformations. Herein we report on an adolescent patient with Gorlin syndrome and coexisting congenital mirror movements. To our knowledge, this is the first patient in the literature who has both of these very rare conditions.
Source: PEDIATRICS - March 1, 2016 Category: Pediatrics Authors: Sag, E., Gocmen, R., Yildiz, F. G., Ozturk, Z., Temucin, C., Teksam, O., Utine, E. Tags: Genetics, Radiology Case Report Source Type: research

Myelodysplastic Syndrome Occurring in a Patient with Gorlin Syndrome
We report a case of myelodysplastic syndrome (MDS) occurring in an African American boy with Gorlin syndrome with a novel PTCH1 mutation. Before developing MDS, the patient had been treated with chemotherapy and radiation for a medulloblastoma. He received a bone marrow transplant for the MDS and eventually died of treatment complications. Secondary hematologic malignancies are a known complication of certain chemotherapeutics, although whether a patient with Gorlin syndrome has a greater propensity for the development of such malignancies is unclear.
Source: Pediatric Dermatology - May 30, 2016 Category: Dermatology Authors: Jamie L. Mull, Lisa M. Madden, Susan J. Bayliss Tags: Brief Report Source Type: research

A novel PTCH1 gene mutation in a pediatric patient associated multiple keratocystic odontogenic tumors of the jaws and Gorlin-Goltz syndrome.
This report documents a case of GGS with a novel mutation in the PTCH1 gene in an 11-year-old child. The clinical, radiographic, histopathologic and molecular findings of this condition, and treatment are described, and a review of GGS was carried out. PMID: 27510672 [PubMed - in process]
Source: Indian Journal of Pathology and Microbiology - June 30, 2016 Category: Pathology Authors: Ozcan G, Balta B, Sekerci AE, Etoz OA, Martinuzzi C, Kara O, Pastorino L, Kocoglu F, Ulker O, Erdogan M Tags: Indian J Pathol Microbiol Source Type: research

Development of mediastinal lymphoma after radiotherapy for concurrent medulloblastoma and PNET in a patient with Gorlin syndrome
Very young children with Gorlin syndrome are at risk for developing medulloblastoma. Patients with Gorlin syndrome may have multiple system abnormalities, including basal cell carcinomas, jaw cysts, desmoplast...
Source: World Journal of Surgical Oncology - August 12, 2016 Category: Cancer & Oncology Authors: Tao Jiang, Junmei Wang, Ying Wang and Chunde Li Source Type: research

Odontogenic keratocysts in the Basal Cell Nevus (Gorlin-Goltz) Syndrome associated with paresthesia of the lower jaw: case report, retrospective analysis of a representative Czech cohort and recommendations for the early diagnosis.
CONCLUSIONS: Analysis of the reported case and retrospective data analysis provided evidence that paresthesia of the lower jaw should be considered as one of the early presenting signs of this rare disorder in stomatological and neurological practice. Obtained results allowed us to formulate recommendations for diagnostic practice in stomatology and neurology. PMID: 27857042 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - November 21, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

How are physicians treating patients with Gorlin syndrome in the real world? Data from the RegiSONIC disease registry
We describe clinical characteristics, first-line treatment patterns, and preliminary outcomes in pts with Gorlin syndrome from RegiSONIC (NCT01604252), a prospective, multicenter, observational study.
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research

Genotype-Phenotype Correlations in Gorlin Syndrome Genotype-Phenotype Correlations in Gorlin Syndrome
What do we currently know about the genotype and phenotype correlations in Gorlin syndrome?Journal of Medical Genetics
Source: Medscape Today Headlines - October 10, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Colloid cyst and multiple meningiomata in Gorlin syndrome
Publication date: Available online 4 November 2017 Source:Journal of Clinical Neuroscience Author(s): Yan-Lin Li, Stephen Kai-Yan Kwok, Kenneth Chun-Kit Shiu A middle-aged man presented with syncope and confusion. Neuroimaging revealed a third ventricular mass with obstructive hydrocephalus and bilateral convexity meningiomata. The masses were excised and pathology showed a colloid cyst and WHO grade 1 meningiomata respectively. Multisystem workup confirmed Gorlin syndrome. To our knowledge, this is the fourth reported case of Gorlin syndrome associated with colloid cyst, and the first case where multiple meningiomata are also present.
Source: Journal of Clinical Neuroscience - November 5, 2017 Category: Neuroscience Source Type: research

Intratarsal Keratinous Eyelid Cysts in Gorlin Syndrome: A Review and Reappraisal
A 38-year-old woman presented with multiple bilateral recurrent eyelid cysts. Her medical history was notable for Gorlin (nevoid basal cell carcinoma) syndrome. Histopathologic and immunohistochemical examinations revealed that the lesions were intratarsal keratinous cysts. They were similar in appearance to sporadic intratarsal keratinous cysts and closely resembled odontogenic keratocysts of the jaw. Eyelid cysts occur in up to 40 percent of patients with Gorlin syndrome; however, their description has been cursory and for the most part, outside of the ophthalmic literature.
Source: Survey of Ophthalmology - December 26, 2017 Category: Opthalmology Authors: Natalie Wolkow, Frederick A. Jakobiec, Michael K. Yoon Tags: Clinical Pathologic Reviews Source Type: research

Nevoid basal-cell carcinoma syndrome (Gorlin Syndrome): report of two cases and review of the literature.
This study is the first to report cases in Peru of patients with GS who underwent genetic evaluation and counseling. We present two GS cases that meet the clinical criteria for the syndrome and review the literature. PMID: 29364426 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - January 26, 2018 Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research

Gorlin Syndrome
Publication date: Available online 24 February 2018 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): I. Palacios-Álvarez, R. González-Sarmiento, E. Fernández-López Gorlin syndrome is a rare autosomal dominant disease caused by mutations in the sonic hedgehog signaling pathway. Of particular importance is the PTCH1 gene. The disease is characterized by the development of multiple basal cell carcinomas at young ages. These tumors may present with other skin manifestations such as palmoplantar pits and with extracutaneous manifestations such as odontogenic keratocysts and medulloblastoma. Although the der...
Source: Actas Dermo-Sifiliograficas - February 24, 2018 Category: Dermatology Source Type: research