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Chapter 8 Basal cell nevus syndrome or Gorlin syndrome
Publication date: 2015 Source:Handbook of Clinical Neurology, Volume 132 Author(s): Srikanth Thalakoti, Thomas Geller Basal cell nevus syndrome (BCNS) or Gorlin syndrome is a rare neurocutaneous syndrome sometimes known as the fifth phacomatosis, inherited in autosomal dominant fashion with complete penetrance and variable expressivity. Gorlin syndrome is characterized by development of multiple basal cell carcinomas (BCCs), jaw cysts, palmar or plantar pits, calcification of falx cerebri, various developmental skeletal abnormalities such as bifid rib, hemi- or bifid vertebra and predisposition to the development of va...
Source: Handbook of Clinical Neurology - November 18, 2015 Category: Neurology Source Type: research

Severe PATCHED1 Deficiency in Cancer-Prone Gorlin Patient Cells Results in Intrinsic Radiosensitivity
Gorlin syndrome (or basal-cell nevus syndrome) is a cancer-prone genetic disease in which hypersusceptibility to secondary cancer and tissue reaction after radiation therapy is debated, as is increased radiosensitivity at cellular level. Gorlin syndrome results from heterozygous mutations in the PTCH1 gene for 60% of patients, and we therefore aimed to highlight correlations between intrinsic radiosensitivity and PTCH1 gene expression in fibroblasts from adult patients with Gorlin syndrome.
Source: International Journal of Radiation Oncology * Biology * Physics - June 1, 2018 Category: Radiology Authors: Adeline Vulin, Melissa Sedkaoui, Sandra Moratille, Nicolas Sevenet, Pascal Soularue, Odile Rigaud, Laure Guibbal, Joshua Dulong, Penny Jeggo, Jean-Fran çois Deleuze, Jérôme Lamartine, Michèle T. Martin Tags: Biology Contribution Source Type: research

Medulloblastoma in a toddler with Gorlin syndrome.
We report a male toddler with multicentric posterior fossa tumor and calcifications along the falx cerebri, suggesting MB and GS. Pathology revealed nodular MB. His testing confirmed a germline SUFU mutation. His tumor resolved with three induction cycles of chemotherapy, but he died of respiratory failure due to infection at 20 months of age. Overlooking calcifications along the falx cerebri in children with MB can induce significant morbidity. PMID: 29706825 [PubMed]
Source: Baylor University Medical Center Proceedings - April 1, 2018 Category: Universities & Medical Training Authors: Al-Rahawan MG, Trevino S, Jacob R, Murray JC, Al-Rahawan MM Tags: Proc (Bayl Univ Med Cent) Source Type: research

Cancer-Related Search for Meaning Increases Willingness to Participate in Mindfulness-Based Stress Reduction
Conclusion. Our study indicates that patients searching for meaning are receptive to MBSR. Nonwhite patients and those experiencing high levels of anxiety are most likely to endorse a search for meaning. Future research is needed to understand how best to support patients who are searching for meaning and remove barriers to evidence-based programs like MBSR.
Source: Integrative Cancer Therapies - April 13, 2015 Category: Cancer & Oncology Authors: Garland, S. N., Stainken, C., Ahluwalia, K., Vapiwala, N., Mao, J. J. Tags: Articles Source Type: research

Radiotherapy Planning Using an Improved Search Strategy in Particle Swarm Optimization
Conclusion: The proposed virtual search approach boosts the swarm search efficiency, and consequently, improves the optimization convergence rate and robustness for PSO. Significance: RT planning is a large-scale, nonconvex optimization problem, where finding optimal solutions in a clinically practical time is critical. Our proposed approach can potentially improve the optimization efficiency in similar time-sensitive problems.
Source: IEEE Transactions on Biomedical Engineering - April 21, 2017 Category: Biomedical Engineering Source Type: research

Pareto Optimal Projection Search (POPS): Automated Radiation Therapy Treatment Planning by Direct Search of the Pareto Surface
Conclusion: Our proposed POPS algorithm provides a general framework for fully automated treatment planning that achieves clinically acceptable dosimetric quality without requiring active planning from human planners. Significance: Our fully automated POPS algorithm addresses many key limitations of other automated planning approaches, and we anticipate that it will substantially improve treatment planning workflow.
Source: IEEE Transactions on Biomedical Engineering - September 21, 2021 Category: Biomedical Engineering Source Type: research

Malignant transformation in vestibular schwannoma: report of a single case, literature search, and debate.
Conclusions Despite more frequent reports of MTVS after radiation treatment recently, there has been no accurate quantification of the risk, except in patients with NF, in whom the incidence of malignancy is high in relation to the numbers treated. The present analysis indicates that the risk of malignancy over 20 years in cases in which no radiation treatment has occurred is 1.32-2.08 per 100,000, and this risk decreases to 1.09-1.74 per 100,000 if cases of NF are excluded. After radiation treatment, the overall risk over 20 years is 25.1 per 100,000, and this risk decreases to 15.6 per 100,000 if cases of NF are excluded...
Source: Journal of Neurosurgery - December 1, 2014 Category: Neurosurgery Authors: Seferis C, Torrens M, Paraskevopoulou C, Psichidis G Tags: J Neurosurg Source Type: research

Monte Carlo tree search -based non-coplanar trajectory design for station parameter optimized radiation therapy (SPORT).
Conclusion: AI based on MCTS is valuable to facilitate the design of beam trajectory and paves the way for future clinical use of non-coplanar treatment delivery. &#13. PMID: 29863493 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - June 4, 2018 Category: Physics Authors: Dong P, Liu H, Xing L Tags: Phys Med Biol Source Type: research

The Scatter Search Based Algorithm for Beam Angle Optimization in Intensity-Modulated Radiation Therapy.
This article introduces a new framework for beam angle optimization (BAO) in intensity-modulated radiation therapy (IMRT) using the Scatter Search Based Algorithm. The potential benefits of plans employing the coplanar optimized beam sets are also examined. In the proposed beam angle selection algorithm, the problem is solved in two steps. Initially, the gantry angles are selected using the Scatter Search Based Algorithm, which is a global optimization method. Then, for each beam configuration, the intensity profile is calculated by the conjugate gradient method to score each beam angle set chosen. A simulated phantom case...
Source: Computational and Mathematical Methods in Medicine - July 5, 2018 Category: Statistics Tags: Comput Math Methods Med Source Type: research

Optimal marker placement in hadrontherapy: Intelligent optimization strategies with augmented Lagrangian pattern search
Conclusions The SAPS algorithm is a valuable strategy for fiducial configuration optimization in IR optical tracking applied for patient set-up error detection and correction in radiation therapy, showing that taking into account prior knowledge is valuable in this optimization process. Further work will be focused on the computational optimization of the SAPS algorithm toward fast point-of-care applications. Graphical abstract
Source: Journal of Biomedical Informatics - November 3, 2014 Category: Information Technology Source Type: research

Cancers, Vol. 14, Pages 3693: Intra-Operative Electron Radiation Therapy: An Update of the Evidence Collected in 40 Years to Search for Models for Electron-FLASH Studies
Conclusions: IOeRT represents an evidence-based approach for several tumor types. A specific risk analysis for local recurrences supports the identification of cancer models that are candidates for FLASH studies.
Source: Cancers - July 29, 2022 Category: Cancer & Oncology Authors: Felipe A. Calvo Javier Serrano Mauricio Cambeiro Javier Aristu Jose Manuel Asencio Isabel Rubio Jose Miguel Delgado Carlos Ferrer Manuel Desco Javier Pascau Tags: Review Source Type: research

Investigational therapies for Ewing's sarcoma: a search without a clear finding.
Authors: Vornicova O, Bar-Sela G Abstract INTRODUCTION: Ewing sarcoma family tumors (ESFT) are a group of aggressive diseases, characterized histologically by small, round, blue cells and genetically by translocation involving EWS and ETS partner genes. The current treatment of localized Ewing sarcoma (ES) requires a multi-disciplinary approach, including multidrug chemotherapy, administrated before and after local treatment, surgery and radiation therapy. Unfortunately, the cure rate of metastatic or refractory/recurrent disease is still very poor. Areas covered: In this review, the authors summarize the new types...
Source: Expert Opinion on Investigational Drugs - March 20, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

Chest wall pain following lung stereotactic body radiation therapy using 48Gy in three fractions: A search for predictors.
CONCLUSION: Our analysis could not find any correlation between the studied parameters and chest wall pain. Considering our present study and the wide range of differing results from the literature, a reasonable conclusion is that a constraint for chest wall pain is yet to be defined. PMID: 30952561 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - April 1, 2019 Category: Cancer & Oncology Authors: Albers J, Parker W, Kildea J, Pembroke C, Faria S Tags: Cancer Radiother Source Type: research

Pure abscopal effect of radiotherapy in a salivary gland carcinoma: Case report, literature review, and a search for new approaches.
We report the case of an 84-year-old woman with poorly differentiated non-small cell carcinoma of the right parotid who presented with headache, was found to have a primary right parotid gland cancer as well as metastatic disease, and underwent palliative radiotherapy to the primary site. The patient received no chemotherapy or immunotherapy, but both the primary site and several non-irradiated foci in the lungs regressed or completely resolved. The patient remained free of disease for about one year before progression. The case is a rare instance of abscopal regression of metastatic disease in the absence of pharmacologic...
Source: Cancer Radiotherapie - March 15, 2020 Category: Cancer & Oncology Authors: Ellerin BE, Demandante CGN, Martins JT Tags: Cancer Radiother Source Type: research