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Total 29834 results found since Jan 2013.

Adapting psychedelic medicine for headache and chronic pain disorders
Expert Rev Neurother. 2023 Jul-Dec;23(10):867-882. doi: 10.1080/14737175.2023.2246655. Epub 2023 Aug 31.ABSTRACTINTRODUCTION: While the majority of current research and development surrounds depression, demoralization, and substance use disorders, there are numerous reports of psychedelics having beneficial effects in other branches of medicine, including for headache disorders and chronic pain.AREAS COVERED: This perspective reviews conventional forms of treatment for headache and other chronic pain disorders and describes historical, recent, and ongoing investigations of the therapeutic effects of psychedelics in these d...
Source: Expert Review of Neurotherapeutics - August 31, 2023 Category: Neurology Authors: Emmanuelle A D Schindler Peter S Hendricks Source Type: research

Exploring the cortical habituation in migraine patients based on contingent negative variation
DiscussionOur study has revealed that migraine attacks may influence responsivity, pre-activation, habituation, and cortical inhibition not only on the behavioral level but also on the electrophysiological level. Abnormal changes in cortical habituation and inhibition can be interpreted as CNV components. Additionally, analyses have revealed correlations between CNV components and various factors, including age, the clinical course of the condition, attack frequency, pain intensity, and duration. Thus, repetitive migraine attacks can lead to a reduction in cortical inhibition and subsequent impairment in executive function.
Source: Frontiers in Neurology - August 30, 2023 Category: Neurology Source Type: research

Cutaneous allodynia as predictor for treatment response in chronic migraine: a cohort study
ConclusionsCutaneous allodynia, an important marker for central sensitization, likely has predictive value for treatment response in chronic migraine.Graphical Abstract
Source: The Journal of Headache and Pain - August 30, 2023 Category: Neurology Source Type: research

A meta-analytic review of acceptance-based interventions for migraine
CONCLUSION: Results suggest that acceptance-based interventions are effective in improving disability among adults with migraine and are a viable non-pharmacological treatment option, in addition to well-established behavioral migraine management approaches, for patients seeking functional improvement.PMID:37635382 | DOI:10.1111/head.14614
Source: Headache - August 28, 2023 Category: Neurology Authors: Ashley N Polk Todd A Smitherman Source Type: research

Immunotherapy-Responsive Neuropathic Pain and Allodynia in a Patient With Glycine Receptor Autoantibodies: A Case Report
We describe the case of a previously well adult presenting with severe neuropathic pain and allodynia as part of an autoimmune brainstem and spinal syndrome with glycine receptor autoantibodies. Results Our patient experienced a severe illness, including marked neuropathic pain and allodynia, hypoventilation, tetraparesis, and ophthalmoplegia. A diagnosis of progressive encephalomyelitis with rigidity and myoclonus was made. Neuropathic pain was characterized with validated instruments and responded promptly to cause-directed immunotherapy. Discussion A detailed longitudinal phenotyping, using validated pain measurement ...
Source: Neurology Neuroimmunology and Neuroinflammation - August 28, 2023 Category: Neurology Authors: Soleimani, B., Board, C., Yu, T., Tracey, I., Irani, S. R., Foley, P. Tags: Autoimmune diseases, All Clinical Neurology, Central pain, Neuropathic pain Clinical/Scientific Note Source Type: research

Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization
Individuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chronic pain. Despite extensive studies investigating the underlying mechanisms of mTBI-assoc...
Source: Journal of Neuroinflammation - August 27, 2023 Category: Neurology Authors: Tyler Nguyen, Natalie Nguyen, Ashlyn G. Cochran, Jared A. Smith, Mohammed Al-Juboori, Andrew Brumett, Saahil Saxena, Sarah Talley, Edward M. Campbell, Alexander G. Obukhov and Fletcher A. White Tags: Research Source Type: research