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Total 29834 results found since Jan 2013.
Oxytocin increases itch sensitivity of mice in late pregnancy and its peripheral receptor mechanism of itch-promoting effect
Brain Res Bull. 2023 Aug 24:110749. doi: 10.1016/j.brainresbull.2023.110749. Online ahead of print.ABSTRACTOxytocin (OXT) is secreted in a large amount during the middle and late pregnancy. Except for the regulation of functions related to childbirth, OXT is involved in the regulation of cognition, social behavior, addiction, pain and so on. Our aim is to confirm the increase of OXT content in mice in late pregnancy is the main cause of itch during pregnancy and observe whether exogenously administered OXT can induce or increase itch sensitivity. The research shows that itch sensitivity of mice increased significantly in l...
Source: Brain Research Bulletin - August 26, 2023 Category: Neurology Authors: Gang Yang Xiao-Dong Wang Lu-Ying Chen Zhen-Yu Wu Er-Ping Xi Hui Li Source Type: research
New Daily Persistent Headache (NDPH): Unraveling the Complexities of Diagnosis, Pathophysiology, and Treatment
AbstractPurpose of ReviewThe current article aims to provide an overview of new daily persistent headache (NDPH), with a particular emphasis on its pathophysiology, evaluation, and current treatment options.Recent FindingsNDPH is an uncommon and heterogeneous condition associated with various comorbidities and is of great significance due to its prolonged duration and high severity. Variable causes and clinical aspects of NDPH may reflect differences in its underlying pathophysiological mechanisms, including genetics, environmental triggers, neuroinflammation, and brain changes. When assessing a patient with NDPH, potentia...
Source: Current Pain and Headache Reports - August 26, 2023 Category: Neurology Source Type: research
Beyond biopsychosocial: The keystone mechanism theory of pain
Brain Behav Immun. 2023 Aug 23;114:187-192. doi: 10.1016/j.bbi.2023.08.018. Online ahead of print.ABSTRACTPain is a deeply personal experience, with interindividual differences in its chronification and treatment presenting a formidable healthcare challenge. The biopsychosocial model (BPSm) has been hugely influential within nascent attempts at precision pain medicine, steering the field away from a reductionist biomechanical viewpoint and emphasising complex interactions of biological, psychological, and social factors which shape the individuality of pain. However, despite offering a strong theoretical foundation and hol...
Source: Brain, Behavior, and Immunity - August 25, 2023 Category: Neurology Authors: Timothy Lawn Manon Sendel Ralf Baron Jan Vollert Source Type: research
Chest Wall and Abdominal Blocks for Thoracic and Abdominal Surgeries: A Review
AbstractPurpose of ReviewThe purpose of this review is to provide an up-to-date description and overview of the rapidly growing literature pertaining to techniques and clinical applications of chest wall and abdominal fascial plane blocks in managing perioperative pain.Recent FindingsClinical evidence suggests that regional anesthesia blocks, including fascial plane blocks, such as pectoralis, serratus, erector spinae, transversus abdominis, and quadratus lumborum blocks, are effective in providing analgesia for various surgical procedures and have more desirable side effect profile when compared to traditional neuraxial t...
Source: Current Pain and Headache Reports - August 25, 2023 Category: Neurology Source Type: research
Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
ConclusionOur study elucidates a novel signaling cascade wherein adiponectin stimulates TG Cav3.2 channels via adipoR1 coupled to a novel CK2 α-dependent PKCβ1. This process induces neuronal hyperexcitability and pain hypersensitivity. Insight into adipoR-Cav3.2 signaling in sensory neurons provides attractive targets for pain treatment.
Source: The Journal of Headache and Pain - August 25, 2023 Category: Neurology Source Type: research
Clinical significance of small nerve fiber involvement in the early diagnosis and treatment of patients with Fabry disease
Peripheral nervous system is early involved in Fabry disease (FD) and preferentially the small nerve fibers, causing the characteristic neuropathic pain crises usually beginning in childhood. Early detection of this likely underdiagnosed disease is an important approach because causal therapies are available.
Source: Journal of the Neurological Sciences - August 25, 2023 Category: Neurology Authors: Panagiotis Kokotis, Christina Zompola, Aris Anastasakis, Aikaterini Damianaki, Chrysanthi Bountziouka, Margarita Mpora, Stathis Papatheodorou, Georgios Tsivgoulis Source Type: research
Extensive spinal epidural abscess due to Streptococcus intermedius: a case report treated conservatively and literature review
ConclusionRepeat examinations or gadolinium-enhanced MRI should be considered when initial MRI findings are not diagnostic of SEA. For extensive SEA caused by Streptococcus intermedius infection, surgery may be non-essential, and the judicious antibiotic selection and adequate treatment duration are pivotal for successful conservative management. Furthermore, for patients who are not amenable to surgery, a comprehensive evaluation of their condition and meticulous implementation of a precise pharmacological regimen holds noteworthy clinical significance.
Source: Frontiers in Neurology - August 24, 2023 Category: Neurology Source Type: research
