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Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma
Subcell Biochem. 2021;97:247-273. doi: 10.1007/978-3-030-67171-6_10.ABSTRACTGlioblastoma (GBM) is an incurable, infiltrative high-grade brain tumour associated with dramatic vascular responses observed both locally (angiogenesis, vascular cooption, angiocrine effects, microthrombosis) and systemically (venous thromboembolism). GBM-associated vascular pathology is diagnostically relevant and constitutes a source of morbidity, mortality and progressive changes in tumour biology. Extracellular vesicles (EVs) have emerged as unique mediators of vascular effects in brain tumours acting as vehicles for intercellular transfer of ...
Source: Sub-Cellular Biochemistry - March 29, 2021 Category: Biochemistry Authors: Cristiana Spinelli Nadim Tawil Lata Adnani Janusz Rak Dongsic Choi Source Type: research
Nitric oxide-releasing poly( ε-caprolactone)/S-nitrosylated keratin biocomposite scaffolds for potential small-diameter vascular grafts
Int J Biol Macromol. 2021 Aug 24:S0141-8130(21)01813-4. doi: 10.1016/j.ijbiomac.2021.08.147. Online ahead of print.ABSTRACTRapid endothelialization and regulation of smooth muscle cell proliferation are crucial for small-diameter vascular grafts to address poor compliance, thromboembolism, and intimal hyperplasia, and achieve revascularization. As a gaseous signaling molecule, nitric oxide (NO) regulates cardiovascular homeostasis, inhibits blood clotting and intimal hyperplasia, and promotes the growth of endothelial cells. Due to the instability and burst release of small molecular NO donors, a novel biomacromolecular do...
Source: International Journal of Biological Macromolecules - August 27, 2021 Category: Biochemistry Authors: Pengfei Li Dawei Jin Jie Dou Lijuan Wang Yanfang Wang Xingxing Jin Xiao Han Inn-Kyu Kang Jiang Yuan Jian Shen Meng Yin Source Type: research
Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma
Subcell Biochem. 2021;97:247-273. doi: 10.1007/978-3-030-67171-6_10.ABSTRACTGlioblastoma (GBM) is an incurable, infiltrative high-grade brain tumour associated with dramatic vascular responses observed both locally (angiogenesis, vascular cooption, angiocrine effects, microthrombosis) and systemically (venous thromboembolism). GBM-associated vascular pathology is diagnostically relevant and constitutes a source of morbidity, mortality and progressive changes in tumour biology. Extracellular vesicles (EVs) have emerged as unique mediators of vascular effects in brain tumours acting as vehicles for intercellular transfer of ...
Source: Sub-Cellular Biochemistry - March 29, 2021 Category: Biochemistry Authors: Cristiana Spinelli Nadim Tawil Lata Adnani Janusz Rak Dongsic Choi Source Type: research
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases
Biochem Soc Trans. 2021 Sep 8:BST20210138. doi: 10.1042/BST20210138. Online ahead of print.ABSTRACTIn contrast with the heart, the adult mammalian vasculature retains significant remodelling capacity, dysregulation of which is implicated in disease development. In particular, vascular smooth muscle cells (VSMCs) play major roles in the pathological vascular remodelling characteristic of atherosclerosis, restenosis, aneurysm and pulmonary arterial hypertension. Clonal lineage tracing revealed that the VSMC-contribution to disease results from the hyperproliferation of few pre-existing medial cells and suggested that VSMC-de...
Source: Biochemical Society Transactions - September 8, 2021 Category: Biochemistry Authors: Matthew D Worssam Helle F J ørgensen Source Type: research
Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma
Subcell Biochem. 2021;97:247-273. doi: 10.1007/978-3-030-67171-6_10.ABSTRACTGlioblastoma (GBM) is an incurable, infiltrative high-grade brain tumour associated with dramatic vascular responses observed both locally (angiogenesis, vascular cooption, angiocrine effects, microthrombosis) and systemically (venous thromboembolism). GBM-associated vascular pathology is diagnostically relevant and constitutes a source of morbidity, mortality and progressive changes in tumour biology. Extracellular vesicles (EVs) have emerged as unique mediators of vascular effects in brain tumours acting as vehicles for intercellular transfer of ...
Source: Sub-Cellular Biochemistry - March 29, 2021 Category: Biochemistry Authors: Cristiana Spinelli Nadim Tawil Lata Adnani Janusz Rak Dongsic Choi Source Type: research
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases
Biochem Soc Trans. 2021 Sep 8:BST20210138. doi: 10.1042/BST20210138. Online ahead of print.ABSTRACTIn contrast with the heart, the adult mammalian vasculature retains significant remodelling capacity, dysregulation of which is implicated in disease development. In particular, vascular smooth muscle cells (VSMCs) play major roles in the pathological vascular remodelling characteristic of atherosclerosis, restenosis, aneurysm and pulmonary arterial hypertension. Clonal lineage tracing revealed that the VSMC-contribution to disease results from the hyperproliferation of few pre-existing medial cells and suggested that VSMC-de...
Source: Biochemical Society Transactions - September 8, 2021 Category: Biochemistry Authors: Matthew D Worssam Helle F J ørgensen Source Type: research
HIF-1 α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury
CONCLUSIONS: These findings provide novel evidence that the HIF-1α/JMJD1A signaling pathway is involved in inflammation and oxidative stress in HUVECs induced by high glucose and hypoxia. Also, this pathway might act as a novel regulator of oxidative stress and inflammatory-related events in response to diabetic vascular injury and thus contribute to the pathological progression of diabetes and vascular disease.PMID:34479471 | PMC:PMC8414688 | DOI:10.1186/s11658-021-00283-8
Source: Cellular and Molecular Biology Letters - September 4, 2021 Category: Biochemistry Authors: Min Zhao Shaoting Wang Anna Zuo Jiaxing Zhang Weiheng Wen Weiqiang Jiang Hong Chen Donghui Liang Jia Sun Ming Wang Source Type: research
Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma
Subcell Biochem. 2021;97:247-273. doi: 10.1007/978-3-030-67171-6_10.ABSTRACTGlioblastoma (GBM) is an incurable, infiltrative high-grade brain tumour associated with dramatic vascular responses observed both locally (angiogenesis, vascular cooption, angiocrine effects, microthrombosis) and systemically (venous thromboembolism). GBM-associated vascular pathology is diagnostically relevant and constitutes a source of morbidity, mortality and progressive changes in tumour biology. Extracellular vesicles (EVs) have emerged as unique mediators of vascular effects in brain tumours acting as vehicles for intercellular transfer of ...
Source: Sub-Cellular Biochemistry - March 29, 2021 Category: Biochemistry Authors: Cristiana Spinelli Nadim Tawil Lata Adnani Janusz Rak Dongsic Choi Source Type: research
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases
Biochem Soc Trans. 2021 Sep 8:BST20210138. doi: 10.1042/BST20210138. Online ahead of print.ABSTRACTIn contrast with the heart, the adult mammalian vasculature retains significant remodelling capacity, dysregulation of which is implicated in disease development. In particular, vascular smooth muscle cells (VSMCs) play major roles in the pathological vascular remodelling characteristic of atherosclerosis, restenosis, aneurysm and pulmonary arterial hypertension. Clonal lineage tracing revealed that the VSMC-contribution to disease results from the hyperproliferation of few pre-existing medial cells and suggested that VSMC-de...
Source: Biochemical Society Transactions - September 8, 2021 Category: Biochemistry Authors: Matthew D Worssam Helle F J ørgensen Source Type: research
HIF-1 α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury
CONCLUSIONS: These findings provide novel evidence that the HIF-1α/JMJD1A signaling pathway is involved in inflammation and oxidative stress in HUVECs induced by high glucose and hypoxia. Also, this pathway might act as a novel regulator of oxidative stress and inflammatory-related events in response to diabetic vascular injury and thus contribute to the pathological progression of diabetes and vascular disease.PMID:34479471 | PMC:PMC8414688 | DOI:10.1186/s11658-021-00283-8
Source: Cellular and Molecular Biology Letters - September 4, 2021 Category: Biochemistry Authors: Min Zhao Shaoting Wang Anna Zuo Jiaxing Zhang Weiheng Wen Weiqiang Jiang Hong Chen Donghui Liang Jia Sun Ming Wang Source Type: research
