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Specialty: Neurology

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Total 29834 results found since Jan 2013.

White matter microstructural alterations in patients with neuropathic pain after spinal cord injury: a diffusion tensor imaging study
ConclusionThe results demonstrated that compared with the non-NP group, NP pathogenesis after SCI was potentially related to higher values in FA that are associated with microstructural changes in the posterior body and splenium of the corpus callosum, which could be regarded as central sensitization or network hyperexcitability.
Source: Frontiers in Neurology - August 24, 2023 Category: Neurology Source Type: research

Impact of headache frequency and preventive medication failure on quality of life, functioning, and costs among individuals with migraine across several European countries: need for effective preventive treatment
ConclusionsIncreased burden, quality-of-life impairment, and functional impairment exist among individuals with migraine experiencing  ≥ 4 MHDs and more treatment failures. While cause and directionality cannot be determined, these results suggest the need for effective preventive migraine treatments.Graphical Abstract
Source: The Journal of Headache and Pain - August 24, 2023 Category: Neurology Source Type: research

Neuromodulation for the Sphenopalatine Ganglion —a Narrative Review
AbstractPurpose of ReviewTo provide an integrated overview of the current state of knowledge of neuromodulation for the sphenopalatine ganglion (SPG) by reviewing relevant and significant literature.Recent FindingsThere are several case reports and clinical trials evaluating neuromodulation for the SPG. We identified two blinded, randomized clinical trials for patients with chronic cluster headache. The randomized trials and additional studies demonstrated the long-term safety, efficacy, and cost-effectiveness of neuromodulation for the SPG.SummaryRecent studies in Europe and the USA suggest that SPG neuromodulation is a n...
Source: Current Pain and Headache Reports - August 23, 2023 Category: Neurology Source Type: research

Unique Considerations in Episodic Migraine: Underserved Populations
AbstractPurpose of ReviewEpisodic migraine is a common and disabling neurological disorder that is underdiagnosed and undertreated. Additional barriers are put in place for those who belong to an underserved population. This could be based on race, ethnicity, gender, sexual orientation, or socioeconomic status.Recent FindingsThere has been a lot of interest in understanding the extent of these disparities, but studies for many of these groups are lacking. More work is needed to understand the disparities and needs of underserved populations. Most of the literature has been done for Black populations but there are many othe...
Source: Current Pain and Headache Reports - August 23, 2023 Category: Neurology Source Type: research

Non-Pharmacological Treatment for Chronic Migraine
AbstractPurpose of ReviewChronic migraine (CM) affects a large proportion of the population and is a significant source of disability and lost productivity. Numerous non-pharmacological approaches have been attempted during the past decades. This review discusses the most recent and evidence-based advances in acute and preventive non-pharmacological therapeutic approaches for CM, offering alternatives to drug treatment.Recent FindingsA growing number of non-pharmacological treatment options, including non-invasive or invasive neuromodulation, acupuncture, psychotherapy, and physiotherapy, have shown promising efficacy in C...
Source: Current Pain and Headache Reports - August 23, 2023 Category: Neurology Source Type: research

Relationship between alcohol and primary headaches: a systematic review and meta-analysis
ConclusionsAlcohol consumption and migraine are inversely correlated. The exact mechanism behind this observation may indicate that migraine leads to alcohol-avoidance, rather than alcohol having any protective role against migraine. There was no relationship between TTH and drinking. However, further studies related to primary headaches and alcohol consumption with low risk of bias are required. Additionally, patients and physicians should consider the latest medical data, in order to avoid the myths about alcohol consumption and primary headaches.
Source: The Journal of Headache and Pain - August 23, 2023 Category: Neurology Source Type: research

Trigeminal Nerve Involvement in Bulbar-Onset Anti-IgLON5 Disease
We report 2 cases of atypical trigeminal neuropathy in bulbar-onset IgLON5-D. Methods Trigeminal nerve involvement was assessed using comprehensive clinical, laboratory, electrophysiologic, and MRI workup. Results Both patients were referred for progressive dysphagia, sialorrhea, and hoarseness. They were treated with bilevel positive airway pressure for nocturnal hypoventilation. Patient 1 complained of continuous facial burning pain with allodynia, exacerbated by mastication and prolonged speech. Patient 2 reported no facial pain. Anti-IgLON5 autoantibodies (IgLON5-Abs) were positive in serum for both patients and CSF ...
Source: Neurology Neuroimmunology and Neuroinflammation - August 22, 2023 Category: Neurology Authors: Cluse, F., Hermier, M., Demarquay, G., Rogemond, V., Mallaret, M., Svahn, J., Pegat, A., Honnorat, J., Bernard, E. Tags: MRI, Autoimmune diseases, Anterior nerve cell disease, Trigeminal neuralgia, All clinical neurophysiology Clinical/Scientific Note Source Type: research

Where Art Thou O treatment for diabetic neuropathy: the sequel
This article challenges the rationale for the FDA insisting on symptoms/signs and nerve conduction as primary endpoints for clinical trials in DPN.EXPERT OPINION: Quantitative sensory testing, intraepidermal nerve fiber density, and especially corneal confocal microscopy remain an after-thought, demoted at best to exploratory secondary endpoints in clinical trials of diabetic neuropathy. If pharma are to be given a fighting chance to secure approval for a new therapy for diabetic neuropathy, the FDA needs to reassess the evidence rather than rely on 'opinion' for the most suitable endpoint(s) in clinical trials of diabetic...
Source: Expert Review of Neurotherapeutics - August 21, 2023 Category: Neurology Authors: Yigit Can Guldiken Ayesha Malik Ioannis N Petropoulos Hoda Gad Einas Elgassim Iuliia Salivon Georgios Ponirakis Uazman Alam Rayaz A Malik Source Type: research

Treatment of chronic cluster headache with burst and tonic occipital nerve stimulation: A case series
CONCLUSION: Occipital nerve stimulation significantly reduced the number of weekly headache attacks and their intensity. Burst ONS seems to function well alone or as a supplement to conventional tonic ONS as a preventive treatment for CCH; however, larger prospective studies are needed to determine whether the effect can be confirmed and whether the efficacy of the two stimulation paradigms is even.PMID:37602914 | DOI:10.1111/head.14617
Source: Headache - August 21, 2023 Category: Neurology Authors: Ida Stisen Fogh-Andersen Jens Christian Hedemann S ørensen Rigmor H øjland Jensen Anne Lene Knudsen Kaare Meier Source Type: research

Where Art Thou O treatment for diabetic neuropathy: the sequel
This article challenges the rationale for the FDA insisting on symptoms/signs and nerve conduction as primary endpoints for clinical trials in DPN.EXPERT OPINION: Quantitative sensory testing, intraepidermal nerve fiber density, and especially corneal confocal microscopy remain an after-thought, demoted at best to exploratory secondary endpoints in clinical trials of diabetic neuropathy. If pharma are to be given a fighting chance to secure approval for a new therapy for diabetic neuropathy, the FDA needs to reassess the evidence rather than rely on 'opinion' for the most suitable endpoint(s) in clinical trials of diabetic...
Source: Expert Review of Neurotherapeutics - August 21, 2023 Category: Neurology Authors: Yigit Can Guldiken Ayesha Malik Ioannis N Petropoulos Hoda Gad Einas Elgassim Iuliia Salivon Georgios Ponirakis Uazman Alam Rayaz A Malik Source Type: research

The Impact of Sciatic Nerve Injury and Social Interactions Testing on Glucocorticoid Receptor Expression in Catecholaminergic Medullary Cell Populations
In this study, we investigated whether these changes were driven in part by altered sensitivity of the brainstem catecholaminergic pathways (known to regulate the PVH) to glucocorticoids. GR expression in adrenergic (C1,C2) and noradrenergic (A1,A2) cells was determined using immunohistochemistry in behaviourally tested CCI rats and in uninjured controls. We found no differences between Persistent Effect and No Effect rats in (1) the glucocorticoid sensitivity of these cells, or (2) the numbers of adrenergic and noradrenergic cells in each region. However, we discovered an overall reduction in GR expression in the non-cate...
Source: Brain Research - August 21, 2023 Category: Neurology Authors: Maria K S Sosa Damien C Boorman Kevin A Keay Source Type: research

Where Art Thou O treatment for diabetic neuropathy: the sequel
This article challenges the rationale for the FDA insisting on symptoms/signs and nerve conduction as primary endpoints for clinical trials in DPN.EXPERT OPINION: Quantitative sensory testing, intraepidermal nerve fiber density, and especially corneal confocal microscopy remain an after-thought, demoted at best to exploratory secondary endpoints in clinical trials of diabetic neuropathy. If pharma are to be given a fighting chance to secure approval for a new therapy for diabetic neuropathy, the FDA needs to reassess the evidence rather than rely on 'opinion' for the most suitable endpoint(s) in clinical trials of diabetic...
Source: Expert Review of Neurotherapeutics - August 21, 2023 Category: Neurology Authors: Yigit Can Guldiken Ayesha Malik Ioannis N Petropoulos Hoda Gad Einas Elgassim Iuliia Salivon Georgios Ponirakis Uazman Alam Rayaz A Malik Source Type: research