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Total 13617 results found since Jan 2013.
Fight, flight, and freeze!
Cell Metab. 2023 Sep 5;35(9):1493-1495. doi: 10.1016/j.cmet.2023.08.007.ABSTRACTJust like time and tide, embryonic development waits for no man but progresses forcefully to its completion, with just one exception. Diapause is an enigmatic, reversible, dormant halt that protects the developing embryo. Cancer cells have evolved to hijack many useful stem cell capabilities, and diapause is no exception. Recent work has revealed a diapause-like cancer cell state, prompting the quest for its key molecular regulators useful for cancer therapies. The present paper by Sun et al.1 addresses this knowledge gap by revealing a key pla...
Source: Cell Metabolism - September 6, 2023 Category: Cytology Authors: Riya Keshri Julie Mathieu Hannele Ruohola-Baker Source Type: research
Autophagy/ferroptosis in colorectal cancer: Carcinogenic view and nanoparticle-mediated cell death regulation
Environ Res. 2023 Sep 3:117006. doi: 10.1016/j.envres.2023.117006. Online ahead of print.ABSTRACTThe cell death mechanisms have a long history of being evaluated in diseases and pathological events. The ability of triggering cell death is considered to be a promising strategy in cancer therapy, but some mechanisms have dual functions in cancer, requiring more elucidation of underlying factors. Colorectal cancer (CRC) is a disease and malignant condition of colon and rectal that causes high mortality and morbidity. The autophagy targeting in CRC is therapeutic importance and this cell death mechanism can interact with apopt...
Source: Environmental Research - September 5, 2023 Category: Environmental Health Authors: Zhibin Zhang Yintao Zhao Yuman Wang Yutang Zhao Jianen Guo Source Type: research
A Cocktail Therapeutic Strategy Based on Clofarabine-Containing Aptamer-PROTAC for Enhanced Cancer Therapy
Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC02904B, CommunicationZhenzhen Chen, Mohan Chen, Ran Liu, Huanhuan Fan, Jingjing Zhang By introducing a therapeutic nucleoside analogue tail to the parent Aptamer-PROTACs, a PROTAC-cocktail system (ApTCs-3X) was designed and evaluated. ApTCs-3X exhibited improved nuclease resistance and efficiently degraded target protein with... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 4, 2023 Category: Chemistry Authors: Zhenzhen Chen Source Type: research
NIR-II photoacoustic imaging-guided synergistic cancer therapy with a tumor-targeting copper selenide-iron manganese layered double hydroxide nanocomplex
Chem. Commun., 2023, Advance Article DOI: 10.1039/D3CC03080F, CommunicationYanting Yang, Shulong Wang, Shengqiang Hu, Yanni Luo, Zongyi He, Shulin Zhao A novel biodegradable copper selenide-iron manganese layered double hydroxide nanocomplex was developed. This nanocomplex was used for NIR-II photoacoustic imaging-guided synergistic cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 4, 2023 Category: Chemistry Authors: Yanting Yang Source Type: research
A new biphenanthrene with cytotoxic activity from < em > Liparis nervosa < /em > (Thunb.) Lindl
Nat Prod Res. 2023 Sep 3:1-7. doi: 10.1080/14786419.2023.2233670. Online ahead of print.ABSTRACT2,7,2'-Trihydroxy-3,4,4'7'-tetramethoxy-1,1'-biphenanthrene (1), a previously undescribed biphenanthrene, and five known phenanthrenes, i.e. 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (2), 2,4-dihydroxy -7-methoxy-9,10-dihydroxyphenanthrene (3), 7-hydroxy-2-methoxy-phenanthrene-1,4-dione (4), 7-hydroxy-2-methoxy-9,10-dihydro-phenanthrene-1,4-dione (5), and 4,4',7,7'-tetrahydroxy-2,2'-dimethoxy-9,9',10,10'-tetrahydro-1,1'-biphenanthrene (6) were isolated from the whole plant (stems, leaves, roots and fruits) of Liparis ne...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Liang Liu Qi-Meng Yin Qi-Jun Dai Xuan-Yuan Chen Xi-Qing Chen Jian-Bin Wang Han-Qing Pang Xian-Wen Zhang Source Type: research
Intratumoral heterogeneity after targeted therapy in murine cancer models with differing degrees of malignancy
In conclusion, mp MRI enables to assess dedicated therapy-related intratumoral changes and may serve as a biomarker for treatment response assessment.PMID:37666208 | DOI:10.1016/j.tranon.2023.101773
Source: Translational Oncology - September 4, 2023 Category: Cancer & Oncology Authors: M Gerwing E Hoffmann C Geyer A Helfen B Maus R Schinner L Wachsmuth W Heindel M Eisenblaetter C Faber M Wildgruber Source Type: research
Flexibility in the bridge of chalcone derivatives is important for the inhibition of cellular growth
Bioorg Med Chem Lett. 2023 Sep 2:129467. doi: 10.1016/j.bmcl.2023.129467. Online ahead of print.ABSTRACTChalcones and their derivatives are a privileged scaffold in medicinal chemistry, demonstrating numerous biological activities. These molecules have shown significant potential toward the development of novel cancer therapies. While much is known about modification to the chalcone aryl rings, little is known about conformations of the bridge between the aryl rings. Here we report the synthesis and biological evaluation of a series of molecules with flexible and rigid bridge conformations. Crystal structures of a select g...
Source: Bioorganic and Medicinal Chemistry Letters - September 4, 2023 Category: Chemistry Authors: Trevor M Stantliff Amber Hill Mary Elaine Kuo Hadley E Neal Tighe C Harrod Katy Goens Mark Mashuta Anna M Christianson Amanda J Krzysiak Source Type: research
A new biphenanthrene with cytotoxic activity from < em > Liparis nervosa < /em > (Thunb.) Lindl
Nat Prod Res. 2023 Sep 3:1-7. doi: 10.1080/14786419.2023.2233670. Online ahead of print.ABSTRACT2,7,2'-Trihydroxy-3,4,4'7'-tetramethoxy-1,1'-biphenanthrene (1), a previously undescribed biphenanthrene, and five known phenanthrenes, i.e. 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (2), 2,4-dihydroxy -7-methoxy-9,10-dihydroxyphenanthrene (3), 7-hydroxy-2-methoxy-phenanthrene-1,4-dione (4), 7-hydroxy-2-methoxy-9,10-dihydro-phenanthrene-1,4-dione (5), and 4,4',7,7'-tetrahydroxy-2,2'-dimethoxy-9,9',10,10'-tetrahydro-1,1'-biphenanthrene (6) were isolated from the whole plant (stems, leaves, roots and fruits) of Liparis ne...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Liang Liu Qi-Meng Yin Qi-Jun Dai Xuan-Yuan Chen Xi-Qing Chen Jian-Bin Wang Han-Qing Pang Xian-Wen Zhang Source Type: research
New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & amp; therapeutics
Front Oncol. 2023 Aug 17;13:1193736. doi: 10.3389/fonc.2023.1193736. eCollection 2023.ABSTRACTProstate adenocarcinoma accounts for more than 20% of deaths among males due to cancer. It is the fifth-leading cancer diagnosed in males across the globe. The mortality rate is quite high due to prostate cancer. Despite the fact that advancements in diagnostics and therapeutics have been made, there is a lack of effective drugs. Metabolic pathways are altered due to the triggering of androgen receptor (AR) signaling pathways, and elevated levels of dihydrotestosterone are produced due to defects in AR signaling that accelerate th...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Neha Thakur Sameer Quazi Bindu Naik Saurabh Kumar Jha Pallavi Singh Source Type: research
Influence of GO-Antisense miRNA-21 on the Expression of Selected Cytokines at Glioblastoma Cell Lines
This study aimed to detect cytokine expression levels after the administration of GO-antisense miRNA-21 into U87, U118, U251 and T98 glioma cell lines.METHODS: U87, U118, U251 and T98 glioma cell line were investigated in term of viability, human cytokine expression level at protein and genes after treatment with GO, GO-antisense miRNA-21 and antisense miRNA-21. The delivery of antisense miRNA-21 into the glioma cell at in vitro investigation were conducted by GO based transfection and electroporation.RESULTS: The results of the protein microarray and gene expression profile showed that complexes of GO-antisense miRNA-21 m...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Marta Kutwin Malwina Sosnowska Agnieszka Ostrowska Maciej Trzaskowski Agata Lange Mateusz Wierzbicki S ławomir Jaworski Source Type: research
CRISPR based therapeutic targeting of signaling pathways in breast cancer
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 2:166872. doi: 10.1016/j.bbadis.2023.166872. Online ahead of print.ABSTRACTBreast cancer represents the prevailing malignancy in females and contributing towards mortality on a global scale. There are innumerable anomalous genes that are responsible in the multi factorial carcinogenesis pathway. Although several disease-causing mutations have been detected, therapy frequently focuses on attenuating the manifestation of the disease rather than harmonizing the mutation in the target area. However, the emergence of the CRISPR-Cas system as a DNA modifying tool has proved to be a pr...
Source: Biochimica et Biophysica Acta - September 4, 2023 Category: Biochemistry Authors: Gauri Misra Sidra Qaisar Priyanshi Singh Source Type: research
NIR-II photoacoustic imaging-guided synergistic cancer therapy with a tumor-targeting copper selenide-iron manganese layered double hydroxide nanocomplex
Chem Commun (Camb). 2023 Sep 4. doi: 10.1039/d3cc03080f. Online ahead of print.ABSTRACTA novel biodegradable layered double hydroxide-copper selenide nanocomplex was prepared by anchoring copper selenide on manganese iron layered double hydroxide nanosheets. This nanocomplex can specifically release CuSe, Mn2+ and Fe3+ in the tumor microenvironment, which implements NIR-II photoacoustic imaging-guided synergistic cancer therapy under 1064 nm laser irradiation.PMID:37665627 | DOI:10.1039/d3cc03080f
Source: Chemical Communications - September 4, 2023 Category: Chemistry Authors: Yanting Yang Shulong Wang Shengqiang Hu Yanni Luo Zongyi He Shulin Zhao Source Type: research
