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Total 409719 results found since Jan 2013.

Polymorphs of two dimensional phosphorus and arsenic: insight from an evolutionary search
Phys. Chem. Chem. Phys., 2017, Advance Article DOI: 10.1039/C6CP08807D, PaperSuhas Nahas, Akash Bajaj, Somnath Bhowmick Using an evolutionary algorithm, in conjunction with density functional theory (DFT) based electronic, ionic and cell relaxation, we perform an extensive search for the crystal structures of possible two dimensional (2D) allotropes of phosphorus and arsenic. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 18, 2017 Category: Chemistry Authors: Suhas Nahas Source Type: research

A label-free colorimetric biosensor for sensitive detection of vascular endothelial growth factor-165
Analyst, 2017, Accepted Manuscript DOI: 10.1039/C7AN00541E, PaperHui-ge Zhang, liang Peng, maoxin Li, Ji Ma, Shengda Qi, Hongli Chen, Lei Zhou, Xingguo Chen Sensitive detection of low abundant protein is essential to biomedical research and clinical diagnostics. Herein, we develop a label-free colorimetric biosensor for sensitive detection of recombinant human vascular endothelial growth... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - May 17, 2017 Category: Chemistry Authors: Hui-ge Zhang Source Type: research

Hybrid polymer microfluidic platform to mimic varying vascular compliance and topology
Lab Chip, 2017, Accepted Manuscript DOI: 10.1039/C7LC00340D, PaperMitesh L Rathod, Jungho Ahn, Noo Li Jeon, Junghoon Lee Several cardiovascular pathologies and aging have been associated with alterations in mechanical and structural properties of vascular wall, leading to reduction in arterial compliance and development of constriction. In the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - June 7, 2017 Category: Chemistry Authors: Mitesh L Rathod Source Type: research

In search of invariants for viscous liquids in the density scaling regime: Investigations of dynamic and thermodynamic moduli
Phys. Chem. Chem. Phys., 2017, Accepted Manuscript DOI: 10.1039/C7CP01144J, PaperAgnieszka Jedrzejowska, Andrzej Grzybowski, Marian Paluch In this paper, we report on nontrivial results of our investigations of dynamic and thermodynamic moduli in search of invariants for viscous liquids in the density scaling regime by using... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - June 26, 2017 Category: Chemistry Authors: Agnieszka Jedrzejowska Source Type: research

Spatial and spectral resolution of carbonaceous material from hematite (small alpha-Fe2O3) using multivariate curve resolution-alternating least squares (MCR-ALS) with Raman microspectroscopic mapping: implications for the search for life on Mars
We report a novel application of multivariate analysis with Raman microspectroscopic mapping to enhance the search for life on Mars. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - July 5, 2017 Category: Chemistry Authors: Joseph P. Smith Source Type: research

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Pedro F. Costa, Hugo J. Albers, John E. A. Linssen, Heleen H. T. Middelkamp, Linda van der Hout, Robert Passier, Albert van den Berg, Jos Malda, Andries D. van der Meer Studying blood clotting in stereolithography 3D-printed microfluidic chips with endothelialised vascular structures. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - July 18, 2017 Category: Chemistry Authors: Pedro F. Costa Source Type: research

p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation Signal Transduction
Although the involvement of Rho proteins in the pathogenesis of vascular diseases is well studied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs). Here, we sought to identify the RhoGEFs involved in monocyte chemotactic protein 1 (MCP1)–induced vascular wall remodeling. We found that, among the RhoGEFs tested, MCP1 induced tyrosine phosphorylation of p115 RhoGEF but not of PDZ RhoGEF or leukemia-associated RhoGEF in human aortic smooth muscle cells (HASMCs). Moreover, p115 RhoGEF inhibition suppressed MCP1-induced HASMC migration and proliferation. Consi...
Source: Journal of Biological Chemistry - August 25, 2017 Category: Chemistry Authors: Nikhlesh K. Singh, Jagadeesh Janjanam, Gadiparthi N. Rao Tags: Molecular Bases of Disease Source Type: research

The mechanism of action and role of hydrogen sulfide in the control of vascular tone
Publication date: Available online 31 October 2017 Source:Nitric Oxide Author(s): Eleni Dongó, Gabriella Beliczai-Marosi, Ane Stensønes Dybvig, Levente Kiss Our knowledge about hydrogen sulfide (H2S) significantly changed over the last two decades. Today it is considered as not only a toxic gas but also as a gasotransmitter with diverse roles in different physiological and pathophysiological processes. H2S has pleiotropic effects and its possible mechanisms of action involve (1) a reversible protein sulfhydration which can alter the function of the modified proteins similar to nitrosylation or phosphorylation; (2) direc...
Source: Nitric Oxide - November 1, 2017 Category: Chemistry Source Type: research

Supplementary search methods were more effective and offered better value than bibliographic database searching: a case study from public health and environmental enhancement.
ConclusionsThis case study found value in aligning primary methods of study identification to maximise location of relevant evidence.
Source: Research Synthesis Methods - September 1, 2017 Category: Chemistry Authors: Chris Cooper, Rebecca Lovell, Kerryn Husk, Andrew Booth, Ruth Garside Tags: RESEARCH ARTICLE Source Type: research

Acceleration of bursty multi-protein target-search kinetics on DNA by colocalisation
Phys. Chem. Chem. Phys., 2017, Accepted Manuscript DOI: 10.1039/C7CP06922G, PaperPrathitha Kar, Andrey G. Cherstvy, Ralf Metzler Proteins are capable of locating specific targets on the DNA employing the facilitated diffusion process, with intermittent 1D and 3D search steps. Gene colocalisation and coregulation---i.e. spatial proximity of two... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - December 20, 2017 Category: Chemistry Authors: Prathitha Kar Source Type: research

The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability Signal Transduction
Increased retinal vascular permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as diabetic retinopathy, age-related macular degeneration, and central retinal vein occlusions. Pathological changes in vascular permeability are driven by growth factors such as VEGF and pro-inflammatory cytokines such as TNF-α. Identifying the pro-barrier mechanisms that block vascular permeability and restore the blood–retinal barrier (BRB) may lead to new therapies. The cAMP-dependent guanine nucleotide exchange factor (EPAC) exchange-protein directly activated by cAMP promotes exchange of GTP...
Source: Journal of Biological Chemistry - January 12, 2018 Category: Chemistry Authors: Carla J. Ramos, Chengmao Lin, Xuwen Liu, David A. Antonetti Tags: Cell Biology Source Type: research

Acceleration of bursty multiprotein target search kinetics on DNA by colocalisation
Phys. Chem. Chem. Phys., 2018, Advance Article DOI: 10.1039/C7CP06922G, PaperPrathitha Kar, Andrey G. Cherstvy, Ralf Metzler Proteins are capable of locating specific targets on DNA by employing a facilitated diffusion process with intermittent 1D and 3D search steps. We here uncover the implications of colocalisation of protein production and DNA binding sitesvia computer simulations. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - January 15, 2018 Category: Chemistry Authors: Prathitha Kar Source Type: research

The mechanism of action and role of hydrogen sulfide in the control of vascular tone
Publication date: Available online 31 October 2017Source: Nitric OxideAuthor(s): Eleni Dongó, Gabriella Beliczai-Marosi, Ane Stensønes Dybvig, Levente KissAbstractOur knowledge about hydrogen sulfide (H2S) significantly changed over the last two decades. Today it is considered as not only a toxic gas but also as a gasotransmitter with diverse roles in different physiological and pathophysiological processes. H2S has pleiotropic effects and its possible mechanisms of action involve (1) a reversible protein sulfhydration which can alter the function of the modified proteins similar to nitrosylation or phosphorylation; (2) ...
Source: Nitric Oxide - July 5, 2018 Category: Chemistry Source Type: research

Recent Progress in the Development of Microfluidic Vascular Models.
Abstract The blood vessel is part of the circulatory system, and systemic circulation provides the blood supply to all tissues. Arteries are pathways through which the blood is carried, and the capillaries have a key role in material exchange to maintain the tissue environment. Blood vessels have structures appropriate for their functions, and their sizes and cell types are different. In this review, we introduced recent studies of the microfluidic vascular models. The model structures are classified mainly as poly(dimethylsiloxane) and hydrogel microchannels and self-assembled networks. Basic phenomena and functi...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - July 13, 2018 Category: Chemistry Authors: Sato K, Sato K Tags: Anal Sci Source Type: research