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Specialty: Cancer & Oncology
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Total 132960 results found since Jan 2013.
Vascular Invasion Predicts Recurrence in Stage IA2-IB Lung Adenocarcinoma but not Squamous Cell Carcinoma
CONCLUSION: Vascular invasion is a strong predictor of recurrence in stage IA2-IB LUAD but not in LUSC. Adjuvant therapy trials should be directed at this subgroup.PMID:36631388 | DOI:10.1016/j.cllc.2022.12.006
Source: Clinical Lung Cancer - January 11, 2023 Category: Cancer & Oncology Authors: Lubna Suaiti Travis B Sullivan Kimberly M Rieger-Christ Elliot L Servais Kei Suzuki Eric J Burks Source Type: research
Associations of human papillomavirus genotypes and cervical vascular abnormality in a cohort of women underwent colposcopy, a retrospective study of 6716 patients
ConclusionHPV16 and 33 are the most dangerous HPV genotypes correlated with abnormal vascular patterns. Combined HPV16 and HPV33 infection increases the risk of abnormal vascular patterns. Combined HPV16 and HPV33 infection increases the risk of developing HSIL+.
Source: Frontiers in Oncology - April 5, 2023 Category: Cancer & Oncology Source Type: research
TJP1 promotes vascular mimicry in bladder cancer by facilitating VEGFA expression and transcriptional activity through TWIST1
Transl Oncol. 2023 Apr 7;32:101666. doi: 10.1016/j.tranon.2023.101666. Online ahead of print.ABSTRACTTight junction protein 1 (TJP1) is a recently identified prominent regulator of bladder cancer (BLCA) angiogenesis and tumorigenesis. Vascular mimicry (VM) is a newly described tumor feature and is correlated with an increased risk of tumor metastasis. However, the relationship between TJP1 expression and VM in bladder cancer remains elusive. In the present study, we report a novel function for TJP1 in accommodating VM to promote tumor progression. We found that the elevated TJP1 expression was positively related to VM in p...
Source: Translational Oncology - April 9, 2023 Category: Cancer & Oncology Authors: Zhao-Xia Dong Sze-Hoi Chan Shu-Na Chen Miao Li Xing-Ding Zhang Xue-Qi Liu Source Type: research
CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process
Cancer Gene Ther. 2023 Jun 30. doi: 10.1038/s41417-023-00642-x. Online ahead of print.ABSTRACTTo enhance the potency of chimeric antigen receptor (CAR) engineered T cells in solid cancers, we designed a novel cell-based combination strategy with an additional therapeutic mode of action. CAR T cells are used as micropharmacies to produce a targeted pro-coagulatory fusion protein, truncated tissue factor (tTF)-NGR, which exerts pro-coagulatory activity and hypoxia upon relocalization to the vascular endothelial cells that invade tumor tissues. Delivery by CAR T cells aimed to induce locoregional tumor vascular infarction for...
Source: Cancer Control - June 30, 2023 Category: Cancer & Oncology Authors: Bianca Altvater Sareetha Kailayangiri Christian Spurny Maike Fl ügge Jutta Meltzer Lea Greune Katja Urban Christian Schw öppe Caroline Brand Christoph Schliemann Heike Hintelmann Saliha Harrach Wolfgang Hartmann Hinrich Abken Johannes Kuehle Axel Schamb Source Type: research
Influence of background cardiovascular risk factors on VEGF inhibitor-related adverse vascular events in patients with non-small cell lung cancer: a retrospective study
CONCLUSION: Our study demonstrated that history of hypertension was independently associated with increased risk of both VEGF-related AVEs and discontinuation due to VEGF-related AVEs. In conclusion, we need to be aware of VEGF-related AVEs when using VEGF inhibitors for patients with ≥ 3 cardiovascular risk factors.PMID:37439826 | DOI:10.1007/s00432-023-05092-4
Source: Clinical Lung Cancer - July 13, 2023 Category: Cancer & Oncology Authors: Tomoyuki Naito Yuji Minegishi Hideaki Shiraishi Tatsuhiko Hoshino Junichi Maeda Toshiya Yokota Shingo Ikeda Miyanaga Akihiko Masahiro Seike Source Type: research
Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
CONCLUSIONS: These findings establish the direct role and mechanism by which fructose promotes tumor progression through increased angiogenesis, and provide reliable evidence for a better understanding of tumor metabolic reprogramming.PMID:37507736 | DOI:10.1186/s13046-023-02765-3
Source: Clinical Colorectal Cancer - July 28, 2023 Category: Cancer & Oncology Authors: Yanfen Cui Hui Liu Zhaosong Wang He Zhang Jianfei Tian Zhiyong Wang Weijie Song Hui Guo Liming Liu Ruinan Tian Xiaoyan Zuo Sixin Ren Fei Zhang Ruifang Niu Source Type: research
Expression of endocan and vascular endothelial growth factor and their correlation with histopathological prognostic parameters in pheochromocytoma
CONCLUSION: If our findings are supported by studies with a larger sample size, we think that endocan has the potential to be used both as a tumor marker and in predicting malignancy potential in patients with pheochromocytoma, and that the detection of VEGF expression in these tumors is also associated with an increase in malignancy potential.PMID:37596456 | DOI:10.1007/s12020-023-03489-2
Source: Cancer Control - August 18, 2023 Category: Cancer & Oncology Authors: Muhammet Kocaba ş Mustafa Can Melia Karak öse Hac ı Hasan Esen Mustafa Kulaksizo ğlu Feridun Karakurt Source Type: research
Increased circulation of galectin-3 in cancer induces secretion of metastasis-promoting cytokines from blood vascular endothelium.
CONCLUSIONS: The increased circulation of galectin-3 in cancer patients induces secretion of several metastasis-promoting cytokines from the blood vascular endothelium that enhances endothelial cell activities in metastasis. Targeting the actions of circulating galectin-3 in cancer patients therefore represents a promising therapeutic strategy to reduce metastasis and improve survival.
PMID: 23401226 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - February 11, 2013 Category: Cancer & Oncology Authors: Chen C, Duckworth CA, Zhao Q, Pritchard DM, Rhodes JM, Yu LG Tags: Clin Cancer Res Source Type: research
Functional imaging to monitor vascular and metabolic response in canine head and neck tumors during fractionated radiotherapy.
Conclusion. Changes in vascular and metabolic parameters could be detected by the current functional imaging methods. Vascular tumor features from CE-CBCT and D-PET corresponded well. CE-CBCT is a potential method for easy response assessment when the patient is at the treatment unit.
PMID: 23879646 [PubMed - as supplied by publisher]
Source: Acta Oncologica - July 23, 2013 Category: Cancer & Oncology Authors: Rødal J, Rusten E, Søvik A, Skogmo HK, Malinen E Tags: Acta Oncol Source Type: research
The impact of lymph vascular space invasion on recurrence and survival in patients with early stage endometrial cancer
The aim of this study was to determine impact of lymph vascular space involvement (LVSI) on recurrence and survival in early stage of endometrial cancer. From 1991 through 2010, all endometrial cancer patients at University Hospital of Bari, Italy were identified. The Log‐rank test and Kaplan–Meyer methods were used for time‐to‐event analysis to evaluate the effects of on lymph vascular space involvement recurrence rate and survival time. Of the 560 endometrial cancer patients, 525 underwent primary surgery. Of those, 399 had early stage disease. Three hundred and forty women were not found to have LVSI, whereas 59...
Source: European Journal of Cancer Care - September 23, 2013 Category: Cancer & Oncology Authors: V. Loizzi, G. Cormio, M. Lorusso, D. Latorre, M. Falagario, P. Demitri, D. Scardigno, L.E. Selvaggi Tags: Original article Source Type: research
Breast contrast-enhanced MR imaging: semiautomatic detection of vascular map.
CONCLUSIONS: In conclusion, detection of vascularity increase as risk factor for developing breast cancer could be performed with semiautomatic vascular mapping of contrast-enhanced MR imaging.
PMID: 25239166 [PubMed - as supplied by publisher]
Source: Breast Cancer - September 20, 2014 Category: Cancer & Oncology Authors: Fusco R, Sansone M, Filice S, Petrillo A Tags: Breast Cancer Source Type: research
Diagnosis and surgical treatment of esophageal carcinoma with coexistent intrathoracic vascular malformations
ConclusionsThe coexistence of intrathoracic vascular malformations with esophageal carcinoma is rare, but easily missed in routine X‐ray and endoscopy. Enhanced chest CT must be performed to confirm. Surgery should be designed individually in consideration of the anatomic features of the vascular anomalies. A routine prophylactic ligation of the thoracic duct is recommended.
Source: Thoracic Cancer - August 25, 2014 Category: Cancer & Oncology Authors: Zhong‐Xi Niu, Qiang Gao, Jun Peng, Hui Shi, Long‐Qi Chen Tags: ORIGINAL ARTICLE Source Type: research
