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Total 27983 results found since Jan 2013.

Treatment of voluminous and complicated superficial slow-flow vascular malformations with sirolimus (PERFORMUS): protocol for a multicenter phase 2 trial with a randomized observational-phase design
The objective of this trial is to evaluate the efficacy and safety of sirolimus in children with complicated superficial slow-flow VMs.Methods/designThis French multicenter randomized observational-phase, phase 2 trial aims to include 50 pediatric patients 6 to 18  years old who have slow-flow (lymphatic, venous or lymphatico-venous) voluminous complicated superficial VM. Patients will be followed up for 12 months. All patients will start with an observational period (no treatment). Then at a time randomly selected between month 4 and month 8, they will swi tch to the experimental period (switch time), when they will rec...
Source: Trials - June 27, 2018 Category: Research Source Type: clinical trials

An integrated multidisciplinary team approach to the management of vascular anomalies: challenges and benefits
ConclusionsThe complex nature of vascular anomalies and high proportion of patients requiring multi-specialty management justified the establishment of an MDT VAC in our centre. Our experience demonstrates the success of an efficient one-stop MDT environment in the management of these challenging conditions.Level of evidenceIV
Source: Pediatric Surgery International - September 5, 2020 Category: Surgery Source Type: research

Treatment of deep seated palatal vascular malformations by bleomycin sclerotherapy
Background: Vascular malformations of the head and neck are common. The management of these lesions is complex and challenging due to the high complication rate and recurrence following treatment. Palatal vascular malformations are infrequent and present as slow growing lesions in the palate with recurrent bleeding and pain. These lesions are best managed by sclerotherapy due to their posterior location and risk of bleeding if surgery surgery is attempted. Many sclerosants have been used for treating palatal vascular malformations but the use of intralesional bleomycin for these lesions has not been reported at length.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - January 9, 2021 Category: Cosmetic Surgery Authors: Rajiv Agarwal, Mallika Agarwal, Devisha Agarwal, Ramesh Chandra, Raghunandan Prasad Source Type: research

Imaging of benign cervicofacial vascular anomalies and associated syndromes
Interv Neuroradiol. 2021 Aug 16:15910199211034989. doi: 10.1177/15910199211034989. Online ahead of print.ABSTRACTCervicofacial vascular anomalies can result in morbidity, pain, and cosmetic concerns in affected individuals. Each anomaly has its own unique natural history, treatment, and associations with underlying genetic syndromes. For optimal patient care, it is important for the neuroradiologist to accurately recognize and characterize these entities to ensure appropriate treatment and management. In this review, we discuss the general characteristics, classifications, and imaging features associated with the most comm...
Source: Interventional Neuroradiology - August 16, 2021 Category: Radiology Authors: Anthony S Larson Waleed Brinjikji Katelyn R Anderson Megha Tollefson V Michelle Silvera Julie B Guerin Source Type: research

Targeting MET and Vascular Endothelial Growth Factor Receptor Signaling in Castration-Resistant Prostate Cancer.
Abstract ABSTRACT: Effective management of bone metastases in men with castration-resistant prostate cancer (CRPC) remains an important unmet medical need. MET and vascular endothelial growth factor receptor (VEGFR) are rational targets for intervention in CRPC. Clinical trials involving agents that inhibit one but not both pathways have reported modest activity and no improvement in overall survival. Cabozantinib is an oral multitargeted tyrosine kinase inhibitor that inhibits both MET and VEGFR-2. A phase II randomized discontinuation study involving subjects with CRPC demonstrated that cabozantinib therapy is a...
Source: Cancer Journal - January 1, 2013 Category: Cancer & Oncology Authors: Lee RJ, Smith MR Tags: Cancer J Source Type: research

Total hip arthroplasty in patients with cerebral vascular event. Case report.
CONCLUSIONS: There is no experience documented in neurological disorders associated with hip diseases that requires a total hip arthroplasty. Loosening of the implants, dislocation and heterotopic ossification has been described as complications of the procedure. Large heads in total hip arthroplasty and a correct surgical technique associated with a multidisciplinary management in patients with neurological disorders offers an opportunity as a treatment in patient with hip disorders. PMID: 23461923 [PubMed - in process]
Source: Cirugia y Cirujanos - January 1, 2013 Category: Surgery Authors: Camacho-Galindo J, Soria-Bastida Mde L, Torres-Higuita JK, Ilizaliturri-Sánchez VM Tags: Cir Cir Source Type: research

Optimal medical therapy predicts amputation-free survival in chronic critical limb ischemia
Objective: Determine the proportion of patients with chronic critical limb ischemia (CLI) who failed to adhere to Trans-Atlantic Inter-Society Consensus II guidelines of medical therapy and to quantify the effect of baseline suboptimal medical management on amputation-free survival (AFS).Methods: The patients were identified from a prospectively maintained database of consecutive patients presenting with CLI to the Vascular Surgery service at a single hospital. The primary outcome variable was AFS. The effects of baseline demographics, comorbid medical conditions, ambulatory status, optimal medical management, and Rutherfo...
Source: Journal of Vascular Surgery - August 29, 2013 Category: Surgery Authors: Jayer Chung, David A. Timaran, J. Gregory Modrall, Chul Ahn, Carlos H. Timaran, Melissa L. Kirkwood, Mirza S. Baig, R. James Valentine Tags: Clinical research studies Source Type: research

Optimal Perioperative Medical Management of the Vascular Surgery Patient
Perioperative medical management of patients undergoing vascular surgery can be challenging because they represent the surgical population at highest risk. β-Blockers should be continued perioperatively in patients already taking them preoperatively. Statins may be used in the perioperative period in patients who are not on statin therapy preoperatively. Institutional guidelines should be used to guide insulin replacement. Recent research suggests that measurement of troponins may provide some risk stratification in clinically stable patients following vascular surgery. Multimodal pain therapy including nonopioid strategi...
Source: Anesthesiology Clinics - June 26, 2014 Category: Anesthesiology Authors: Saket Singh, Yasdet Maldonado, Mark A. Taylor Source Type: research

Pulmonary Vascular Diseases
Pulmonary vascular diseases encompass a large and diverse group of underlying pathologies ranging from venous thromboembolism to congenital malformations to inflammatory vasculitides. As a result, patients can present either acutely with dyspnea and chest pain or chronically with dyspnea on exertion, hypoxia, and right heart failure. Imaging, particularly with multidetector CT, plays a key role in the evaluation and management of patients with suspected pulmonary vascular disease and, given the widespread routine use of high-quality CT pulmonary angiography, it is imperative that radiologists be familiar these pathologies.
Source: Clinics in Chest Medicine - March 26, 2015 Category: Respiratory Medicine Authors: Kristopher W. Cummings, Sanjeev Bhalla Source Type: research