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Fight Aging! Newsletter, January 25th 2021
In conclusion, our studies highlight the important role of the tyrosine degradation pathway and position TAT as a link between neuromediator production, dysfunctional mitochondria, and aging.
Source: Fight Aging! - January 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 8th 2021
Conclusion Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome. The Role of Reactive Oxygen Species in Aging is Complex https://www.fightaging.org/archives/2021/03/the-role-of-reactive-oxygen-species-in-ag...
Source: Fight Aging! - March 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Navigating the Treatment Landscape
for Advanced-stage Kidney CancerMayer N. Fishman, MD, PhDFor the patient with advanced-stage kidney cancer, deciding on a course of treatment presents diverse choices. The physician must weigh how quickly the cancer is spreading, the pattern of that spread, and relative risks from other medical conditions against the patient’s individual treatment goals and medical needs. In many cases of patients with advanced disease, there are therapies that can realistically be used to meet the goals of longer survival, longer time to disease progression, and tumor shrinkage. While choosing a kidney cancer treatment can be a com...
Source: Kidney Cancer Association - December 3, 2014 Category: Urology & Nephrology Source Type: news

Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns. First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Immune escape mechanisms and immunotherapy of urothelial bladder cancer
CONCLUSION: At present, BCG and immune checkpoint blockades have been approved by the US Food and Drug Administration for the treatment of UBC patients and have achieved encouraging therapeutic results, expanding the traditional chemotherapy and surgery-based treatment for UBC.RELEVANCE FOR PATIENTS: Immunotherapy has achieved desirable results in the treatment of UBC, which not only improve the overall survival but also reduce the recurrence rate and the occurrence of treatment-related adverse events of UBC patients. In addition, the indicators to predict the effectiveness and novel therapy strategies, such as combination...
Source: Cell Research - September 20, 2021 Category: Cytology Authors: Zhao Yang Yinyan Xu Ying Bi Nan Zhang Haifeng Wang Tianying Xing Suhang Bai Zongyi Shen Faiza Naz Zichen Zhang Liqi Yin Mengran Shi Luyao Wang Lei Wang Shihui Wang Lida Xu Xin Su Song Wu Changyuan Yu Source Type: research

Immune response to anti-SARS-CoV-2 prime-vaccination in patients with cancer: a systematic review and meta-analysis
CONCLUSION: This meta-analysis provides compelling evidence of humoral and adaptive immune responses against SARS-CoV-2 in patients with cancer, which last for at least 2 months following complete prime-vaccination.PMID:35867203 | PMC:PMC9304540 | DOI:10.1007/s00432-022-04185-w
Source: Clinical Breast Cancer - July 22, 2022 Category: Cancer & Oncology Authors: Diogo Martins-Branco Guilherme Nader-Marta Ana Tecic Vuger Veronique Debien Lieveke Ameye Mariana Brand ão Kevin Punie Angela Loizidou Karen Willard-Gallo Chloe Spilleboudt Ahmad Awada Martine Piccart Evandro de Azambuja Source Type: research

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer
CONCLUSIONS: There was no evidence for or against debulking hysterectomy followed by CCRT versus CCRT alone for FIGO (2019) stage IB3/II cervical cancer.PMID:36111784 | PMC:PMC9479467 | DOI:10.1002/14651858.CD012246.pub2
Source: Cochrane Database of Systematic Reviews - September 16, 2022 Category: General Medicine Authors: Manas Chakrabarti Andy Nordin Juneida Khodabocus Source Type: research

Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Meta-analysis and Critical Review: Association Between Radio-induced Lymphopenia and Overall Survival in Solid Cancers
CONCLUSIONS: RIL is a significant prognostic factor for mortality in virtually all solid cancers. Pooled-effect estimates indicate a significantly reduced risk of death in patients without RIL. Tailoring RT regimens to spare the immune system and updating dosimetric constraints for new organs at risk, such as major blood vessels, organs with rich blood supplies, bones, and all lymph node areas, may improve prognoses.PMID:36561078 | PMC:PMC9763695 | DOI:10.1016/j.adro.2022.101038
Source: Adv Data - December 23, 2022 Category: Epidemiology Authors: Yasmine El Houat Christophe Massard Veronique Quillien Renaud de Crevoisier Jo ël Castelli Source Type: research