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Vaccination: Influenza Vaccine

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Total 6581 results found since Jan 2013.

Influenza virus infection in pregnancy: a review
ConclusionsThere is level 2b evidence that maternal health and pregnancy outcome can be severely affected by influenza virus infection. Antiviral treatment may diminish these effects and vaccination protects pregnant women and neonates from infection (level of evidence 2b and 1b respectively).This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - May 25, 2015 Category: OBGYN Authors: Wouter J Meijer, Aleid GA Noortwijk, Hein W Bruinse, Annemarie MJ Wensing Tags: Review Article Source Type: research

The narcolepsy-pandemic influenza story: Can the truth ever be unraveled?
Abstract A safety signal around Pandemrix, an AS03 adjuvanted influenza A(H1N1) pdm09 vaccine potentially causing narcolepsy in children and adolescents became public in August 2010, long after cessation of the influenza A(H1N1) pdm09 campaigns in Europe. The signal originated from Finland and Sweden, two countries with school based pandemic vaccination campaigns, with high vaccine coverage, and vaccinations being provided at the peak of the circulating wild virus. Since the announcement awareness grew in Europe, with extensive public media dissemination and regulatory actions. This resulted in a steep increase in...
Source: Vaccine - May 31, 2015 Category: Allergy & Immunology Authors: Sturkenboom MC Tags: Vaccine Source Type: research

Using combinatorial bioinformatics methods to analyze annual perspective changes of influenza viruses and to accelerate development of effective vaccines
This study identified the changes in biological sequences and associated alignment alterations, which would ultimately affect epitope structures, as well as the plausible hidden features to search for the most conserved and effective epitopes for vaccine development. Addition our newly designed systemic analysis method to supplement the WHO guidelines could accelerate the development of urgently needed vaccines that might concurrently combat several strains of viruses within a shorter period.
Source: Journal of the Formosan Medical Association - June 1, 2015 Category: Journals (General) Source Type: research

Vaccines for Patients with COPD.
This article presents a brief overview of the different studies found, on the new patents, and the future strategies on the field. PMID: 25706527 [PubMed - in process]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 4, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Your viral past
Did you ever wonder what different virus infections you have had in your lifetime? Now you can find out with just a drop of your blood and about $25. Immune defense systems of many hosts produce antibodies in response to virus infections. These large proteins, which are generally virus specific, can block or inhibit virus infection, and persist at low levels for many years after the initial infection. Hence it is possible to determine whether an individual has had a virus infection by looking for anti-viral antibodies in the blood. Up to now the process of identifying such antibodies has been slow and limited to one or a...
Source: virology blog - June 5, 2015 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antibody bacteriophage infection phage display proteome public epitopes serology unbiased assay viral virome VirScan virus Source Type: blogs

Using combinatorial bioinformatics methods to analyze annual perspective changes of influenza viruses and to accelerate development of effective vaccines.
This study identified the changes in biological sequences and associated alignment alterations, which would ultimately affect epitope structures, as well as the plausible hidden features to search for the most conserved and effective epitopes for vaccine development. Addition our newly designed systemic analysis method to supplement the WHO guidelines could accelerate the development of urgently needed vaccines that might concurrently combat several strains of viruses within a shorter period. PMID: 26044364 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - June 1, 2015 Category: Journals (General) Authors: Hu YJ, Chow KC, Liu CC, Lin LJ, Wang SC, Wang S Tags: J Formos Med Assoc Source Type: research

Impact of Haemophilus influenzae type B (Hib) and viral influenza vaccinations in pregnancy for improving maternal, neonatal and infant health outcomes.
CONCLUSIONS: There is limited evidence (from one small trial at a high risk of bias) on the effectiveness on Hib during pregnancy for improving maternal, neonatal and infant health outcomes.Evidence from one large high quality trial on the effectiveness of viral influenza vaccine during pregnancy suggests reduced RT-PCR confirmed influenza among women and their babies, suggesting the potential of this strategy for scale up but further evidence from varying contexts is required.Further trials for both Hib and viral influenza vaccines with appropriate study designs and suitable comparison groups are required. There are curre...
Source: Cochrane Database of Systematic Reviews - June 9, 2015 Category: Journals (General) Authors: Salam RA, Das JK, Dojo Soeandy C, Lassi ZS, Bhutta ZA Tags: Cochrane Database Syst Rev Source Type: research

Knowledge gaps on paediatric respiratory infections in Morocco, Northern Africa
Conclusions Further efforts should be made towards the development of adequate surveillance programs to better clarify the epidemiology, etiology, antimicrobial susceptibility patterns and the effectiveness of the preventives and curatives strategies in place against paediatric ARIs in Morocco. Additionally, a holistical approach should be used to identify the heath determinants of ARIs among children.
Source: Archives of Public Health - June 15, 2015 Category: Global & Universal Source Type: research

Needle size for vaccination procedures in children and adolescents.
CONCLUSIONS: Using 25 mm needles (either 23 G or 25 G) for intramuscular vaccination procedures in the anterolateral thigh of infants using the WHO injection technique probably reduces the occurrence of local reactions while achieving a comparable immune response to 25 G 16 mm needles. These findings are applicable to healthy infants aged two to six months receiving combination DTwP vaccines with a reactogenic whole-cell pertussis antigen component. These vaccines are predominantly used in developing countries. The applicability of the findings to vaccines with acellular pertussis components and other vaccines with differe...
Source: Cochrane Database of Systematic Reviews - June 18, 2015 Category: Journals (General) Authors: Beirne PV, Hennessy S, Cadogan SL, Shiely F, Fitzgerald T, MacLeod F Tags: Cochrane Database Syst Rev Source Type: research

Vaccines for women for preventing neonatal tetanus.
CONCLUSIONS: Available evidence supports the implementation of immunisation practices on women of reproductive age or pregnant women in communities with similar, or higher, levels of risk of neonatal tetanus, to the two study sites. PMID: 26144877 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 6, 2015 Category: Journals (General) Authors: Demicheli V, Barale A, Rivetti A Tags: Cochrane Database Syst Rev Source Type: research

The ‘Must Do’ List: Certain Patient Safety Rules Should Not Be Elective
The modern patient safety field was built on a foundation of “systems thinking,” namely, that we should avoid assigning individual blame for errors, instead focusing on identifying and fixing dysfunctional systems. While this approach is largely correct and is responsible for many of the field’s successes, it needs to be balanced with a need for accountability. Today, while there is an increasing appreciation of the importance of achieving such balance, leaders of health care delivery systems are unsure about how and when to enforce certain safety standards and rules. We believe that the time has come to articulate c...
Source: Health Affairs Blog - August 20, 2015 Category: Health Management Authors: Robert Wachter Tags: Health Policy Lab Health Professionals Hospitals Organization and Delivery Population Health Public Health Quality Just Culture Lucian Leape Institute National Patient Safety Foundation National Quality Forum Robert Wachter Source Type: blogs

Wheeze as an adverse event in pediatric vaccine and drug randomized controlled trials: A systematic review.
CONCLUSION: Standardized wheeze definitions and severity grading scales for use in pediatric vaccine or drug trials are lacking. Standardized definitions of wheeze are needed for assessment of possible adverse events as new vaccines and drugs are evaluated. PMID: 26319071 [PubMed - as supplied by publisher]
Source: Vaccine - August 25, 2015 Category: Allergy & Immunology Authors: Marangu D, Kovacs S, Walson J, Bonhoeffer J, Ortiz JR, John-Stewart G, Horne DJ Tags: Vaccine Source Type: research

Response of transplant recipients to influenza vaccination based on type of immunosuppression: A meta-analysis.
Abstract Influenza vaccination is widely used in transplant recipients, but there is little known about the significance and correlating factors of its effectiveness. In the current study, we reviewed the existing literature on clinical trials performed in transplant recipients on the effectiveness of influenza vaccination and to evaluate the relevance of the type of immunosuppression employed in these patients on the humoral reaction to the vaccine. A comprehensive search of the literature was performed through Pubmed and Google Scholar to find reports indicating immunogenicity of influenza vaccination in transpl...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2015 Category: Urology & Nephrology Authors: Karbasi-Afshar R, Izadi M, Fazel M, Khedmat H Tags: Saudi J Kidney Dis Transpl Source Type: research

Vasculitis as an adverse event following immunization - Systematic literature review.
CONCLUSIONS: Existing literature does not allow establishing a causative link between vaccination and vasculitides. Further investigations were strengthened by the use of standardized case definitions and methods for data collection, analysis and presentation to improve data comparability and interpretation of vasculitis cases following immunization. PMID: 26398442 [PubMed - as supplied by publisher]
Source: Vaccine - September 19, 2015 Category: Allergy & Immunology Authors: Bonetto C, Trotta F, Felicetti P, Santuccio C, Bachtiar NS, Pernus YB, Chandler R, Girolomoni G, Hadden RD, Kucuku M, Ozen S, Pahud B, Top K, Varricchio F, Wise RP, Zanoni G, Živković S, Bonhoeffer J, Brighton Collaboration Vasculitis Working Group Tags: Vaccine Source Type: research

Maternal Influenza Vaccination and Risk for Congenital Malformations: A Systematic Review and Meta-analysis.
CONCLUSION: This systematic review did not indicate an increased risk for congenital anomalies after maternal influenza immunization adding to the evidence base on the safety of influenza vaccination in pregnancy. PMID: 26444106 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - October 5, 2015 Category: OBGYN Authors: Polyzos KA, Konstantelias AA, Pitsa CE, Falagas ME Tags: Obstet Gynecol Source Type: research