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Total 86699 results found since Jan 2013.

Perivascular Tissue Stem Cells Are Crucial Players in Vascular Disease.
Abstract Perivascular tissue including adipose layer and adventitia have been considered to play pivotal roles in vascular development and disease progression. Recent studies showed that abundant stem/progenitorcells (SPCs) are present in perivascular tissues. These SPCs exhibit capability to proliferate and differentiate into specific terminal cells. Adult perivascular SPCs are quiescent in normal condition, once activated by specific molecules (e.g., cytokines), they migrate toward the lumen side where they differentiate into both smooth muscle cells (SMCs) and endothelial cells (ECs), thus promoting intima hype...
Source: Free Radical Biology and Medicine - February 5, 2021 Category: Biology Authors: Wu H, Zhou X, Gong H, Ni Z, Xu Q Tags: Free Radic Biol Med Source Type: research

Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality
ConclusionsIn conclusion, in males GDF-15 and YKL-40 were related to vascular calcification, inflammation, and oxidative stress, whilst in females GDF-15 was related to TMAO. Increased levels of YKL-40 and GDF-15 in males, and only GDF-15 in females, were associated with all-cause mortality. Our findings suggest that sex-specific associations of novel CVD biomarkers have a potential to affect development of cardiovascular complications in patients with ESKD.
Source: Biology of Sex Differences - September 15, 2021 Category: Biology Source Type: research

Segmentation-Less, Automated, Vascular Vectorization
by Samuel A. Mihelic, William A. Sikora, Ahmed M. Hassan, Michael R. Williamson, Theresa A. Jones, Andrew K. Dunn Recent advances in two-photon fluorescence microscopy (2PM) have allowed large scale imaging and analysis of blood vessel networks in living mice. However, extracting network graphs and vector representations for the dense capillary bed remains a bottleneck in many applications. Vascular vectoriza tion is algorithmically difficult because blood vessels have many shapes and sizes, the samples are often unevenly illuminated, and large image volumes are required to achieve good statistical power. State-of-the-art...
Source: PLoS Computational Biology - October 8, 2021 Category: Biology Authors: Samuel A. Mihelic Source Type: research

Multiscale modeling of tumor response to vascular endothelial growth factor (VEGF) inhibitor
In Silico Biol. 2021;14(3-4):71-88. doi: 10.3233/ISB-210235.ABSTRACTVascular endothelial growth factor (VEGF) has been known as a key mediator of angiogenesis in cancer. Bevacizumab is anti-VEGF monoclonal antibody that has been approved by the FDA as a first-line treatment in many types of cancer. In this paper, we extend a previously validated multiscale tumor model to comprehensively include the multiple roles of VEGF during the course of angiogenesis and its binding mechanism with bevacizumab. We use the model to simulate tumor system response under various bevacizumab concentrations, both in stand-alone treatment and ...
Source: In Silico Biol - January 10, 2022 Category: Biology Authors: Melisa Hendrata Janti Sudiono Source Type: research