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Vaccination: Cancer Vaccines
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Total 7854 results found since Jan 2013.
Tonsillectomy as a Cancer Preventive Strategy
The rate of vaccination against human papillomavirus (HPV) among adolescent girls and boys over the past few years has been stagnant in spite of the increase in incidence of HPV-positive oropharyngeal (OPX) squamous cell carcinoma (SCC). The indirect relationship between HPV cancer incidence and preventive vaccination poses a public health concern and has caused clinicians to search for other methods toward eradicating the ongoing oropharyngeal carcinoma epidemic. This alarming increase in OPX is motivating a search for therapeutic prevention strategies, including biomarker discovery, risk assessment, therapeutic vaccines,...
Source: Cancer Prevention Research - July 1, 2015 Category: Cancer & Oncology Authors: Misiukiewicz, K., Posner, M. Tags: Editorials Source Type: research
Human papillomavirus and oral cancer: a primer for dental public health professionals.
CONCLUSIONS: Given the mounting literature on the association between HPV and oropharyngeal cancer, the dental community must be prepared to answer patients' HPV-related questions and to educate patients about the role of HPV as a risk factor for oral and oropharyngeal cancers.
PMID: 26263606 [PubMed - in process]
Source: Community Dental Health - August 14, 2015 Category: Dentistry Tags: Community Dent Health Source Type: research
Management of Vaginal Cancer.
CONCLUSION: Primary vaginal cancer is a rare entity, if there is no history of cancer cervix or vulva in past or absence of cervical squamous cell carcinoma or vulvar carcinoma within 5 years is usually considered as primary vaginal cancer. Though early stage vaginal cancers have better outcome treated with surgery or radiotherapy or surgery followed by radiotherapy, radiotherapy alone is preferred mode of treatment in vaginal cancers.
PMID: 26411952 [PubMed - as supplied by publisher]
Source: Reviews on Recent Clinical Trials - September 23, 2015 Category: Cancer & Oncology Authors: Shrivastava S, Agrawal G, Mittal M, Mishra P Tags: Rev Recent Clin Trials Source Type: research
Phenotypic profile of dendritic and t cells in the lymph node of balb/c mice with breast cancer submitted to dendritic cells immunotherapy.
PHENOTYPIC PROFILE OF DENDRITIC AND T CELLS IN THE LYMPH NODE OF BALB/C MICE WITH BREAST CANCER SUBMITTED TO DENDRITIC CELLS IMMUNOTHERAPY.
Immunol Lett. 2016 Jul 13;
Authors: da Cunha A, Antoniazi Michelin M, Cândido Murta EF
Abstract
Breast cancer (BC) is the most common malignant neoplasm and the cause of death by cancer among women worldwide. Its development influenced by various mutations that occur in the tumor cell and by the immune system's status, which has a direct influence on the tumor microenvironment and, consequently, on interactions with non-tumor cells involved in the immunological r...
Source: Immunology Letters - July 12, 2016 Category: Allergy & Immunology Authors: da Cunha A, Antoniazi Michelin M, Cândido Murta EF Tags: Immunol Lett Source Type: research
Fight Aging! Newsletter, August 29th 2016
This study demonstrates that TNTs play a significant part in the intercellular transfer of α-synuclein fibrils and reveals the specific role of lysosomes in this process. This represents a major breakthrough in understanding the mechanisms underlying the progression of synucleinopathies. These compelling findings, together with previous reports from the same team, point to the general role of TNTs in the propagation of prion-like proteins in neurodegenerative diseases and identify TNTs as a new therapeutic target to combat the progression of these incurable diseases.
Shorter Period of Rapamycin Treatment in Mice...
Source: Fight Aging! - August 28, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Visual Introduction to SENS Rejuvenation Research
The SENS Research Foundation has assembled a set of narrated cellular biochemistry animations that serve as an introduction to the various distinct projects that make up the field of rejuvenation biotechnology. The videos outline the forms of cell and tissue damage that are the root cause of aging and age-related disease, as well as the classes of therapy that could, once constructed, either repair that damage or bypass it entirely. Since aging is exactly an accumulation of damage and the consequences of that damage, repair of the damage is the basis for rejuvenation, the reversal and prevention of degenerative aging and a...
Source: Fight Aging! - September 15, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Gaming the System
By NIRAN Al-AGBA, MD
As physicians ready themselves for the future of medicine under onerous MACRA regulations, it seems appropriate to glance into the future and visualize the medical utopia anticipated by so many. Value-based care, determined by statistical analysis, is going to replace fee for service.
Six months ago, I received my first set of statistics from a state Medicaid plan and was told my ER utilization numbers were on the higher end compared to most practices in the region. This was perplexing as my patients tend to avoid ER visits at all costs and can be found milling about in my parking lot at 7am o...
Source: The Health Care Blog - February 11, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, May 8th 2017
This report captures the state of the research community in a nutshell: progress in the sense that ever more scientists are willing to make the treatment of aging the explicit goal of their research, but, unfortunately, there is still a long way to go in improving the nature of that research. It is still near entirely made up of projects that cannot possibly produce a robust and large impact on human life span. The only course of action likely to extend life by decades in the near future is implementation of the SENS vision for rejuvenation therapies - to repair the molecular damage that causes aging. Everything else on th...
Source: Fight Aging! - May 7, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Antitumor immunity induced by VE-cadherin modified DC vaccine.
Authors: Zhou J, Xi Y, Mu X, Zhao R, Chen H, Zhang L, Wu Y, Li Q
Abstract
Dendritic cells (DCs) are the most potent antigen-presenting cells. A strong interest has been developed in DC vaccines for cancer immunotherapy. Besides, angiogenesis is essential for tumor growth. VE-cadherin has a crucial function in various aspects of vascular biological functions. Here, we produced the full VE-cadherin gene modified DC vaccine (DC-VEC). Its antitumor immunity and chief mechanism driving antitumor effect was evaluated. Analyses were performed including test of antitumor antibody, CTL-mediated cytotoxicity experiment, vasc...
Source: Oncotarget - July 2, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Immunotherapy for thoracic malignancies
ConclusionWe have highlighted the successes, as well as the limitations, of immunotherapy for non-small cell lung cancer and malignant pleural mesothelioma. We have identified early phase clinical trials that assess immunotherapy as first-line, second-line, and maintenance therapy, and compared these drugs as monotherapeutics or in combination with chemotherapy or other types of immunotherapy.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - July 28, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research
Fight Aging! Newsletter, March 19th 2018
In this study, we did not observe significant age-dependent upregulation of the prominent SASP cytokine Il6 in any tissue, although an upward trend was observed that was consistent in magnitude with previous observations in the heart and kidney. This modest age-related upward trend could be explained by a previous report which demonstrated that senescent cell-secreted IL-6 acts in an autocrine manner, reinforcing the senescent state, rather than inducing senescence or promoting dysfunction in neighboring cells.
The decreased expression of Il6 with age we observed in the hypothalamus could be indicative of a lack or ...
Source: Fight Aging! - March 18, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The first case of bacillus Calmette-Gu érin-induced small-vessel central nervous system vasculitis
AbstractTo present an unrecognized vascular complication of bacillus Calmette-Gu érin (BCG) therapy administered for superficial bladder carcinoma. We also review the potential mimickers for primary angiitis of the central nervous system (PACNS) as well as complications of intravesical BCG therapy. An 89-year-old Caucasian man with a history of relapsing high-grade bladder carc inoma treated with intravesical BCG presented with recurring episodes of right upper limb paresthesia with clumsiness and dysarthria. Magnetic resonance imaging of the head revealed multiple predominantly left-sided frontotemporal micronodular peri...
Source: Clinical Rheumatology - May 9, 2018 Category: Rheumatology Source Type: research
Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition.
In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Six Ways Artificial Intelligence Is Impacting Patients
It ’s difficult to open a newspaper nowadays without seeing an article about artificial intelligence. These column-inches spark our imaginations with heady visions of possible futures and crease our brows with concern in equal measure. But one thing you cannot escape is that AI is here now and it’s only going to become more pervasive.While fear of an unknown technology is understandable, in many ways it does a disservice to the incredible impact that AI is already having on the world around us. In the healthcare space alone, it is offering ways to fundamentally rethink clinical practice, speeding up diagnosis, driving ...
Source: EyeForPharma - July 24, 2018 Category: Pharmaceuticals Authors: Lucy Fulford Source Type: news
