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Vaccination: Shingles (Herpes Zoster) Vaccine
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Total 1796 results found since Jan 2013.
Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases
CONCLUSIONS: The COVID-19 vaccines work by generating both adaptive humoral and cellular immune responses in humans, including elevation of anti-spike neutralizing antibody titers, antigen-specific CD4+ and CD8+ T-cell responses, and increased levels of proinflammatory cytokines such as interferon gamma (IFNγ). The general activation of the T-cell-mediated immune response and proinflammatory cytokines such as IFNγ may underlie the role of the COVID vaccines in reactivation of herpetic stromal keratitis and the clinical findings in our reported cases.PMID:35601874 | PMC:PMC9121224 | DOI:10.1155/2022/7094893
Source: Herpes - May 23, 2022 Category: Infectious Diseases Authors: Ali Mahdavi Fard Jeffrey Desilets Sangita Patel Source Type: research
The Biology of Varicella-Zoster Virus Replication in the Skin
Viruses. 2022 May 6;14(5):982. doi: 10.3390/v14050982.ABSTRACTThe replication of varicella-zoster virus (VZV) in skin is critical to its pathogenesis and spread. Primary infection causes chickenpox, which is characterised by centrally distributed skin blistering lesions that are rich in infectious virus. Cell-free virus in the cutaneous blistering lesions not only spreads to cause further cases, but infects sensory nerve endings, leading to the establishment of lifelong latency in sensory and autonomic ganglia. The reactivation of virus to cause herpes zoster is again characterised by localised painful skin blistering rash...
Source: Herpes - May 28, 2022 Category: Infectious Diseases Authors: Cristina Tommasi Judith Breuer Source Type: research
Ionizable Lipid Nanoparticles Enhanced the Synergistic Adjuvant Effect of CpG ODNs and QS21 in a Varicella Zoster Virus Glycoprotein E Subunit Vaccine
In this report, we found that ionizable lipid nanoparticles (LNPs) approved by the Food and Drug Administration (FDA) as vectors for coronavirus disease 2019 (COVID-19) mRNA vaccines could enhance the synergistic adjuvant effect of CpG oligodeoxynucleotides (CpG ODNs) and QS21 on VZV-gE, affecting both humoral immunity and CMI. Vaccines made with these LNPs showed promise as varicella vaccines without a potential risk of herpes zoster, which identifies them as a novel type of herpes zoster vaccine similar to ShingrixTM. All of the components in this LNP-CpG-QS21 adjuvant system were proven to be safe after mass vaccination...
Source: Herpes - May 28, 2022 Category: Infectious Diseases Authors: Ning Luan Han Cao Yunfei Wang Kangyang Lin Cunbao Liu Source Type: research
The Biology of Varicella-Zoster Virus Replication in the Skin
Viruses. 2022 May 6;14(5):982. doi: 10.3390/v14050982.ABSTRACTThe replication of varicella-zoster virus (VZV) in skin is critical to its pathogenesis and spread. Primary infection causes chickenpox, which is characterised by centrally distributed skin blistering lesions that are rich in infectious virus. Cell-free virus in the cutaneous blistering lesions not only spreads to cause further cases, but infects sensory nerve endings, leading to the establishment of lifelong latency in sensory and autonomic ganglia. The reactivation of virus to cause herpes zoster is again characterised by localised painful skin blistering rash...
Source: Herpes - May 28, 2022 Category: Infectious Diseases Authors: Cristina Tommasi Judith Breuer Source Type: research
Ionizable Lipid Nanoparticles Enhanced the Synergistic Adjuvant Effect of CpG ODNs and QS21 in a Varicella Zoster Virus Glycoprotein E Subunit Vaccine
In this report, we found that ionizable lipid nanoparticles (LNPs) approved by the Food and Drug Administration (FDA) as vectors for coronavirus disease 2019 (COVID-19) mRNA vaccines could enhance the synergistic adjuvant effect of CpG oligodeoxynucleotides (CpG ODNs) and QS21 on VZV-gE, affecting both humoral immunity and CMI. Vaccines made with these LNPs showed promise as varicella vaccines without a potential risk of herpes zoster, which identifies them as a novel type of herpes zoster vaccine similar to ShingrixTM. All of the components in this LNP-CpG-QS21 adjuvant system were proven to be safe after mass vaccination...
Source: Herpes - May 28, 2022 Category: Infectious Diseases Authors: Ning Luan Han Cao Yunfei Wang Kangyang Lin Cunbao Liu Source Type: research
A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination
J Korean Med Sci. 2022 May 23;37(20):e165. doi: 10.3346/jkms.2022.37.e165.ABSTRACTThere are several reports that herpes zoster characterized by reactivation of varicella zoster virus (VZV) following coronavirus disease 2019 (COVID-19) vaccines can occur. Herein, we report VZV meningitis, herpes zoster ophthalmicus (HZO), and late neurotrophic keratitis after receiving a second dose of messenger RNA (mRNA) COVID-19 vaccine. A 74-year-old man developed a vesicular skin rash on the forehead, scalp, nose, and left upper eyelid with a severe headache. Five days earlier, he received a second dose of the BNT162b2 mRNA vaccine on ...
Source: J Korean Med Sci - May 24, 2022 Category: General Medicine Authors: In-Cheon You Min Ahn Nam-Chun Cho Source Type: research
COVID-19 mRNA vaccine in pregnancy: Results of the Swiss COVI-PREG registry, an observational prospective cohort study
Lancet Reg Health Eur. 2022 May 29;18:100410. doi: 10.1016/j.lanepe.2022.100410. eCollection 2022 Jul.ABSTRACTBACKGROUND: Pregnant individuals with coronavirus disease 2019 (COVID-19) are at increased risk of severe disease, prematurity, and stillbirth. In March 2021, vaccination for at risk pregnant women was recommended in Switzerland, expanding this to all pregnant women in May 2021. Our aim was to assess the safety of mRNA COVID-19 vaccines in pregnancy.METHODS: This multicentre prospective cohort study describes early adverse events and perinatal outcomes in pregnant women who received at least one dose of mRNA vaccin...
Source: Herpes - June 2, 2022 Category: Infectious Diseases Authors: Guillaume Favre Emeline Maisonneuve L éo Pomar Ursula Winterfeld Charlotte Daire Bego ña Martinez de Tejada Dominique Delecraz Sonia Campelo Mirjam Moser Monya Todesco-Bernasconi Stefanie Sturm Irene H ösli C écile Monod Brigitte Frey Tirri Stylianos Source Type: research
LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix < sup > TM < /sup > in VZV-primed mice
Virol Sin. 2022 Jun 4:S1995-820X(22)00108-0. doi: 10.1016/j.virs.2022.06.002. Online ahead of print.ABSTRACTLatent varicella-zoster virus (VZV) may be reactivated to cause herpes zoster, which affects one in three people during their lifetime. The currently available subunit vaccine ShingrixTM is superior to the attenuated vaccine Zostavax® in terms of both safety and efficacy, but the supply of its key adjuvant component QS21 is limited. With Ionizable lipid nanoparticles (LNPs) that were recently approved by the FDA for COVID-19 mRNA vaccines as carriers, and oligodeoxynucleotides containing CpG motifs (CpG ODNs) approv...
Source: Herpes - June 7, 2022 Category: Infectious Diseases Authors: Ning Luan Han Cao Yunfei Wang Kangyang Lin Cunbao Liu Source Type: research
Case Report: Various Clinical Manifestations Caused by Varicella-Zoster Virus in a Family
Front Pediatr. 2022 Jun 6;10:876250. doi: 10.3389/fped.2022.876250. eCollection 2022.ABSTRACTA family cluster of varicella-zoster virus (VZV) infections was reported. Four family members (two children and their parents) continuously develop varicella after the grandmother's herpes zoster. The unvaccinated 16-month-old infant and his mother developed primary varicella with atypical clinical presentation; however, his 28-year-old father presented with a typical generalized vesicular rash. His vaccinated 4-year-old sister was clinically mild, which could be defined as a breakthrough varicella case. They infected the same viru...
Source: Herpes - June 23, 2022 Category: Infectious Diseases Authors: Qinghong Meng Bingsong Wang Xianlai Zhang Zhen Li Wenjie Wang Kaihu Yao Source Type: research
Reactivation of Herpes Zoster Virus After COVID-19 Vaccination: Is There Any Association?
We report 10 incidences of herpes zoster reactivation within 7-21 days of getting the COVID-19 vaccination. Transient immunomodulation following vaccination, similar to that seen in COVID-19 illness, could be one explanation for this reactivation. These cases highlight the significance of continuing to examine vaccine safety during the COVID-19 pandemic's ongoing mass vaccination campaign. We also underline the importance of peripheral health professionals in the management and reporting of any vaccination-associated adverse event.PMID:35746994 | PMC:PMC9209775 | DOI:10.7759/cureus.25195
Source: Herpes - June 24, 2022 Category: Infectious Diseases Authors: Surbhi Agrawal Kapila Verma Ishan Verma Jagriti Gandhi Source Type: research
Case Report: Various Clinical Manifestations Caused by Varicella-Zoster Virus in a Family
Front Pediatr. 2022 Jun 6;10:876250. doi: 10.3389/fped.2022.876250. eCollection 2022.ABSTRACTA family cluster of varicella-zoster virus (VZV) infections was reported. Four family members (two children and their parents) continuously develop varicella after the grandmother's herpes zoster. The unvaccinated 16-month-old infant and his mother developed primary varicella with atypical clinical presentation; however, his 28-year-old father presented with a typical generalized vesicular rash. His vaccinated 4-year-old sister was clinically mild, which could be defined as a breakthrough varicella case. They infected the same viru...
Source: Herpes - June 23, 2022 Category: Infectious Diseases Authors: Qinghong Meng Bingsong Wang Xianlai Zhang Zhen Li Wenjie Wang Kaihu Yao Source Type: research
Reactivation of Herpes Zoster Virus After COVID-19 Vaccination: Is There Any Association?
We report 10 incidences of herpes zoster reactivation within 7-21 days of getting the COVID-19 vaccination. Transient immunomodulation following vaccination, similar to that seen in COVID-19 illness, could be one explanation for this reactivation. These cases highlight the significance of continuing to examine vaccine safety during the COVID-19 pandemic's ongoing mass vaccination campaign. We also underline the importance of peripheral health professionals in the management and reporting of any vaccination-associated adverse event.PMID:35746994 | PMC:PMC9209775 | DOI:10.7759/cureus.25195
Source: Herpes - June 24, 2022 Category: Infectious Diseases Authors: Surbhi Agrawal Kapila Verma Ishan Verma Jagriti Gandhi Source Type: research
Survey of Physician Practices, Attitudes, and Knowledge Regarding Recombinant Zoster Vaccine
CONCLUSION: Most primary care physicians welcome updated ACIP RZV recommendations for immunocompromised adults. Knowledge gaps, communication issues, and financial barriers need to be addressed to optimize vaccination delivery.PMID:35794307 | PMC:PMC9261227 | DOI:10.1007/s11606-022-07721-z
Source: Topics in HIV Medicine - July 6, 2022 Category: Infectious Diseases Authors: Laura P Hurley Sean T O'Leary Kathleen Dooling Tara C Anderson Lori A Crane Jessica R Cataldi Michaela Brtnikova Brenda L Beaty Carol Gorman Angela Guo Megan C Lindley Allison Kempe Source Type: research
