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Total 29834 results found since Jan 2013.

Where Art Thou O treatment for diabetic neuropathy: the sequel
This article challenges the rationale for the FDA insisting on symptoms/signs and nerve conduction as primary endpoints for clinical trials in DPN.EXPERT OPINION: Quantitative sensory testing, intraepidermal nerve fiber density, and especially corneal confocal microscopy remain an after-thought, demoted at best to exploratory secondary endpoints in clinical trials of diabetic neuropathy. If pharma are to be given a fighting chance to secure approval for a new therapy for diabetic neuropathy, the FDA needs to reassess the evidence rather than rely on 'opinion' for the most suitable endpoint(s) in clinical trials of diabetic...
Source: Expert Review of Neurotherapeutics - August 21, 2023 Category: Neurology Authors: Yigit Can Guldiken Ayesha Malik Ioannis N Petropoulos Hoda Gad Einas Elgassim Iuliia Salivon Georgios Ponirakis Uazman Alam Rayaz A Malik Source Type: research

Effects of Repetitive Pinprick Stimulation on Preterm Offspring: Alterations in Nociceptive Responses and Inflammatory Hypersensitivity in Adulthood
CONCLUSION: PP stimulation in preterm rats during the neonatal period resulted in changes in nociceptive responses in adulthood, leading to increased inflammatory hypersensitivity. The study emphasizes how early development can significantly impact sensory processing and further highlights the potential long-term consequences of prematurity and neonatal pain on this processing.PMID:37597588 | DOI:10.1016/j.bbr.2023.114633
Source: Behavioural Brain Research - August 19, 2023 Category: Neurology Authors: Ravena Carolina de Carvalho Laura Pereira Generoso Ana Laura da Silva Gabrielly Santos Pereira Danielle Cavalcante de Paula Natalie Lange Candido Maria Gabriela Maziero Capello Josie Resende Torres da Silva Marcelo Louren ço da Silva Source Type: research

Changes in opioid prescribing in veterans with headache during the COVID-19 pandemic: A regression discontinuity in time analysis
CONCLUSION: Prescription opioid access was maintained for veterans within VHA during the pandemic. The de-escalation of opioid prescribing observed prior to the pandemic was not seen in our study.PMID:37596904 | DOI:10.1111/head.14605
Source: Headache - August 19, 2023 Category: Neurology Authors: Kaicheng Wang Brenda T Fenton Melissa Skanderson Anne C Black William C Becker Elizabeth K Seng Sarah E Anthony Alexander B Guirguis Hamada H Altalib Addison Kimber Nancy Lorenze Joel D Scholten Glenn D Graham Friedhelm Sandbrink Jason J Sico Source Type: research

Effects of Repetitive Pinprick Stimulation on Preterm Offspring: Alterations in Nociceptive Responses and Inflammatory Hypersensitivity in Adulthood
CONCLUSION: PP stimulation in preterm rats during the neonatal period resulted in changes in nociceptive responses in adulthood, leading to increased inflammatory hypersensitivity. The study emphasizes how early development can significantly impact sensory processing and further highlights the potential long-term consequences of prematurity and neonatal pain on this processing.PMID:37597588 | DOI:10.1016/j.bbr.2023.114633
Source: Brain Research - August 19, 2023 Category: Neurology Authors: Ravena Carolina de Carvalho Laura Pereira Generoso Ana Laura da Silva Gabrielly Santos Pereira Danielle Cavalcante de Paula Natalie Lange Candido Maria Gabriela Maziero Capello Josie Resende Torres da Silva Marcelo Louren ço da Silva Source Type: research