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Vaccination: Influenza Vaccine

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Finding the Origin of Human Disease
We're still trying to eradicate diseases that have plagued humans for centuries. References to malaria, for instance, have been found in recorded history in 2700 BC China. Riaan Rifkin, a prehistoric archaeologist, together with geneticists at the University of Pretoria, South Africa gets down to the root of origins of human disease pathogens in sub-Saharan Africa, the cradle of mankind. He and his team are trying to pin down the origins of human disease and establish a sub-Saharan African disease baseline that precedes the exodus of Homo sapiens from Africa 65000 years ago and, perhaps, to also assist in the discovery of ...
Source: Science - The Huffington Post - May 18, 2016 Category: Science Source Type: news

Nurses' knowledge, attitudes and practices regarding influenza vaccination: an integrative review
ConclusionsDespite the evidence for the protective effects of influenza vaccination, rates of vaccination among nurses remain sub‐optimal. Nurses' influenza vaccination practices likely relate to their level of knowledge and perception of risk; the greater nurses' knowledge regarding influenza and influenza vaccination the higher their perception of risk and the more likely they are to be vaccinated. This also translates to the advice that they give patients with vaccinated nurses more inclined to recommend vaccination than those unvaccinated. Relevance to clinical practiceThe practices of nurses related to influenza vac...
Source: Journal of Clinical Nursing - May 20, 2016 Category: Nursing Authors: Sarah Smith, Jenny Sim, Elizabeth Halcomb Tags: Review Source Type: research

Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions.
CONCLUSIONS: Our review findings have not identified conclusive evidence of benefit of HCW vaccination programmes on specific outcomes of laboratory-proven influenza, its complications (lower respiratory tract infection, hospitalisation or death due to lower respiratory tract illness), or all cause mortality in people over the age of 60 who live in care institutions. This review did not find information on co-interventions with healthcare worker vaccination: hand-washing, face masks, early detection of laboratory-proven influenza, quarantine, avoiding admissions, antivirals and asking healthcare workers with influenza or i...
Source: Cochrane Database of Systematic Reviews - June 1, 2016 Category: Journals (General) Authors: Thomas RE, Jefferson T, Lasserson TJ Tags: Cochrane Database Syst Rev Source Type: research

Japanese Government Continues to Ban the MMR Vaccine
Conclusion Japanese officials have made decisions that value the health and safety of their citizens when they have removed vaccines with dangerous side effects from their national vaccination program. Japan boasts a low infant mortality rate, despite — or perhaps because of  — mandating only a fraction of the vaccines required by other developed countries, including the United States. If you wish to learn more about the harmful ingredients in vaccines or the potential adverse reactions, we have compiled an easy-to-navigate list of vaccine package inserts from the manufacturers that you can view or download he...
Source: vactruth.com - June 23, 2016 Category: Allergy & Immunology Authors: Missy Fluegge Tags: Logical Missy Fluegge Top Stories HPV Vaccine MMR vaccine truth about vaccines Vaccine Death Source Type: blogs

CDC Halts Use of Nasal Spray Flu Vaccine
Conclusion Finally, after years of data cannot hide the lack of efficacy, even government and professional organizations are taking note: flu vaccines don’t work. Informed parents know there are safer and more effective ways to keep their children healthy, without injecting their sons and daughters with vaccines and the associated toxic ingredients. Do you vaccinate your child or yourself against the flu? How do you promote good health in your family during the winter months? Please share your comments below and share the important information in this article with others! References: http://www.cdc.gov/media/release...
Source: vactruth.com - June 30, 2016 Category: Allergy & Immunology Authors: Missy Fluegge Tags: Missy Fluegge Top Stories Advisory Committee on Immunization Practices (ACIP) flu mist influenza vaccine LAIV live attenuated influenza vaccine (LAIV) nasal spray flu vaccine truth about vaccines US Centers for Disease Control and Preven Source Type: blogs

A novel endonuclease inhibitor exhibits broad-spectrum anti-influenza activity in vitro.
Abstract Antiviral drugs are important in preventing and controlling influenza, particularly when vaccines are ineffective or unavailable. A single class of antiviral drugs, the neuraminidase inhibitors (NAIs), is recommended for treating influenza. The limited therapeutic options and the potential risk of antiviral resistance are driving the search for additional small-molecule inhibitors that act on influenza virus proteins. The acid polymerase (PA) of influenza viruses is a promising target for new antivirals because of its essential role in initiating virus transcription. Here, we characterized a novel compoun...
Source: Antimicrobial Agents and Chemotherapy - July 4, 2016 Category: Microbiology Authors: Jones JC, Marathe BM, Lerner C, Kreis L, Gasser R, Pascua PN, Najera I, Govorkova EA Tags: Antimicrob Agents Chemother Source Type: research

Unintentional administration of insulin instead of influenza vaccine: a case study and review of reports to US vaccine and drug safety monitoring systems
ConclusionInsulin and vaccine mix-ups have the potential to cause serious harm to patients, and are preventable with proper training and application of standards. Our investigation indicated that improper storage —including inadequate segregation of insulin and influenza vaccine products in clearly labeled containers or bins—lack of standardized procedures for confirming the contents of vials, and decreased vigilance in preparation and administration likely contributed to the primary cluster incident.
Source: Drugs and Therapy Perspectives - August 18, 2016 Category: Drugs & Pharmacology Source Type: research

Exercise prior to influenza vaccination for limiting influenza incidence and its related complications in adults.
CONCLUSIONS: From the available evidence, we found that exercising before influenza vaccination is neither beneficial nor harmful. However, study data were limited and of low quality. Small sample sizes, study design limitations, exercise types, and focus on biochemical rather than participant-centred outcomes strongly influenced our findings. PMID: 27545762 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 21, 2016 Category: Journals (General) Authors: Grande AJ, Reid H, Thomas EE, Nunan D, Foster C Tags: Cochrane Database Syst Rev Source Type: research

Vaccines against major ICU pathogens: where do we stand?
Purpose of review: Multidrug resistance of bacterial pathogens has confronted physicians around the world with the threat of inefficacy of the antibiotic regime, which is particularly important for patients with sepsis. Antibiotic resistance has revived search for alternative nonantibiotic strategies. Among them, prophylaxis by vaccination is an appealing concept. Recent findings: This review provides a compact overview on available vaccines against community-acquired pathogens such as pneumococci (in synergy with influenza) and meningococci and provides an overview on the ongoing developments of vaccines targeting typica...
Source: Current Opinion in Critical Care - September 2, 2016 Category: Nursing Tags: INFECTIOUS DISEASES: Edited by Tobias Welte Source Type: research

The seasonal flu vaccination among caregivers in geriatric units: Up-to-date.
CONCLUSION: Flu vaccinations must be included in the education and training of caregivers. PMID: 27816309 [PubMed - as supplied by publisher]
Source: Revue d Epidemiologie et de Sante Publique - November 7, 2016 Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research

Do antibody responses to the influenza vaccine persist year-round in the elderly? A systematic review and meta-analysis.
CONCLUSIONS: The review found consistent evidence that HI antibody responses following influenza vaccination do not reliably persist year-round in older adults. Alternative vaccination strategies could provide clinical benefits in regions where year-round protection is important. PMID: 27939013 [PubMed - as supplied by publisher]
Source: Vaccine - December 6, 2016 Category: Allergy & Immunology Authors: Young B, Zhao X, Cook AR, Parry CM, Wilder-Smith A, I-Cheng MC Tags: Vaccine Source Type: research

Vaccination in Hajj: An Overview of the Recent Findings
Conclusions: The findings regarding influenza vaccine effectiveness are contradictory. A few studies confirmed the flu vaccine effectiveness while some others rejected its usefulness.Meningococcal immunization is an effective preventive tool with high compliance for Hajj pilgrims. Further investigations are recommended for the other vaccines.Keywords: Communicable diseases, preventive medicine, travel medicine, vaccination
Source: International Journal of Preventive Medicine - December 6, 2016 Category: Global & Universal Source Type: research

The 2009 influenza A virus subtype H1N1 pandemic, a glance from Greece.
Authors: Tsoucalas G, Sgantzos M Abstract The 2009 influenza A - subtype H1N1 pandemic tested the public health care systems all around the globe, infecting millions and leading to thousands of deaths. Greece became the epidemic centre of the 2009 flu pandemic due to the low compliance of the general population towards the vaccination programme, the resistance acquired against antiviral drugs and the economic scenario at the time. Our study, after a thorough research in the "Medline/PubMed, Scopus, Google Scholars" medical databases, accompanied by a wide range search of medical literature from Greece, sought to ha...
Source: Infezioni in Medicina - December 26, 2016 Category: Infectious Diseases Tags: Infez Med Source Type: research

Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen.
Abstract The malaria parasite Plasmodium falciparum presents antigens on the infected erythrocyte surface that bind human receptors expressed on the vascular endothelium. The VAR2CSA mediated binding to a distinct chondroitin sulphate A (CSA) is a crucial step in the pathophysiology of placental malaria and the CSA binding region of VAR2CSA has been identified as a promising vaccine target against placental malaria. Here we designed adenovirus encoded virus-like particles (VLP) by co-encoding Simian Immunodeficiency Virus (SIV) gag and VAR2CSA. The VAR2CSA antigen was fused to the transmembrane (TM) and cytoplasmi...
Source: Vaccine - January 24, 2017 Category: Allergy & Immunology Authors: Andersson AC, Resende M, Salanti A, Nielsen MA, Holst PJ Tags: Vaccine Source Type: research

The Development of a Veterans Health Administration Emergency Management Research Agenda
Conclusions Using a systematic evidence base and consensus development process among stakeholders within and outside VA, we report on the first national VA comprehensive emergency management program evaluation and research agenda. VA provides a unique national laboratory for the conduct of high quality research that will improve VA’s and our Nation’s emergency medical and public health preparedness and the role of health delivery systems in that endeavor. To effectively foster the conduct and expansion of emergency management evaluation and research within VA, the consensus was that VA needs to build program evaluation...
Source: PLOS Currents Disasters - March 23, 2017 Category: Global & Universal Authors: Aram Dobalian Source Type: research