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Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging
Thymic Involution Contributes to Immunosenescence and Inflammaging
The Potential for Exosome Therapies to Treat Sarcopenia
Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures
Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice
The Aging Retina, a Mirror of the Aging Brain
Evidence for Loss of Capillary Density to be Important in Heart Disease
Aspects of Immune System Aging Proceed More Rapidly in Men
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Transplantation of Senescent Cells is an ...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Clinical and Immunological Outcomes in High-Risk Resected Melanoma Patients Receiving Peptide-Based Vaccination and Interferon Alpha, With or Without Dacarbazine Preconditioning: A Phase II Study
Clinical studies based on novel rationales and mechanisms of action of chemotherapy agents and cytokines can contribute to the development of new concepts and strategies of antitumor combination therapies. In previous studies, we investigated the paradoxical immunostimulating effects of some chemotherapeutics and the immunoadjuvant activity of interferon alpha (IFN-α) in preclinical and clinical models, thus unraveling novel rationales and mechanisms of action of chemotherapy agents and cytokines for cancer immunotherapy. Here, we carried out a randomized, phase II clinical trial, in which we analyzed the relapse-free (RF...
Source: Frontiers in Oncology - March 5, 2020 Category: Cancer & Oncology Source Type: research
Leading the hunt for a COVID-19 vaccine
Paul Stoffels, J&J ’s Chief Scientific Officer, has given delegates at eyeforpharma’s Barcelona Virtual conference exclusive insights into its rapid progress in the search for a vaccine to the COVID-19 virus. Speaking to Reuters News on day two of the five-day conference, Stoffels said J&J ’s potential vaccine, which has just been chosen as a lead candidate to help tackle the pandemic, could be ready for clinical trials as soon as early September with evidence of its safety and efficacy expected by the end of the year. This means that the first vaccinations could be given in the first quarter of 2021. ...
Source: EyeForPharma - April 1, 2020 Category: Pharmaceuticals Authors: Andrew Stone Source Type: news
An Open-Label Study of the Safety and Efficacy of Tag-7 Gene-Modified Tumor Cells-Based Vaccine in Patients with Locally Advanced or Metastatic Malignant Melanoma or Renal Cell Cancer.
CONCLUSION: GMV showed high results in carefully selected patients with low ISF (TGF-β1, IL-10, and VEGF) production. The method should be further investigated in patients with FP. This article is protected by copyright. All rights reserved.
PMID: 32240562 [PubMed - as supplied by publisher]
Source: The Oncologist - April 1, 2020 Category: Cancer & Oncology Authors: Novik A, Danilova AB, Sluzhev MI, Nehaeva TL, Larin SS, Girdyuk DV, Protsenko SA, Semenova AI, Danilov AO, Moiseyenko VM, Georgiev GP, Baldueva IA Tags: Oncologist Source Type: research
Anti-epidermal growth factor receptor therapy for glioblastoma in adults.
CONCLUSIONS: In summary, there is no evidence of a demonstrable overall survival benefit with the addition of anti-EGFR therapy in first-line and recurrent glioblastomas. Newer drugs that are specially designed for glioblastoma targets may raise the possibility of success in this population, but data are lacking at present. Future studies should be more selective in pursuing people displaying specific EGFR targets.
PMID: 32395825 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - May 11, 2020 Category: General Medicine Authors: Lee A, Arasaratnam M, Chan DLH, Khasraw M, Howell VM, Wheeler H Tags: Cochrane Database Syst Rev Source Type: research
Leading the hunt for a COVID-19 vaccine
Paul Stoffels, J&J ’s Chief Scientific Officer, has given delegates ateyeforpharma ’s Barcelona Virtual conference exclusive insights into its rapid progress in the search for a vaccine to the COVID-19 virus. Speaking to Reuters News on day two of the five-day conference, Stoffels said J&J ’s potential vaccine, which has just been chosen as a lead candidate to help tackle the pandemic, could be ready for clinical trials as soon as early September with evidence of its safety and efficacy expected by the end of the year. This means that the first vaccinations could be given in the first quarter of 2021. ...
Source: EyeForPharma - April 1, 2020 Category: Pharmaceuticals Authors: Andrew Stone Source Type: news
'Secondary prevention' against female HPV infection: literature review of the role of carrageenan.
Authors: Calagna G, Maranto M, Paola C, Capra G, Perino A, Chiantera V, Cucinella G
Abstract
INTRODUCTION: Human papillomaviruses (HPVs) are common sexually transmitted pathogens, causally associated with cervical cancer and other anogenital cancers, as well as approximately 20% of head and neck cancers. The HPV vaccine is an exceptional primary prevention tool, but the question of adequate secondary-prevention strategies remains open. The aim of this review is to better clarify the role of carrageenan in HPV prevention-strategies.
AREAS COVERED: A comprehensive literature search was performed (PubMed/MEDLINE, ...
Source: Expert Review of Anti-Infective Therapy - June 21, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Inside the Global Quest to Trace the Origins of COVID-19 —and Predict Where It Will Go Next
It wasn’t greed, or curiosity, that made Li Rusheng grab his shotgun and enter Shitou Cave. It was about survival. During Mao-era collectivization of the early 1970s, food was so scarce in the emerald valleys of southwestern China’s Yunnan province that farmers like Li could expect to eat meat only once a year–if they were lucky. So, craving protein, Li and his friends would sneak into the cave to hunt the creatures they could hear squeaking and fluttering inside: bats.
Li would creep into the gloom and fire blindly at the vaulted ceiling, picking up any quarry that fell to the ground, while his companion...
Source: TIME: Health - July 23, 2020 Category: Consumer Health News Authors: Charlie Campbell/ Yuxi, Yunnan and Alice Park Tags: Uncategorized COVID-19 feature Magazine Source Type: news
Leading the hunt for a COVID-19 vaccine
Paul Stoffels, J&J ’s Chief Scientific Officer, has given delegates ateyeforpharma ’s Barcelona Virtual conference exclusive insights into its rapid progress in the search for a vaccine to the COVID-19 virus. Speaking to Reuters News on day two of the five-day conference, Stoffels said J&J ’s potential vaccine, which has just been chosen as a lead candidate to help tackle the pandemic, could be ready for clinical trials as soon as early September with evidence of its safety and efficacy expected by the end of the year. This means that the first vaccinations could be given in the first quarter of 2021. ...
Source: EyeForPharma - April 1, 2020 Category: Pharmaceuticals Authors: Andrew Stone Source Type: news
Fight Aging! Newsletter, December 28th 2020
In conclusion, our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue's specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.
Mouse Age Matters: How Age Affects the Murine Plasma Metabolome
A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may l...
Source: Fight Aging! - December 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Male circumcision and Sexually transmitted Infections & #8211; An update
Kajal S Mehta, Yogesh S Marfatia, Apexa P Jain, Dhiral J Shah, Disha S BaxiIndian Journal of Sexually Transmitted Diseases and AIDS 2021 42(1):1-6Role of male circumcision (MC) as a tool to prevent sexually transmitted infections (STIs)/human immunodeficiency virus (HIV) was assessed. An attempt was made to search articles related to association between MC and STIs/HIV. A thorough search was carried out to find out quality articles published in indexed specialty journals. Centers for Disease Control and Prevention and World Health Organization (WHO) sites were also referred. Warm and moist environment of area under foreski...
Source: Indian Journal of Sexually Transmitted Diseases - May 4, 2021 Category: Infectious Diseases Authors: Kajal S Mehta Yogesh S Marfatia Apexa P Jain Dhiral J Shah Disha S Baxi Source Type: research
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Network of the National Lib...
Source: NN/LM Middle Atlantic Region Blog - March 5, 2021 Category: Databases & Libraries Authors: Tessa Zindren Tags: Weekly Postings Source Type: news
NIDCR's Summer 2021 E-Newsletter
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NIDCR's Summer 2021 E-Newsletter
In this issue:
NIDCR News
Funding Opportunities & Related Notices
NIH/HHS News
Subscribe to NICDR News
Science Advances
Grantee News
NIDCR News
NIDCR to Release Report on Oral Health in America
As a 20-year follow-up to the seminal Oral Health in America: A Report of the Surgeon General, NIDCR will release Oral Health in America: Advances and Challenges in the fall of 2021. The report will illuminate new directions in the prevention and t...
Source: NIDCR Science News - July 1, 2021 Category: Dentistry Source Type: news
