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Total 29834 results found since Jan 2013.

Simulation-Based Education in Acute and Chronic Pain Training
AbstractPurpose of ReviewThe use of simulation-based education (SBE) in medical training has expanded greatly and has grown to include high fidelity and task simulation along with hybrid models using patient actors to enhance education and training of critical events as well as technical skills.Recent FindingsIn the field of anesthesiology, SBE has been particularly useful for crisis resource management and rare critical scenarios and new research into the use of SBE using task simulation for procedural skill development has been done highlighting the benefits to subspecialty procedural training.SummaryMedical simulation h...
Source: Current Pain and Headache Reports - September 16, 2023 Category: Neurology Source Type: research

Balance and gait in individuals with diabetic peripheral neuropathy
CONCLUSIONS: The results of this study indicate that the individuals with DPN have an increased step width, their left single support line was shortened, and the maximum force on the heel decreased. The NP did not cause any change in balance and gait parameters.PMID:37712608 | DOI:10.1080/01616412.2023.2257445
Source: Neurological Research - September 15, 2023 Category: Neurology Authors: S üleyman Korkusuz B üşra Seçkinoğulları Zeliha Özlem Yürük Naime Ulu ğ Sibel Kibar Source Type: research

Understanding the potential causes of gastrointestinal dysfunctions in multiple system atrophy
Neurobiol Dis. 2023 Sep 13:106296. doi: 10.1016/j.nbd.2023.106296. Online ahead of print.ABSTRACTMultiple system atrophy (MSA) is a rare, progressive neurodegenerative disorder characterised by autonomic, pyramidal, parkinsonian and/or cerebellar dysfunction. Autonomic symptoms of MSA include deficits associated with the gastrointestinal (GI) system, such as difficulty swallowing, abdominal pain and bloating, nausea, delayed gastric emptying, and constipation. To date, studies assessing GI dysfunctions in MSA have primarily focused on alterations of the gut microbiome, however growing evidence indicates other structural co...
Source: Neurobiology of Disease - September 15, 2023 Category: Neurology Authors: Colin F Craig David I Finkelstein Rachel M McQuade Shanti Diwakarla Source Type: research

Balance and gait in individuals with diabetic peripheral neuropathy
CONCLUSIONS: The results of this study indicate that the individuals with DPN have an increased step width, their left single support line was shortened, and the maximum force on the heel decreased. The NP did not cause any change in balance and gait parameters.PMID:37712608 | DOI:10.1080/01616412.2023.2257445
Source: Neurological Research - September 15, 2023 Category: Neurology Authors: S üleyman Korkusuz B üşra Seçkinoğulları Zeliha Özlem Yürük Naime Ulu ğ Sibel Kibar Source Type: research

Mood instability and low back pain: a mendelian randomization study
ConclusionThis study provides robust evidence supporting a causal relationship between mood instability and the development of low back pain. Our findings suggest that addressing mood instability may play a crucial role in prevention and management strategies for individuals experiencing low back pain.
Source: Frontiers in Neurology - September 15, 2023 Category: Neurology Source Type: research

When Does Intervention End and Surgery Begin? The Role of Interventional Pain Management in the Treatment of Spine Pathology
AbstractPurpose of ReviewRecent advances in the field of interventional pain management (IPM) involve minimally invasive procedures such as percutaneous lumbar decompression, interspinous spacer placement, interspinous-interlaminar fusion and sacroiliac joint fusion. These developments have received pushback from surgical professional societies, who state spinal instrumentation and arthrodesis should only be performed by spine surgeons. The purpose of this review is to evaluate the validity of this claim. A literature search was conducted on Google Scholar and PubMed databases. Articles were included which examined IPM in ...
Source: Current Pain and Headache Reports - September 15, 2023 Category: Neurology Source Type: research

Low Uptake in Nondrug Treatment for Low Back Pain With OUD Low Uptake in Nondrug Treatment for Low Back Pain With OUD
For chronic low back pain comorbid with opioid abuse, physical therapy and chiropractic care are widely recommended, yet vastly underutilized, especially in racial and ethnic minority groups.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - September 14, 2023 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Phosphorylation of the AMPARs regulated by protein kinase C (PKC) and protein interacting with C-kinase 1 (PICK1) contribute to orofacial neuropathic pain
In conclusion, activation of PKC and PICK1 contribute to orofacial allodynia by regulating AMPAR phosphorylation in the TG of male mice, which provides potential therapeutic targets for alleviating orofacial neuropathic pain.PMID:37709161 | DOI:10.1016/j.brainres.2023.148578
Source: Brain Research - September 14, 2023 Category: Neurology Authors: Fei Liu Yu-Han Zhang Yan-Yan Zhang Jiu Lin Ya-Jing Liu Yue-Ling Li Zhong-Han Fang Hong-Lin Liao Hang Wang Jie-Fei Shen Source Type: research

Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report
Eperisone hydrochloride is a central muscle relaxant used to treat osteoporosis. Seizures are rare side effects of eperisone hydrochloride and have been previously reported in the medical literature in overdose situations but not at regular doses. This case report describes a 42-year-old male painter who developed severe bilateral tonic seizures after the initiation of eperisone hydrochloride at regular doses for low back pain. Symptoms gradually eased in the days following the discontinuation of eperisone hydrochloride and antiepileptic treatment, with no recurrence. This rare adverse drug reaction warrants clinical aware...
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research

Effect of acupuncture on BDNF signaling pathways in several nervous system diseases
In recent years, the understanding of the mechanisms of acupuncture in the treatment of neurological disorders has deepened, and considerable progress has been made in basic and clinical research on acupuncture, but the relationship between acupuncture treatment mechanisms and brain-derived neurotrophic factor (BDNF) has not yet been elucidated. A wealth of evidence has shown that acupuncture exhibits a dual regulatory function of activating or inhibiting different BDNF pathways. This review focuses on recent research advances on the effect of acupuncture on BDNF and downstream signaling pathways in several neurological di...
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research

rTMS targeted to the secondary somatosensory cortex influences sleep in CRPS patients, as measured with the OURA ring
ConclusionS2-targeted rTMS influenced sleep in patients with CRPS. Improved sleep may enhance CRPS symptom alleviation and be of clinical importance. A univariate analysis could separate the rTMS and sham treatments. The multivariate analysis revealed that including multiple sleep-related parameters can be beneficial when analyzing rTMS effects on sleep. As sleep is related both to pain and quality of life, and sleep rTMS can be directly affected by rTMS, objective monitoring of sleep in various future rTMS trials could be fruitful.
Source: Brain and Behavior - September 13, 2023 Category: Neurology Authors: Jukka Vanhanen, Jan Kujala, Mia Liljestr öm, Eija Kalso, Jussi Virkkala, Hanna Harno Tags: ORIGINAL ARTICLE Source Type: research

CT-guided paravertebral injection of doxorubicin for treatment of postherpetic neuralgia: a database-based retrospective stratified study
ConclusionCT-guided doxorubicin injection therapy has the potential to alleviate pain and enhance the quality of life in patients with PHN. Notably, the use of a 0.5% doxorubicin concentration yields more pronounced pain relief compared to a 0.33% concentration. While longer durations of PHN and specific affected sites may influence the response to treatment, the overall improvements in quality of life remain consistent.
Source: Frontiers in Neurology - September 12, 2023 Category: Neurology Source Type: research

Treatment of non-epileptic episodes of anxious, fearful behavior in adolescent juvenile neuronal ceroid lipofuscinosis (CLN3 disease)
DiscussionTheoretically, there are three points of attack how to prevent or treat the episodes: (1) increase in threshold of discomfort impact; (2) modulation of imbalance of central network inhibition and excitation, and (3) restoring the balance between the sympathetic and parasympathetic neural systems prompted by a parasympathetic withdrawal. As to (1) and (2), prevention should have the greatest priority. As regards (3), research of transcutaneous vagal stimulation treatment in JNCL is warranted.
Source: Frontiers in Neurology - September 12, 2023 Category: Neurology Source Type: research