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Total 29834 results found since Jan 2013.
Trajectory of blood pressure after initiating anti-calcitonin gene-related peptide treatment of migraine: a target trial emulation from the veterans health administration
ConclusionsOur findings suggest that anti-CGRP treatment is safe regarding blood pressure in patients without hypertension. However, for those with baseline hypertension, anti-CGRP treatment resulted in a small but persistent increase in the number of antihypertensives, indicating an exacerbation of hypertension. Future studies are needed to evaluate the cardio-cerebrovascular safety of anti-CGRP treatment beyond the first four years.
Source: The Journal of Headache and Pain - August 15, 2023 Category: Neurology Source Type: research
Local subcutaneous lidocaine injection for the treatment of complex regional pain syndrome: a case report and literature review
A 14-year-old child was diagnosed with complex regional pain syndrome (CRPS) after bromhidrosis surgery. She experienced a stinging, knife-like, and intermittent attack pain, accompanied by numbness of both upper limbs and limited movements. Ultrasound-guided radiofrequency surgery on the peripheral nerve did not reduce pain. Then, gabapentin 300 mg three times a day and 2% lidocaine by local subcutaneous injection once a day for 3 days were administrated. After the local subcutaneous injection of lidocaine, the pain was significantly relieved, and the pain induced by skin touch at the scar disappeared. No pain recurred af...
Source: Frontiers in Neurology - August 14, 2023 Category: Neurology Source Type: research
Correction: Changes of migraine aura with advancing age of patients
Source: The Journal of Headache and Pain - August 14, 2023 Category: Neurology Source Type: research
Low-Level Laser Therapy for Acute Pain: A Comprehensive Review
AbstractPurpose of ReviewAn analysis of data conducted in 2015 by the National Health Interview Survey (NHIS) found that an estimated 25.3 million adults (11.2%) have experienced pain every day for the preceding 3 months, and nearly 40 million adults (17.6%) have experienced a severe level of pain.Recent FindingsMultiple reviews have analyzed the current management of acute pain; however, much of the current literature only focuses on pharmacological methods of analgesia, such as opiates, ketamine, or non-steroidal anti-inflammatory drugs (NSAIDs). Publications that discuss non-pharmacological options often criticize the...
Source: Current Pain and Headache Reports - August 14, 2023 Category: Neurology Source Type: research
Utilization of Regional Anesthesia in the Electrophysiology Lab: A Narrative Review
AbstractPurpose of ReviewThe electrophysiology lab is an important source of growth of anesthetic volume as the indications and evidence for catheter ablations and various cardiac implantable electronic devices improve. Paired with this increase in volume is an increasing number of patients with substantial comorbid conditions presenting for their EP procedures. For these patients, the interaction between their comorbidities and traditional anesthesia practices may create the risk of hemodynamic instability, cardiovascular or respiratory complications, and potential need for prolonged post-operative monitoring negatively i...
Source: Current Pain and Headache Reports - August 12, 2023 Category: Neurology Source Type: research
Ketamine for Chronic Pain and Mental Health: Regulations, Legalities, and the Growth of Infusion Clinics
AbstractPurpose of ReviewIn this article, we will review evidence for ketamine ’s role in chronic pain and mental health conditions, its current legal status and abuse potential, and the regulations related to its administration in stand-alone infusion clinics, as well as future considerations.Recent FindingsIn the management of chronic pain, ketamine has shown potential to manage neuropathic pain and complex regional pain syndrome and has been used as a treatment for chronic pain management by clinics across the USA. Analogous to the historic rise of lidocaine clinics, ketamine clinics are demonstrating a similar patter...
Source: Current Pain and Headache Reports - August 12, 2023 Category: Neurology Source Type: research
Headache in Individuals with Neurodevelopmental Disorders
AbstractPurpose of ReviewMigraine is a common condition affecting an estimated billion people across the world. The incidence in individuals with neurodevelopmental disorders or intellectual disabilities like those seen in severe autism spectrum disorder (ASD) is unknown. This is likely due to the limited capacity to communicate the specifics of pain. The expression of pain with maladaptive behaviors, such as self-injurious behavior (SIB), has been described and can alert the clinician to the presence of untreated pain. This review article serves to educate the reader about clinical and treatment considerations when managi...
Source: Current Pain and Headache Reports - August 11, 2023 Category: Neurology Source Type: research
Hemicrania Continua: An Update
AbstractPurpose of ReviewHemicrania Continua (HC) is a rare and disabling primary headache disorder that is characterized by persistent, unilateral headache with ipsilateral, cranial autonomic symptoms and restlessness or agitation. The diagnosis requires patients to experience an absolute response to therapeutic doses of indomethacin.Recent FindingsHC is diagnosed in in about 1.8% of adult patients who were evaluated for headache in tertiary care services, albeit this estimate should be interpreted with caution. The most prevalent accompanying symptoms appear to be lacrimation, conjunctival injection and restlessness or a...
Source: Current Pain and Headache Reports - August 11, 2023 Category: Neurology Source Type: research
Pediatric hypnic headache: a systematic review
DiscussionFurther evaluation of the clinical features of HH in children is needed. The development of specific diagnostic criteria for pediatric cases could improve diagnostic rates and enhance the management of children with HH.
Source: Frontiers in Neurology - August 11, 2023 Category: Neurology Source Type: research
Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
ConclusionAdvances in human migraine research, including the use of functional imaging techniques lacking radiation or radio-isotope exposure, have led to an exciting opportunity to study the premonitory phase using repeated measures imaging designs. These studies have provided novel insights into attack initiation, migraine neurochemistry and therapeutic targets. Emerging migraine-specific therapies, such as those targeting calcitonin gene-related peptide (CGRP), are showing promise acutely when taken during premonitory phase to reduce symptoms and prevent subsequent headache. Therapeutic research in this area using PS fo...
Source: The Journal of Headache and Pain - August 11, 2023 Category: Neurology Source Type: research
Saffron and crocin ameliorate prenatal valproic acid-induced autistic-like behaviors and brain oxidative stress in the male offspring rats
This study aimed to determine the effects of saffron extract and crocin against brain oxidative stress and behavioral, motor, and cognitive deficits in an animal model of autism in male offspring rats. 14 female rats were randomly divided into the saline and valproic acid (VPA) groups. Then, they were placed with mature male rats to mate and produce offspring. VPA (500 mg/kg, i.p.) was injected on day 12.5 of pregnancy (gestational day, GD 12.5) to induce an experimental model of autism. 48 male pups were left undisturbed for 29 days. First-round behavioral tests (before treatments) were performed on 30–33 post-natal ...
Source: Metabolic Brain Disease - August 11, 2023 Category: Neurology Source Type: research
Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats
AbstractMechanical sensing Piezo2 channel in primary sensory neurons has been shown contribute to mechanical allodynia in somatic chronic pain conditions. Interstitial cystitis (IC)-associated pain is often triggered by bladder filling, a presentation that mimics the mechanical allodynia. In the present study, we aimed to examine the involvement of sensory Piezo2 channel in IC-associated mechanical allodynia using a commonly employed cyclophosphamide (CYP)-induced IC model rat. Piezo2 channels in dorsal root ganglia (DRGs) was knocked down by intrathecal injections of Piezo2 anti-sense oligodeoxynucleotides (ODNs) in CYP-i...
Source: Molecular Neurobiology - August 10, 2023 Category: Neurology Source Type: research
Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition
This study aimed to assess the efficacy of ethanolic extract ofSolanum torvum L. fruit (EESTF) containing solasodine in treating chronic constriction injury (CCI) –induced neuropathic pain in rats. Three-dimensional (3D) simulation studies of solasodine binding were conducted on the TRPV1 receptor, IL-6, and TNF-α structures. For in vivo justification, an assessment of behavioral, biochemical, and histological changes was designed after a CCI-induced neuro pathic pain model in rats. On days 7, 14, and 21, CCI significantly increased mechanical, thermal, and cold allodynia while producing a functional deficit. IL-6, TNF-...
Source: Molecular Neurobiology - August 10, 2023 Category: Neurology Source Type: research
Complain like you mean it! How prosody conveys suffering even about innocuous events
Brain Lang. 2023 Aug 8;244:105305. doi: 10.1016/j.bandl.2023.105305. Online ahead of print.ABSTRACTWhen complaining, speakers can use their voice to convey a feeling of pain, even when describing innocuous events. Rapid detection of emotive and identity features of the voice may constrain how the semantic content of complaints is processed, as indexed by N400 and P600 effects evoked by the final, pain-related word. Twenty-six participants listened to statements describing painful and innocuous events expressed in a neutral or complaining voice, produced by ingroup and outgroup accented speakers. Participants evaluated how ...
Source: Brain and Language - August 10, 2023 Category: Neurology Authors: Ma ël Mauchand Marc D Pell Source Type: research
