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Specialty: Biochemistry
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Total 112299 results found since Jan 2013.
Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2022 Dec 25;54(12):1-11. doi: 10.3724/abbs.2022179.ABSTRACTThe large-conductance calcium-activated potassium (BK) channel is a critical regulator and potential therapeutic target of vascular tone and architecture, and abnormal expression or dysfunction of this channel is linked to many vascular diseases. Vascular remodelling is the early pathological basis of severe vascular diseases. Delaying the progression of vascular remodelling can reduce cardiovascular events, but the pathogenesis remains unclear. To clarify the role of BK channels in vascular remodelling, we use rats with BK chan...
Source: Acta Biochimica et Biophysica Sinica - December 14, 2022 Category: Biochemistry Authors: Jing Bi Yanru Duan Meili Wang Chunyu He Xiaoyue Li Xi Zhang Yan Tao Yunhui Du Huirong Liu Source Type: research
miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells
In this study, the role and mechanism of miR-339-3p in AT1-AA-induced vascular inflammation are studied. RT-PCR detection shows that the miR-339-3p levels in the thoracic aorta and serum exosomes of AT1-AA-positive rats are significantly increased. The miRwalk database predicts the mRNAs that miR-339-3p can bind to their 5'UTR. Subsequently, it is found that the number of genes contained in the T cell receptor pathway is high through KEGG analysis, and NFATc3 among them can promote the secretion of various inflammatory cytokines. AT1-AA-induced upregulation of miR-339-3p expression in vascular smooth muscle cells (VSMCs) c...
Source: Acta Biochimica et Biophysica Sinica - February 24, 2023 Category: Biochemistry Authors: Yang Li Yaolin Long Xiaoyan Zhi Haihu Hao Xiaohui Wang Huirong Liu Li Wang Source Type: research
ReCom: A semi-supervised approach to ultra-tolerant database search for improved identification of modified peptides
We present a proof-of-concept study using Comet-ReCom, an improved version of Comet-PTM. Comet-ReCom increased identification performance of Comet-PTM by 68%. This increased performance of Comet-ReCom to score the MS/MS spectrum comes in parallel with a significantly better assignation of the monoisotopic peak of the precursor peptide in the MS spectrum, even in cases of peptide coelution. Our data demonstrate that open searches using ultra-tolerant mass windows can benefit from using a semi-supervised approach that takes advantage from previous knowledge on the nature of protein modifications. SIGNIFICANCE: The present st...
Source: Journal of Proteomics - July 18, 2023 Category: Biochemistry Authors: Andrea Laguillo-G ómez Enrique Calvo Noa Mart ín-Cófreces Marta Lozano-Prieto Francisco S ánchez-Madrid Jes ús Vázquez Source Type: research
Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1 α signaling
In this study, we explore the effect of cocaine on the proliferation of vascular smooth muscle cells by in vitro experiments. The findings indicated that the cocaine-induced vascular smooth muscle cell hyperproliferation is achieved by enhancing DRP1-mediated mitochondrial fission and activating PI3K/HIF-1α signaling. Current findings suggested that mitochondrial fission would play a pivotal role in cocaine-related vascular remodeling and would be helpful in understanding the vascular toxicity of cocaine.PMID:37481940 | DOI:10.1016/j.bbrc.2023.07.020
Source: Biochemical and Biophysical Research communications - July 23, 2023 Category: Biochemistry Authors: Shuheng Wen Kana Unuma Takeshi Funakoshi Toshihiko Aki Koichi Uemura Source Type: research
