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Specialty: Neurology
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Total 29834 results found since Jan 2013.
Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
AbstractIn individuals with chronic neuropathic pain, the posterior insular cortex (PIC) has been found to exhibit increased glutamatergic activity, and the dysgranular portion of PIC (DPIC) has been investigated as a novel cortical target for pain modulation. However, the role of DPIC glutamatergic neurons (DPICg) in trigeminal neuropathic pain (TNP) remains unclear. Here, we examined the outcomes of DPICg inhibition in a rat model of chronic constriction injury of the infraorbital nerve (CCI-ION). Animals were randomly divided into TNP, sham, and control groups. TNP animals underwent CCI-ION surgery. Either optogenetic o...
Source: NeuroMolecular Medicine - September 12, 2023 Category: Neurology Source Type: research
Enhancing European Management of Analgesia, Sedation, and Delirium: A Multinational, Prospective, Interventional Before-After Trial
ConclusionsIn routine care, many patients were not assessed for PAD. Assessment rates increased significantly 1 year after the intervention.Clinical trial registration ClinicalTrials.gov: NCT03553719.
Source: Neurocritical Care - September 11, 2023 Category: Neurology Source Type: research
Mode and site of action of therapies targeting CGRP signaling
AbstractTargeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and ra...
Source: The Journal of Headache and Pain - September 11, 2023 Category: Neurology Source Type: research
Spontaneous Intracranial Hypotension in Pregnancy
AbstractPurpose of ReviewSpontaneous intracranial hypotension (SIH) is a debilitating disease typically featuring orthostatic headache and caused by a spinal CSF leak. This review will describe the characteristics of SIH in pregnant patients and the associated unique management and treatment considerations.Recent FindingsHerein, a novel case is reported of a 41-year-old woman who presented with SIH pre-conception but saw marked improvement of symptoms after 5 weeks antepartum and symptom recurrence 2 months post-partum. A literature review of SIH in pregnancy revealed 14 reported patients across 10 studies since 2000. A...
Source: Current Pain and Headache Reports - September 9, 2023 Category: Neurology Source Type: research
The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research
Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex
Brain Behav Immun. 2023 Sep 6:S0889-1591(23)00267-2. doi: 10.1016/j.bbi.2023.09.003. Online ahead of print.ABSTRACTRecent translational work has shown that fibromyalgia (FM) might be an autoimmune condition with pathogenic mechanisms mediated by a peripheral, pain-inducing action of IgG antibodies binding to satellite glia cells (SGC) in the dorsal root ganglia (DRG). A first clinical assessment of the postulated autoimmunity showed that fibromyalgia subjects (FMS) had elevated levels of antibodies against SGC (termed anti-SGC IgG) compared to healthy controls and that anti-SGC IgG were associated with a more severe diseas...
Source: Brain, Behavior, and Immunity - September 8, 2023 Category: Neurology Authors: Silvia Fanton Joana Menezes Emerson Krock Angelica Sandstr öm Jeanette Tour Katalin Sandor Alexandra Jurczak Matthew Hunt Azar Baharpoor Diana Kadetoff Karin B Jensen Peter Fransson Isabel Ellerbrock Rouslan Sitnikov Camilla I Svensson Eva Kosek Source Type: research
The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish
Neurotoxicology. 2023 Sep 6:S0161-813X(23)00111-0. doi: 10.1016/j.neuro.2023.09.004. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease caused by the degeneration of dopaminergic neurons and the accumulation of Lewy bodies. Pain is one of the most common non-motor symptoms in PD, but the molecular mechanism of pain in PD is not fully understood, which prevents early diagnosis of PD. We aimed to determine the changes in opioidergic pathways when external pain is inflicted by inducing pain intraperitoneally in zebrafish, for which we generated a rotenone-induced PD mode...
Source: Neurotoxicology - September 8, 2023 Category: Neurology Authors: Derya Cansiz Ismail Unal Merih Beler Unsal Veli Ustundag Esin Ak Ebru Emekli-Alturfan Ahmet Ata Alturfan Source Type: research
Investigating the relationship between sleep and migraine in a global sample: a Bayesian cross-sectional approach
ConclusionsSleep fragmentation and deviation from typical sleep are the main drivers of the relationship between sleep and migraine. Having a migraine attack does not predict sleep duration, yet the pain associated with it does. This study highlights sleep as crucial in migraine management.
Source: The Journal of Headache and Pain - September 8, 2023 Category: Neurology Source Type: research
Transcriptome Profiling of miRNA-mRNA Interactions and Associated Mechanisms in Chemotherapy-Induced Neuropathic Pain
AbstractChemotherapy-induced neuropathic pain (CINP) is a dose-limiting adverse event affecting 40% of chemotherapy patients. MiRNA-mRNA interaction plays an important role in various processes. However, detailed profiling of miRNA-mRNA interactions in CINP remains unclear. Here, a rat-based CINP model was established using paclitaxel, followed by nociceptive behavioral tests related to mechanical allodynia, thermal hyperalgesia, and cold allodynia. The landscape of miRNA-mRNA interaction in the spinal dorsal horn was investigated through mRNA transcriptomics and small RNA sequencing. Under CINP condition, 86 differentiall...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research
Glutamatergic Neurons in the Zona Incerta Modulate Pain and Itch Behaviors in Mice
AbstractEmerging evidence suggest that parvalbumin neurons in zona incerta (ZI) modulate pain and itch behavior in opposite manners. However, the role of ZI glutamatergic neurons, a unique incertal neuronal subpopulation residing in the caudal division, in pain and itch modulation remains unknown. In the present study, by combining chemogenetic manipulation, fiber photometry, and behavioral tests, we proved that incertal glutamatergic neurons served as an endogenous negative diencephalic modulator for both pain and itch processing. We demonstrated that ZI vesicular glutamate transporter 2 (VGluT2) neurons exhibited increas...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research
Aesthetic transaxillary subpectoral placement of vagus nerve stimulator in children and young adults: A technical note
CONCLUSION: The transaxillary subpectoral placement of theVNS generator is an aesthetic and anatomic approach, which provides several benefits to children and young adults.PMID:37677901 | DOI:10.1016/j.yebeh.2023.109419
Source: Epilepsy and Behaviour - September 7, 2023 Category: Neurology Authors: Giulia Melinda Furlanis Francesco Fascetti Leon Nicola Bresolin Jacopo Favaro Valentina Baro Alberto D'Amico Luca Denaro Stefano Sartori Andrea Landi Source Type: research
Patterns and predictors of sexual dysfunction in women with epilepsy
CONCLUSION: The pattern of sexual dysfunction among Egyptian WWE is characterized by reduced sexual desire, arousal deficits, and sexual-related pain. Seizure frequency, epilepsy duration, enzyme-inducing medications, and multiple anti-seizure medications (ASMs) may adversely affect WWE's sexual health. The only factor that could predict higher sexual dysfunction in WWE was higher seizure frequency.PMID:37677900 | DOI:10.1016/j.yebeh.2023.109421
Source: Epilepsy and Behaviour - September 7, 2023 Category: Neurology Authors: Salsabil Abo Al-Azayem Nirmeen A Kishk Reham Shamloul Abeer Attia Radwa M Elsayed Rehab Magdy Source Type: research
Acute angle closure glaucoma misdiagnosed as sinusitis
Pract Neurol. 2023 Sep 7:pn-2023-003864. doi: 10.1136/pn-2023-003864. Online ahead of print.ABSTRACTA 69-year-old woman developed severe right suprabulbar pain with blurred right-sided vision. There were no haloes around lights, photophobia, nausea or vomiting. Investigations in the emergency department excluded a posterior communicating/internal carotid artery aneurysm. However, she did not have an ophthalmological assessment and the initial diagnosis was of sinusitis-related headache. An urgent ear, nose and throat assessment found no abnormality, but a local ophthalmologist subsequently diagnosed and managed the patient...
Source: Practical Neurology - September 7, 2023 Category: Neurology Authors: Natalie Si-Yi Lee Thomas L Woo Ashish Agar Ian C Francis Source Type: research
