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Procedure: Gastroschisis Repair
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Relationship between the Arthroscopic Findings and Pathology of Greater Trochanteric Pain Syndrome
Acta Med Okayama. 2023 Aug;77(4):371-375. doi: 10.18926/AMO/65746.ABSTRACTIn recent publications on greater trochanteric pain syndrome (GTPS), the pathology receiving the most attention has been gluteus medius muscle tendinous injury, and surgical techniques such as gluteus medius tendon repair and their outcomes for GTPS have been reported. In our department-related facilities, arthroscopic surgeries are routinely performed for the patients with recalcitrant GTPS. A total of 51 patients were diagnosed with GTPS. Surgical treatment was carried out 22 patients (24 joints; 4 males and 18 females; mean age at surgery of 52.0 ...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Yosuke Iwamoto Mitsunori Kaya Hiroaki Kijima Masashi Fujii Itsuki Nagahata Naohisa Miyakoshi Source Type: research
Triazolothiadiazine derivative positively modulates CXCR4 signaling and improves diabetic wound healing
We report here, the discovery of a second chemical agonist scaffold demonstrating increased agonist potency and represented by thiadiazine derivative, UCUF-965. UCUF-965 is a potent partial agonist of β-arrestin recruitment in CXCR4 receptor overexpressing cell line. Furthermore, UCUF-965 potentiates the CXCL12 maximal response in cAMP signaling pathway, activates CXCL12 stimulated migration in lymphoblast cells and modulates the levels of specific microRNA involved in the complex wound repair process, specifically in mouse fibroblasts. Our results indicate that UCUF-965 acts as a PAM agonist of the CXCR4 receptor. Furthe...
Source: Biochemical Pharmacology - August 27, 2023 Category: Drugs & Pharmacology Authors: Satyamaheshwar Peddibhotla Karly Caples Alka Mehta Qi-Yin Chen Junyi Hu Shaquia Idlett-Ali Liping Zhang Carlos Zgheib Junwang Xu Kenneth W Liechty Siobhan Malany Source Type: research
Relationship between the Arthroscopic Findings and Pathology of Greater Trochanteric Pain Syndrome
Acta Med Okayama. 2023 Aug;77(4):371-375. doi: 10.18926/AMO/65746.ABSTRACTIn recent publications on greater trochanteric pain syndrome (GTPS), the pathology receiving the most attention has been gluteus medius muscle tendinous injury, and surgical techniques such as gluteus medius tendon repair and their outcomes for GTPS have been reported. In our department-related facilities, arthroscopic surgeries are routinely performed for the patients with recalcitrant GTPS. A total of 51 patients were diagnosed with GTPS. Surgical treatment was carried out 22 patients (24 joints; 4 males and 18 females; mean age at surgery of 52.0 ...
Source: Acta Medica Okayama - August 27, 2023 Category: General Medicine Authors: Yosuke Iwamoto Mitsunori Kaya Hiroaki Kijima Masashi Fujii Itsuki Nagahata Naohisa Miyakoshi Source Type: research
Triazolothiadiazine derivative positively modulates CXCR4 signaling and improves diabetic wound healing
We report here, the discovery of a second chemical agonist scaffold demonstrating increased agonist potency and represented by thiadiazine derivative, UCUF-965. UCUF-965 is a potent partial agonist of β-arrestin recruitment in CXCR4 receptor overexpressing cell line. Furthermore, UCUF-965 potentiates the CXCL12 maximal response in cAMP signaling pathway, activates CXCL12 stimulated migration in lymphoblast cells and modulates the levels of specific microRNA involved in the complex wound repair process, specifically in mouse fibroblasts. Our results indicate that UCUF-965 acts as a PAM agonist of the CXCR4 receptor. Furthe...
Source: Biochemical Pharmacology - August 27, 2023 Category: Drugs & Pharmacology Authors: Satyamaheshwar Peddibhotla Karly Caples Alka Mehta Qi-Yin Chen Junyi Hu Shaquia Idlett-Ali Liping Zhang Carlos Zgheib Junwang Xu Kenneth W Liechty Siobhan Malany Source Type: research
