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Therapy: Stem Cell Therapy
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Total 60732 results found since Jan 2013.
Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells: Methods, Applications, and Considerations
Circ Res. 2021 Mar 5;128(5):670-686. doi: 10.1161/CIRCRESAHA.120.318049. Epub 2021 Mar 4.ABSTRACTThe developmental origin of vascular smooth muscle cells (VSMCs) has been increasingly recognized as a major determinant for regional susceptibility or resistance to vascular diseases. As a human material-based complement to animal models and human primary cultures, patient induced pluripotent stem cell iPSC-derived VSMCs have been leveraged to conduct basic research and develop therapeutic applications in vascular diseases. However, iPSC-VSMCs (induced pluripotent stem cell VSMCs) derived by most existing induction protocols a...
Source: Circulation Research - April 5, 2021 Category: Cardiology Authors: Mengcheng Shen Thomas Quertermous Michael P Fischbein Joseph C Wu Source Type: research
Extracellular Vesicle Mediated Vascular Pathology in Glioblastoma
Subcell Biochem. 2021;97:247-273. doi: 10.1007/978-3-030-67171-6_10.ABSTRACTGlioblastoma (GBM) is an incurable, infiltrative high-grade brain tumour associated with dramatic vascular responses observed both locally (angiogenesis, vascular cooption, angiocrine effects, microthrombosis) and systemically (venous thromboembolism). GBM-associated vascular pathology is diagnostically relevant and constitutes a source of morbidity, mortality and progressive changes in tumour biology. Extracellular vesicles (EVs) have emerged as unique mediators of vascular effects in brain tumours acting as vehicles for intercellular transfer of ...
Source: Sub-Cellular Biochemistry - March 29, 2021 Category: Biochemistry Authors: Cristiana Spinelli Nadim Tawil Lata Adnani Janusz Rak Dongsic Choi Source Type: research
