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Gates Foundation gives $15M to combat sleeping sicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Bill & Melinda Gates Foundation is giving $15 million to the Drugs for Neglected Diseases initiative to treat human African trypanosomiasis, also known as sleeping sickness. (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - November 20, 2009 Category: American Health Source Type: journals

Gates Foundation gives $15M to combat sleeping sicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Bill & Melinda Gates Foundation is giving $15 million to the Drugs for Neglected Diseases initiative to treat human African trypanosomiasis, also known as sleeping sickness. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 20, 2009 Category: Biotechnology Source Type: journals

Pfizer, DNDi Partner To Identify NTD Drugs; Sanofi-Aventis, Medicines For Malaria Launch Drug StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pfizer and the Drugs for Neglected Diseases Initiative (DNDi) on Wednesday announced plans to team up in an effort to identify new drug candidates for the treatment of three tropical diseases, the Associated Press/Business Week reports. The scientists will test the efficacy of Pfizer drug candidates against sleeping sickness, visceral leishmaniasis, and Chagas disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

Pfizer, DNDi Partner To Identify NTD Drugs; Sanofi-Aventis, Medicines For Malaria Launch Drug StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pfizer and the Drugs for Neglected Diseases Initiative (DNDi) on Wednesday announced plans to team up in an effort to identify new drug candidates for the treatment of three tropical diseases, the Associated Press/Business Week reports. The scientists will test the efficacy of Pfizer drug candidates against sleeping sickness, visceral leishmaniasis, and Chagas disease. (Source: Tropical Diseases News From Medical News Today)
Source: Tropical Diseases News From Medical News Today - November 20, 2009 Category: Tropical Medicine Tags: Tropical Diseases Source Type: news

Also In Global Health News: Sleeping Sickness; Aid For Philippines; U.S., China In Africa; Polio Eradication In Afghanistan; Ethiopia FamineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lancet Infectious Diseases Examines Hold-Ups In Implementation Of Sleeping Sickness Therapy Lancet Infectious Diseases Newsdesk examines how despite evidence that a new therapy to treat sleeping sickness, called nifurtimox-eflornithine (NECT) is a step forward in treating the (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

Also In Global Health News: Sleeping Sickness; Aid For Philippines; U.S., China In Africa; Polio Eradication In Afghanistan; Ethiopia FamineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lancet Infectious Diseases Examines Hold-Ups In Implementation Of Sleeping Sickness Therapy (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Tropical Diseases Source Type: news

Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks [Biophysics_And_Computational_Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Trypanosoma brucei, a parasitic protist with a single flagellum, is the causative agent of African sleeping sickness. Propulsion of T.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 17, 2009 Category: Science Authors: Rodriguez, J. A., Lopez, M. A., Thayer, M. C., Zhao, Y., Oberholzer, M., Chang, D. D., Kisalu, N. K., Penichet, M. L., Helguera, G., Bruinsma, R., Hill, K. L., Miao, J. Tags: Biophysics_And_Computational_Biology Source Type: journals

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the LeishmaniasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 16, 2009 Category: Chemistry Tags: article Source Type: journals

[Newsdesk] New treatment for sleeping sickness still not implementedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A major advance in the treatment of sleeping sickness is still awaiting implementation 13 months after data from a successful trial was presented. Kits of the combination treatment nifurtimox–eflornithine (NECT) are sitting in a Médecins Sans Frontières (MSF) warehouse pending the resolution of legal barriers to their use. Experts are optimistic that NECT will be a major advance in the fight against sleeping sickness but are warning against complacency over the disease—in particular, the belief that sleeping sickness might be soon eradicated. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - November 16, 2009 Category: Infectious Diseases Authors: Kelly Morris Tags: Newsdesk Source Type: journals

Identification of a Parasitic Immunomodulatory Protein Triggering the Development of Suppressive M1 Macrophages during African TrypanosomiasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the identification of a novel putative Trypanosoma brucei M1 cell–triggering protein. The recombinant trypanosome‐suppressive immunomodulating factor (rTSIF) induced TNF and NO secretion by macrophages. Moreover, M1 cells triggered by rTSIF block T cell proliferation in a manner dependent on NO, interferon γ, and cell contact. Furthermore, rTSIF could down‐regulate type 2–oriented immune responses. Therefore, trypanosome‐suppressive immunomodulating factor (TSIF) may represent a new parasite molecule with the potential to modulate the host immune network, whereby it could contribute to the inflammatory...
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

A luciferase based viability assay for ATP detection in 384- well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Due to the reproducibility and sensitivity of this assay it is recommended for potential HTS application. As it is commercially available this assay can also be utilised in many laboratories for both large and small scale screening. (Source: Parasites and Vectors)
Source: Parasites and Vectors - November 12, 2009 Category: Microbiology Authors: Melissa SykesVicky Avery Source Type: journals

Three Redox States of Trypanosoma brucei Alternative Oxidase Identified by Infrared Spectroscopy and Electrochemistry [Metabolism and Bioenergetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Electrochemistry coupled with Fourier transform infrared (IR) spectroscopy was used to investigate the redox properties of recombinant alternative ubiquinol oxidase from Trypanosoma brucei, the organism responsible for African sleeping sickness. Stepwise reduction of the fully oxidized resting state of recombinant alternative ubiquinol oxidase revealed two distinct IR redox difference spectra. The first of these, signal 1, titrates in the reductive direction as an n = 2 Nernstian component with an apparent midpoint potential of 80 mV at pH 7.0. However, reoxidation of signal 1 in the same potential range under anaerobic co...
Source: Journal of Biological Chemistry - November 6, 2009 Category: Chemistry Authors: Marechal, A., Kido, Y., Kita, K., Moore, A. L., Rich, P. R. Tags: Metabolism and Bioenergetics Source Type: journals

Uganda: Nation Unveils Plan to Eliminate Tsetse FliesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WAILS cut through the darkness blanketing the eastern Uganda district of Mayuge. Moments later a vehicle roves through the village's bumpy and narrow tracks. It has just returned Sam Ikoba's body. Ikoba succumbed to sleeping sickness. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 2, 2009 Category: African Health Source Type: news

Improved Treatment For Sleeping Sickness Now AvailableEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NECT (Nifurtimox-Eflornithine Combination Therapy), the first new treatment in 25 years against Human African trypanosomiasis (HAT) or sleeping sickness, is now available. Endemic countries have now begun the process of ordering the new combination treatment and kits through the World Health Organization (WHO). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 1, 2009 Category: Consumer Health News Tags: Sleep / Sleep Disorders / Insomnia Source Type: news

East African trypanosomiasis in a pregnant traveler.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19891893 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Nadjm B, Van Tulleken C, Macdonald D, Chiodini PL Tags: Emerg Infect Dis Source Type: journals

Trypanocidal drugs: mechanisms, resistance and new targetsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review ArticlesShane R. Wilkinson, John M. Kelly, Expert Reviews in Molecular Medicine, Volume 11 , pp e31AbstractThe protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating infections that exert a considerable health burden on some of the poorest people on the planet. Treatment of trypanosome infections is dependent on a small number of drugs that have limited efficacy and can cause severe side effects. Here, we review the properties of these drugs and describe new findings on their modes of action and the mec...
Source: Expert Reviews in Molecular Medicine - October 30, 2009 Category: Molecular Biology Source Type: journals

Switched off: sleeping sickness in conflictEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deaths from treatable diseases such as sleeping sickness are rising due to renewed conflict and aid agencies need to be vigilant once they have save access to the population (Source: MSF News)
Source: MSF News - October 30, 2009 Category: Global & Universal Source Type: organizations

Six months later in the Congo: how many are dead?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
How many people have died unnecessarily because their sleeping sickness has not been diagnosed or treated due to the violent conflict in DRC? (Source: MSF News)
Source: MSF News - October 30, 2009 Category: Global & Universal Source Type: organizations

Sleeping sickness: advances in treatment put to the testEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New drug treatment offers hope for people infected with human African tripanosomiasis, but only if the affected regions can be made secure enough to allow healthcare workers access to the population. (Source: MSF News)
Source: MSF News - October 30, 2009 Category: Global & Universal Source Type: organizations

[Video] NECT: An Improved Therapy for Sleeping SicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
.videoItem { margin:0 auto; } .videoItem div { width:550px; height:309px; } Sleeping sickness is a major health problem in the Democratic Republic of Congo. With existing medicines either cumbersome to administer or a cause of intense side effects, a new and cheaper therapy, NECT, holds great promise of benefiting thousands of vulnerable patients. (Source: MSF Multimedia)
Source: MSF Multimedia - October 29, 2009 Category: Global & Universal Source Type: organizations

Tripartite Interactions between Tsetse Flies, Sodalisglossinidius and Trypanosomes - An Epidemiological Approach in Two Historical Human African Trypanosomiasis Foci in Cameroon.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epidemiological surveys were conducted in two historical human African trypanosomiasis foci in South Cameroon, Bipindi and Campo. In each focus, three sampling areas were defined. In Bipindi, only Glossina palpalis was identified, whereas four species were identified in Campo, G. palpalis being highly predominant (93%). For further analyses, 75 flies were randomly chosen among the flies trapped in each of the six villages. Large and statistically significant differences were recorded between both (1) the prevalence of Sodalis glossinidius (tsetse symbiont) and the prevalence of trypanosome infection of the major fly sp...
Source: Infection, Genetics and Evolution - October 28, 2009 Category: Genetics & Stem Cells Authors: Farikou O, Njiokou F, Mbida JA, Njitchouang GR, Djeunga HN, Asonganyi T, Simarro PP, Cuny G, Geiger A Tags: Infect Genet Evol Source Type: journals

Improved Treatment for Sleeping Sickness Now AvailableEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Geneva/Kampala, September 22, 2009 - NECT (Nifurtimox-Eflornithine Combination Therapy), the first new treatment in 25 years against Human African trypanosomiasis (HAT) or sleeping sickness, is now available. Endemic countries have now begun the process of ordering the new combination treatment and kits through the World Health Organization (WHO). Developed by DNDi and its partners, NECT cuts the cost of treatment by half and significantly reduces the burden on health workers. The announcement was made today at the International Scientific Council for Trypanosomiasi Research and Control (ISCTRC), in Kampala, Uganda. &ldquo...
Source: MSF News - October 26, 2009 Category: Global & Universal Source Type: organizations

Widespread variation in transcript abundance within and across developmental stages of Trypanosoma bruceiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite the lack of gene regulation at the level of transcription initiation, our results reveal extensive regulation of mRNA abundance associated with different life cycle and growth stages. In addition, analysis of variant surface glycoprotein gene expression reveals a more complex picture than previously thought. These data provide a valuable resource to the community of researchers studying this lethal agent. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - October 18, 2009 Category: Genetics & Stem Cells Authors: Bryan JensenDhileep SivamCharles KiferPeter MylerMarilyn Parsons Source Type: journals

Expression and Role of CXCL10 during the Encephalitic Stage of Experimental and Clinical African TrypanosomiasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. IFN‐γ–dependent CXCL10 is critical for accumulation of T cells and trypanosomes in the brain during experimental African trypanosomiasis. Data suggest CXCL10 as a candidate marker for late stage human African trypanosomiasis . (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - October 14, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

African trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Microbiology , October 2009, Vol. 4, No. 8, Pages 1075-1087. (Source: Future Microbiology)
Source: Future Microbiology - October 13, 2009 Category: Cardiology Tags: article Source Type: journals

Sub-Saharan Africa news in brief: 24 September–7 October 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Africa defeating sleeping sickness, Kenyan research gets financial boost, African leaders plan alliance for malaria control, and more. (Source: SciDev.Net)
Source: SciDev.Net - October 7, 2009 Category: Global & Universal Source Type: info

Cerebrospinal fluid B lymphocyte identification for diagnosis and follow-up in human African trypanosomiasis in the fieldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion B cell rosettes being easily detected in the CSF in field conditions may be proposed to replace white cell count for defining HAT stages 1 and 2 and limit uncertainty in treatment decision in patients with intermediate stage. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - October 4, 2009 Category: Tropical Medicine Authors: Bernard Bouteille, Ghislain Mpandzou, Raymond Cespuglio, Stéphane Ngampo, Rosanna W. Peeling, Philippe Vincendeau, Alain Buguet Source Type: journals

Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is an urgent need for new compounds for the drug development pipeline for treatment of patients with African sleeping sickness. One approach for identifying such compounds is by high throughput screening (HTS) of compound collections. For time and cost considerations, there is a need for the development of an assay that uses at least 384-well formats. To our knowledge, there are currently no viability assays for whole cell screening of trypanosomes in the 384-well plate format. We have developed and optimized an Alamar Blue viability assay in a 384-well format for Trypanosoma brucei brucei bloodstream form strain...
Source: The American Journal of Tropical Medicine and Hygiene - September 30, 2009 Category: Tropical Medicine Authors: Sykes ML, Avery VM Tags: Am J Trop Med Hyg Source Type: journals

Africa: New Treatment for Sleeping SicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients at an advanced stage of Human African Trypanosomiasis, or sleeping sickness, can now access more convenient, safer and cheaper treatment after the introduction of Nifurtimox-Eflornithine Combination Therapy (NECT). (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 30, 2009 Category: African Health Source Type: news

First isolation of Enterobacter, Enterococcus, and Acinetobacter spp. as inhabitants of the tsetse fly (Glossina palpalis palpalis) midgut.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper reports the first evidence of the presence of bacteria, other than the three previously described as symbionts, Wigglesworthia glossinidia, Wolbachia, and Sodalis glossinidius, in the midgut of Glossina palpalis palpalis, the tsetse fly, a vector of the chronic form of human African trypanosomiasis in sub-Saharan African countries. Based on morphological, nutritional, physiological, and phylogenetic results, we identified Enterobacter, Enterococcus, and Acinetobacter spp. as inhabitants of the midgut of the tsetse fly. Enterobacter spp. was the most frequently isolated. The role of these bacteria in the gut,...
Source: Infection, Genetics and Evolution - September 28, 2009 Category: Genetics & Stem Cells Authors: Geiger A, Fardeau ML, Grebaut P, Vatunga G, Josénando T, Herder S, Cuny G, Truc P, Ollivier B Tags: Infect Genet Evol Source Type: journals

Uganda: WHO Brings Life to Sleeping Sickness VictimsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The World Health Organisation and the Drugs for Neglected Diseases Initiative (DNDi) will extend a life line to several victims of sleeping sickness across Africa with plans of producing two drugs to treat the disease in its late stages. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 24, 2009 Category: African Health Source Type: news

Also In Global Health News: Combating Sleeping Sickness In Eastern Africa; China Commits To Developing Countries; Latin America DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
African Development Bank Gives $70M To Help Fight Sleeping Sickness In Eastern Africa The African Development Bank on Tuesday announced it will award eastern African countries $70 million to help fight the neglected tropical disease, trypanasomiasis, commonly known as sleeping sickness, over six years, the Monitor/allAfrica.com reports (Pacutho, 9/22). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 23, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

Uganda: New Drug for Treating Sleeping Sickness LaunchedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After 25 years of waiting and research, a new and improved drug for the treatment of sleeping sickness has been launched in Kampala. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 22, 2009 Category: African Health Source Type: news

East Africa: Region Gets Money to Fight Sleeping SicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eastern African countries have received $70 million from the African Development Bank to fight trypanasomiasis, commonly known as sleeping sickness. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 22, 2009 Category: African Health Source Type: news

[Newsdesk] Is the end in sight for sleeping sickness in Africa?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reports at the International Scientific Council for Trypanosomiasis Research and Control (ISCTRC) biennial scientific conference (Kampala, Uganda, September 21–25, 2009) will indicate that Africa is winning its battle against sleeping sickness. Aerial spraying and localised use of insecticides has eradicated the tsetse fly that carries Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense from 36 000 km2 of land across Botswana, Namibia, Angola, and Zambia. “Plans are in place to progressively tackle further areas, and we expect tsetse eradication to be achieved in the entire Kwando-Zambezi tsetse belt by 20...
Source: The Lancet Infectious Diseases - September 21, 2009 Category: Infectious Diseases Authors: Kathryn Senior Tags: Newsdesk Source Type: journals

Imported human African trypanosomiasis in Europe, 2005-2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Physicians in Europe are likely to see more African trypanosomiasis cases because of the increasing popularity of travel to Africa. In this paper the literature on imported cases in Europe, since 2005 is reviewed. Because of the high mortality risk associated with acute Rhodesian trypanosomiasis, travellers should be informed about preventive measures and the early disease manifestations. PMID: 19758542 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - September 19, 2009 Category: Infectious Diseases Authors: Gautret P, Clerinx J, Caumes E, Simon F, Jensenius M, Loutan L, Schlagenhauf P, Castelli F, Freedman D, Miller A, Bronner U, Parola P Tags: Euro Surveill Source Type: journals

Uganda: 10 Million At Risk of Sleeping SicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ABOUT 10 million people are at the risk of getting sleeping sickness, the agriculture minister has said. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 15, 2009 Category: African Health Source Type: news

Uganda: Ten Million Citizens Risk Catching Sleeping SicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
At least 10million Ugandans are at risk of getting Sleeping Sickness, the minister of health Stephen Mallinga has said. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 14, 2009 Category: African Health Source Type: news

Imported human African trypanosomiasis in Europe, 2005-2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Physicians in Europe are likely to see more African trypanosomiasis cases because of the increasing popularity of travel to Africa. In this paper the literature on imported cases in Europe, since 2005 is reviewed. Because of the high mortality risk associated with acute Rhodesian trypanosomiasis, travellers should be informed about preventive measures and the early disease manifestations. (Source: Eurosurveillance latest news)
Source: Eurosurveillance latest news - September 10, 2009 Category: Infectious Diseases Source Type: journals

Medical Microbiology: Laboratory Diagnosis of Infections Due to Blood and Tissue ParasitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 49, Issue 7, Page 1103-1108, 1 October 2009. Microscopy remains the cornerstone of the laboratory diagnosis of infections due to blood and tissue parasites. Examination of thick and thin peripheral blood smears stained with Giemsa or other appropriate stains is used for detection and identification of species of Plasmodium, Babesia, Trypanosoma, Brugia, Mansonella, and Wuchereria. Even in the hands of well‐trained technologists, diagnosis may be hampered by the sparseness of organisms on the slide and by the subjective nature of differentiating similar‐appearing organisms. Mic...
Source: Clinical Infectious Diseases Latest Issue - September 9, 2009 Category: Infectious Diseases Tags: article MEDICAL MICROBIOLOGY Source Type: journals

Influence of habitat and seasonal variation on wild mammal diversity and distribution with special reference to the Trypanosoma brucei gambiense host-reservoir in Bipindi (Cameroon).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the role of wildlife in the resurgence and perenisation of human African trypanosomiasis (HAT), we investigated the influence of habitat and seasonal variations on the diversity and spatial distribution of wild mammals, with special reference to those recognised as potential host reservoirs of Trypanosoma brucei gambiense in Bipindi (southwestern Cameroon). To achieve this, we carried out transect surveys in four habitat types over two years. A total of 31 mammal species were recorded, of which 14 occurred in the undisturbed forest, 9 in cocoa plantations, 11 in farmlands and 11 in village-adjacent gallery ...
Source: Acta Tropica - August 31, 2009 Category: Infectious Diseases Authors: Anselme MJ, Champlain DL, Flobert N, Claude L, Ploeg JD Tags: Acta Trop Source Type: journals

Immunolocalization and challenge studies using a recombinant Vibrio cholerae ghost expressing Trypanosoma brucei Ca(2+) ATPase (TBCA2) antigen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human African trypanosomiasis is a neglected disease caused by Trypanosoma brucei spp. A parasite cation pump (Ca(2+) ATPase; TBCA2) essential for survival and cation homeostasis was identified and characterized. It was hypothesized that targeting this pump using a Vibrio cholerae ghost (VCG)-based vaccine could protect against murine T. brucei infection. mRNA and protein expression of TBCA2 was differentially expressed in blood and insect stages of parasites and immunolocalized in the pericellular membrane and the flagellar pocket of bloodstream forms. Antigen-specific antibodies and Th1 cytokines, interleukin-2, inte...
Source: The American Journal of Tropical Medicine and Hygiene - August 29, 2009 Category: Tropical Medicine Authors: Ramey K, Eko FO, Thompson WE, Armah H, Igietseme JU, Stiles JK Tags: Am J Trop Med Hyg Source Type: journals

Jama 100 years ago: sleeping sicknessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: JAMA)
Source: JAMA - August 24, 2009 Category: Journals (General) Tags: Humanities JAMA 100 Years Ago Source Type: journals

Chemotherapy of Human African TrypanosomiasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent development of promising non-toxic combination chemotherapy suitable for use in rural clinics. (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - August 21, 2009 Category: Infectious Diseases Source Type: journals

Laboratory Diagnosis of Infections Due to Blood and Tissue ParasitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Microscopy remains the cornerstone of the laboratory diagnosis of infections due to blood and tissue parasites. Examination of thick and thin peripheral blood smears stained with Giemsa or other appropriate stains is used for detection and identification of species of Plasmodium, Babesia, Trypanosoma, Brugia, Mansonella, and Wuchereria. Even in the hands of well‐trained technologists, diagnosis may be hampered by the sparseness of organisms on the slide and by the subjective nature of differentiating similar‐appearing organisms. Microscop...
Source: Clinical Infectious Diseases Latest Issue - August 19, 2009 Category: Infectious Diseases Tags: article MEDICAL MICROBIOLOGY Source Type: journals

Also In Global Health News: NTD Consortium; Clean Water Access; PEPFAR Lab Donation; River Blindness Elimination; Vaccines In IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
European Laboratories Form Consortium To Study Neglected Tropical Diseases A handful of European universities and industries have formed a consortium to "boost drug development for the treatment of two deadly diseases, the African sleeping sickness and Leishmaniasis, which affect millions of people worldwide," afrol News reports. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 18, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

New Consortium To Develop Drugs For Neglected Tropical DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new consortium has been formed to boost drug development for the treatment of two deadly diseases, African sleeping sickness and Leishmaniasis, which affect millions of people worldwide. A total budget of nearly 3.6 million euros has been allocated over the next 4 years, to develop effective drugs for these diseases. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 18, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

The interaction of an antiparasitic peptide active against African Sleeping Sickness with cell membrane models.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we use the Langmuir monolayer technique to investigate the surface properties of an antiparasitic peptide, namely S-(2,4-dinitrophenyl)glutathione di-2-propyl ester, and its interaction with a model membrane comprising a phospholipid monolayer. The drug formed stable Langmuir monolayers, whose main feature was a phase transition accompanied by a negative surface elasticity. This was attributed to aggregation upon compression due to intermolecular bond associations of the molecules, inferred from surface pressure and surface potential isotherms, Brewster angle microscopy (BAM) images, infrared spectroscopy an...
Source: Colloids and Surfaces - August 17, 2009 Category: Biotechnology Authors: Pascholati CP, Lopera EP, Pavinatto FJ, Caseli L, Nobre TM, Zaniquelli ME, Viitala T, D'Silva C, Oliveira ON Tags: Colloids Surf B Biointerfaces Source Type: journals

Probing for primary functions of prohibitin in Trypanosoma brucei.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prohibitin (PHB) 1 and 2 are small conserved proteins implicated in a number of functions in the mitochondrion, as well as in the nucleus of eukaryotic cells. The current understanding of PHB functions comes from studies of model organisms such as yeast, worm and mouse, but considerable debate remains with regard to the primary functions of these ubiquitous proteins. We exploit the tractable reverse genetics of Trypanosoma brucei, the causative agent of African sleeping sickness, in order to specifically analyze the function of PHB in this highly divergent eukaryote. Using inducible RNA interference (RNAi) we show that...
Source: International Journal for Parasitology - August 12, 2009 Category: Parasitology Authors: Týč J, Faktorová D, Kriegová E, Jirků M, Vávrová Z, Maslov DA, Lukeš J Tags: Int J Parasitol Source Type: journals

Characterization of Serratia glossinae sp. nov., isolated from the midgut of the tsetse fly, Glossina palpalis gambiensis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present paper reports on the isolation of a novel bacterium (strain C1T) from the midgut of Glossina palpalis gambiensis, the tsetse fly that transmits the trypanosomes responsible for sleeping sickness in sub-Saharan African countries. It is a motile, facultative anaerobic rod-like bacterium (0.8-1.0 microm in diameter; 2-6 microm in length) which grows as single cells or chain-wise. Optimum growth occurred at 25-35 degrees C, at pH 6.7-8.4, in media containing 5-20 g/l NaCl. The bacterium hydrolysed the following substrates: 2-nitrophenyl-betaD galactopyranoside, urea and used L-lysine, L-ornithine, citrate, pyru...
Source: International Journal of Systematic and Evolutionary Microbiology - August 9, 2009 Category: Microbiology Authors: Geiger A, Fardeau ML, Falsen E, Ollivier B, Cuny G Tags: Int J Syst Evol Microbiol Source Type: journals