Baylor College of Medicine
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Ultrasound enhances noninvasive Down syndrome tests
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(Baylor College of Medicine) The addition of a "genetic sonogram" maximizes the accuracy of noninvasive testing for Down syndrome, said a Baylor College of Medicine researcher who was lead author of a landmark study in the current issue of Obstetrics and Gynecology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 20, 2009 Category: Global & Universal Source Type: news
Food, environmental allergies pose threat to children
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When introducing your newborn to new foods, be sure to look out for signs of food allergies, said an expert at Baylor College of Medicine . "Food allergies can occur in babies as young as six months old," said Dr. Carla Davis, assistant professor of pediatrics - allergy and immunology at BCM. There are eight foods that cause 90 percent of allergies in kids, said Davis. These include: Cow's milk Eggs Soy beans Wheat Tree nuts Peanuts Fish and shellfish Introduce foods one at a time Davis, who sees patients at Texas Children's Hospital, emphasizes the importance of introducing one food at a time to infants, so it i...
Source: Baylor College of Medicine News - November 20, 2009 Category: Universities & Medical Training Source Type: news
HIV-positive volunteers needed for H1N1 clinical trials
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Baylor College of Medicine is recruiting HIV-positive volunteers for a clinical trial sponsored by the National Institutes of Health to evaluate the immune response to the 2009 H1N1 vaccine. To qualify for the trial, HIV-positive volunteers must be in general good health and must have already received the 2009-2010 seasonal flu vaccine. Volunteers will receive two doses of the 2009 H1N1 vaccine as well as follow-up clinic visits and phone calls. Volunteers will be compensated for their time. For more information about the study, call 713-798-4912. (Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - November 19, 2009 Category: Universities & Medical Training Source Type: news
Bisexual behavior puts many teens at risk
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Young men are not always forthcoming about their sexual identity and history, a disturbing trend that highlights the importance of condom use, according to a Baylor College of Medicine expert on sexual health. Sexual health risk assessments of 18 male patients at the Baylor Teen Health Clinic who tested positive for HIV from 2007 to 2009 revealed that the majority have had sex with both men and women. However, they did not classify themselves as either gay or bisexual, said Dr. Ruth Buzi, director of social services at the clinic. Deadly silence "Homosexuality is stigmatized in some cultures, and many young men think ...
Source: Baylor College of Medicine News - November 18, 2009 Category: Universities & Medical Training Source Type: news
Study reveals significant limitations to ultrasound diagnosis among obese pregnant women
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Ultrasound performed in the second trimester of pregnancy on obese mothers is less likely to detect structural anomalies or other markers of chromosomal disease in the developing fetus, said a consortium of researchers led by one from Baylor College of Medicine in a report that appears in the current issue of the journal Prenatal Diagnosis . "The incidence of obesity in pregnancy has steadily increased over the past two decades. Interestingly, multiple population studies have demonstrated that obese women are more likely to have babies affected by neural tube (failure of the brain, spinal cord and/or their coverings t...
Source: Baylor College of Medicine News - November 18, 2009 Category: Universities & Medical Training Source Type: news
Undisclosed sexual behaviors put teens at risk
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Young men are not always forthcoming about their sexual identity and history, a disturbing trend that highlights the importance of condom use, according to a Baylor College of Medicine expert on sexual health. Sexual health risk assessments of 18 male patients at the Baylor Teen Health Clinic who tested positive for HIV from 2007 to 2009 revealed that the majority have had sex with both men and women. However, they did not classify themselves as either gay or bisexual, said Dr. Ruth Buzi, director of social services at the clinic. Deadly silence "Homosexuality is stigmatized in some cultures, and many young men think ...
Source: Baylor College of Medicine News - November 18, 2009 Category: Universities & Medical Training Source Type: news
Erectile Dysfunction Drug Receipt, Risky Sexual Behavior and Sexually Transmitted Diseases in HIV-infected and HIV-uninfected Men
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CONCLUSION EDD receipt was common but not associated with risky sexual behavior or STDs in this sample of HIV-infected and uninfected
men. However, risky sexual behaviors persist in a minority of HIV-infected men, indicating ongoing need for prevention interventions.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11606-009-1164-9Authors
Robert L. Cook, University of Florida Departments of Epidemiology and Biostatistics and Medicine PO Box 100231 Gainesville FL 32610 USAKathleen A. McGinnis, Pittsburgh VA Healthcare System Pittsburgh PA USAJeffrey H. Samet, Boston University Boston M...
Source: Journal of General Internal Medicine - November 17, 2009 Category: Internal Medicine Tags: Journal of General Internal Medicine Source Type: journals
Breast cancer expert fields questions about new mammogram recommendations
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The U.S. Preventive Services Task Force has issued new guidelines on screening mammograms that include these major changes in the current recommendations: Women should begin routine breast cancer screening at the age of 50; those with risk factors should consult their physician on when to start screening The interval between mammograms is every other year for women 50 – 74 Women 74 and older do not need mammograms Breast self-examinations are not necessary Dr. C. Kent Osborne, director of the Lester and Sue Smith Breast Center and the Dan L. Duncan Cancer Center at Baylor College of Medicine, answers questions about ...
Source: Baylor College of Medicine News - November 17, 2009 Category: Universities & Medical Training Source Type: news
BCM graduate program awarded Howard Hughes grant renewal
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The Translational Biology and Molecular Medicine Graduate Program at Baylor College of Medicine has received a renewed grant from the Howard Hughes Medical Institute Med Into Grad Initiative. In total, 23 institutions were awarded grants up to $700,000. The Translational Biology and Molecular Medicine Graduate program was one of 11 renewals and will receive $700,000 over a four-year period. The program is led by co-directors Dr. Mary K. Estes, professor of molecular virology and microbiology, and Dr. Ignatia Van den Veyver, associate professor of obstetrics and gynecology. "The translational biology and molecular medi...
Source: Baylor College of Medicine News - November 17, 2009 Category: Universities & Medical Training Source Type: news
Classrooms participate in 'Butterflies in Space' education project
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Students of all ages can follow the "butterflynauts" aboard the International Space Station as they develop from larvae into Painted Lady butterflies. The educational experiment launched today on space shuttle Atlantis, and the butterfly habitat will be transferred to the Space Station within the first 2-3 days of the mission. Ground-based habitats "About 100 elementary and middle school classrooms across the U.S. are participating in a pilot study by setting up ground-based habitats. Students will replicate the space experiment and compare the growth and behavior of their butterfly larvae with those living ...
Source: Baylor College of Medicine News - November 16, 2009 Category: Universities & Medical Training Source Type: news
BCM's Guntupalli inducted as president of American College of Chest Physicians
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Dr. Kalpalatha Guntupalli, professor and chief of pulmonary, critical care and sleep medicine at Baylor College of Medicine, was inducted as president of the American College of Chest Physicians at the 75th annual international scientific assembly of the college. Guntupalli, who has been practicing medicine for more than 35 years, will lead over 17,400 members who provide patient care in the areas of pulmonary, critical care and sleep medicine around the world. "I am very honored to represent the interests of a large number of my peers and their patients – it gives me a chance to advocate and strive for better p...
Source: Baylor College of Medicine News - November 16, 2009 Category: Universities & Medical Training Source Type: news
Report: School lunch, breakfast programs need menu updates
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A new report from the Institute of Medicine provides recommendations for the National School Lunch and School Breakfast Program guidelines to be in line with the latest Dietary Guidelines for Americans and Dietary Reference Intakes. "The key goal is to align school meal standards with current research. The menus have not been updated since the early 1990s, and the latest Dietary Guidelines for Americans were released in 2005," said Dr. Karen Cullen, associate professor of pediatrics – nutrition at the USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine and Texas Children's Hospital a...
Source: Baylor College of Medicine News - November 16, 2009 Category: Universities & Medical Training Source Type: news
Complexin function varies with species
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Complexins are small proteins that regulate the release of neurotransmitters and hormones from neurons, a fundamental function of the brain. Whether complexins helped or hindered this release was unclear until a new study by Baylor College of Medicine researchers demonstrated that they can do both, depending on the species in which they act. "The balance between these two opposing forces is critical for neurotransmitter release, but during evolution, the balance changed. Complexins have a predominantly inhibitory effect in flies and a facilitatory one in mammals," said Dr. Christian Rosenmund , professor of molec...
Source: Baylor College of Medicine News - November 16, 2009 Category: Universities & Medical Training Source Type: news
H1N1, children focus of FAQs
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(Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - November 16, 2009 Category: Universities & Medical Training Source Type: news
Lack of Math1 gene steals newborns' breath
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Mice born lacking the gene Math1 – known to affect balance, hearing and the sense of physical self in relation to the world (proprioception) – die shortly after birth because they cannot breathe on their own. Why this occurred was a mystery until researchers from Baylor College of Medicine and the University of Alberta in Edmonton, Canada, teamed up to find that lack of the gene disrupts the differentiation and migration of a group of neurons that enable respiration right after birth. Without these neurons (the parafacial respiratory group/retrotrapezoid nucleus), the infant mice die. Mutations in a gene (PHOX2...
Source: Baylor College of Medicine News - November 12, 2009 Category: Universities & Medical Training Source Type: news
Volunteers needed for study on dietary supplements
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Baylor College of Medicine is recruiting overweight volunteers for a study that examines the effectiveness of dietary supplements. Participants must be between 20 and 70 years of age, and women must not be pregnant or breastfeeding. Participants will receive study dietary supplements, laboratory testing, physical exams and dietary counseling at no cost and will be compensated for their time and effort. For more information, call 713-798-7684. (Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - November 11, 2009 Category: Universities & Medical Training Source Type: news
Nicotinic Receptor Deletion Could Result In Developmental Delay
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The loss of a gene through deletion of genetic material on chromosome 15 is associated with significant abnormalities in learning and behavior, said a consortium of researchers led by Baylor College of Medicine in a report that appears online in the journal Nature Genetics. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 9, 2009 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
Nicotinic Receptor Deletion Could Result In Developmental Delay
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The loss of a gene through deletion of genetic material on chromosome 15 is associated with significant abnormalities in learning and behavior, said a consortium of researchers led by Baylor College of Medicine in a report that appears online in the journal Nature Genetics. "This research goes about 95 percent of the way to pinning these problems in a specific group of individuals to this gene," said Dr. Arthur L. Beaudet, chair of molecular and human genetics at BCM. (Source: Smoking / Quit Smoking News From Medical News Today)
Source: Smoking / Quit Smoking News From Medical News Today - November 9, 2009 Category: Respiratory Medicine Tags: Neurology / Neuroscience Source Type: news
Enzyme block reduces death in mice with myotonic dystrophy
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Using drugs to block the action of an enzyme called protein kinase C can reduce or even eliminate heart problems in mice with myotonic dystrophy, said researchers from Baylor College of Medicine in a report that appears today in the Journal of Clinical Investigation. "The disease is very severe in these mice," said Dr. Thomas Cooper, professor of pathology and molecular and cellular biology at BCM and senior author of the report. "Eighty percent of them die within three weeks of turning on the mutation. If we give an inhibitor of protein kinase C, less than 20 percent die." Skeletal muscle disease Myoto...
Source: Baylor College of Medicine News - November 9, 2009 Category: Universities & Medical Training Source Type: news
Developmental delay could stem from nicotinic receptor deletion
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The loss of a gene through deletion of genetic material on chromosome 15 is associated with significant abnormalities in learning and behavior, said a consortium of researchers led by Baylor College of Medicine in a report that appears online today in the journal Nature Genetics . "This research goes about 95 percent of the way to pinning these problems in a specific group of individuals to this gene," said Dr. Arthur L. Beaudet , chair of molecular and human genetics at BCM. He believes that the deletion will be identified in other people with behavioral problems as well as schizophrenia, developmental delay and...
Source: Baylor College of Medicine News - November 8, 2009 Category: Universities & Medical Training Source Type: news
Developmental delay could stem from nicotinic receptor deletion
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(Baylor College of Medicine) The loss of a gene through deletion of genetic material on chromosome 15 is associated with significant abnormalities in learning and behavior, said a consortium of researchers led by Baylor College of Medicine in a report that appears online today in the journal Nature Genetics. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 8, 2009 Category: Biology Source Type: news
Glycosylation Regulates Prestin Cellular Activity
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Abstract Glycosylation is a common post-translational modification of proteins and is implicated in a variety of cellular functions
including protein folding, degradation, sorting and trafficking, and membrane protein recycling. The membrane protein prestin
is an essential component of the membrane-based motor driving electromotility changes (electromotility) in the outer hair
cell (OHC), a central process in auditory transduction. Prestin was earlier identified to possess two N-glycosylation sites
(N163, N166) that, when mutated, marginally affect prestin nonlinear capacitance (NLC) function in cultured cel...
Source: JARO - Journal of the Association for Research in Otolaryngology - November 7, 2009 Category: ENT & OMF Tags: JARO - Journal of the Association for Research in Otolaryngology Source Type: journals
DeBakey awardees explore diabetes, epigenetics, DNA recombination and mechanisms of ovulation
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The five recipients of the 2009 Michael E. DeBakey, M.D., Excellence in Research Awards at Baylor College of Medicine explore a variety of phenomena in their labs – gene therapy for diabetes, epigenetic inheritance, the mechanisms of DNA recombination and the regulation of ovarian follicular development, ovulation and subsequent events. From left: Drs. Vijay Yechoor, Lawrence Chan, JoAnne Richard, Gregory Ira and Christophe Herman This year's award recipients include: Dr. Lawrence Chan, professor of medicine – endocrinology at BCM and director of the federally designated Diabetes and Endocrinology Research Cent...
Source: Baylor College of Medicine News - November 6, 2009 Category: Universities & Medical Training Source Type: news
San Antonio Breast Cancer Symposium: CTRC, AACR And Baylor College Of Medicine To Host
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Premier international conference highlights breakthroughs in breast cancer research What: Now in its 32nd year, the CTRC-AACR San Antonio Breast Cancer Symposium remains the top venue for research and discovery in breast cancer. This year's conference will bring together delegates from all over the world. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 5, 2009 Category: Consumer Health News Tags: Breast Cancer Source Type: news
San Antonio Breast Cancer Symposium: CTRC, AACR And Baylor College Of Medicine To Host
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Premier international conference highlights breakthroughs in breast cancer research What: Now in its 32nd year, the CTRC-AACR San Antonio Breast Cancer Symposium remains the top venue for research and discovery in breast cancer. This year's conference will bring together delegates from all over the world. Among the expected highlights: Five-year results of the groundbreaking Herceptin trial. (Source: Breast Cancer News From Medical News Today)
Source: Breast Cancer News From Medical News Today - November 5, 2009 Category: Cancer & Oncology Tags: Breast Cancer Source Type: news
Cancer center outreach group schedules Nov. 10 colorectal cancer play
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The Office of Outreach and Health Disparities in the Dan L. Duncan Cancer Center at Baylor College of Medicine will continue its efforts to educate Hispanics about the importance of preventing colorectal cancer with a Spanish-language play Nov. 10. The play, free and open to the public, begins at 8:30 a.m. at the Cleveland Ripley Neighborhood Center, 720 Fairmont Parkway, Pasadena, Texas, 77504. The performance will addresses the need for colorectal cancer screening and early detection in this high-risk group. Hispanics at high risk Titled "Educando a Papa," the play tells the story of a family divided by culture...
Source: Baylor College of Medicine News - November 5, 2009 Category: Universities & Medical Training Source Type: news
CTRC, AACR and Baylor College of Medicine to host San Antonio Breast Cancer Symposium
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(American Association for Cancer Research) Now in its 32nd year, the CTRC-AACR San Antonio Breast Cancer Symposium remains the top venue for research and discovery in breast cancer. This years conference will bring together delegates from all over the world. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 4, 2009 Category: Biology Source Type: news
Laparoscopic surgery cuts down on incisions
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Minimally invasive surgery is even more minimal now that doctors at Baylor College of Medicine are using only one incision for some procedures, leaving behind little to no scar. "This technique has been around for a couple of years. What we are doing now is expanding the types of surgeries for which we can use this method and understanding the benefits in a research setting," said Dr. Vadim Sherman , assistant professor of surgery and director of the Comprehensive Bariatric Surgery Center at BCM. Belly button One-incision surgeries use the same type of devices as traditional laparoscopic surgeries. However, inste...
Source: Baylor College of Medicine News - November 4, 2009 Category: Universities & Medical Training Source Type: news
Successful treatment of recurrent Buschke–Lowenstein tumor by radiation therapy and chemotherapy
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Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00384-009-0826-8Authors
Waqar Haque, Baylor College of Medicine Department of Radiology, Section of Radiation Oncology One Baylor Plaza, BCM 620 Houston Texas 77030 USAElisabeth Kelly, Baylor College of Medicine Department of Radiology, Section of Radiation Oncology One Baylor Plaza, BCM 620 Houston Texas 77030 USASadhna Dhingra, The University of Texas at Houston Medical Center Department of Pathology Houston Texas USALarry Steven Carpenter, Baylor College of Medicine Department of Radiology, Section of Radiation Oncology One Baylor Plaza, BCM 620 H...
Source: International Journal of Colorectal Disease - November 3, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals
Immune Therapy Can Protect Against Or Treat Later Lymphoma
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Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection, said a group of researchers led by those from Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 3, 2009 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news
Immune therapy can protect against or treat later lymphoma
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(Baylor College of Medicine) Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection, said a group of researchers led by those from Baylor College of Medicine, the Methodist Hospital and Texas Children's Hospital. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 2, 2009 Category: Global & Universal Source Type: news
Men needed for low testosterone trial
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Baylor College of Medicine has been selected as one of 12 sites nationwide to conduct a study to determine if elderly men with low testosterone will benefit from testosterone treatment. "We are conducting this study because low testosterone levels can adversely affect the health of older men in several critical areas," said Dr. Glenn Cunningham, professor of medicine-endocrinology and principal investigator for the study at BCM. "If this treatment proves effective, we may be able to help older men with low testosterone levels remain healthy and independent longer than would have been possible otherwise."...
Source: Baylor College of Medicine News - November 2, 2009 Category: Universities & Medical Training Source Type: news
Immune therapy can protect against or treat later lymphoma
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Specially developed immune system cells that target the common Epstein-Barr virus can protect immune-suppressed bone marrow transplant recipients against lymph system disease and cancers that arise from the viral infection, said a group of researchers led by those from Baylor College of Medicine , The Methodist Hospital and Texas Children's Hospital. "Therapy with EBV-specific CTLs (cytotoxic lymphocytes) was effective for these patients who were severely immune-compromised, as the cells successfully reached the tumor, multiplied and were able to kill tumor cells," said Dr. Helen Heslop, lead author of the study,...
Source: Baylor College of Medicine News - November 2, 2009 Category: Universities & Medical Training Source Type: news
Organ dysfunction is associated with hyperglycemia in critically ill children
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Conclusions Organ dysfunction (≥3 versus <3) was significantly associated with hyperglycemia for ≥24 h and hypoglycemia. Hyperglycemia
trended toward significance with mortality in critically ill children. There was no association between hypoglycemia and mortality.
Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1703-1Authors
Ursula G. Kyle, Baylor College of Medicine Pediatric Critical Care Medicine, Texas Children’s Hospital 6621 Fannin, WT6-006 Houston Texas 77030 USAJorge A. Coss Bu, Baylor College of Medicine Pediatric Critical Care Medicine, Texas Children’s H...
Source: Intensive Care Medicine - October 31, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals
Conference addresses chronic illness, transition from childhood to adulthood
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When dealing with a chronic illness, the transition from childhood to adulthood has unique challenges. To address these issues, national and international experts will gather in Houston for the 10th annual conference on Chronic Disease and Disability: Transition from Pediatric to Adult-Based Care. The conference, presented by the Maternal and Child Health Bureau-funded Leadership Education in Adolescent Health Training Program in the Department of Pediatrics at Baylor College of Medicine and Texas Children's Hospital, will take place Nov. 5-6 in the Texas Medical Center. "The conference creates a forum for youth and y...
Source: Baylor College of Medicine News - October 29, 2009 Category: Universities & Medical Training Source Type: news
Challenges for pediatric radiology using Computed Radiography
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Conclusions Many of the challenges that we encountered may be overcome through experience, proper configuration of system, and further
software enhancements. The overwhelming benefits of improved image access and immediate consultations create a demand for
CR, even with sub-optimal images. The challenge for radiology departments is to execute a deliberate implementation of CR,
ensuring that we produce the best quality images without greater radiation dose to the patient.
Content Type Journal ArticleCategory SessionsDOI 10.1007/BF03168290Authors
Charles E. Willis, Baylor College of Medicine Department of ...
Source: Journal of Digital Imaging - October 28, 2009 Category: Radiology Tags: Journal of Digital Imaging Source Type: journals
Teens need protection from 'sexting'
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Gone are the days when teens passed love notes in class. Today's adolescents have taken their notes electronic, in a form of flirting known as "sexting" that can have unwanted and even dangerous outcomes, according to an expert on teen sexual health at Baylor College of Medicine . Sexting refers to sending sexually explicit text messages and photographs over a cell phone. Teens also use social media sites like Facebook and Myspace as well as instant messaging to communicate things of a sexual nature. No such thing as private message "This is a practice that sets young people up for consequences that they may...
Source: Baylor College of Medicine News - October 28, 2009 Category: Universities & Medical Training Source Type: news
Dendritic cells responsible for smoldering inflammation in smokers' lungs
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Inflammation still ravages the lungs of some smokers years after they quit the habit. What sparks that smoldering destruction remained a mystery until a consortium of researchers led by Baylor College of Medicine found that certain dendritic cells in the lung – the cells that "present" a foreign antigen or protein to the immune system – provoke production of destructive T-cells that attack a key protein called elastin, leading to death of lung tissue and emphysema. A report of their work appears in the current issue of Science Transformational Medicine . The National Heart, Lung and Blood Institute es...
Source: Baylor College of Medicine News - October 28, 2009 Category: Universities & Medical Training Source Type: news
Cameras zoom in on cause of obstructive sleep apnea
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The best time to have your picture taken is usually not while you are sleeping, that is unless you suffer from sleep apnea. Doctors at Baylor College of Medicine are using a small video camera inserted into the airway to help pinpoint the cause of obstructions that happen during sleep apnea. Obstructive sleep apnea is a condition in which tissues in the back of the throat collapse during sleep, resulting in the cessation of breathing, restless sleep, daytime fatigue, loud snoring, as well as frequently waking up gasping for breath. Airway obstructions "In the past, most doctors assumed it was always the soft palate an...
Source: Baylor College of Medicine News - October 27, 2009 Category: Universities & Medical Training Source Type: news
Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations
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In this study,
we tested the hypothesis that the CHEK2 gene contains one or more polymorphic variants that are associated with type 2 diabetes in HyperGEN individuals. In addition,
we replicated our findings in two other Family Blood Pressure Program (FBPP) populations and in the population-based Atherosclerosis
Risk in Communities (ARIC) study. We genotyped 1,584 African-American and 1,531 white HyperGEN participants, 1,843 African-American
and 1,569 white GENOA participants, 871 African-American and 1,009 white GenNet participants, and 4,266 African-American and
11,478 white ARIC participants for four single nucleot...
Source: Acta Diabetologica - October 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals
Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice
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In this study we have evaluated the effect of TA on lung cancer using both in vitro and in vivo models. TA
in a dose dependent manner inhibited proliferation and cell viability of two different lung cancer cells, A549 and CRL5803.
TA treatment for 48 h significantly decreased the expression of Sp1, Sp3 and Sp4. The hepatocyte growth factor receptor, c-Met
is overexpressed in a variety of cancers including lung cancer and Sp proteins mediate the regulation of c-Met. TA diminished
the expression of c-Met protein and modulates its downstream signaling pathway. Furthermore, TA treatment significantly increased
the nu...
Source: Investigational New Drugs - October 22, 2009 Category: Drugs & Pharmacology Tags: Investigational New Drugs Source Type: journals
A new way to look at brain injuries
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Neurons are structurally complex, with specific parts of the cell responsible for information input and other parts responsible for information output. When neurons lose the ability to distinguish between inputs and outputs, the nervous system stops working. In a report published today in The Journal of Neuroscience, researchers at Baylor College of Medicine and the University of Connecticut Health Center show that this is exactly what happens after nervous system injury. "This is a new way to think about nervous system injuries," said Dr. Matthew N. Rasband, associate professor of neuroscience at Baylor College ...
Source: Baylor College of Medicine News - October 22, 2009 Category: Universities & Medical Training Source Type: news
A hypersensitive estrogen receptor α mutation that alters dynamic protein interactions
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Abstract Estrogen receptor α (ERα) is highly regulated through multiple mechanisms including cell signaling, posttranslational modifications,
and protein–protein interactions. We have previously identified a K303R ERα mutation within the hinge region of ERα. This
mutation results in an altered posttranslational regulation and increased in vitro growth in the presence of low estrogen
concentrations. We sought to determine if cells expressing this mutant ERα would display hypersensitive tumor growth in in
vivo athymic ovariectomized nude mice. MCF-7 cells, stably expressing the K303R ERα, formed tumors...
Source: Breast Cancer Research and Treatment - October 20, 2009 Category: Cancer & Oncology Tags: Breast Cancer Research and Treatment Source Type: journals
Women's Health Summit hosts world-renowned author
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The Huffington Center on Aging at Baylor College of Medicine will host the 2009 Women's Health Summit starting at 10 a.m. Wednesday, Oct. 28, at the River Oaks Country Club. The event will feature presentations on women's health as well as a book signing with internationally renowned best-selling author Barbara Taylor Bradford, the recipient of this year's Ann Morrow Lindbergh Award for Living with Grace and Distinction. For more information or to reserve a table, contact Zineera Seth at 713-798-3802. (Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - October 20, 2009 Category: Universities & Medical Training Source Type: news
Breast Cancer Treatments Improve
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More women are surviving breast cancer as a result of improvements in early detection methods and more effective, targeted treatment, say experts at Baylor College of Medicine. (Source: Disabled World)
Source: Disabled World - October 19, 2009 Category: Disability Tags: Breast Cancer Source Type: info
Update on H1N1 vaccine
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(Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - October 19, 2009 Category: Universities & Medical Training Source Type: news
'Molecular Trigger' For Sudden Death In Epilepsy Revealed By BCM Scientists
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The most common gene for a syndrome associated with abnormal heart rhythms and sudden death triggers epileptic seizures and could explain sudden unexplained death in epilepsy, said researchers from Baylor College of Medicine in a report that appears today in the journal Science Translational Medicine. (Source: Neurology / Neuroscience News From Medical News Today)
Source: Neurology / Neuroscience News From Medical News Today - October 15, 2009 Category: Neuroscience Tags: Epilepsy Source Type: news
Friends play critical role in cancer patients' emotional state
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Support from family and friends can contribute to a woman's positive state of mind following a breast cancer diagnosis, says a Baylor College of Medicine expert. Many people don't know how to treat a friend with cancer, though, and they worry about saying or doing the wrong thing or, worse, retraumatizing their friend, said Dr. Catherine Barber , assistant professor of psychiatry and behavioral sciences at BCM. She offers advice on how to be a good friend to someone who has been diagnosed with cancer and is going through treatment. Be an empathic listener "The No. 1 thing is to be an empathic listener," Barber sa...
Source: Baylor College of Medicine News - October 15, 2009 Category: Universities & Medical Training Source Type: news
Treatments improve for breast cancer patients
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More women are surviving breast cancer as a result of improvements in early detection methods and more effective, targeted treatment, say experts at Baylor College of Medicine . "We continue to make great strides in research and patient care," said Dr. Heather West, assistant professor in the Lester and Sue Smith Breast Center at Baylor College of Medicine. "Survival rates have greatly improved the past 10 years." Early detection Early detection remains key to survival, West said. Advancements have improved doctors' ability to catch the tumors when they are at a curable stage. "Yearly screening mam...
Source: Baylor College of Medicine News - October 15, 2009 Category: Universities & Medical Training Source Type: news
BCM scientists find 'molecular trigger' for sudden death in epilepsy
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The most common gene for a syndrome associated with abnormal heart rhythms and sudden death triggers epileptic seizures and could explain sudden unexplained death in epilepsy, said researchers from Baylor College of Medicine in a report that appears today in the journal Science Translational Medicine . The identification of this particular potassium channel KvLQT in neurons of the central nervous system gives scientists a clue about which epilepsy patients face the greatest risk of dying unexpectedly, said Dr. Jeffrey Noebels , the study's senior author and director of the Blue Bird Circle Developmental Neurogenetics Labor...
Source: Baylor College of Medicine News - October 14, 2009 Category: Universities & Medical Training Source Type: news
