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A long journey to understand Borrelia burgdorferi in BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Neurological manifestations in Baggio-Yoshinari Syndrome (Brazilian Lyme disease-like syndrome)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The BYS is considered a new tick borne disease in Brazil that differs from classical LD observed in the Northern hemisphere. BYS replicates most of the neurological symptoms observed in LD, except for the additional presence of relapsing episodes and the tendency to cause chronic neurological and articular manifestations. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

Yale Researchers Target Tick Saliva In Their Search For Lyme DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites. Traditionally, vaccines have directly targeted specific pathogens. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Yale Researchers Target Tick Saliva In Their Search For Lyme DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites. Traditionally, vaccines have directly targeted specific pathogens. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

On the trail of a vaccine for Lyme disease: Yale researchers target tick salivaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Yale University) A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the Nov. 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news

Antibodies against a Tick Protein, Salp15, Protect Mice from the Lyme Disease Agent.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Traditionally, vaccines directly target a pathogen or microbial toxin. Lyme disease, caused by Borrelia burgdorferi, is a tick-borne illness for which a human vaccine is not currently available. B. burgdorferi binds a tick salivary protein, Salp15, during transmission from the vector, and this interaction facilitates infection of mice. We now show that Salp15 antiserum significantly protected mice from B. burgdorferi infection. Salp15 antiserum also markedly enhanced the protective capacity of antibodies against B. burgdorferi antigens, such as OspA or OspC. Mice actively immunized with Salp15 were also significantly p...
Source: Cell Host and Microbe - November 18, 2009 Category: Microbiology Authors: Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E Tags: Cell Host Microbe Source Type: journals

Lyme Disease-Causing Microbes Seen Moving In TicksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lyme disease is caused by the microbe Borrelia burgdorferi, which is transmitted to humans from feeding ticks. Justin Radolf and colleagues, at the University of Connecticut Health Center, Farmington, have now visualized the microbe moving through the feeding tick and determined that it has a biphasic mode of dissemination. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 17, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Lyme Disease-Causing Microbes Seen Moving In TicksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lyme disease is caused by the microbe Borrelia burgdorferi, which is transmitted to humans from feeding ticks. Justin Radolf and colleagues, at the University of Connecticut Health Center, Farmington, have now visualized the microbe moving through the feeding tick and determined that it has a biphasic mode of dissemination. (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - November 17, 2009 Category: Biochemistry Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

How ticks transmit Lyme disease to humans: Imaging technique leads to better understandingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using a powerful microscopic live imaging technique, researchers have discovered the way ticks transmit Lyme disease to humans is different than previously thought. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 17, 2009 Category: Science Source Type: news

JCI online early table of contents: Nov. 16, 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov. 16 2009, in the JCI, including: New cause of osteoporosis: mutation in a miroRNA; Watching Lyme disease-causing microbes move in ticks; MIFfed about protection for the heart; Th22 immune cell subset: a therapeutic target in chronic inflammatory skin disorders?; Loop the loop: speeding up a serious blood vessel condition; and others. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: news

Watching Lyme disease-causing microbes move in ticksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Journal of Clinical Investigation) Lyme disease is caused by the microbe Borrelia burgdorferi, which is transmitted to humans from feeding ticks. Researchers have now visualized the microbe moving through the feeding tick and determined that it has a biphasic mode of dissemination. Information such as this is essential if new methods of preventing human infection with Borrelia burgdorferi are to be developed. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 16, 2009 Category: Infectious Diseases Source Type: news

Low White Blood Cell Count Distinguishes Lyme Arthritis From Septic ArthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Children are more likely than adults to present with arthritis as the initial manifestation of Lyme disease; the leukocyte count can help differentiate between Lyme arthritis and septic arthritis. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 14, 2009 Category: Consumer Health News Tags: Pediatrics Source Type: news

UK travel news round upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Bath Film festival, Santa's grotto deep underground and courses in fossil collectingIt's ancient history Those who don't know their ammonite from their belemnite can book a place at Lyme Regis's Jurassic Coast Centre next spring. In conjunction with London's Natural History Museum, it is to host short courses on palaeontology, botany, mineralogy and zoology throughout February and March. Accommodation is provided at Victoria House (non-residential guests also welcome). Prices from £210, shared occupancy.0845 345 4071, field-studies-council.org/2010/walkingandgeology/jurassiccoast.aspx.Hostel goes greenYouth hostels al...
Source: Guardian Unlimited Science - November 14, 2009 Category: Science Tags: United Kingdom Travel Dorset Yorkshire Bath Scotland Fossils Science Film Museums Culture Christmas UK news guardian.co.uk Source Type: news

Borrelia burgdorferi Stimulates Macrophages to Secrete Higher Levels of Cytokines and Chemokines than Borrelia afzelii or Borrelia gariniiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. To delineate the inflammatory potential of the 3 pathogenic species of Borrelia burgdorferi sensu lato, we stimulated monocyte‐derived macrophages from healthy human donors with 10 isolates each of B. burgdorferi, Borrelia afzelii, or Borrelia garinii recovered from erythema migrans skin lesions of patients with Lyme borreliosis from the United States or Slovenia. B. burgdorferi isolates from the United States induced macrophages to secrete significantly higher levels of interleukin (IL)‐8, CCL3, CCL4, IL‐6, IL‐10, and tumor nec...
Source: The Journal of Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

First detection and molecular identification of Borrelia garinii isolated from human skin in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Borrelia garinii, a causative agent for Lyme disease, was detected and identified from human skin for the first time in Taiwan. Lyme disease infection was confirmed by Western immunoblot tests and isolation of Borrelia spirochetes from skin biopsy specimens. The genetic identity of this detected spirochete was determined by analyzing the gene sequence amplified by a genospecies-specific polymerase chain reaction (PCR) assay based on the 5S (rrf)-23S (rrl) intergenic spacer amplicon gene of B. burgdorferi sensu lato. Phylogenetic analysis reveals that the sequence similarity of this detected spirochete is highly homogen...
Source: Journal of Medical Microbiology - November 12, 2009 Category: Microbiology Authors: Chao LL, Chen YJ, Shih CM Tags: J Med Microbiol Source Type: journals

Borrelia burgdorferi, a great chameleon: know it to recognize it!Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a clinical case of neuroborreliosis that occurred in the absence of classical erythema migrans or arthralgia. Magnetic resonance imaging findings compatible with simil-vasculitis and demyelinating lesions associated with the presence of anti-B. burgdorferi antibodies in the plasma or cerebrospinal liquid is an indication for antimicrobial treatment against B. burgdorferi. An early diagnosis and a prompt establishment of an adequate antibiotic treatment is needed for a successful recovery. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0175-yAuthors Iolanda Santino, Sapienza Univer...
Source: Neurological Sciences - November 6, 2009 Category: Neurology Tags: Neurological Sciences Source Type: journals

Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic Tigecycline [Evolution]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Persistence of tissue spirochetes of Borrelia burgdorferi as helices and round bodies (RBs) explains many erythema-Lyme disease symptoms. Spirochete RBs... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 3, 2009 Category: Science Authors: Brorson, O., Brorson, S.-H., Scythes, J., MacAllister, J., Wier, A., Margulis, L. Tags: Evolution Source Type: journals

Blood Cultures for Patients with Extracutaneous Manifestations of Lyme Disease in the United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, blood culture results were positive for 5 (19.2%; 95% confidence interval, 6.6%–39.4%) of 26 untreated adult patients with extracutaneous manifestations but only for patients with clinical evidence for a short duration of infection. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - November 3, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals

BosR (BB0647) governs virulence expression in Borrelia burgdorferiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study thus not only has elucidated another key virulence gene of Bb, but also provides new insights into a previously unknown layer of gene regulation governing RpoS in Bb. (Source: Molecular Microbiology)
Source: Molecular Microbiology - November 2, 2009 Category: Microbiology Authors: Zhiming Ouyang, Manish Kumar, Toru Kariu, Shayma Haq, Martin Goldberg, Utpal Pal, Michael V. Norgard Source Type: journals

sent'> Sentinel Symptoms of Climate Change Indicators for Related Health Effects Greenhouse gas emissions are widely acknowledged to be contributing to climate change�related health effects that vary by location, and are expected to continue doing so for many years, even if substantial emission cuts occur. A workgroup of the Council of State and Territorial Epidemiologists has identified a set of indicators that it says will allow national and local officials in the United States to better predict any such changes and consequences and to take appropriate action as it becomes warranted [EHP 117:1673�1681; English et al.]. The team also identified the data needed for tracking these indicators and ascertained whether the data exist, must be improved, or must be generated. They say this is the first effort to synthesize and evaluate related information published by many sources. photo collage showing flooding, pathogens, fire and waste. images (clockwise from lower left): AP Photo/Francis Specker; AP Photo/Bullit Marquez; � 2009 Dennis Kunkel Microscopy; � Kevin Schafer/Corbis The team determined the best indicators of environmental changes due to climate change are quantity of greenhouse gas emissions, air quality (in particular ozone), air mass stagnation events (such as those caused by temperature inversions), temperature and humidity, pollen loads, ragweed occurrence, drought incidence, drinking water scarcity, and occurrence of wildfires and harmful algal blooms. Data for some of these indicators are strong and/or expected to improve soon, as in the case of greenhouse gases, temperature, air mass stagnation events, and drought. Data on other indicators, such as pollen, harmful algal blooms, and ozone, require substantial improvement. For indicators of human death and illness, the authors recommend tracking excess numbers of each that can be attributed to events related to climate change. Doing so will require significant improvements in existing data and methods, such as more comprehensive reporting of emergency room visits and hospitalizations related to heat waves, floods, and other extreme weather events. For infectious diseases, the targeted culprits are West Nile virus, Lyme disease, dengue fever, coccidioidomycosis, and hantavirus cardiopulmonary syndrome. The authors note that some segments of the population may be especially vulnerable to certain effects of climate change. These groups include children; the elderly; pregnant and nursing women; those with disabilities and preexisting conditions such as asthma, chronic obstructive pulmonary disease, and obesity; people living in poverty or social isolation or without access to transportation; and those living within 5 km of a coast that is highly vulnerable to sea level rise, or in a 100- or 500-year flood zone. Awareness of these vulnerable subpopulations will be important in planning appropriate prevention and intervention activities. Data for indicators of adaptability are sparse because most efforts so far have focused on mitigating climate change, not adapting to it. The authors propose that such indicators might include access to public cooling centers during heat waves, the existence of early warning systems for heat waves, mitigation plans to reduce urban heat islands, the number and quality of surveillance systems available to collect data on climate�health effects, and the availability of local public health workers and task forces trained in climate change research, surveillance, and adaptation. Bob Weinhold, MA, has covered environmental health issues for numerous outlets since 1996. He is a member of the Society of Environmental Journalists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
sent"> Sentinel Symptoms of Climate Change Indicators for Related Health Effects Greenhouse gas emissions are widely acknowledged to be contributing to climate change�related health effects that vary by location, and are expected to continue doing so for many years, even if substantial emission cuts occur. A workgroup of the Council of State and Territorial Epidemiologists has identified a set of indicators that it says will allow national and local officials in the United States to better predict any such changes and consequences and to take appropriate action as it becomes warranted [EHP 117:1673�1681; English et a...
Source: Science Selections from EHP - November 1, 2009 Category: Environmental Health Authors: webmaster at ehp.niehs.nih.gov Source Type: journals

Natural killer cells in chronic lyme disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19880717 [PubMed - in process] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - November 1, 2009 Category: Allergy & Immunology Authors: Stricker RB, Winger EE, Marques A, Brown MR, Fleisher TA Tags: Clin Vaccine Immunol Source Type: journals

Seroprevalence Survey of Equine Lyme Borreliosis in France and in Sub-Saharan AfricaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - October 30, 2009 Category: Infectious Diseases Tags: article Source Type: journals

Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemoglobin digestion is an essential process for blood-feeding parasites. Using chemical tools, we deconvoluted the intracellular hemoglobinolytic cascade in the tick Ixodes ricinus, a vector of Lyme disease and tick-borne encephalitis. In tick gut tissue, a network of peptidases was demonstrated through imaging with specific activity-based probes and activity profiling with peptidic substrates and inhibitors. This peptidase network is induced upon blood feeding and degrades hemoglobin at acidic pH. Selective inhibitors were applied to dissect the roles of the individual peptidases and to determine the peptidase-specif...
Source: Chemistry & Biology - October 30, 2009 Category: Chemistry Authors: Horn M, Nussbaumerová M, Sanda M, Kovárová Z, Srba J, Franta Z, Sojka D, Bogyo M, Caffrey CR, Kopácek P, Mares M Tags: Chem Biol Source Type: journals

Distribution of Antibodies Reactive to Borrelia lonestari and Borrelia burgdorferi in White-Tailed Deer (Odocoileus virginianus) Populations in the Eastern United StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - October 29, 2009 Category: Infectious Diseases Tags: article Source Type: journals

Forgotten treasure seekerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature 461, 1211 (2009). doi:10.1038/4611211a Author: Jennifer Rohn Until recently, histories of science were written almost entirely by, for and about men. The nineteenth-century hunt for Jurassic-era fossils along the beaches of the British town of Lyme Regis was no different. Although the names of naturalists such as Georges Cuvier, William Buckland and (Source: Nature)
Source: Nature - October 28, 2009 Category: Research Authors: Jennifer Rohn Tags: Autumn Books Source Type: journals

Profit Driven Swine Flu Propaganda - Pump Up the Volume - Part FourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is part four in a six-part series. Be sure to read part three at http://www.naturalnews.com/027310_swine_flu_health_Tamiflu.htmlThose in control of the mainstream media have joined together with public health officials to provide the pharmaceutical industry with the best swine flu promotional campaign that money can buy.In an October 7, 2009, OpEd News article titled, "The Centers for Disease Control: The Best Vaccination PR Firm Taxes Can Buy," the makers of the documentaries, "Vaccine Nation," and "Autism: Made in the USA," Richard Gale and Dr Gary Null wrote: "If the flu season goes according to schedule, t...
Source: NaturalNews.com - October 27, 2009 Category: Consumer Health Advice Source Type: news

Gender Bias in Chronic Lyme DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Women's Health Oct 2009, Vol. 18, No. 10: 1717-1718. (Source: Journal of Women)
Source: Journal of Women - October 26, 2009 Category: OBGYN Tags: article Source Type: journals

Non-linear dynamics of the complement system activation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The complement system (CS) plays a prominent role in the immune defense. The goal of this work is to study the dynamics of activation of the classic and alternative CS pathways based on the method of mathematical modeling. The principal difficulty that hinders modeling effort is the absence of the measured values of kinetic constants of many biochemical reactions forming the CS. To surmount this difficulty, an optimization procedure consisting of constrained minimization of the total protein consumption by the CS was designed. The constraints made use of published data on the in vitro kinetics of elimination of the Bor...
Source: Mathematical Biosciences - October 22, 2009 Category: Statistics Authors: Korotaevskiy AA, Hanin LG, Khanin MA Tags: Math Biosci Source Type: journals

Mary Anning and the Birth of PaleontologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Editor's note: The following is an excerpt from The Fossil Hunter: Dinosaurs, Evolution and the Woman Whose Discoveries Changed the World by Shelley Emling , published on October 13 by Palgrave Macmillan ( Scientific American is a Macmillan publication). The Fossil Hunter chronicles the work of Mary Anning , a woman born in 1799 in Lyme Regis on the south coast of England, who discovered the first documented dinosaur skeleton. In the following passage from the chapter entitled "A Long-Necked Beauty" Anning first discovers the skeleton of a previously unknown dinosaur type. Her find ...
Source: Scientific American - Official RSS Feed - October 21, 2009 Category: Science Tags: Archaeology & Paleontology,Biology,History of Science,Society Policy,Basic Science,Science Education,Dinosaurs Source Type: journals

One mother’s story: How strep throat attacked my child’s brainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maura Heckmann and her son, Chris Eleven-year-old Chris Heckmann was healthy and in good spirits when his mother, Maura, left him with friends for the night. But when she returned, 24 hours later, her son was unrecognizable. Stricken with paranoia, he refused to eat and paced around the family room, fear in his eyes. At first, doctors thought Chris had obsessive-compulsive disorder (OCD). But he was ultimately diagnosed with PANDAS, a controversial neuropsychiatric disorder thought to be related to routine childhood strep infections. Here, Maura tells the story of her son’s rapid decent into illness, and his road to re...
Source: Thrive, Children's Hospital Boston - October 20, 2009 Category: Pediatrics Authors: Kristin Cantu Tags: All posts mental illness OCD PANDAS strep throat Source Type: organizations

How to Avoid Health Harming ParasitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Technically a parasite is any organism that lives off another organism, so this could include bacteria, fungi and viruses. However for the purposes of health, when talking about parasites we are referring to protozoa (single celled organisms), arthropods (insects) and worms that invade and feed off the host organism, often causing them harm. This can range from mild symptoms to serious illness, as well as chronic health issues.Parasites can range from microscopic single cell protozoa to worms that are 15 feet long. The most common protozoan parasites in humans are Giardia lamblia, Enteramoeba histolytica, Bla...
Source: NaturalNews.com - October 18, 2009 Category: Consumer Health Advice Source Type: news

Is juvenile localized scleroderma related to Lyme borreliosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: The article by Prinz et al in the February 2009 issue of the Journal regarding 11 patients with “Borrelia-associated early-onset morphea” was solely based on serologic findings; the authors attributed the occurrence of localized scleroderma (morphea) in their patients to autoimmunity after a previous infection with Borrelia burgdorferi sensu lato. I have several objections to this attribution: (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - October 17, 2009 Category: Dermatology Authors: Klaus Weber Tags: Notes & Comments Source Type: journals

Toll-like receptors and NOD-like receptors in rheumatic diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The past 10 years has seen the description of families of receptors which drive pro-inflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease - the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology of rheumatoid arthritis, ankylosing spondylitis, lyme arthritis and osteoarthritis. Nalp3 has been identified as a key NLR for IL-1beta production and has been shown to have a particular role in gout. These findings present new therapeutic opportunities, possibly allowi...
Source: Arthritis Research and Therapy - October 13, 2009 Category: Rheumatology Authors: William McCormackAndrew ParkerLuke O'Neill Source Type: journals

CMO Update 49Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: CMO's Update Area: News The latest CMO Update includes the following topics: . Swine flu update . Making progress on revalidation . Brief advice to help smokers quit . Guidance for expert witnesses . Recording MRSA on death certificates . Testing for Lyme disease . Improving medicine safety . Safer pain management . Tackling alcohol-related harms . E-learning on venous thromboembolism (Source: NeLM - News)
Source: NeLM - News - October 7, 2009 Category: Drugs & Pharmacology Source Type: organizations

Small fiber neuropathy following vaccination for rabies, varicella or Lyme disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report five patients who developed paresthesias within one day to two months following vaccination for rabies, varicella zoster, or Lyme disease. On examination, there was mild sensory loss in distal extremities, preserved strength, normal or minimally abnormal electrodiagnostic findings, and decreased epidermal nerve fiber densities per skin biopsy. Empiric immunomodulatory therapy was tried in two patients and was ineffective. All patients' symptoms have improved, but persist. We conclude that an acute or subacute, post-vaccination small fiber neuropathy may occur and follow a chronic course. PMID: 19808027 [PubMe...
Source: Vaccine - October 2, 2009 Category: Allergy & Immunology Authors: Souayah N, Ajroud-Driss S, Sander HW, Brannagan TH, Hays AP, Chin RL Tags: Vaccine Source Type: journals

Peripheral neuropathy of the upper extremity: medical comorbidity that confounds common orthopedic pathology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the orthopedic patient, the diagnosis of a compression neuropathy may be straightforward. However, various medical comorbidities can obscure this diagnosis. It is paramount for the practicing orthopedic surgeon to have an appreciation for the medical pathology of common axonal neuropathies to properly diagnose, treat, and refer a patient with altered sensation in the upper extremity. The prevalence of diabetes in the United States is 10%, and roughly 20% of diabetic patients have peripheral neuropathy. In addition to diabetes, 32% of heavy alcohol users present with polyneuropathy. With advancements in the treatment...
Source: Orthopedics - September 30, 2009 Category: Orthopaedics Authors: Bales JG, Meals R Tags: Orthopedics Source Type: journals

Bell's palsy and Lyme disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843426 [PubMed - in process] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - September 30, 2009 Category: Primary Care Authors: Struthers S Tags: Br J Gen Pract Source Type: journals

Population structure of the Lyme borreliosis spirochete Borrelia burgdorferi in the western black-legged tick (Ixodes pacificus) in northern California.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Factors potentially contributing to the lower incidence of Lyme borreliosis (LB) in the far-western, as compared to the northeastern, US include tick host-seeking behavior resulting in fewer human tick encounters, lower densities of Borrelia burgdorferi-infected vector ticks in peridomestic environments, and genetic variation among B. burgdorferi spirochetes to which humans are exposed. We determined the population structure of B. burgdorferi in over 200 infected nymphs of the primary bridging vector to humans, Ixodes pacificus, collected in Mendocino County, CA. This was accomplished by sequence typing the spirochete ...
Source: Applied and Environmental Microbiology - September 24, 2009 Category: Microbiology Authors: Girard YA, Travinsky B, Schotthoefer A, Fedorova N, Eisen RJ, Eisen L, Barbour AG, Lane RS Tags: Appl Environ Microbiol Source Type: journals

Choropleth map legend design for visualizing community health disparitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cumulative frequency legends are useful supplements for choropleth maps. These legends can be constructed using readily available software. They contain all of the information found in standard choropleth map legends, and they can be used with any choropleth map classification scheme. Cumulative frequency legends effectively communicate the proportion of areas, the proportion of health events, and/or the proportion of the denominator population in which the health events occurred that falls within each class interval. They illuminate the context of disease through graphing associations with other variables. (So...
Source: International Journal of Health Geographics - September 23, 2009 Category: Global & Universal Authors: Robert CromleyEllen Cromley Source Type: journals

BBK07, a dominant in vivo antigen of Borrelia burgdorferi, is a potential marker for serodiagnosis of Lyme disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the recently identified Borrelia burgdorferi immunogens, BBK07, is characterized for its expression in the spirochete infection cycle and evaluated for its potential use as a serodiagostic marker for Lyme disease. We show that bbk07 is expressed at extremely low levels in vitro and in ticks, but is dramatically induced by spirochetes once introduced into the host, and is highly expressed throughout mammalian infection. In contrast, the expression of bbk12, a paralog of bbk07 with 87% amino acid identity, although expressed in vitro, remained undetectable in vivo throughout murine infection and in ticks. BBK07 is...
Source: Clinical and Vaccine Immunology - September 22, 2009 Category: Allergy & Immunology Authors: Coleman AS, Pal U Tags: Clin Vaccine Immunol Source Type: journals

Lyme disease patients rally for better diagnostic testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Canadian Lyme disease patients are calling for better doctor training and more accurate tests so sufferers can be diagnosed and treated quickly before their side effects become crippling and chronic. (Source: CTV Health)
Source: CTV Health - September 21, 2009 Category: Consumer Health News Source Type: news

Researchers To Probe Whether Lyme Disease Will Follow Spread Of Ticks Across U.S.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Potentially debilitating Lyme disease doesn't afflict people everywhere that the ticks harboring it are found. At least not yet. A five-university consortium led by a Michigan State University researcher wants to find out why. "These ticks are on the move. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 17, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Researchers To Probe Whether Lyme Disease Will Follow Spread Of Ticks Across U.S.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Potentially debilitating Lyme disease doesn't afflict people everywhere that the ticks harboring it are found. At least not yet. A five-university consortium wants to find out why. "These ticks are on the move. As ticks expand into new areas, more people will likely become infected," said Michigan State University fisheries and wildlife assistant professor Jean Tsao. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 17, 2009 Category: Science Source Type: news

Researchers to probe whether Lyme disease will follow spread of ticks across USEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Michigan State University) Potentially debilitating Lyme disease doesn't afflict people everywhere that the ticks harboring it are found. At least not yet. A five-university consortium led by a Michigan State University researcher wants to find out why. "These ticks are on the move. As ticks expand into new areas, more people will likely become infected," said MSU fisheries and wildlife assistant professor Jean Tsao. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 16, 2009 Category: Global & Universal Source Type: news

Canine Granulocytic Anaplasmosis: A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anaplasma phagocytophilum is an emerging pathogen of humans, horses, and dogs worldwide that is transmitted by Ixodid ticks and maintained in a variety of small wild mammal species. Recent studies suggest that multiple strains of A. phagocytophilum may be circulating in wild and domestic animal populations, and these strains may have differential host tropisms and pathogenicity. The organism infects and survives within neutrophils by disabling key neutrophil functions, including neutrophil motility, phagocytosis, the oxidative burst mechanism, and neutrophil-endothelial cell interactions, as well as interfering with neutro...
Source: Journal of Veterinary Internal Medicine - September 15, 2009 Category: Veterinary Research Authors: D.D. Carrade, J.E. Foley, D.L. Borjesson, J.E. Sykes Source Type: journals

BB0323 Function Is Essential for Borrelia burgdorferi Virulence and Persistence through Tick‐Rodent Transmission CycleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Borrelia burgdorferi bb0323 encodes an immunogenic protein in mammalian hosts, including humans. An analysis of bb0323 expression in vivo showed variable transcription throughout the spirochete infection cycle, with elevated expression during tick‐mouse transmission. Deletion of bb0323 in infectious B. burgdorferi did not affect microbial survival in vitro, despite considerable alterations in growth kinetics and cell morphology. The bb0323 mutants were unable to infect either mice or ticks and were quickly eliminated from immunocompet...
Source: The Journal of Infectious Diseases Latest Issue - September 15, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Toll‐Like Receptors 1 and 2 Heterodimers Alter Borrelia burgdorferi Gene Expression in Mice and TicksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Borrelia burgdorferi, the agent of Lyme disease, is recognized by Toll‐like receptor (TLR) 1 and 2 heterodimers. Microarray analysis of in vivo B. burgdorferi gene expression in murine skin showed that several genes were altered in TLR1/2‐deficient animals compared with wild‐type mice. For example, expression of bbe21 (a gene involved in B. burgdorferi lp25 plasmid maintenance) and bb0665 (a gene encoding a glycosyl transferase) were higher in TLR1/2‐deficient mice than in control animals. In contrast, messenger RNA levels for b...
Source: The Journal of Infectious Diseases Latest Issue - September 15, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

[News Focus] Evolutionary Biology: Melding Mammals and Molecules to Track EvolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Harvard University evolutionary biologist Hopi Hoekstra's first college summer job—as a tick target for researchers assessing where and when hikers were most susceptible to attacks by Lyme disease–transmitting ticks—made her itch for more fieldwork and, eventually, a life as a biologist.Author: Elizabeth Pennisi (Source: Science: Current Issue)
Source: Science: Current Issue - September 11, 2009 Category: Science Authors: Elizabeth Pennisi Source Type: journals

Uncommon manifestations of neuroborreliosis in children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report four unusual cases of childhood neuroborreliosis and show that seizures with regional leptomeningeal enhancement, acute transverse myelitis, meningoradiculitis with pain and paraesthesia and cranial nerve palsies other than facial nerve palsy can be the leading symptoms of children with neuroborreliosis. All children had serological evidence of an acute infection with Borrelia burgdorferi, a pleocytosis in the cerebrospinal fluid and a complete response to antibiotic treatment. An intrathecal synthesis of IgG antibodies was detected in three children. Thus, diagnostic work up in children with unusual neurological...
Source: European Journal of Paediatric Neurology - September 10, 2009 Category: Neurology Authors: Baumann M, Birnbacher R, Koch J, Strobl R, Rostásy K Tags: Eur J Paediatr Neurol Source Type: journals

Insect Repellants Dangerous?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Annoying mosquitoes can ruin your evening around the campfire, but the painful aftermath of a bite can be hazardous, as more diseases are spread by mosquitoes than any other insect or animal. Lyme disease, transmitted by ticks, has been detected in 49... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - September 8, 2009 Category: American Health Source Type: news