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No effect of irinotecan in patients with resistant desmoplastic small round cell tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 28, 2009 Category: Cancer & Oncology Authors: Gianni Bisogno, Riccardo Riccardi, Angela Scagnellato, Giampaolo Arcamone, Lucia Miglionico, Modesto Carli Source Type: journals

Pitfalls in the differential diagnosis of renal tumor in an adolescentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe an 11-year-old female with a primary intra-renal mass. Initial differential diagnoses included primitive neuroectodermal tumor (PNET), desmoplastic small round cell tumor (DSRCT), and Wilms Tumor (WT). Extensive pathologic and molecular analysis on initial and relapsed tumor samples confirmed WT. The EWS-WT1 and EWS-FLI1 rearrangements, distinctive of DSRCT and PNET were negative. The differential diagnosis on monophasic blastemal WT may be complex. Primary renal DSRCT and PNET have been rarely described. Nevertheless, molecular confirmation for these rare conditions may be necessary in selected cases. Pediatr ...
Source: Pediatric Blood and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Elvis Terci Valera, María Sol Brassesco, Maria Angélica Abdalla de Freitas Cortez, Rosane Gomes Queiroz, Angel Mauricio Castro-Gamero, Marcus Vinicius de Castro Barros, Yvone Avalloni Vicente, Silvio Tucci Junior, Carlos Alberto Scrideli, Luiz Gonzaga T Source Type: journals

Sequential intensified chemotherapy with stem cell rescue for children and adolescents with desmoplastic small round-cell tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
mone & M Carli (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - October 4, 2009 Category: Hematology Authors: G BisognoA FerrariA RosolenR AlaggioG ScarzelloA GaraventaG ArcamoneM Carli Source Type: journals

Retroperitoneal desmoplastic small round cell tumor: pediatric patient treated with multimodal therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe the case of an 8-year-old boy diagnosed with DSRCT located in the retroperitoneal space. The patient has undergone surgical resection and adjuvant chemoradiation therapy, and is currently alive without disease recurrence. PMID: 19725162 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 4, 2009 Category: Gastroenterology Authors: Kim YS, Cha SJ, Choi YS, Kim BG, Park SJ, Chang IT Tags: World J Gastroenterol Source Type: journals

Evaluation of pediatric abdominal masses by fine-needle aspiration cytology: A clinicoradiologic approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pathologist forms a very important part of the clinical team in the management of pediatric intra-abdominal masses in giving a rapid, accurate diagnosis for these potentially curable tumors. Fine-needle aspiration cytology (FNAC) is an invaluable tool in this regard when interpreted with clinicoradiologic parameters. With this in mind, we decided to evaluate the role of FNAC in pediatric abdominal masses in our institution. A total of 83 of 105 FNAC accessioned in the pathology department over 5 years (2003-2007) were studied. These included only cases where a diagnosis could be offered on cytology. Detailed clinicorad...
Source: Diagnostic Cytopathology - August 16, 2009 Category: Pathology Authors: Seethalakshmi Viswanathan, Sophia George, Mukta Ramadwar, Seema Medhi, Brijesh Arora, Purna Kurkure Source Type: journals

Long-term remission after CD34+-selected PBSCT in a patient with advanced intra-abdominal desmoplastic small round-cell tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Long-term remission after CD34+-selected PBSCT in a patient with advanced intra-abdominal desmoplastic small round-cell tumor Bone Marrow Transplantation advance online publication, August 31, 2009. doi:10.1038/bmt.2009.226 Authors: L Houet, I Möller, M Engelhardt, G Köhler, H Schmidt, D Herchenbach, M Schnitzler, A Schmitt-Graeff, A A Jungbluth, R Mertelsmann, B Rumstadt & C F Waller (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - July 30, 2009 Category: Hematology Authors: L HouetI MöllerM EngelhardtG KöhlerH SchmidtD HerchenbachM SchnitzlerA Schmitt-GraeffA A JungbluthR MertelsmannB RumstadtC F Waller Source Type: journals

[Sarcomas] Multicenter Phase II Trial of Sunitinib in the Treatment of Nongastrointestinal Stromal Tumor SarcomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Sunitinib demonstrated notable evidence of metabolic response in several patients with non-GIST sarcoma. The relevance of disease control observed in subtypes with an indolent natural history is unknown, however, the durable disease control observed in DSRCT, solitary fibrous tumor, and giant cell tumor of bone suggests that future evaluation of sunitinib in these subtypes may be warranted. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: George, Merriam, Maki, Van den Abbeele, Yap, Akhurst, Harmon, Bhuchar, O'Mara, D'Adamo, Morgan, Schwartz, Wagner, Butrynski, Demetri, Keohan Tags: Chemotherapy, Sarcomas Source Type: journals

Multicenter Phase II Trial of Sunitinib in the Treatment of Nongastrointestinal Stromal Tumor Sarcomas [Sarcomas]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Sunitinib demonstrated notable evidence of metabolic response in several patients with non-GIST sarcoma. The relevance of disease control observed in subtypes with an indolent natural history is unknown, however, the durable disease control observed in DSRCT, solitary fibrous tumor, and giant cell tumor of bone suggests that future evaluation of sunitinib in these subtypes may be warranted. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: George, Merriam, Maki, Van den Abbeele, Yap, Akhurst, Harmon, Bhuchar, O'Mara, D'Adamo, Morgan, Schwartz, Wagner, Butrynski, Demetri, Keohan Tags: Chemotherapy, Sarcomas Source Type: journals

Outpatient and Home Chemotherapy with Novel Local Control Strategies in Desmoplastic Small Round Cell TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report illustrates novel chemotherapy and local control interventions in a 5-year old patient. The patient was treated in the outpatient setting, achieved remission, with excellent quality of life. The patient presented with massive ascites and >1000 abdominal tumors. Neoadjuvant chemotherapy included vincristine (1.5 mg/m2), ifosfamide (3 g/m2/day×3), dexrazoxane/doxorubicin (750/75 mg/m2), and etoposide (150 mg/m2). Continuous hyperthermic peritoneal perfusion (CHPP) with cisplatin (100 mg/m2) was given after extensive cytoreductive surgery. This was followed by irinot...
Source: Sarcoma - June 9, 2009 Category: Cancer & Oncology Source Type: journals

Friend leukemia virus integration-1 (FLI-1) expression in gastrointestinal stromal tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Friend leukemia virus integration-1 can be expressed in a variety of tumors, and is helpful in making the diagnosis of Ewing's sarcoma/primitive neuroectodermal tumor. We think that this protein is not expressed in gastrointestinal stromal tumors and it is not a part of the pathogenesis of this disease. PMID: 19530039 [PubMed - in process] (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 31, 2009 Category: Gastroenterology Authors: Kaygusuz G, Kuzu I Tags: Turk J Gastroenterol Source Type: journals

Desmoplastic small round cell tumor in children: a new therapeutic approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The patients DSRCT are sensitive to an aggressive combination of chemotherapy, surgical debulking, and radiation therapy, followed by autologous BMT. It appears that this new multifaceted treatment offers good palliation, which may prolong survival and a possible cure. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - May 1, 2009 Category: Surgery Authors: Zainab Al Balushi, Sabrina Bulduc, Claudia Mulleur, Michel Lallier Tags: Caps Original Papers Source Type: journals

[Desmoplastic small round cell tumor of the abdomen: CT findings and radiologic-pathologic correlation in 3 cases.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the CT findings of abdominal desmoplastic small round cell tumor (DSRCT) in three patients. The most common imaging finding was the presence of single or multiple soft-tissue density intraperitoneal masses without apparent origin in an abdominal organ. In the first patient, a single peritoneal mass was located in the mesentery between the stomach and pancreas. In the second patient, an intraperitoneal pelvic mass was seen in the retrovesical space. In the third patient, a large homogeneous soft-tissue mass that nearly filled the entire peritoneal space was found. Two patients had multiple liver metastases and a...
Source: Radiologia - March 17, 2009 Category: Radiology Authors: Eiriz Martínez S, Conceição E Silva JP Tags: Radiologia Source Type: journals

Desmoplastic small round cell tumor of the central nervous system: report of two cases and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, CNS DSRCT follows a similar aggressive course as do peritoneal examples. Although rare, DSRCT warrants consideration in the differential diagnosis of “malignant small blue cell tumors” of the CNS. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00428-009-0750-xAuthors Luciano Neder, Mayo Clinic Department of Laboratory Medicine and Pathology 200 First Street, SW Rochester MN 55905 USABernd W. Scheithauer, Mayo Clinic Department of Laboratory Medicine and Pathology 200 First Street, SW Rochester MN 55905 USAKeki E. Turel, Bombay Hospital Institute of Medical Sciences Department of ...
Source: Virchows Archiv - March 5, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Potential Mesothelioma Treatment May Stop the Growth of TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A newly used cancer treatment has recently stopped the growth of aggressive sarcomas in two patients. One of the patients was diagnosed with malignant fibrous histiocytoma (MFH) and the other patient was diagnosed with desmoplastic small round cell tumor (DSRCT). After multiple surgeries and several different chemotherapy regimens had failed, the cancers were continuing to spread to other areas of their bodies. However, after just eight weeks of the NeoPlas Innovation’s treatment, scans revealed that both patients’ cancers had stopped spreading and some tumors had actually regressed. NeoPlas’ treatment is a combinati...
Source: Asbestos and Mesothelioma News - March 2, 2009 Category: Environmental Health Authors: jwhitmer Tags: Asbestos Exposure Mesothelioma Mesothelioma Treatment Mesothelioma Treatments Source Type: news

[Small round cell desmoplastic tumour. Atypical morphology in the sub-maxillary gland]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of desmoplastic small round cell tumour of the sub-maxillary gland, with an evolution of 8 months, affecting a 36 year old male. He suffered chronic lymphatic leukaemia five years ago and needed a bone marrow transplant. There was a 4x3 cm tumour. There were no signs of malignancy on the CT scan. A right sub-maxillectomy was performed. The pathology analysis gave a diagnosis of DSRCT. Post-surgical radiotherapy was given. The definitive diagnosis was reached using immunohistochemical techniques, such as polyphenotypical differentiation (epithelial, mesenchymal and neural), and by demonstration of transloca...
Source: Acta Otorrinolaringologica Espanola - March 1, 2009 Category: ENT & OMF Authors: Santos Gorjón P, Gómez González JL, Batuecas Caletrío A, Flores Corral MT, Sánchez González F Tags: Acta Otorrinolaringol Esp Source Type: journals

New Cancer Treatment Stops Aggressive SarcomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NASHVILLE, Tenn. -- After all standard treatments had failed, a new cancer treatment has stopped the growth of aggressive sarcomas in two recent patients. These results are similar to the new protocol's previous success against several cancers, including melanoma, pancreatic, colon, mesothelioma and other sarcomas. One of the patients is an 18-year-old with malignant fibrous histiocytoma (MFH) that arose in the largest bone of his leg. The cancer spread throughout his lungs, despite aggressive surgery that replaced most of his leg with metal implants. The second patient was losing a battle with desmoplastic small round cel...
Source: Cancercompass News: Other Cancer - February 27, 2009 Category: Cancer & Oncology Source Type: news

Comparative evaluation of flow-cytometric immunophenotyping and immunocytochemistry in the categorization of malignant small round cell tumors in fine-needle aspiration cytologic specimensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the authors evaluated the applicability of flow-cytometric immunophenotyping (FCI) and compared it with immunocytochemistry (ICC) for the accurate categorization of MSRCTs.In total, 37 consecutive MSRCTs that had been diagnosed with FNA cytology were analyzed by ICC and FCI using a panel of antibodies against desmin, vimentin, CD99/major histocompatibility class I-related antigen 2, neuron-specific enolase, and pancytokeratin. The final diagnoses included Ewing sarcoma (n = 17), rhabdomyosarcoma (n = 6; 4 embryonal and 2 alveolar subtypes), neuroblastoma (n = 10), desmoplastic small round cell tumor (n = 2),...
Source: Cancer Cytopathology - December 17, 2008 Category: Pathology Authors: Upasana Gautam, Radhika Srinivasan, Arvind Rajwanshi, Deepak Bansal, Ram Kumar Marwaha Source Type: journals

[Diagnosis in Oncology] Solitary Relapse of Desmoplastic Small Round Cell Tumor Detected by Positron Emission Tomography/Computed TomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2008 Category: Cancer & Oncology Authors: Kushner, Laquaglia, Gerald, Kramer, Modak, Cheung Tags: Rare tumor types, Diagnosis & Staging, Nuclear Medicine Diagnosis in Oncology Source Type: journals

A new molecular variant of desmoplastic small round cell tumor: significance of WT1 immunostaining in this entity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Desmoplastic small round cell tumor is a rare aggressive neoplasm, often presenting in young adult males. Although the classic features are well described, considerable clinical, pathologic, and immunohistochemical variation has been reported. The defining feature is a reciprocal translocation, t(11;22)(p13;q12), which fuses EWS on chromosome 22 to WT1 on chromosome 11. WT1 immunohistochemistry is reportedly useful in distinguishing desmoplastic small round cell tumor from other tumors. Herein, we describe a desmoplastic small round cell tumor of soft tissue with an unusual pattern of WT1 expression associated with a n...
Source: Human Pathology - August 12, 2008 Category: Pathology Authors: Murphy AJ, Bishop K, Pereira C, Chilton-Macneill S, Ho M, Zielenska M, Thorner PS Tags: Hum Pathol Source Type: journals

Paediatric renal tumours: recent developments, new entities and pathological features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Paediatric renal tumours represent a relatively common group of childhood solid neoplasms, in which both diagnosis and treatment are highly dependent on the histopathological findings. In addition to Wilms' tumour (nephroblastoma), a number of specific distinct entities are now reported, including (congenital) mesoblastic nephroma, clear cell sarcoma of the kidney, rhabdoid tumour of the kidney, specific paediatric variants of renal cell carcinoma, and others such as renal primitive neuroectodermal tumour and desmoplastic small round cell tumour. Recent advances in both molecular biological findings and immunohistochem...
Source: Histopathology - August 11, 2008 Category: Pathology Authors: Sebire NJ, Vujanic GM Tags: Histopathology Source Type: journals

Fine needle biopsy and genetics, two allied weapons in the diagnosis, prognosis, and target therapeutics of solid pediatric tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The recognition that genetic defects identify some pediatric solid tumors and may represent prognostic markers has provided cytologists with an extra tool for dealing with such tumors. Using some entities as archetypes, we discuss the importance of the association of fine needle biopsy and genetics, in the diagnosis, prognosis, and therapy selection of solid pediatric tumors. Immunocytochemistry is important to differentiate neuroblastoma, PNET/Ewing sarcoma, alveolar rhabdomyosarcoma, lymphoma, and desmoplastic small round cell tumor. Despite its usefulness in many cases, it is not conclusive and some of the aforementione...
Source: Diagnostic Cytopathology - August 1, 2008 Category: Pathology Authors: Helena Barroca Tags: Timely Review Source Type: journals

Imprint cytology of high-grade immature ovarian teratoma: A case report, literature review, and distinction from other ovarian small round cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immature ovarian teratoma (IOT) is a rare and aggressive malignant neoplasm characterized by immature neural tissue. The cytomorphologic features have only rarely been described. We herein describe an additional case and review the literature regarding this entity. To the best of our knowledge, this is the first reported case with imprint cytology. A 35-year-old woman presented with a pelvic mass which was resected and sent for frozen section evaluation. Imprint smears and frozen section of the mass were diagnostic of IOT. IOT has diagnostic cytologic features which show complete concordance with histology. Differential di...
Source: Diagnostic Cytopathology - July 10, 2008 Category: Pathology Authors: Preetha Ramalingam, Daniel Teague, Michelle Reid-Nicholson Tags: Brief Reports Source Type: journals

Desmoplastic small round cell tumor - abdomen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18723992 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - July 1, 2008 Category: Pathology Authors: Kinra P, Pujahari AK Tags: Indian J Pathol Microbiol Source Type: journals

Desmoplastic Small Round Cell Tumor: A Clinical, Pathological, and Immunohistochemical Study of 18 Chinese CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Desmoplastic small round cell tumor (DSRCT) was first reported in 1989. Generally, DSRCT is considered to be an aggressive malignant neoplasm that mainly occurs in the abdominal cavity and has been often seen in adolescents and young male adults. In the present study, a total of 18 cases of DSRCT reported in China between October 1998 and June 2006, including one case treated by the authors, were reviewed and analyzed. Among them, 14 had tumors in the abdominal cavity; the other four cases had tumors in the left fossa orbitalis, the root of the tongue, the soft tissue behind the left eyeball, and the abdominal wall (umbili...
Source: International Journal of Surgical Pathology - June 22, 2008 Category: Pathology Authors: Liping Cao, , Jun Ni, , Risheng Que, , Zhengrong Wu, , Zhenya Song, Tags: Article Source Type: journals

Intracerebral small round cell tumor: An unusual case with EWS-WT1 translocationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Desmoplastic small round cell tumor (DSRCT) is a rare tumor, seen both in children and young adults with a marked predilection for the peritoneal cavity. Histology showed a small round cell tumor with a fibromyxoïd stroma and immunohistochemistry indicated neural and mesenchymal differentiation, and diagnosis was made by molecular detection of the EWS-WT1 fusion gene product. DSRCT should be considered in the differential diagnosis of intracranial small round cell tumors. Pediatr Blood Cancer © 2008 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - June 16, 2008 Category: Cancer & Oncology Authors: Karim Bouchireb, Nathalie Auger, Ranjeev Bhangoo, Federico Di Rocco, Nicole Brousse, Olivier Delattre, Pascale Varlet, Jacques Grill Source Type: journals

Outpatient and Home Chemotherapy with Novel Local Control Strategies in Desmoplastic Small Round Cell TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report illustrates novel chemotherapy and local control interventions in a 5-year old patient. The patient was treated in the outpatient setting, achieved remission, with excellent quality of life. The patient presented with massive ascites and >1000 abdominal tumors. Neoadjuvant chemotherapy included vincristine (1.5 mg/m2), ifosfamide (3 g/m2/day×3), dexrazoxane/doxorubicin (750/75 mg/m2), and etoposide (150 mg/m2). Continuous hyperthermic peritoneal perfusion (CHPP) with cisplatin (100 mg/m2) was given after extensive cytoreductive surgery. This was followed by irinot...
Source: Sarcoma - June 12, 2008 Category: Cancer & Oncology Source Type: journals

[RSNA Education Exhibits] Neoplastic and Nonneoplastic Conditions of Serosal Membrane Origin: CT FindingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Computed tomography (CT) is an important imaging modality for diagnosis and follow-up of neoplastic or nonneoplastic conditions of the serosal membrane. The characteristic CT findings of malignant pleural mesothelioma include unilateral pleural effusion, thickening of the mediastinal pleura, and circumferential and nodular pleural thickening of greater than 1 cm. Malignant peritoneal mesothelioma manifests as a large mass or diffuse peritoneal thickening without a definable mass and is difficult to differentiate from peritoneal carcinomatosis or tuberculosis. The imaging features of primary serous papillary carcinoma of th...
Source: Radiographics recent issues - May 14, 2008 Category: Radiology Authors: Jeong, Y. J., Kim, S., Kwak, S. W., Lee, N. K., Lee, J. W., Kim, K.-I., Choi, K. U., Jeon, T. Y. Tags: Computed Tomography, General RSNA Education Exhibits Source Type: journals

Primary desmoplastic small round cell tumor of the femurEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 10-year-old girl with primary DSRCT arising within the left femur. The patient presented with knee pain, and radiological findings were strongly suggestive of osteogenic sarcoma. In addition to the typical microscopic appearance and immunophenotype, RT-PCR demonstrated the chimeric transcript of EWS-WT1, which is diagnostic of DSRCT. Pulmonary metastases were present at initial staging studies, but no abdominal or pelvic lesion was present. Despite chemotherapy and complete tumor excision, the patient developed progressive lung and bone metastases and died 3 years after initial presentation. This is the se...
Source: Skeletal Radiology - May 10, 2008 Category: Radiology Tags: Skeletal Radiology Source Type: journals

[AFIP Archives] From the Archives of the AFIP: Primary Peritoneal Tumors: Imaging Features with Pathologic CorrelationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Primary peritoneal tumors are uncommon lesions that arise from the mesothelial or submesothelial layers of the peritoneum. Primary malignant mesothelioma, multicystic mesothelioma, primary peritoneal serous carcinoma, leiomyomatosis peritonealis disseminata, and desmoplastic small round cell tumor are the most prominent of these rare lesions. Primary malignant mesothelioma is a highly aggressive malignancy that occurs most commonly in older men and that has a strong association with high levels of asbestos exposure. It manifests most often as diffuse sheetlike or nodular thickening of the peritoneal surfaces, but it may oc...
Source: Radiographics recent issues - March 18, 2008 Category: Radiology Authors: Levy, A. D., Arnaiz, J., Shaw, J. C., Sobin, L. H. Tags: AFIP Archives Source Type: journals

Significant clinical benefit of first-line palliative chemotherapy in advanced soft-tissue sarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The efficacy of palliative chemotherapy was investigated in a large group of patients with advanced soft-tissue sarcomas (STS) treated on routine palliative protocols.Patients with STS who had first-line chemotherapy for advanced and/or metastatic disease between 1991 and 2005 were identified from the Royal Marsden Hospital's sarcoma database. Patients with Ewing sarcoma, rhabdomyosarcoma, desmoplastic small round cell tumor, and gastrointestinal stromal tumors were excluded from the study.In all, 488 patients (242 male, 246 female) fulfilled the study criteria. The median age was 49 years and the majority (83%) received c...
Source: Cancer - February 15, 2008 Category: Cancer & Oncology Authors: Vasilios Karavasilis, Beatrice M. Seddon, Susan Ashley, Omar Al-Muderis, Cyril Fisher, Ian Judson Source Type: journals

Desmoplastic small round cell tumour: A review of literature and treatment options.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Surgical excision is only recommended for non-metastatic disease with combination chemo-radiotherapy as an adjunct. These modalities used in isolation may have less impact. Furthermore, the side effect profile from radiotherapy may outweigh any survival benefit. For advanced disease, symptom control is most important as these modalities impact survival minimally and palliation of secondary symptoms is paramount. Multi-disciplinary team and specialist centre review for histology and oncology are essential in managing this disease process and will enable greater numbers of patients to be enrolled into therapeutic...
Source: Surgical Oncology - January 9, 2008 Category: Surgery Authors: Stuart-Buttle CE, Smart CJ, Pritchard S, Martin D, Welch IM Tags: Surg Oncol Source Type: journals

Desmoplastic Small Round Cell Tumor (DSRCT) With Ovarian Involvement in 2 Young Women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 94DOI: 10.1097/01.pai.0000213158.71934.9cAuthors: Fang, Xueping MD *; Rodabaugh, Kerry MD +; Penetrante, Remedios MD ++; Wong, Michael MD, PhD [S]; Wagner, Timothy MD [//]; Sait, Sheila PhD + [sharp]; Mhawech-Fauceglia, Paulette MD + (Source: Applied Immunohistochemistry & Molecular Morphology)
Source: Applied Immunohistochemistry & Molecular Morphology - December 25, 2007 Category: Chemistry Tags: Abstract HTML PDF (405 K) Source Type: journals

Desmoplastic small round cell tumor of the lung: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18167230 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - December 20, 2007 Category: Journals (General) Authors: Wang ZM, Xiao WB, Zheng SS Tags: Chin Med J (Engl) Source Type: journals

Desmoplastic small round cell tumor masquerading as advanced ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
International Journal of Gynecological Cancer, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Bland AE, Shah AA, Piscitelli JT, Bentley RC, Secord AA. Desmoplastic small round cell tumor masquerading as advanced ovarian cancer. Int J Gynecol Cancer 2008.Desmoplastic small round cell tumor (DSRCT) is a rare abdominal malignancy usually diagnosed in ... (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - December 14, 2007 Category: Cancer & Oncology Tags: article CASE REPORTS Source Type: journals

Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the clinico-pathologic features of 18 cases of mesenchymal neoplasms of the major salivary glands experienced at Asan Medical Center, Seoul, Korea, from 1998 to 2004. Mesenchymal neoplasms accounted for 3.4% of the total of 524 major salivary gland tumors. The parotid gland was the preponderant site (15 cases). Thirteen tumors were benign, constituting 3.5% of the total of 371 benign neoplasms. Schwannomas were the most common benign tumors (six cases), followed by lipomas (three cases), plexiform neurofibroma, hemangioma, desmoid tumor, and solitary fibrous tumor (one each). The malignant tumors consisted ...
Source: European Archives of Oto-Rhino-Laryngology - October 13, 2007 Category: ENT & OMF Tags: European Archives of Oto-Rhino-Laryngology Source Type: journals

Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical and molecular study of four patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:</strong> DSRCT is an aggressive tumor that usually occurs in the peritoneum of young males. The tumor is characterized by the expression of cytokeratin, vimentin, desmin and WT-1. RT-PCR, using paraffin-embedded tissue sections, can effectively detect the characteristic <em>EWS-WT1</em> fusion gene transcript. PMID: 17964965 [PubMed - in process] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - October 1, 2007 Category: Journals (General) Authors: Lee YS, Hsiao CH Tags: J Formos Med Assoc Source Type: journals

[Diagnosis in Oncology] Desmoplastic Small Round Cell Tumor of Meckels DiverticulumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - July 30, 2007 Category: Cancer & Oncology Authors: Qureshi, Ramadwar, Viswanathan, Bakshi, Arora, Gupta, Laskar, Medhi, Muckaden, Banavali, Pai, Desai, Kurkure Tags: Diagnosis in Oncology Source Type: journals

Desmoplastic small round cell tumor: Using FISH as an ancillary technique to support cytologic diagnosis in an unusual caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Desmoplastic small round cell tumor is a rare and aggressive neoplasm that predominantly affects young males. In almost all cases, a reciprocal translocation is present resulting in the fusion of the Ewing sarcoma gene with the Wilms' tumor gene. Here we describe an unusual case occurring in a 59-year-old male, in which fluorescence in situ hybridization (FISH) was used in conjunction with immunohistochemical studies to confirm the diagnosis. To our knowledge, this is the first reported case of using FISH as an ancillary technique to confirm the cytologic diagnosis of this tumor. Diagn. Cytopathol. 2007;35:516-520. © 2007...
Source: Diagnostic Cytopathology - July 18, 2007 Category: Pathology Authors: Michael S. Waugh, Rajesh C. Dash, Kristi C. Turner, Leslie G. Dodd Source Type: journals

[Original articles] Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibodyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study was the first to show that FLI-1 can be seen in a variety of solid tumours, some of which had never been explored before. This finding should be kept in mind, especially when using FLI-1 as a marker for finding the primary origin of poorly differentiated metastatic tumour. Finally, despite the expression of FLI-1 in numerous malignancies, it is still considered to be highly sensitive and specific in distinguishing EWS/PNET from other tumour types in general and from other SRCTs in particular. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - June 8, 2007 Category: Pathology Authors: Mhawech-Fauceglia, P., Herrmann, F. R, Bshara, W., Odunsi, K., Terracciano, L., Sauter, G., Cheney, R. T, Groth, J., Penetrante, R., Mhawech-Fauceglia, P. Tags: Original articles Source Type: journals

From Krukenberg to Today: The Ever Present Problems Posed by Metastatic Tumors in the Ovary. Part IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is the second of a two-part consideration of metastatic tumors to the ovary. Here, the matter is considered in 16 categories, largely site-specific. The first tumor discussed is gastric carcinoma of intestinal-type whose ovarian manifestations have been the subject of a recent paper which emphasized its differences from the Krukenberg tumor. Coverage of intestinal adenocarcinoma emphasizes the landmark 1987 paper of RH Lash and WR Hart. The section on pancreatic neoplasms reemphasizes the problems caused by metastatic ductal carcinoma, considered primarily in Part I, and discusses less common issues such as spread of ...
Source: Advances in Anatomic Pathology - April 30, 2007 Category: Pathology Tags: Review Articles Source Type: journals

[Diagnosis in Oncology] Desmoplastic Small Round-Cell Tumor of the PancreasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - April 6, 2007 Category: Cancer & Oncology Authors: Ryan, Razak, Graham, Benson, Rowe, Haugk, Verrill Tags: Diagnosis in Oncology Source Type: journals

Hepatic metastasectomy in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There are little data regarding the safety and efficacy of hepatic metastasectomy for solid tumors in childhood. We reviewed our institutional experience to assess operative mortality and morbidity, technique of resection, local control, and survival in pediatric patients undergoing liver resection for metastases.All pediatric patients who underwent hepatic resection for metastatic disease from August 1988 to July 2005 were retrospectively identified and clinical data were collected.Fifteen patients were identified during this period and primary malignancies included neuroblastoma (7), Wilms tumor (3), osteogenic sarcoma (...
Source: Cancer - April 5, 2007 Category: Cancer & Oncology Authors: Wendy T. Su, Daniel N. Rutigliano, Maryam Gholizadeh, William R. Jarnagin, Leslie H. Blumgart, Michael P. La Quaglia Source Type: journals

Desmoplastic Small Round Cell Tumor of the Kidney in Childhood.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The American Journal of Surgical Pathology)
Source: The American Journal of Surgical Pathology - March 27, 2007 Category: Pathology Tags: Abstract HTML PDF (1.313 M) Source Type: journals

[Atypical desmoplastic small round cell tumor in a very young child]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 17568363 [PubMed - indexed for MEDLINE] (Source: Annales de Pathologie)
Source: Annales de Pathologie - February 1, 2007 Category: Pathology Authors: Berrebi D, Benkirane A, Ferkdadji L, de Lagausie P, Delattre O, Chomette P, Schleiermacher G, Michon J, Peuchmaur M Tags: Ann Pathol Source Type: journals

A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A Children's Oncology Group studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Imatinib mesylate is a small molecule inhibitor of certain tyrosine kinases, most notably the chimeric bcr-abl fusion protein found in CML. It also inhibits KIT and PDGF receptor tyrosine kinases in vitro. Ewing sarcoma, osteosarcoma, neuroblastoma, desmoplastic small round cell, and synovial sarcomas often overexpress KIT or the PDGF receptor. A phase II study of imatinib in children and young adults with select solid tumors was performed.Patients less than 30 years of age with refractory or recurrent Ewing sarcoma, osteosarcoma, neuroblastoma, desmoplastic small round cell, synovial sarcomas or GIST were eligible. Imatin...
Source: Pediatric Blood and Cancer - January 29, 2007 Category: Cancer & Oncology Authors: Mason Bond, Mark L. Bernstein, Alberto Pappo, Kirk R. Schultz, Mark Krailo, Susan M. Blaney, Peter C. Adamson Source Type: journals

Malignant small round cell tumor of the heart: a diagnostic dilemma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare malignant small round cell tumor of the heart in a 26-year-old woman. She had been symptomatic 15 days after vaginal delivery. Immunohistochemistry revealed divergent differentiation; hence, the tumor was designated as desmoplastic small round cell tumor. This is the first report of such a tumor in the heart. PMID: 17218216 [PubMed - indexed for MEDLINE] (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 1, 2007 Category: Cardiology Authors: George S, Vaideeswar P, Pandit S, Kane S, Khandeparkar J Tags: Cardiovasc Pathol Source Type: journals

Cytology of desmoplastic small round-cell tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to compare prechemotherapy and postchemotherapy cytomorphology of DSRCT and to evaluate for distinct chemotherapy-induced changes.The authors searched their respective institutional databases for all DSRCT cases with an associated FNAB. FNAB slides, immunocytochemistry, and cytogenetic results were reviewed.Six aspirates from 5 patients were identified, 3 of which were postchemotherapy. The postchemotherapy cases demonstrated cytologic findings not typically described in DSRCTs, including prominent and conspicuous nucleoli, discohesive single-cell architecture, and slightly larger cell size.Cytomorp...
Source: Cancer Cytopathology - December 15, 2006 Category: Pathology Authors: Alison E. Presley, Christina S. Kong, David M. Rowe, Kristen A. Atkins Source Type: journals

[Short reports] Coexpression of an unusual form of the EWS-WT1 fusion transcript and interleukin 2/15 receptor {beta}mRNA in a desmoplastic small round cell tumourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The induction of the IL-2/15 receptor signalling pathway may contribute to tumorigenesis in DSRCT through a paracrine or an autocrine system, even though the EWS–WT1 was an unusual form. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 4, 2006 Category: Pathology Authors: Nakanishi, Y, Oinuma, T, Sano, M, Fuchinoue, F, Komatsu, K, Seki, T, Obana, Y, Tabata, M, Kikuchi, K, Shimamura, M, Ohmori, K, Nemoto, N Source Type: journals

Sister Mary Joseph's nodule as presenting sign of a desmoplastic small round cell tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Umbilical metastases, also named Sister Mary Joseph's nodules, are well documented in the adult population and most often represent an underlying intra-abdominal malignancy, usually a carcinoma of gastrointestinal or gynecologic origin. They are indicative of widespread abdominal disease and are associated with a poor prognosis. An extensive review of the literature reveals only two such presentations in the pediatric population. A 14-year-old male presented with an umbilical mass, which was found to be a metastatic lesion of a desmoplastic small round cell tumor (DSRCT) of the abdomen. The diagnosis of an intra-abdominal ...
Source: Pediatric Blood and Cancer - September 26, 2006 Category: Cancer & Oncology Authors: Leslie Doros, Sue C. Kaste, Carlos Rodriguez-Galindo Source Type: journals