HIB Vaccine This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Microbiological characterization of Streptococcus pneumoniae and non-typeable Haemophilus influenzae isolates as primary causes of acute otitis media in Bulgarian children before the introduction of conjugate vaccines
Background: Pneumococcal and Haemophilus influenzae type b (Hib) vaccines were introduced in our national immunisation program in April 2010. The aims of this retrospective, laboratory-based study were to determine the serotypes and antibiotic resistance of Streptococcus pneumoniae and H. influenzae isolates from middle ear fluid (MEF) collected before the introduction of immunization. Methods: S. pneumoniae (n = 128) and H. influenzae (n = 40) strains isolated from MEF of children with AOM between 1994 and 2011 were studied. MICs were determined by a microdilution assay. Serotyping of S. pneumoniae was done by Que...
Source: Annals of Clinical Microbiology and Antimicrobials - March 25, 2013 Category: Microbiology Authors: Lena SetchanovaTomislav KostyanevAlexandra AlexandrovaIvan MitovDimitar NashevTodor Kantardjiev Source Type: research

ACIP Issues New Hib Statement
(MedPage Today) -- The Advisory Committee on Immunization Practices has approved the first statement on routine Haemophilus influenzae type b (Hib) vaccination since 1993. (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - February 21, 2013 Category: American Health Source Type: news

DTaP-IPV-Hep B-Hib Vaccine (Hexaxim(®)) : A Review of its Use in Primary and Booster Vaccination.
Abstract Hexaxim(®) (DTaP-IPV-Hep B-Hib) is a new, thiomersal-free, fully liquid, hexavalent combination pediatric vaccine containing diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, recombinant hepatitis B virus surface antigen produced in the yeast Hansenula polymorpha, and Haemophilus influenzae type b polysaccharide (polyribosylribitol phosphate) conjugated to tetanus toxoid. It is currently registered in markets outside of the EU for primary vaccination of infants from 6 weeks of age and for booster vaccination up to 24 months of age. In randomized controlled trials, primary vacc...
Source: Paediatric Drugs - January 22, 2013 Category: Pediatrics Authors: McCormack PL Tags: Paediatr Drugs Source Type: research

Adapting Group Sequential Methods to Observational Postlicensure Vaccine Safety Surveillance: Results of a Pentavalent Combination DTaP-IPV-Hib Vaccine Safety Study
To address gaps in traditional postlicensure vaccine safety surveillance and to promote rapid signal identification, new prospective monitoring systems using large health-care database cohorts have been developed. We newly adapted clinical trial group sequential methods to this observational setting in an original safety study of a combination diphtheria and tetanus toxoids and acellular pertussis adsorbed (DTaP), inactivated poliovirus (IPV), and Haemophilus influenzae type b (Hib) conjugate vaccine (DTaP-IPV-Hib) among children within the Vaccine Safety Datalink population. For each prespecified outcome, we conducted 11 ...
Source: American Journal of Epidemiology - January 10, 2013 Category: Epidemiology Authors: Nelson, J. C., Yu, O., Dominguez-Islas, C. P., Cook, A. J., Peterson, D., Greene, S. K., Yih, W. K., Daley, M. F., Jacobsen, S. J., Klein, N. P., Weintraub, E. S., Broder, K. R., Jackson, L. A. Tags: RESEARCH-ARTICLE Source Type: research

Uptake of oral rotavirus vaccine and timeliness of routine immunization in Brazil's National Immunization Program.
CONCLUSION: To maximize benefits of rotavirus vaccination, strategies are needed to improve timeliness of routine immunizations; monitoring rotavirus vaccine uptake and intussusception risk is needed to guide further recommendations for rotavirus vaccination. PMID: 23313652 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 10, 2013 Category: Allergy & Immunology Authors: Flannery B, Samad S, de Moraes JC, Tate JE, Danovaro-Holliday MC, de Oliveira LH, Rainey JJ Tags: Vaccine Source Type: research

Cost-effectiveness of Haemophilus influenzae type b (Hib) vaccine introduction in the universal immunization schedule in Haryana State, India
Conclusion Hib vaccine introduction is a cost-effective strategy in India. (Source: Health Policy and Planning)
Source: Health Policy and Planning - January 7, 2013 Category: Health Management Authors: Gupta, M., Prinja, S., Kumar, R., Kaur, M. Tags: Original articles Source Type: research

Global Immunization Vision and Strategy (GIVS): a mid-term analysis of progress in 50 countries
Within the overall framework set out in the Global Immunization Vision and Strategy (GIVS) for the period 2006–2015, over 70 countries had developed comprehensive Multi-Year Plans (cMYPs) by 2008, outlining their plans for implementing the GIVS strategies and for attaining the GIVS Goals at the midpoint in 2010 or earlier. These goals are to: (1) reach ≥90% and ≥80% vaccination coverage at national and district level, respectively; and (2) reduce measles-related mortality by 90% compared with the 2000 level. Fifty cMYPs were analysed along the four strategic areas of the GIVS: (1) protecting more people in a ch...
Source: Health Policy and Planning - January 7, 2013 Category: Health Management Authors: Kamara, L., Lydon, P., Bilous, J., Vandelaer, J., Eggers, R., Gacic-Dobo, M., Meaney, W., Okwo-Bele, J.-M. Tags: Original articles Source Type: research

Haemophilus influenzae type b combination vaccines and atopic disorders: A prospective cohort study.
CONCLUSION: There is a potential risk for AD after receiving Hib combination vaccines. Hib vaccination is important to the public health, and therefore the observation requires further investigations. PMID: 23265751 [PubMed - in process] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 1, 2012 Category: Journals (General) Authors: Wang IJ, Huang LM, Guo YL, Hsieh WS, Lin TJ, Chen PC Tags: J Formos Med Assoc Source Type: research

The Changing Profile of Pediatric Meningitis at a Referral Centre in Cape Town, South Africa
Conclusion: TBM remains the commonest cause of pediatric bacterial meningitis in the Western Cape. It is concerning that the percentage of TBM cases out of the total study population has more than doubled compared with that in previous surveys. The low prevalence and young age of H. influenzae meningitis cases confirm the benefits derived from H. influenzae type b (Hib) vaccination. (Source: Journal of Tropical Pediatrics)
Source: Journal of Tropical Pediatrics - November 30, 2012 Category: Tropical Medicine Authors: Wolzak, N. K., Cooke, M. L., Orth, H., van Toorn, R. Tags: Original Papers Source Type: research

New meningitis B vaccine gets go-ahead
The announcement of a new meningitis vaccine has been widely reported in the papers, with the Daily Star claiming it could soon save thousands of lives in the UK. The Daily Mail predicts it will "soon be offered to all babies" to protect against "the deadliest form of meningitis". The newly-approved Bexsero vaccine protects against group B meningococcus, which is the most common cause of bacterial meningitis in the UK. Meningitis is inflammation of the protective membranes around the brain and spinal cord. It can be caused by infection with various organisms, including bacteria, viruses and fungi. Bact...
Source: NHS News Feed - November 19, 2012 Category: Consumer Health News Tags: Medication Pregnancy/child Source Type: news

Antibiotic susceptibility in relation to genotype of Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae responsible for community-acquired pneumonia in children
Abstract Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae are the main pathogens causing community-acquired pneumonia (CAP). We identified S. pneumoniae (n = 241), H. influenzae (n = 123), and M. pneumoniae (n = 54) as causative pathogens from clinical findings and blood tests from pediatric CAP patients (n = 903) between April 2008 and April 2009. Identification of genes mediating antimicrobial resistance by real-time PCR was performed for all isolates of these three pathogens, as was antibiotic susceptibility testing using an agar dilution m...
Source: Journal of Infection and Chemotherapy - October 29, 2012 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: research

Acute epiglottitis in the era of post-Haemophilus influenzae type B (HIB) vaccine
Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00540-012-1500-9Authors Brian K. Reilly, Division of Otolaryngology, Children’s National Medical Center, 111 Michigan Avenue, N.W., Washington, D.C., 20010 USASrijaya K. Reddy, Department of Anesthesiology, Children’s National Medical Center, 111 Michigan Avenue, N.W., Washington, D.C., 20010 USASusan T. Verghese, Department of Anesthesiology, Children’s National Medical Center, 111 Michigan Avenue, N.W., Washington, D.C., 20010 USA Journal Journal of AnesthesiaOnline ISSN 1438-8359Print ISSN 0913-8668 (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - October 18, 2012 Category: Anesthesiology Tags: Journal of Anesthesia Source Type: research

Introduction of Haemophilus Influenzae type b (Hib) as Pentavalent(DPT-HepB-Hib) Vaccine in Two States of India.
PMID: 23024078 [PubMed - in process] (Source: Indian Pediatrics)
Source: Indian Pediatrics - September 8, 2012 Category: Pediatrics Authors: Gupta SK, Sosler S, Lahariya C Tags: Indian Pediatr Source Type: research

Combination vaccines in the South African setting.
Abstract The number of vaccines available and included as part of the national immunization schedules, has increased significantly over the past few decades. This impacts on patient/parent compliance and creates a challenge for health care providers for implementation of schedules necessitating training and infrastructure improvements. Use of combination rather than component vaccines offers advantages for compliance by single dose administration of various antigens, reducing stock costing as well as reducing cost of additional health care visits. Combination vaccines are often significantly more expensive than ind...
Source: Vaccine - September 7, 2012 Category: Allergy & Immunology Authors: Visser A, Hoosen A Tags: Vaccine Source Type: research

Haemophilus influenzae type b conjugate vaccines - A South African perspective.
Abstract Introduction of Hib vaccine is known to positively impact on reduction of both morbidity and mortality in children less than 5 years of age. Incorporation of this vaccine into a National EPI, however, does come at a significant cost, which is especially important in non-GAVI funded countries. Compounded reduction in response in certain patient populations and possible indication of booster doses further impacts on cost-benefit analyses. Despite these issues, South Africa has supplied Hib vaccine as part of the National EPI in the form of a combination vaccine, Pentaxim(®), which combines Hib with Diphther...
Source: Vaccine - September 7, 2012 Category: Allergy & Immunology Authors: Visser A, Hoosen A Tags: Vaccine Source Type: research

Immunogenicity and safety of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) co-administered with routine childhood vaccines in Taiwan.
CONCLUSION: PHiD-CV co-administered with routine childhood vaccines within the first 6 months of life, was highly immunogenic, and well tolerated in Taiwanese infants. PMID: 23021506 [PubMed - in process] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - September 1, 2012 Category: Journals (General) Authors: Lin TY, Lu CY, Chang LY, Chiu CH, Huang YC, Bock HL, Tang H, François N, Moreira M, Schuerman L, Huang LM Tags: J Formos Med Assoc Source Type: research

Haemophilus influenzae Type b Disease and Vaccine Booster Dose Deferral, United States, 1998-2009
CONCLUSIONS: The booster deferral did not have a significant impact on the burden of invasive Hib disease in children <5 years of age. Continued surveillance and serotype data are important to monitor changes in Hib incidence, especially during vaccine deferrals. Hib booster deferral is a reasonable short-term approach to a Hib vaccine shortage. (Source: PEDIATRICS)
Source: PEDIATRICS - August 31, 2012 Category: Pediatrics Authors: Briere, E. C., Jackson, M., Shah, S. G., Cohn, A. C., Anderson, R. D., MacNeil, J. R., Coronado, F. M., Mayer, L. W., Clark, T. A., Messonnier, N. E. Tags: Infectious Disease & Immunity Article Source Type: research

Haemophilus influenzae Type b Disease and Vaccine Booster Dose Deferral, United States, 1998-2009
Since the introduction of effective vaccines in the United States, the incidence of invasive Haemophilus influenzae type b (Hib) disease in children aged <5 years has decreased by 99%. In 2007, in response to limited vaccine supply, Hib booster doses were deferred for 18 months. This review found no significant change in the incidence of invasive Hib disease in the United States during the booster dose deferral period, suggesting that booster dose deferral is a reasonable approach to Hib vaccine shortages in the short-term. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - August 31, 2012 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

DTPa-HBV-IPV/Hib Vaccine (Infanrix hexa™): A Guide to Its Use in Infants.
Abstract Infanrix hexa™, a diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliomyelitis, and Haemophilus influenzae type b (Hib) conjugate vaccine, is indicated for primary and booster vaccination of infants. Available clinical data from more than a decade of experience with the vaccine indicate that primary and booster vaccination with Infanrix hexa™ is a safe and useful option for providing protection against the common childhood diseases of diphtheria, tetanus, poliomyelitis, pertussis, hepatitis B, and disease caused by Hib. PMID: 22873778 [PubMed - as supplied by publisher] (Source: Paediatric Drugs)
Source: Paediatric Drugs - August 8, 2012 Category: Pediatrics Authors: Lyseng-Williamson KA, Dhillon S Tags: Paediatr Drugs Source Type: research

Urinary tract infections
Even in the pre-Prevnar, pre-conjugated Hib vaccine era, urinary tract infection was the most common bacterial infection found in infants who presented with fever without localizing clinical findings. (Source: Modern Medicine Contemporary Pediatrics)
Source: Modern Medicine Contemporary Pediatrics - August 1, 2012 Category: Pediatrics Source Type: news

Quantitative proton magnetic resonance determination of N,N-dimethylformamide in one intermediate of the Quimi-Hib vaccine.
Abstract Quimi-Hib is a conjugate vaccine against Haemophilus influenza type b (Hib) where the Hib antigen is the only one produced by chemical synthesis. NMR has become the alternative of choice for the identity of intermediates during the chemical synthesis of Hib antigen. We explore a rapid quantitative proton magnetic resonance (qHNMR) assay for the determination of N,N-dimethylformamide (DMF) as a residual in one of the critical intermediates. The proposed assay has been shown to be accurate, precise for intermediate precision conditions (relative standard deviation <3% for spectrometer-to-spectrometer vari...
Source: Magnetic Resonance in Chemistry : MRC - August 1, 2012 Category: Chemistry Authors: Garrido Arteaga R, Cardoso San Jorge F, Rodríguez Montero Mdel C, Santana VF, Vérez Bencomo V, Castro HV Tags: Magn Reson Chem Source Type: research

Clinical trials field strategies with novel vaccines produced in Brazil
CONCLUSIONS: The field strategies were important to guarantee enrollment and protocol compliance, causing little interference in families' daily routine, pediatrics appointments and children's vaccine.OBJETIVO: Relatar las estrategias de campo utilizadas en dos ensayos clínicos con vacunas desarrolladas por el Instituto Butantan, en 2004 y 2006. MÉTODOS: Estudio de tipo relato de experiencia, en que se describe la planificación y la operacionalización de los ensayos clínicos, que evaluaron la imunogenicidad y la seguridad de la vacuna BCG combinada con la vacuna de la hepatitis B (VrHB-IB) y de la tetravalente bacteri...
Source: Revista Paulista de Pediatria - July 20, 2012 Category: Pediatrics Source Type: research

Consensus Recommendations on Immunization and IAP Immunization Timetable 2012.
Consensus Recommendations on Immunization and IAP Immunization Timetable 2012. Indian Pediatr. 2012 Jul 8;49(7):549-64 Authors: Indian Academy of Pediatrics Committee on Immunization (IAPCOI), Vashishtha VM, Sukumaran TU, Agrawal R, Parthasarathy A, Shah N, Shah R, Thacker N, Choudhury P, Prabhu S, Kasi SG, Sanjay S, Chitkara AJ, Mitra M, Yewale V, Mehta P Abstract JUSTIFICATION: Vaccinology today is a rapidly changing specialty of medical science where new developments are regularly taking place. There is a need to review/revise recommendations about existing vaccines in the light of recent information. ...
Source: Indian Pediatrics - July 8, 2012 Category: Pediatrics Authors: Indian Academy of Pediatrics Committee on Immunization (IAPCOI), Vashishtha VM, Sukumaran TU, Agrawal R, Parthasarathy A, Shah N, Shah R, Thacker N, Choudhury P, Prabhu S, Kasi SG, Sanjay S, Chitkara AJ, Mitra M, Yewale V, Mehta P Tags: Indian Pediatr Source Type: research

New Meningococcal-Hib Vaccine Protects Infants as Young as Age 6 Weeks
Family physicians now have a new weapon in their immunization armamentarium, thanks to the FDA's recent approval of GlaxoSmithKline Biologicals' application to market its meningococcal groups C and Y and Haemophilus (Source: AAFP Health of the Public)
Source: AAFP Health of the Public - June 20, 2012 Category: Primary Care Source Type: news

Improvement in the Purification Process of the Capsular Polysaccharide from Haemophilus influenzae Type b by Using Tangential Ultrafiltration and Diafiltration.
In this study, an improved process of polysaccharide purification was established based on tangential flow ultrafiltration using detergents (cocamidopropyl betaine and sodium deoxycholate), two selective ethanol precipitations steps, and extensive enzymatic hydrolysis as strategy. The relative purity (RP) related to protein and nucleic acids were 122∼263 and 294∼480, respectively, and compatible with the specifications established by the World Health Organization for Hib vaccine, RP ≥ 100. These results make this process simple, cheaper, efficient, environmentally friendly, and prone to be scaled up. PMID: 22...
Source: Applied Biochemistry and Biotechnology - June 5, 2012 Category: Biochemistry Authors: Albani SM, da Silva MR, Takagi M, Cabrera-Crespo J Tags: Appl Biochem Biotechnol Source Type: research

Invasive Haemophilus influenzae Serotype e and f Disease, England and Wales.
Abstract Haemophilus influenzae infection causes serious invasive disease, but incidence of the most virulent serotype, Hib, has dropped since introduction of routine Hib vaccination. In England and Wales, the incidence of 2 other serotypes, Hie and Hif, is increasing; during 2001-2010, there was an 11.0% year-on-year increase in Hif and a 7.4% increase in Hie. In 2009-2010, Hif incidence was 0.090/100,000 persons and Hie incidence 0.030/100,000, with higher rates among infants and older adults. Hie had a more severe clinical course; although outcome at 6 months was comparable for the 2 serotypes, case-fatality rat...
Source: Emerging Infectious Diseases - April 28, 2012 Category: Infectious Diseases Authors: Ladhani SN, Collins S, Vickers A, Litt DJ, Crawford C, Ramsay ME, Slack MP Tags: Emerg Infect Dis Source Type: research

Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB).
CONCLUSIONS: We could not conclude that the immune responses elicited by the combined vaccine were different from or equivalent to the separate vaccines. There was significantly less immunological response for HIB and tetanus and more local reactions in the combined injections. However, these differences rely mostly on one study each. Studies did not use an intention-to-treat (ITT) analysis and we were uncertain about the risk of bias in many of the studies. These results are therefore inconclusive. Studies addressing clinical end points whenever possible, using correct methodology and a large enough sample size should be ...
Source: Cochrane Database of Systematic Reviews - April 21, 2012 Category: Journals (General) Authors: Bar-On ES, Goldberg E, Hellmann S, Leibovici L Tags: Cochrane Database Syst Rev Source Type: research

DTaP5-IPV-Hib Vaccine (Pediacel): Profile Report
(Source: BioDrugs)
Source: BioDrugs - March 9, 2012 Category: Drugs & Pharmacology Authors: Frampton, James E. Tags: Adis Profile Report Source Type: research

Immunogenicity of a Haemophilus influenzae type b–tetanus conjugate vaccine when administered separately or in combined vaccines for primary immunization in two consecutive national schedules in Turkey
Conclusion: This study showed that even one dose administered in combination with other vaccines in a primary series decreased the level of anti-PRP. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 5, 2012 Category: Infectious Diseases Authors: Nurullah Yüksel, Ufuk Beyazova, Işil Fidan Balci, Fatma Nur Aksakal, Aysu Duyan Çamurdan, Figen Sahin, Seyyal Rota Tags: Original Reports Source Type: research

Febrile seizure risk raised on day of DTaP-IPV-Hib vaccination
Absolute risk of seizures is very low – and no excess risk of epilepsyRelated items from OnMedicaSuspended hepB jab gives long-term protectionStress in pregnancy may raise asthma riskHib cases down due to vaccine campaignMeasles programme must be stepped-up'MMR should be compulsory', says public health expert (Source: OnMedica Latest News)
Source: OnMedica Latest News - February 23, 2012 Category: UK Health Source Type: news

Pediatric Combo Vaccine Linked To Slight Risk Of Febrile Seizure
A study, published in JAMA of almost 400,000 children, showed that children had an increased risk of febrile seizures, a convulsion that occurs secondary to a rapid increase in body temperature on the day of the first and second vaccination, with the combined diphtheria-tetanus toxoids-acellular pertussis-inactivated poliovirus - Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine. However, the overall risk was low, with researchers observing no higher risk of epilepsy in those who were vaccinated, compared with those who were not... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 21, 2012 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news

Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b [Original Contribution]
Conclusions DTaP-IPV-Hib vaccination was associated with an increased risk of febrile seizures on the day of the first 2 vaccinations given at 3 and 5 months, although the absolute risk was small. Vaccination with DTaP-IPV-Hib was not associated with an increased risk of epilepsy. (Source: JAMA)
Source: JAMA - February 21, 2012 Category: Journals (General) Authors: Sun, Y., Christensen, J., Hviid, A., Li, J., Vedsted, P., Olsen, J., Vestergaard, M. Tags: Neurology, Epilepsy, Pediatric Neurology, Pediatrics, Neonatology and Infant Care, Public Health, Immunization, Quality of Care, Patient Safety/ Medical Error Original Contribution Source Type: research

Meningitis: is a major cause of disability amongst Papua New Guinea children?
Conclusions: A multidisciplinary approach is required to manage the child with meningitis. Adequate knowledge, resources and assistance about the condition among the health professionals, carers and teachers would enable the children to achieve the quality of life. [Box: see text]. PMID: 22256779 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - January 19, 2012 Category: Rehabilitation Authors: Karthikeyan P, Ramalingam KP Tags: Disabil Rehabil Source Type: research

Immunogenicity and safety of LBVH0101, a new Haemophilus influenzae type b tetanus toxoid conjugate vaccine, compared with Hiberix™ in Korean infants and children: A randomized trial.
CONCLUSIONS: LBVH0101 showed a good immunogenicity and safety profile in infants and children. The two-dose infant-priming schedule with a booster dose may suffice for Hib immunization in Korean infants (Clinical trial registration numbers: NCT01019772 and NCT01251133). PMID: 22245607 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 12, 2012 Category: Allergy & Immunology Authors: Kim KH, Kim YK, Kim NH, Chang SH, Lee J, Park EA, Park SE, Eun BW, Lee H, Lee HJ Tags: Vaccine Source Type: research

Two Decades of Experience With the Haemophilus influenzae Serotype b Conjugate Vaccine in the United Kingdom.
CONCLUSIONS: Control of Hib disease is currently the best that has been achieved since the introduction of the routine Hib vaccination almost 20 years ago. PMID: 22244051 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - January 11, 2012 Category: Drugs & Pharmacology Authors: Ladhani SN Tags: Clin Ther Source Type: research

Modeling Insights into Haemophilus influenzae Type b Disease, Transmission, and Vaccine Programs.
Abstract In response to the 2007-2009 Haemophilus influenzae type b (Hib) vaccine shortage in the United States, we developed a flexible model of Hib transmission and disease for optimizing Hib vaccine programs in diverse populations and situations. The model classifies population members by age, colonization/disease status, and antibody levels, with movement across categories defined by differential equations. We implemented the model for the United States as a whole, England and Wales, and the Alaska Native population. This model accurately simulated Hib incidence in all 3 populations, including the increased inc...
Source: Emerging Infectious Diseases - January 1, 2012 Category: Infectious Diseases Authors: Jackson ML, Rose CE, Cohn A, Coronado F, Clark TA, Wenger JD, Bulkow L, Bruce MG, Messonnier NE, Hennessy TW Tags: Emerg Infect Dis Source Type: research

Immune response to Haemophilus influenzae type b conjugate vaccine in preterm infants
Conclusions: There is a possibility that perinatal factors and the environment unique to preterm infants are related to their lower antibody positivity rates compared to full‐term infants. It may therefore be preferable to modify the proposed immunization schedule. (Source: Pediatrics International)
Source: Pediatrics International - December 22, 2011 Category: Pediatrics Authors: Kennosuke Tsuda, Shiho Iwasaki, Haruko Horiguchi, Masaaki Mori, Shigeru Nishimaki, Kazuo Seki, Masataka Taguri, Shumpei Yokota, Naruhiko Ishiwada Source Type: research

Childhood immunisation with conjugate vaccines and prevention of pneumonia
Principi and Esposito1 describe that widespread use of Haemophilus influenzae b (Hib) and pneumococcal conjugate vaccine (PCV7) has nearly eliminated pneumonia due to the first pathogen and significantly reduced the number of cases due to the second pathogen. So, they advise a strong recommendation of these vaccines worldwide. However, the Indonesia probe-trial cited by them actually found more cases of pneumonia admitted to hospital among those vaccinated, and meningitis admissions were not reduced significantly either. The trial did not support a major role for Hib vaccine in overall pneumonia prevention programmes, but ...
Source: Thorax - December 14, 2011 Category: Respiratory Medicine Authors: Das, R. R. Tags: PostScript Source Type: research

Recurrent bacterial meningitis by three different pathogens in an isolated asplenic child
We describe a girl with ICA who developed recurrent meningitis by three different pathogens. The first, meningitis by Escherichia coli, occurred 4 days after premature birth. The other two pathogens were serotype 6B Streptococcus pneumoniae and Haemophilus influenzae type b (Hib), at 18 and 25 months of age, respectively. The patient was successfully treated with prompt antimicrobial therapy in all episodes. Serum anti-polyribosylribitol phosphate (PRP) and anti-6B-type pneumococcal antibodies were below the levels for protective activity after natural infections. Although anti-PRP antibody was significantly ...
Source: Journal of Infection and Chemotherapy - December 6, 2011 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: research

A study of the variation in genetic diversity of Haemophilus Influenzae serotype b (Hib) strains in the UK between 1987 and 2010 using multilocus variable-number tandem repeat analysis (MLVA) Category: Lesson in Microbiology & Infection Control
In 1992 the UK added Haemophilus influenzae serotype b (Hib) vaccine to the infant immunisation schedule (at 2, 3, 4 months), resulting in a dramatic decline in the incidence of invasive Hib disease. From 1999 there was a resurgence of invasive Hib disease in fully vaccinated children, older children and adults, which has been controlled by the introduction in 2006 of a routine booster dose of Hib vaccine at 12 months of age. We have characterised over 700 Hib strains, collected between 1987 and 2010 from UK cases of invasive disease, using multilocus variable-number tandem repeat analysis (MLVA). This enabled us to study ...
Source: Journal of Infection - November 25, 2011 Category: Infectious Diseases Authors: Sapna Manglani, David Litt, Shona Neal, Mary Slack Tags: Abstracts Source Type: research

Hib vaccination changes epidemiology
ATLANTA, Nov. 13 (UPI) -- Vaccination over the past 20 years against the most common cause of bacterial meningitis dramatically reduced the disease in young children, researchers say. (Source: Health News - UPI.com)
Source: Health News - UPI.com - November 13, 2011 Category: Consumer Health News Source Type: news

Study Finds Shifting Disease Burden Following Universal Hib Vaccination
Vaccination against Haemophilus influenzae type b, or Hib, once the most common cause of bacterial meningitis in children, has dramatically reduced the incidence of Hib disease in young children over the past 20 years, according to a study published in Clinical Infectious Diseases and available online. However, other strains of the bacteria continue to cause substantial disease among the nation's youngest and oldest age groups... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 12, 2011 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Study finds shifting disease burden following universal Hib vaccination
(Infectious Diseases Society of America) Vaccination against Haemophilus influenzae type b, or Hib, once the most common cause of bacterial meningitis in children, has dramatically reduced the incidence of Hib disease in young children over the past 20 years, according to a study published in Clinical Infectious Diseases. However, other strains of the bacteria continue to cause substantial disease among the nation's youngest and oldest age groups. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 11, 2011 Category: Global & Universal Source Type: news

Evolving epidemiology of invasive Haemophilus infections in the post‐vaccination era: results from a long‐term population‐based study
Clin Microbiol InfectAbstractHistorically, Haemophilus influenzae (Hi) serotype b (Hib) caused most invasive Haemophilus infections worldwide, mainly in children. In 1989 routine childhood vaccination against Hib was initiated in Iceland. We conducted a population‐based study of all patients in the country with Haemophilus spp. isolated from sterile sites (n = 202), from 1983 to 2008. Epidemiology, clinical characteristics of the infections and serotypes of the isolates were compared during the pre‐vaccination (1983–1989) and post‐vaccination era (1990–2008). Following the vaccination, the overall incidence o...
Source: Clinical Microbiology and Infection - November 9, 2011 Category: Microbiology Authors: M. R. Berndsen, H. Erlendsdóttir, M. Gottfredsson Tags: ORIGINAL ARTICLE Source Type: research

Acute bacterial meningitis in infants and children: epidemiology and management.
Abstract Acute bacterial meningitis (ABM) continues to be associated with high mortality and morbidity, despite advances in antimicrobial therapy. The causative organism varies with age, immune function, immunization status, and geographic region, and empiric therapy for meningitis is based on these factors. Haemophilus influenzae type b (Hib), Streptococcus pneumoniae, and Neisseria meningitidis cause the majority of cases of ABM. Disease epidemiology is changing rapidly due to immunization practices and changing bacterial resistance patterns. Hib was the leading cause of meningitis in children prior to the introd...
Source: Paediatric Drugs - November 3, 2011 Category: Pediatrics Authors: Agrawal S, Nadel S Tags: Paediatr Drugs Source Type: research

DTaP(5)-IPV-Hib Vaccine (Pediacel®).
Abstract Pediacel® is a fully liquid formulation of a diphtheria, tetanus, five-component acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b combination vaccine, which does not require reconstitution. Both vial and prefilled syringe presentations of Pediacel® are available for use in the EU. In active-controlled clinical trials, primary and/or booster vaccination with Pediacel® was highly immunogenic, eliciting strong and sustained serologic responses against all its component toxoids/antigens when administered according to a variety of different schedules. In particular, pivotal studi...
Source: Paediatric Drugs - November 3, 2011 Category: Pediatrics Authors: Frampton JE Tags: Paediatr Drugs Source Type: research

Immune response to Haemophilus influenzae type b conjugate vaccine in preterm infants
Conclusions: There is a possibility that perinatal factors and the environment unique to preterm infants are related to their lower antibody positivity rates compared to full‐term infants. It may therefore be preferable to modify the proposed immunization schedule. (Source: Pediatrics International)
Source: Pediatrics International - November 1, 2011 Category: Pediatrics Authors: Kennosuke TsudaShiho IwasakiHaruko HoriguchiMasaaki MoriShigeru NishimakiKazuo SekiMasataka TaguriShumpei YokotaNaruhiko Ishiwada Source Type: research

DTaP5-IPV-Hib Vaccine (Pediacel)
(Source: Pediatric Drugs)
Source: Pediatric Drugs - October 23, 2011 Category: Pediatrics Authors: Frampton, James E. Tags: Adis Drug Profile Source Type: research

Haemophilus influenzae type b Carriage Among Young Children in Metropolitan Atlanta in the Context of Vaccine Shortage and Booster Dose Deferral.
Abstract Short-term deferral of the Haemophilus influenzae type b (Hib) vaccine booster dose during a recent U.S. Hib vaccine shortage did not result in widespread Hib carriage in Atlanta, as the Hib carriage rate was found to be 0.3% (1/342). Hi colonization was significantly more common among males and daycare attendees. PMID: 22012977 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - October 19, 2011 Category: Allergy & Immunology Authors: Thomas JD, Jackson ML, Sharma D, Mair R, Bach MC, Castillo D, Ejigiri OG, Satola S, Cohn AC, Jerris R, Jain S, Farley MM, Mayer LW, Messonnier NE Tags: Clin Vaccine Immunol Source Type: research